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Journal Articles

Abstract PO-049: Inhibiting MNK kinases promotes macrophage immunosuppressive phenotype to limit anti-tumor immunity

Thao N. D. Pham, Christina Spaulding, Mario A. Shields, Mahmoud G. Khalafalla, Daniel R. Principe, David J. Bentrem, Hidayatullah G. Munshi

Cancer Res (2021) 81 (22_Supplement): PO-049.

DOI: https://doi.org/10.1158/1538-7445.PANCA21-PO-049

Published: 15 November 2021

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Journal Articles

Abstract PO-094: Gα13 loss in KPC mouse model promotes well-differentiated pancreatic tumors that are susceptible to mTOR inhibition

Mario A. Shields, Christina Spaulding, Mahmoud G. Khalafalla, Thao N. D. Pham, Hidayatullah G. Munshi

Cancer Res (2021) 81 (22_Supplement): PO-094.

DOI: https://doi.org/10.1158/1538-7445.PANCA21-PO-094

Published: 15 November 2021

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Journal Articles

Abstract PO-060: Gna13 delays disease progression in mouse models of pancreatitis and pancreatic cancer

Mario A. Shields, Christina Spaulding, Mahmoud G. Khalafalla, Thao D.N. Pham, Hidayatullah G. Munshi

Cancer Res (2020) 80 (22_Supplement): PO-060.

DOI: https://doi.org/10.1158/1538-7445.PANCA20-PO-060

Published: 13 November 2020

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Journal Articles

Abstract 955: Long-term gemcitabine treatment reshapes the pancreatic tumor microenvironment and sensitizes murine carcinoma to combination immunotherapy

Daniel R. Principe, Matthew Narbutis, Sandeep Kumar, Alex Park, Navin Viswakarma, Matthew J. Dorman, Suneel D. Kamath, Paul Grippo, Melissa L. Fishel, Rosa F. Hwang, Dinesh Thummuri, Patrick W. Underwood, Hidayatullah G. Munshi, Jose G. Trevino, Ajay Rana

Cancer Res (2020) 80 (16_Supplement): 955.

DOI: https://doi.org/10.1158/1538-7445.AM2020-955

Published: 15 August 2020

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Journal Articles

Long-Term Gemcitabine Treatment Reshapes the Pancreatic Tumor Microenvironment and Sensitizes Murine Carcinoma to Combination Immunotherapy

Daniel R. Principe, Matthew Narbutis, Sandeep Kumar, Alex Park, Navin Viswakarma, Matthew J. Dorman, Suneel D. Kamath, Paul J. Grippo, Melissa L. Fishel, Rosa F. Hwang, Dinesh Thummuri, Patrick W. Underwood, Hidayatullah G. Munshi, Jose G. Trevino, Ajay Rana

Cancer Res (2020) 80 (15): 3101–3115.

DOI: https://doi.org/10.1158/0008-5472.CAN-19-2959

Published: 04 August 2020

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Includes: Supplementary data

Journal Articles

Abstract A20: Gemcitabine primes the pancreatic tumor microenvironment for second-line immunotherapy

Daniel R. Principe, Matthew Narbutis, Sandeep Kumar, Alex Park, Navin Viswakarma, Matthew J. Dorman, Suneel D. Kamath, Hidayatullah G. Munshi, Ajay Rana

Cancer Res (2019) 79 (24_Supplement): A20.

DOI: https://doi.org/10.1158/1538-7445.PANCA19-A20

Published: 13 December 2019

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Journal Articles

Abstract 2989: BET inhibitors induce Rac1-dependent MNK and eIF4E phosphorylation in cancer cells

Thao Pham, Brian T. Decant, Krishan Kumar, Meng Shang, Maria Matsangou, Kazumi Ebine, Hidayatullah G. Munshi

Cancer Res (2018) 78 (13_Supplement): 2989.

DOI: https://doi.org/10.1158/1538-7445.AM2018-2989

Published: 01 July 2018

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Journal Articles

Abstract 4500: BET proteins regulate hyaluronan synthases in pancreatic ductal adenocarcinoma

Krishan Kumar, Kazumi Ebine, Thao Pham, Meng Shang, Hidayatullah G. Munshi

Cancer Res (2018) 78 (13_Supplement): 4500.

