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Herbert M. Pinedo
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Journal Articles

Sulphasalazine down-regulates the expression of angiogenic factors, platelet derived endothelial cell growth factor / Thymidine phosphorylase (PD-ECGF /TP) and Interleukin 8 (IL-8) in human monocytic THP-1 and U937 cells

Michiel De Bruin, Ruud Oerlemans, Allan J. Masterson, Yehuda G. Assaraf, Ben A. C. Dijkmans, Auke D. Adema, Klaas Hoekman, Herbert M. Pinedo, Gerrit Jansen, Godefridus J. Peters
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 945–946.
Published: 01 April 2004
View article titled, Sulphasalazine down-regulates the expression of angiogenic factors, platelet derived endothelial cell growth factor / Thymidine phosphorylase (PD-ECGF /TP) and Interleukin 8 (IL-8) in human monocytic THP-1 and U937 cells
Journal Articles

Synergistic cytotoxicity of a conditionally replicating adenovirus expressing p53 and oxaliplatin on human colon cancer cell lines

Dinja Oosterhoff, Victor W. Van Beusechem, Epie Boven, Herbert M. Pinedo, Winald R. Gerritsen
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 268.
Published: 01 April 2004
View article titled, Synergistic cytotoxicity of a conditionally replicating adenovirus expressing p53 and oxaliplatin on human colon cancer cell lines
Journal Articles

Induction of drug resistance by basic Fibroblast Growth Factor (bFGF) in human melanoma cells

Dennis Fontijn, Frits J. Peters, Monique C. Duyndam, Herbert M. Pinedo, Epie Boven
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 140–141.
Published: 01 April 2004
View article titled, Induction of drug resistance by basic Fibroblast Growth Factor (bFGF) in human melanoma cells
Journal Articles

Polymorphic tandem repeats in the thymidylate synthase gene correlate with thymidylate synthase activity in normal tissues but not in malignant tissues of colorectal cancer patients

Robert Mauritz, Ines J. Beumer, Cees J. Van Groeningen, Herbert M. Pinedo, Godefridus J. Peters
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 1095–1096.
Published: 01 April 2004
View article titled, Polymorphic tandem repeats in the thymidylate synthase gene correlate with thymidylate synthase activity in normal tissues but not in malignant tissues of colorectal cancer patients
Journal Articles

Polarization of Vα24+ Vβ11+ Natural Killer T Cells of Healthy Volunteers and Cancer Patients Using α-Galactosylceramide-loaded and Environmentally Instructed Dendritic Cells

Hans J. J. van der Vliet, Johan W. Molling, Nobusuke Nishi, Allan J. Masterson, Wendy Kölgen, Steven A. Porcelli, Alfons J. M. van den Eertwegh, B. Mary E. von Blomberg, Herbert M. Pinedo, Giuseppe Giaccone, Rik J. Scheper
Journal: Cancer Research
Cancer Res (2003) 63 (14): 4101–4106.
Published: 21 July 2003
View article titled, Polarization of Vα24<sup>+</sup> Vβ11<sup>+</sup> Natural Killer T Cells of Healthy Volunteers and Cancer Patients Using α-Galactosylceramide-loaded and Environmentally Instructed Dendritic Cells
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Journal Articles

Conditionally Replicative Adenovirus Expressing p53 Exhibits Enhanced Oncolytic Potency

Victor W. van Beusechem, Petra B. van den Doel, Jacques Grill, Herbert M. Pinedo, Winald R. Gerritsen
Journal: Cancer Research
Cancer Res (2002) 62 (21): 6165–6171.
Published: 01 November 2002
View article titled, Conditionally Replicative Adenovirus Expressing p53 Exhibits Enhanced Oncolytic Potency
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Journal Articles

Potential of the Conditionally Replicative Adenovirus Ad5-Δ24RGD in the Treatment of Malignant Gliomas and Its Enhanced Effect with Radiotherapy

Martine L. M. Lamfers, Jacques Grill, Clemens M. F. Dirven, Victor W. van Beusechem, Birgit Geoerger, Jaap van den Berg, Ramon Alemany, Juan Fueyo, David T. Curiel, Gilles Vassal, Herbert M. Pinedo, W. Peter Vandertop, Winald R. Gerritsen
Journal: Cancer Research
Cancer Res (2002) 62 (20): 5736–5742.
Published: 15 October 2002
View article titled, Potential of the Conditionally Replicative Adenovirus Ad5-Δ24RGD in the Treatment of Malignant Gliomas and Its Enhanced Effect with Radiotherapy
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Journal Articles

Determinants of Activity of the Antifolate Thymidylate Synthase Inhibitors Tomudex (ZD1694) and GW1843U89 against Mono- and MultilayeredColon Cancer Cell Lines under Folate-restricted Conditions

Godefridus J. Peters, Evelien Smitskamp-Wilms, Kees Smid, Herbert M. Pinedo, Gerrit Jansen
Journal: Cancer Research
Cancer Res (1999) 59 (21): 5529–5535.
Published: 01 November 1999
View article titled, Determinants of Activity of the Antifolate Thymidylate Synthase Inhibitors Tomudex (ZD1694) and GW1843U89 against Mono- and MultilayeredColon Cancer Cell Lines under Folate-restricted Conditions
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Journal Articles

Antifolate Resistance Mediated by the Multidrug Resistance Proteins MRP1 and MRP2

