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Journal Articles

Abstract LB282: Overcoming chemotherapy resistance in pancreatic cancer: The impact of novel RAS inhibitors and tumor microenvironment modulation

Kevin C. Gulay, Jay Patel, Rithika Medari, Alexei Martsinkovskiy, Timothy Pham, Tatiana Hurtado De Mendoza, Andrew M. Lowy, Hervé Tiriac

Cancer Res (2025) 85 (8_Supplement_2): LB282.

https://doi.org/10.1158/1538-7445.AM2025-LB282

Published: 25 April 2025

View articletitled, Abstract LB282: Overcoming chemotherapy resistance in pancreatic cancer: The impact of novel RAS inhibitors and tumor microenvironment modulation

Journal Articles

Abstract 2582: Silencing MICAL2 expression in pancreatic cancer cells rewires the tumor microenvironment through the IL1-a/p38 MAP kinase/STAT-3 axis and sensitizes tumors to immune checkpoint blockade therapy

Bharti Garg, Evangeline S. Mose, Edgar Esparaze, Jay Patel, Rithika Medari, Sarah Sass, Alexei Martsinkovskiy, Asmina Courelli, Gisselle Gonzalez, Adam Engler, Parag Katira, Herve Tiriac, Andrew Lowy

Cancer Res (2025) 85 (8_Supplement_1): 2582.

https://doi.org/10.1158/1538-7445.AM2025-2582

Published: 21 April 2025

View articletitled, Abstract 2582: Silencing MICAL2 expression in pancreatic cancer cells rewires the tumor microenvironment through the IL1-a/p38 MAP kinase/STAT-3 axis and sensitizes tumors to immune checkpoint blockade therapy

Journal Articles

MICAL2 Promotes Pancreatic Cancer Growth and Metastasis

Cancer Res (2025) 85 (6): 1049–1063.

https://doi.org/10.1158/0008-5472.CAN-24-0744

Published: 14 March 2025

View articletitled, MICAL2 Promotes Pancreatic Cancer Growth and Metastasis

Includes: Supplementary data

Journal Articles

Abstract C052: Repurposing Statins to Target Gemcitabine Resistance in Pancreatic Cancer

Sabrina Calderon, Alica K. Beutel, Ethan Nghiem, Rima Singh, Natalie Yousefian, Cecily Anaraki, Kevin Gulay, Dennis Juarez, Alexander Kleger, Thomas Seufferlein, Alexander Muir, Cholsoon Jang, Herve Tiriac, David Fruman, Christopher Halbrook

Cancer Res (2024) 84 (17_Supplement_2): C052.

https://doi.org/10.1158/1538-7445.PANCREATIC24-C052

Published: 15 September 2024

View articletitled, Abstract C052: Repurposing Statins to Target Gemcitabine Resistance in Pancreatic Cancer

Journal Articles

Abstract A052: Silencing MICAL2 Expression in Pancreatic Cancer Cells rewires the tumor microenvironment through the IL1-a/p38 MAP kinase/STAT-3 axis and Sensitizes Tumors to Immune Checkpoint Blockade therapy

Bharti Garg, Evangeline Mose, Edgar Esparaza, Jay Patel, Rithika Medari, Alexei Martsinkovskiy, Carrie Bishop, Gissele Gonzalez, Adam Engler, Parag Katira, Herve Tiriac, Andrew M Lowy

Cancer Res (2024) 84 (17_Supplement_2): A052.

https://doi.org/10.1158/1538-7445.PANCREATIC24-A052

Published: 15 September 2024

View articletitled, Abstract A052: Silencing MICAL2 Expression in Pancreatic Cancer Cells rewires the tumor microenvironment through the IL1-a/p38 MAP kinase/STAT-3 axis and Sensitizes Tumors to Immune Checkpoint Blockade therapy

Journal Articles

Abstract B053: SUMOylation and TIGIT inhibition: a novel immunotherapy combination for pancreatic cancer

Jorge R de la Torre Medina, Utsav Joshi, Jaynath Shankara Narayanan, Herve Tiriac, Yuan Chen, Rebekah White

