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Abstract 1745: Combining HRI/PERK/GCN2 inhibitor CRD-799 with proteasome inhibitors provides a novel approach to overcoming resistance in multiple myeloma treatment

Yasumichi Inoue, Koki Hikami, Shunsuke Ebara, Midori Sugiyama, Robert Oda, Akio Mizutani, Misaki Yoshida, Hiroko Yamakawa, Shigehiro Yagishita, Akinobu Hamada, Hidetoshi Hayashi, Takaomi Sanda, Masaki Ri, Shinsuke Iida, Daisuke Morishita

Cancer Res (2025) 85 (8_Supplement_1): 1745.

https://doi.org/10.1158/1538-7445.AM2025-1745

Published: 21 April 2025

View articletitled, Abstract 1745: Combining HRI/PERK/GCN2 inhibitor CRD-799 with proteasome inhibitors provides a novel approach to overcoming resistance in multiple myeloma treatment

Journal Articles

Abstract 424: Chromosomal instability leads to EGFR-TKI refractoriness via cGAS-STING activation in EGFR-mutated non-small cell lung cancer

Cancer Res (2025) 85 (8_Supplement_1): 424.

https://doi.org/10.1158/1538-7445.AM2025-424

Published: 21 April 2025

View articletitled, Abstract 424: Chromosomal instability leads to EGFR-TKI refractoriness via cGAS-STING activation in EGFR-mutated non-small cell lung cancer

Journal Articles

Myeloid Cells Induce Infiltration and Activation of B Cells and CD4⁺ T Follicular Helper Cells to Sensitize Brain Metastases to Combination Immunotherapy

Toshifumi Ninomiya, Naoya Kemmotsu, Fumiaki Mukohara, Masaki Magari, Ai Miyamoto, Youki Ueda, Takamasa Ishino, Joji Nagasaki, Tomohiro Fujiwara, Hidetaka Yamamoto, Hidetoshi Hayashi, Kota Tachibana, Joji Ishida, Yoshihiro Otani, Shota Tanaka, Shinichi Toyooka, Isamu Okamoto, Yosuke Togashi

Cancer Res (2025) 85 (6): 1082–1096.

https://doi.org/10.1158/0008-5472.CAN-24-2274

Published: 14 March 2025

View articletitled, Myeloid Cells Induce Infiltration and Activation of B Cells and CD4+ T Follicular Helper Cells to Sensitize Brain Metastases to Combination Immunotherapy

Includes: Supplementary data

Journal Articles

Abstract CT152: FURTHER: A global study to evaluate furmonertinib in patients with EGFR mutant NSCLC including uncommon EGFR mutations

Cancer Res (2024) 84 (7_Supplement): CT152.

https://doi.org/10.1158/1538-7445.AM2024-CT152

Published: 05 April 2024

View articletitled, Abstract CT152: FURTHER: A global study to evaluate furmonertinib in patients with EGFR mutant NSCLC including uncommon EGFR mutations

Journal Articles

Abstract 4331: Machine learning-based classification of tissue origin of cancer using methylation profiles

Marco A. De Velasco, Kazuko Sskai, Seiichiro Mitani, Yurie Kura, Shuji Minamoto, Takahiro Haeno, Hidetoshi Hayashi, Kazuto Nishio

Cancer Res (2024) 84 (6_Supplement): 4331.

https://doi.org/10.1158/1538-7445.AM2024-4331

Published: 22 March 2024

View articletitled, Abstract 4331: Machine learning-based classification of tissue origin of cancer using methylation profiles

Journal Articles

Abstract 1233: Novel inhibitor targeting triple integrated stress response kinase HRI, PERK, and GCN2 provides new insights into overcoming resistance to proteasome inhibitors in multiple myeloma

Cancer Res (2024) 84 (6_Supplement): 1233.

https://doi.org/10.1158/1538-7445.AM2024-1233

Published: 22 March 2024

View articletitled, Abstract 1233: Novel inhibitor targeting triple integrated stress response kinase HRI, PERK, and GCN2 provides new insights into overcoming resistance to proteasome inhibitors in multiple myeloma

Journal Articles

Abstract 2173: A multi-institutional prospective biomarker study of durvalumab after concurrent chemoradiation therapy in patients with unresectable stage III non-small cell lung cancer (WJOG11518L/SUBMARINE)