DOI: https://doi.org/10.1158/1538-7445.AM2018-4500

Published: 01 July 2018

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Journal Articles

Abstract 1679: BET inhibitors suppress PD-L1 expression in pancreatic stellate cells

Kazumi Ebine, Brian T. DeCant, Katharine A. Collier, Thao N. Pham, Krishan Kumar, Hidayatullah G. Munshi

Cancer Res (2017) 77 (13_Supplement): 1679.

DOI: https://doi.org/10.1158/1538-7445.AM2017-1679

Published: 01 July 2017

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Journal Articles

Abstract B17: BET inhibitors block pancreatic stellate cell collagen production and attenuate fibrosis in vivo

Krishan Kumar, Brian DeCant, Hattaway Z. Hattaway, Paul J. Grippo, David J. Bentrem, Kazumi Ebine, Hidayatullah G. Munshi

Cancer Res (2016) 76 (24_Supplement): B17.

DOI: https://doi.org/10.1158/1538-7445.PANCA16-B17

Published: 14 December 2016

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Journal Articles

TGFβ Signaling in the Pancreatic Tumor Microenvironment Promotes Fibrosis and Immune Evasion to Facilitate Tumorigenesis

Daniel R. Principe, Brian DeCant, Emman Mascariñas, Elizabeth A. Wayne, Andrew M. Diaz, Naomi Akagi, Rosa Hwang, Boris Pasche, David W. Dawson, Deyu Fang, David J. Bentrem, Hidayatullah G. Munshi, Barbara Jung, Paul J. Grippo

Cancer Res (2016) 76 (9): 2525–2539.

DOI: https://doi.org/10.1158/0008-5472.CAN-15-1293

Published: 01 May 2016

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Includes: Supplementary data

Journal Articles

Abstract 2361: TGFβ signaling deficiency enhances tumor associated inflammation in colon cancer

Daniel R. Principe, Brian DeCant, Riley J. Mangan, Elizabeth A. Wayne, Andrew M. Diaz, Dominic Vitello, Hidayatullah G. Munshi, Paul Grippo, Barbara Jung

Cancer Res (2015) 75 (15_Supplement): 2361.

DOI: https://doi.org/10.1158/1538-7445.AM2015-2361

Published: 01 August 2015

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Journal Articles

Abstract C52: Collagen-mediated chromatin remodeling promotes chemoresistance in pancreatic cancer

Surabhi Y. Danqi-Garimella, Hidayatullah G. Munshi

Cancer Res (2011) 71 (18_Supplement): C52.

DOI: https://doi.org/10.1158/1538-7445.FBCR11-C52

Published: 28 October 2014

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Journal Articles

Abstract 1517: Pancreatic stellate cells and chemoresistant pancreatic cancer cells induce EMT gene expression in normal pancreatic ductal cells.

Krishan Kumar, Vaibhav Sahai, Kazumi Ebine, Hidayatullah G. Munshi

Cancer Res (2013) 73 (8_Supplement): 1517.

DOI: https://doi.org/10.1158/1538-7445.AM2013-1517

Published: 15 April 2013

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Journal Articles

Abstract 2449: The bromodomain inhibitor JQ1 blocks growth of pancreatic cancer cells in 3D collagen.

Vaibhav Sahai, Krishan Kumar, Kazumi Ebine, Halla Nimeiri, Hidayatullah G. Munshi

Cancer Res (2013) 73 (8_Supplement): 2449.

DOI: https://doi.org/10.1158/1538-7445.AM2013-2449

Published: 15 April 2013

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Journal Articles

Abstract 1336: Concurrent Snail expression and Kras mutation promote pancreatic fibrosis

Mario A. Shields, Mohammad WK Khan, Paul J. Grippo, Hidayatullah G. Munshi

Cancer Res (2012) 72 (8_Supplement): 1336.

DOI: https://doi.org/10.1158/1538-7445.AM2012-1336

Published: 15 April 2012

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Journal Articles

Abstract 3106: Collagen-mediated chromatin remodeling promotes chemoresistance in pancreatic cancer

Surabhi Y. Dangi-Garimella, Hidayatullah G. Munshi

Cancer Res (2012) 72 (8_Supplement): 3106.