Cancer Res (2024) 84 (17_Supplement_2): B053.

https://doi.org/10.1158/1538-7445.PANCREATIC24-B053

Published: 15 September 2024

View articletitled, Abstract B053: SUMOylation and TIGIT inhibition: a novel immunotherapy combination for pancreatic cancer

Journal Articles

Abstract A035: 3D High-Density Collagen I Improves the Modeling of Aggressive Pancreatic Cancer

Kim Nguyen-Ta, Sural Ranamukhaarachchi, Jeffrey Turner, Utsav Joshi, Himangshu Sonowal, Jorge de la Torre Medina, Herve Tiriac, Stephanie Fraley, Rebekah White

Cancer Res (2024) 84 (17_Supplement_2): A035.

https://doi.org/10.1158/1538-7445.PANCREATIC24-A035

Published: 15 September 2024

View articletitled, Abstract A035: 3D High-Density Collagen I Improves the Modeling of Aggressive Pancreatic Cancer

Journal Articles

Abstract B043: Synergy of Subasumstat and anti-CD40 improves survival by augmenting tumor macrophage infiltration

Asimina Courelli, Kevin Li, James Lee, Herve Tiriac, Yuan Chen, Andrew Lowy

Cancer Res (2024) 84 (17_Supplement_2): B043.

https://doi.org/10.1158/1538-7445.PANCREATIC24-B043

Published: 15 September 2024

View articletitled, Abstract B043: Synergy of Subasumstat and anti-CD40 improves survival by augmenting tumor macrophage infiltration

Journal Articles

Abstract 1948: Resistance to RAS inhibition promotes remodeling of the immunosuppressive microenvironment of pancreatic cancer

Herve Tiriac

Cancer Res (2024) 84 (6_Supplement): 1948.

https://doi.org/10.1158/1538-7445.AM2024-1948

Published: 22 March 2024

View articletitled, Abstract 1948: Resistance to RAS inhibition promotes remodeling of the immunosuppressive microenvironment of pancreatic cancer

Journal Articles

Abstract 6777: An ex-vivo organotypic culture platform of mucinous carcinomatosis peritonei identifies CDK4-6 inhibition as a novel treatment

Jonathan Weitz, Daisuke Nishizaki, Jay Patel, Isabella Ng, Siming Sun, Dana Ramms, Jingjing Zou, Joel Baumgartner, Kaitlyn Kelly, Hitendra Patel, Rebekah White, Jula Veerapong, Peter Vu, Silvio Gutkind, Herve Tiriac, Shumei Kato, Andrew Lowy

Cancer Res (2024) 84 (6_Supplement): 6777.

https://doi.org/10.1158/1538-7445.AM2024-6777

Published: 22 March 2024

View articletitled, Abstract 6777: An ex-vivo organotypic culture platform of mucinous carcinomatosis peritonei identifies CDK4-6 inhibition as a novel treatment

Journal Articles

Abstract C114: Engrailed-1 promotes pancreatic cancer metastasis

Cancer Res (2024) 84 (2_Supplement): C114.

https://doi.org/10.1158/1538-7445.PANCA2023-C114

Published: 16 January 2024

View articletitled, Abstract C114: Engrailed-1 promotes pancreatic cancer metastasis

Journal Articles

Abstract A056: Targeting the mevalonate biosynthesis pathway in gemcitabine resistant pancreatic cancer

Alica K. Beutel, Sabrina Calderon, Ethan Nghiem, Rima Singh, Cecily Anaraki, Kevin Gulay, Herve Tiriac, Alexander Kleger, Thomas Seufferlein, Alexander Muir, Cholsoon Jang, Dennis Juarez, David Fruman, Christopher Halbrook

Cancer Res (2024) 84 (2_Supplement): A056.

https://doi.org/10.1158/1538-7445.PANCA2023-A056

Published: 16 January 2024

View articletitled, Abstract A056: Targeting the mevalonate biosynthesis pathway in gemcitabine resistant pancreatic cancer