Cancer Res (2023) 83 (7_Supplement): 2173.

https://doi.org/10.1158/1538-7445.AM2023-2173

Published: 04 April 2023

View articletitled, Abstract 2173: A multi-institutional prospective biomarker study of durvalumab after concurrent chemoradiation therapy in patients with unresectable stage III non-small cell lung cancer (WJOG11518L/SUBMARINE)

Journal Articles

Abstract LB043: Efficacy of Lorlatinib in Treatment-Naïve Patients (pts) With ALK-Positive Advanced Non-Small Cell Lung Cancer (NSCLC) in Relation to EML4-ALK Variant Type and ALK Mutations

Alessandra Bearz, Jean-François Martini, Jacek Jassem, Sang-We Kim, Gee-Chen Chang, Alice Shaw, Deborah Shepard, Elisa Dall'O', Anna Polli, Holger Thurm, Gerard Zalcman, Maria Rosario Garcia Campelo, Konstantin Penkov, Hidetoshi Hayashi, Benjamin J. Solomon

Cancer Res (2021) 81 (13_Supplement): LB043.

https://doi.org/10.1158/1538-7445.AM2021-LB043

Published: 01 July 2021

View articletitled, Abstract LB043: Efficacy of Lorlatinib in Treatment-Naïve Patients (pts) With ALK-Positive Advanced Non-Small Cell Lung Cancer (NSCLC) in Relation to EML4-ALK Variant Type and ALK Mutations

Journal Articles

Abstract 1668: A comparative study of curated contents by knowledge-based curation system in cancer clinical sequencing

Masayuki Takeda, Kazuko Sakai, Shigeki Shimizu, Takayuki Takahama, Takeshi Yoshida, Satomi Watanabe, Tsutomu Iwasa, Kimio Yonesaka, Shinichiro Suzuki, Hidetoshi Hayashi, Hisato Kawakami, Yoshikane Nonagase, Kaoru Tanaka, Junji Tsurutani, Kazumasa Saigo, Akihiko Ito, Tetsuya Mitsudomi, Kazuhiko Nakagawa, Kazuto Nishio

Cancer Res (2019) 79 (13_Supplement): 1668.

https://doi.org/10.1158/1538-7445.AM2019-1668

Published: 01 July 2019

View articletitled, Abstract 1668: A comparative study of curated contents by knowledge-based curation system in cancer clinical sequencing

Journal Articles

Abstract 5169: Novel target molecules for treatment of cancer of unknown primary

Yoshihiko Fujita, Kazuko Sakai, Marco De Velasco, Takayasu Kurata, Hidetoshi Hayashi, Kazuhiko Nakagawa, Kazuto Nishio

Cancer Res (2018) 78 (13_Supplement): 5169.

https://doi.org/10.1158/1538-7445.AM2018-5169

Published: 01 July 2018

View articletitled, Abstract 5169: Novel target molecules for treatment of cancer of unknown primary

Journal Articles

Abstract 2939: Heregulin-induced resistance against HER2-targeted therapies in HER2 positive breast and gastric cancer in vitro and in vivo

Yoshikane Nonagase, Kimio Yonesaka, Satomi Watanabe, Koji Haratani, Takayuki Takahama, Naoki Takegawa, Hiroto Ueda, Hisato Kawakami, Hidetoshi Hayashi, Masayuki Takeda, Haruka Sakamoto, Takao Tamura, Kazuhiko Nakagawa, Junji Tsurutani

Cancer Res (2016) 76 (14_Supplement): 2939.

https://doi.org/10.1158/1538-7445.AM2016-2939

Published: 15 July 2016

View articletitled, Abstract 2939: Heregulin-induced resistance against HER2-targeted therapies in HER2 positive breast and gastric cancer in vitro and in vivo

Journal Articles

Abstract 3402: Activin signal promotes cancer progression and is involved in cachexia in a subset of pancreatic cancer

Yosuke Togashi, Akihiro Kogita, Hiroki Sakamoto, Hidetoshi Hayashi, Masato Terashima, Marco A. de Velasco, Kazuko Sakai, Yoshihiko Fujita, Shuta Tomida, Masayuki Kitano, Masatoshi Kudo, Kazuto Nishio

Cancer Res (2015) 75 (15_Supplement): 3402.