DOI: https://doi.org/10.1158/1538-7445.AM2012-3106

Published: 15 April 2012

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Journal Articles

Abstract 515: Membrane type 1-matrix metalloproteinase cooperates with KrasG12D to promote pancreatic fibrosis through transforming growth factor-β activation of pancreatic stellate cells

Seth B. Krantz, Mario S. Shields, Surabhi Dangi-Garimella, Eric C. Cheon, Morgan R. Barron, Rosa F. Hwang, M Sambasiva Rao, Paul J. Grippo, David J. Bentrem, Hidayatullah G. Munshi

Cancer Res (2011) 71 (8_Supplement): 515.

DOI: https://doi.org/10.1158/1538-7445.AM2011-515

Published: 15 April 2011

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Journal Articles

Mast Cell 5-Lipoxygenase Activity Promotes Intestinal Polyposis in APC^Δ468 Mice

Eric C. Cheon, Khashayarsha Khazaie, Mohammad W. Khan, Matthew J. Strouch, Seth B. Krantz, Joseph Phillips, Nichole R. Blatner, Laura M. Hix, Ming Zhang, Kristen L. Dennis, Mohammed R. Salabat, Michael Heiferman, Paul J. Grippo, Hidayatullah G. Munshi, Elias Gounaris, David J. Bentrem

Cancer Res (2011) 71 (5): 1627–1636.

DOI: https://doi.org/10.1158/0008-5472.CAN-10-1923

Published: 01 March 2011

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Includes: Supplementary data

Journal Articles

Three-Dimensional Collagen I Promotes Gemcitabine Resistance in Pancreatic Cancer through MT1-MMP–Mediated Expression of HMGA2

Surabhi Dangi-Garimella, Seth B. Krantz, Morgan R. Barron, Mario A. Shields, Michael J. Heiferman, Paul J. Grippo, David J. Bentrem, Hidayatullah G. Munshi

Cancer Res (2011) 71 (3): 1019–1028.

DOI: https://doi.org/10.1158/0008-5472.CAN-10-1855

Published: 01 February 2011

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Includes: Supplementary data

NARROW

Abstract PO-049: Inhibiting MNK kinases promotes macrophage immunosuppressive phenotype to limit anti-tumor immunity

Abstract PO-094: Gα13 loss in KPC mouse model promotes well-differentiated pancreatic tumors that are susceptible to mTOR inhibition

Abstract PO-060: Gna13 delays disease progression in mouse models of pancreatitis and pancreatic cancer

Abstract 955: Long-term gemcitabine treatment reshapes the pancreatic tumor microenvironment and sensitizes murine carcinoma to combination immunotherapy

Long-Term Gemcitabine Treatment Reshapes the Pancreatic Tumor Microenvironment and Sensitizes Murine Carcinoma to Combination Immunotherapy

Abstract A20: Gemcitabine primes the pancreatic tumor microenvironment for second-line immunotherapy

Abstract 2989: BET inhibitors induce Rac1-dependent MNK and eIF4E phosphorylation in cancer cells

Abstract 4500: BET proteins regulate hyaluronan synthases in pancreatic ductal adenocarcinoma

Abstract 1679: BET inhibitors suppress PD-L1 expression in pancreatic stellate cells

Abstract B17: BET inhibitors block pancreatic stellate cell collagen production and attenuate fibrosis in vivo

TGFβ Signaling in the Pancreatic Tumor Microenvironment Promotes Fibrosis and Immune Evasion to Facilitate Tumorigenesis

Abstract 2361: TGFβ signaling deficiency enhances tumor associated inflammation in colon cancer

Abstract C52: Collagen-mediated chromatin remodeling promotes chemoresistance in pancreatic cancer

Abstract 1517: Pancreatic stellate cells and chemoresistant pancreatic cancer cells induce EMT gene expression in normal pancreatic ductal cells.

Abstract 2449: The bromodomain inhibitor JQ1 blocks growth of pancreatic cancer cells in 3D collagen.

Abstract 1336: Concurrent Snail expression and Kras mutation promote pancreatic fibrosis

Abstract 3106: Collagen-mediated chromatin remodeling promotes chemoresistance in pancreatic cancer

Abstract 515: Membrane type 1-matrix metalloproteinase cooperates with KrasG12D to promote pancreatic fibrosis through transforming growth factor-β activation of pancreatic stellate cells

Mast Cell 5-Lipoxygenase Activity Promotes Intestinal Polyposis in APC^Δ468 Mice

Three-Dimensional Collagen I Promotes Gemcitabine Resistance in Pancreatic Cancer through MT1-MMP–Mediated Expression of HMGA2

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