Journal Articles

Abstract B096: Acquired resistance to KRAS inhibition modulates the pancreatic cancer tumor microenvironment

Kevin Christian Montecillo Gulay, Jay Patel, Isabella Ng, Tatiana Hurtado de Mendoza, Herve Tiriac, Andrew Lowy

Cancer Res (2024) 84 (2_Supplement): B096.

https://doi.org/10.1158/1538-7445.PANCA2023-B096

Published: 16 January 2024

View articletitled, Abstract B096: Acquired resistance to KRAS inhibition modulates the pancreatic cancer tumor microenvironment

Journal Articles

Abstract A039: Silencing MICAL2 expression in pancreatic cancer cells reduces IL-1A expression and inhibits tumor growth through a CD8+ T cell dependent mechanism

Bharti Garg, EvanGeline Mose, Edgar Esparza, Jay Patel, Sarah Sass, Alexei Martsinkovskiy, Dawn Jacquish, Herve Tiriac, Andrew M. Lowy

Cancer Res (2024) 84 (2_Supplement): A039.

https://doi.org/10.1158/1538-7445.PANCA2023-A039

Published: 16 January 2024

View articletitled, Abstract A039: Silencing MICAL2 expression in pancreatic cancer cells reduces IL-1A expression and inhibits tumor growth through a CD8+ T cell dependent mechanism

Journal Articles

Dual Inhibition of KRAS^G12D and Pan-ERBB Is Synergistic in Pancreatic Ductal Adenocarcinoma

Kevin Christian Montecillo Gulay, Xinlian Zhang, Vasiliki Pantazopoulou, Jay Patel, Edgar Esparza, Deepa Sheik Pran Babu, Satoshi Ogawa, Jonathan Weitz, Isabella Ng, Evangeline S. Mose, Minya Pu, Dannielle D. Engle, Andrew M. Lowy, Hervé Tiriac

Cancer Res (2023) 83 (18): 3001–3012.

https://doi.org/10.1158/0008-5472.CAN-23-1313

Published: 15 September 2023

View articletitled, Dual Inhibition of KRASG12D and Pan-ERBB Is Synergistic in Pancreatic Ductal Adenocarcinoma

Includes: Supplementary data

Journal Articles

Abstract 1328: Building a 3D co-culture model for metastatic pancreatic ductal cancer using Curiochips microphysiological system

Sumin Kim, Yeongmin Choi, Jihye Baek, Bharti Garg, Jan Pencik, Andrew M. Lowy, Herve Tiriac, Sanghee Yoo

Cancer Res (2023) 83 (7_Supplement): 1328.

https://doi.org/10.1158/1538-7445.AM2023-1328

Published: 04 April 2023

View articletitled, Abstract 1328: Building a 3D co-culture model for metastatic pancreatic ductal cancer using Curiochips microphysiological system

Journal Articles

Abstract B017: MICAL2 promotes pancreatic cancer growth and metastasis independent of MRTF-A signaling

Sohini Khan, Shweta Sharma, Divya Sood, Bharti Garg, Dawn Jaquish, Evangeline Mose, Edgar Esparza, Herve Tiriac, Andrew M. Lowy

Cancer Res (2022) 82 (22_Supplement): B017.

https://doi.org/10.1158/1538-7445.PANCA22-B017

Published: 15 November 2022

View articletitled, Abstract B017: MICAL2 promotes pancreatic cancer growth and metastasis independent of MRTF-A signaling

Journal Articles

Abstract A072: Strategies to improve KRAS G12D inhibitor (MRTX1133) therapy in pancreatic ductal adenocarcinoma

Kevin Christian M. Gulay, Edgar Esparza, Xinlian Zhang, Evangeline S. Mose, Jonathan Weitz, Minya Pu, Karen Messer, Andrew M. Lowy, Herve Tiriac

Cancer Res (2022) 82 (22_Supplement): A072.

https://doi.org/10.1158/1538-7445.PANCA22-A072

Published: 15 November 2022

View articletitled, Abstract A072: Strategies to improve KRAS G12D inhibitor (MRTX1133) therapy in pancreatic ductal adenocarcinoma