https://doi.org/10.1158/1538-7445.AM2015-3402

Published: 01 August 2015

View articletitled, Abstract 3402: Activin signal promotes cancer progression and is involved in cachexia in a subset of pancreatic cancer

Journal Articles

Abstract 4958: Melanoma transition is frequently accompanied by a loss of cytoglobin, a putative tumor suppressor, in melanocytes

Yoshihiko Fujita, Satoshi Koinuma, Marco De Velasco, Bolz Jan, Yosuke Togashi, Masato Terashima, Hidetoshi Hayashi, Takuya Matsuo, Kazuto Nishio

Cancer Res (2015) 75 (15_Supplement): 4958.

https://doi.org/10.1158/1538-7445.AM2015-4958

Published: 01 August 2015

View articletitled, Abstract 4958: Melanoma transition is frequently accompanied by a loss of cytoglobin, a putative tumor suppressor, in melanocytes

Journal Articles

Abstract 5271: Homozygous deletion of the activin A receptor, type IB gene is associated with an aggressive cancer phenotype in pancreatic cancer

Yosuke Togashi, Hiroki Sakamoto, Hidetoshi Hayashi, Masato Terashima, Marco A. de Velasco, Yoshihiko Fujita, Yasuo Kodera, Kazuko Sakai, Shuta Tomida, Masayuki Kitano, Masatoshi Kudo, Kazuto Nishio

Cancer Res (2014) 74 (19_Supplement): 5271.

https://doi.org/10.1158/1538-7445.AM2014-5271

Published: 01 October 2014

View articletitled, Abstract 5271: Homozygous deletion of the activin A receptor, type IB gene is associated with an aggressive cancer phenotype in pancreatic cancer

Journal Articles

Abstract 4446: Activation of HER Family signaling as a mechanism of acquired resistance to ALK Inhibitors in EML4-ALK-positive Non-Small Cell Lung Cancer.

Junko Tanizaki, Isamu Okamoto, Takafumi Okabe, Kazuko Sakai, Kaoru Tanaka, Hidetoshi Hayashi, Hiroyasu Kaneda, Ken Takezawa, Kazuto Nishio, Kazuhiko Nakagawa

Cancer Res (2013) 73 (8_Supplement): 4446.

https://doi.org/10.1158/1538-7445.AM2013-4446

Published: 15 April 2013

View articletitled, Abstract 4446: Activation of HER Family signaling as a mechanism of acquired resistance to ALK Inhibitors in EML4-ALK-positive Non-Small Cell Lung Cancer.

Journal Articles

Abstract 4533: Characteristics of HS6ST2 expression in colorectal cancer

Hideharu Kimura, Shigeru Hatabe, Tokuzo Arao, Hidetoshi Hayashi, Tomoyuki Nagai, Kazuko Matsumoto, Yoshihiko Fujita, Masao Fukushima, Akihiko Ito, Kiyotaka Okuno, Kazuto Nishio

Cancer Res (2012) 72 (8_Supplement): 4533.

https://doi.org/10.1158/1538-7445.AM2012-4533

Published: 15 April 2012

View articletitled, Abstract 4533: Characteristics of HS6ST2 expression in colorectal cancer

Journal Articles

Abstract 1209: Detection of EGFR T790M mutation in non-small-cell lung cancer patients using colony hybridization assay

Yoshihiko Fujita, Kenichi Suda, Hideharu Kimura, Kazuko Matsumoto, Tokuzo Arao, Tomoyuki Nagai, Hidetoshi Hayashi, Kazuyuki Furuta, Hiroaki Kato, Nagahiro Saijo, Yasushi Yatabe, Tetsuya Mitsudomi, kazuto Nishio

Cancer Res (2012) 72 (8_Supplement): 1209.

https://doi.org/10.1158/1538-7445.AM2012-1209

Published: 15 April 2012

View articletitled, Abstract 1209: Detection of EGFR T790M mutation in non-small-cell lung cancer patients using colony hybridization assay

Journal Articles

Abstract 424: Amplification of OCT4-pseudogene POU5F1B is a poor prognostic factor in gastric cancer

Hidetoshi Hayashi, Tokuzo Arao, Kazuko Matsumoto, Tomoyuki Nagai, Hideharu Kimura, Marco A. De Velasco, Yoshihiko Fujita, Yasuhide Yamada, Isamu Okamoto, Kazuhiko Nakagawa, Kazuto Nishio

Cancer Res (2012) 72 (8_Supplement): 424.

https://doi.org/10.1158/1538-7445.AM2012-424

Published: 15 April 2012

View articletitled, Abstract 424: Amplification of OCT4-pseudogene POU5F1B is a poor prognostic factor in gastric cancer

Journal Articles

A Human Erythrocyte-derived Growth-promoting Factor with a Wide Target Cell Spectrum: Identification as Catalase

Akihiko Takeuchi, Tomomi Miyamoto, Kayo Yamaji, Yasuhiko Masuho, Masaru Hayashi, Hidetoshi Hayashi, Kikuo Onozaki

Cancer Res (1995) 55 (7): 1586–1589.

Published: 01 April 1995

View articletitled, A Human Erythrocyte-derived Growth-promoting Factor with a Wide Target Cell Spectrum: Identification as Catalase

Journal Articles

Human Myelomonocytic Cell Line THP-1 Produces a Novel Growth-promoting Factor with a Wide Target Cell Spectrum

Akihiko Takeuchi, Hidetoshi Hayashi, Yukiko Naito, Tohru Baba, Takuya Tamatani, Kikuo Onozaki

Cancer Res (1993) 53 (8): 1871–1876.

Published: 01 April 1993

View articletitled, Human Myelomonocytic Cell Line THP-1 Produces a Novel Growth-promoting Factor with a Wide Target Cell Spectrum

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Abstract 1745: Combining HRI/PERK/GCN2 inhibitor CRD-799 with proteasome inhibitors provides a novel approach to overcoming resistance in multiple myeloma treatment

Abstract 424: Chromosomal instability leads to EGFR-TKI refractoriness via cGAS-STING activation in EGFR-mutated non-small cell lung cancer

Myeloid Cells Induce Infiltration and Activation of B Cells and CD4⁺ T Follicular Helper Cells to Sensitize Brain Metastases to Combination Immunotherapy

Abstract CT152: FURTHER: A global study to evaluate furmonertinib in patients with EGFR mutant NSCLC including uncommon EGFR mutations

Abstract 4331: Machine learning-based classification of tissue origin of cancer using methylation profiles

Abstract 1233: Novel inhibitor targeting triple integrated stress response kinase HRI, PERK, and GCN2 provides new insights into overcoming resistance to proteasome inhibitors in multiple myeloma

Abstract 2173: A multi-institutional prospective biomarker study of durvalumab after concurrent chemoradiation therapy in patients with unresectable stage III non-small cell lung cancer (WJOG11518L/SUBMARINE)

Abstract LB043: Efficacy of Lorlatinib in Treatment-Naïve Patients (pts) With ALK-Positive Advanced Non-Small Cell Lung Cancer (NSCLC) in Relation to EML4-ALK Variant Type and ALK Mutations

Abstract 1668: A comparative study of curated contents by knowledge-based curation system in cancer clinical sequencing

Abstract 5169: Novel target molecules for treatment of cancer of unknown primary

Abstract 2939: Heregulin-induced resistance against HER2-targeted therapies in HER2 positive breast and gastric cancer in vitro and in vivo

Abstract 3402: Activin signal promotes cancer progression and is involved in cachexia in a subset of pancreatic cancer

Abstract 4958: Melanoma transition is frequently accompanied by a loss of cytoglobin, a putative tumor suppressor, in melanocytes

Abstract 5271: Homozygous deletion of the activin A receptor, type IB gene is associated with an aggressive cancer phenotype in pancreatic cancer

Abstract 4446: Activation of HER Family signaling as a mechanism of acquired resistance to ALK Inhibitors in EML4-ALK-positive Non-Small Cell Lung Cancer.

Abstract 4533: Characteristics of HS6ST2 expression in colorectal cancer

Abstract 1209: Detection of EGFR T790M mutation in non-small-cell lung cancer patients using colony hybridization assay

Abstract 424: Amplification of OCT4-pseudogene POU5F1B is a poor prognostic factor in gastric cancer

A Human Erythrocyte-derived Growth-promoting Factor with a Wide Target Cell Spectrum: Identification as Catalase

Human Myelomonocytic Cell Line THP-1 Produces a Novel Growth-promoting Factor with a Wide Target Cell Spectrum

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