Journal Articles

Abstract C044: MICAL2 expression in pancreatic cancer cells modulates the tumor microenvironment through the TGF beta pathway

Bharti Garg, Shweta Sharma, Sohini Khan, Edgar Esparza, Sarah Sass, Dawn Jacquish, Evangeline Mose, Herve Tiriac, Andrew Lowy

Cancer Res (2022) 82 (22_Supplement): C044.

https://doi.org/10.1158/1538-7445.PANCA22-C044

Published: 15 November 2022

View articletitled, Abstract C044: MICAL2 expression in pancreatic cancer cells modulates the tumor microenvironment through the TGF beta pathway

Journal Articles

Abstract 289: A novel ex-vivo organotypic culture platform for functional interrogation of human appendiceal neoplasms

Jonathan Weitz, Tatiana Hurtado de Mendoza, Herve Tiriac, Joel Baumgartner, Kaitlyn Kelly, Jula Veerapong, Andrew Lowy

Cancer Res (2022) 82 (12_Supplement): 289.

https://doi.org/10.1158/1538-7445.AM2022-289

Published: 15 June 2022

View articletitled, Abstract 289: A novel ex-vivo organotypic culture platform for functional interrogation of human appendiceal neoplasms

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Abstract LB282: Overcoming chemotherapy resistance in pancreatic cancer: The impact of novel RAS inhibitors and tumor microenvironment modulation

Abstract 2582: Silencing MICAL2 expression in pancreatic cancer cells rewires the tumor microenvironment through the IL1-a/p38 MAP kinase/STAT-3 axis and sensitizes tumors to immune checkpoint blockade therapy

MICAL2 Promotes Pancreatic Cancer Growth and Metastasis

Abstract C052: Repurposing Statins to Target Gemcitabine Resistance in Pancreatic Cancer

Abstract A052: Silencing MICAL2 Expression in Pancreatic Cancer Cells rewires the tumor microenvironment through the IL1-a/p38 MAP kinase/STAT-3 axis and Sensitizes Tumors to Immune Checkpoint Blockade therapy

Abstract B053: SUMOylation and TIGIT inhibition: a novel immunotherapy combination for pancreatic cancer

Abstract A035: 3D High-Density Collagen I Improves the Modeling of Aggressive Pancreatic Cancer

Abstract B043: Synergy of Subasumstat and anti-CD40 improves survival by augmenting tumor macrophage infiltration

Abstract 1948: Resistance to RAS inhibition promotes remodeling of the immunosuppressive microenvironment of pancreatic cancer

Abstract 6777: An ex-vivo organotypic culture platform of mucinous carcinomatosis peritonei identifies CDK4-6 inhibition as a novel treatment

Abstract C114: Engrailed-1 promotes pancreatic cancer metastasis

Abstract A056: Targeting the mevalonate biosynthesis pathway in gemcitabine resistant pancreatic cancer

Abstract B096: Acquired resistance to KRAS inhibition modulates the pancreatic cancer tumor microenvironment

Abstract A039: Silencing MICAL2 expression in pancreatic cancer cells reduces IL-1A expression and inhibits tumor growth through a CD8+ T cell dependent mechanism

Dual Inhibition of KRAS^G12D and Pan-ERBB Is Synergistic in Pancreatic Ductal Adenocarcinoma

Abstract 1328: Building a 3D co-culture model for metastatic pancreatic ductal cancer using Curiochips microphysiological system

Abstract B017: MICAL2 promotes pancreatic cancer growth and metastasis independent of MRTF-A signaling

Abstract A072: Strategies to improve KRAS G12D inhibitor (MRTX1133) therapy in pancreatic ductal adenocarcinoma

Abstract C044: MICAL2 expression in pancreatic cancer cells modulates the tumor microenvironment through the TGF beta pathway

Abstract 289: A novel ex-vivo organotypic culture platform for functional interrogation of human appendiceal neoplasms

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