Jan Hendrik Hooijberg, Henk J. Broxterman, Marcel Kool, Yehuda G. Assaraf, Godefridus J. Peters, Paul Noordhuis, Rik J. Scheper, Piet Borst, Herbert M. Pinedo, Gerrit Jansen
Journal: Cancer Research
Cancer Res (1999) 59 (11): 2532–2535.
Published: 01 June 1999
View article titled, Antifolate Resistance Mediated by the Multidrug Resistance Proteins MRP1 and MRP2
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Journal Articles

Inheritance of Abnormal Expression of SOS-like Response in Xeroderma Pigmentosum and Hereditary Cancer-prone Syndromes

Peter J. Abrahams, Ada Houweling, Paulien D. M. Cornelissen-Steijger, Fré Arwert, Fred H. Menko, Herbert M. Pinedo, Carrol Terleth, Alex J. van der Eb
Journal: Cancer Research
Cancer Res (1996) 56 (11): 2621–2625.
Published: 01 June 1996
View article titled, Inheritance of Abnormal Expression of SOS-like Response in Xeroderma Pigmentosum and Hereditary Cancer-prone Syndromes
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Journal Articles

Functional Activity of the Reduced Folate Carrier in KB, MA104, and IGROV-I Cells Expressing Folate-binding Protein

G. Robbin Westerhof, Simon Rijnboutt, Jan H. Schornagel, Herbert M. Pinedo, Godefridus J. Peters, Gerrit Jansen
Journal: Cancer Research
Cancer Res (1995) 55 (17): 3795–3802.
Published: 01 September 1995
View article titled, Functional Activity of the Reduced Folate Carrier in KB, MA104, and IGROV-I Cells Expressing Folate-binding Protein
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Journal Articles

Development and Molecular Characterization of a 2′,2′-Difluorodeoxycytidine-resistant Variant of the Human Ovarian Carcinoma Cell Line A2780

Veronique W. T. Ruiz van Haperen, Gijsbert Veerman, Staffan Eriksson, Epie Boven, Alexander P. A. Stegmann, Mario Hermsen, Jan B. Vermorken, Herbert M. Pinedo, Godefridus J. Peters
Journal: Cancer Research
Cancer Res (1994) 54 (15): 4138–4143.
Published: 01 August 1994
View article titled, Development and Molecular Characterization of a 2′,2′-Difluorodeoxycytidine-resistant Variant of the Human Ovarian Carcinoma Cell Line A2780
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Journal Articles

Overexpression of a Mr 110,000 Vesicular Protein in Non-P-Glycoprotein-mediated Multidrug Resistance

Rik J. Scheper, Henricus J. Broxterman, George L. Scheffer, Patricia Kaaijk, William S. Dalton, Theodorus H. M. van Heijningen, Coen K. van Kalken, Marilyn L. Slovak, Elisabeth G. E. de Vries, Paul van der Valk, Chris J. L. M. Meijer, Herbert M. Pinedo
Journal: Cancer Research
Cancer Res (1993) 53 (7): 1475–1479.
Published: 01 April 1993
View article titled, Overexpression of a <em>M</em><sub>r</sub> 110,000 Vesicular Protein in Non-P-Glycoprotein-mediated Multidrug Resistance
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Journal Articles

Elevation of Thymidylate Synthase following 5-Fluorouracil Treatment Is Prevented by the Addition of Leucovorin in Murine Colon Tumors

Clasina L. Van der Wilt, Herbert M. Pinedo, Kees Smid, Godefridus J. Peters
Journal: Cancer Research
Cancer Res (1992) 52 (18): 4922–4928.
Published: 01 September 1992
View article titled, Elevation of Thymidylate Synthase following 5-Fluorouracil Treatment Is Prevented by the Addition of Leucovorin in Murine Colon Tumors
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Journal Articles

Time Dependence of the Selective Modulation of Cisplatin-induced Nephrotoxicity by WR2721 in the Mouse

Marco Treskes, Epie Boven, Ulbe Holwerda, Herbert M. Pinedo, Wim J. F. van der Vijgh
Journal: Cancer Research
Cancer Res (1992) 52 (8): 2257–2260.
Published: 01 April 1992
View article titled, Time Dependence of the Selective Modulation of Cisplatin-induced Nephrotoxicity by WR2721 in the Mouse
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Journal Articles

Energy-dependent Processes Involved in Reduced Drug Accumulation in Multidrug-resistant Human Lung Cancer Cell Lines without P-Glycoprotein Expression

Carolina H. M. Versantvoort, Henricus J. Broxterman, Herbert M. Pinedo, Elisabeth G. E. de Vries, Nicole Feller, Catharina M. Kuiper, Jan Lankelma
Journal: Cancer Research
Cancer Res (1992) 52 (1): 17–23.
Published: 01 January 1992
View article titled, Energy-dependent Processes Involved in Reduced Drug Accumulation in Multidrug-resistant Human Lung Cancer Cell Lines without P-Glycoprotein Expression
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Journal Articles

Correlation of Multidrug Resistance with Decreased Drug Accumulation, Altered Subcellular Drug Distribution, and Increased P-Glycoprotein Expression in Cultured SW-1573 Human Lung Tumor Cells

Hiskias G. Keizer, Gerrit J. Schuurhuis, Henk J. Broxterman, Jan Lankelma, Willem G. E. J. Schoonen, Johan van Rijn, Herbert M. Pinedo, Hans Joenje
Journal: Cancer Research
Cancer Res (1989) 49 (11): 2988–2993.
Published: 01 June 1989
View article titled, Correlation of Multidrug Resistance with Decreased Drug Accumulation, Altered Subcellular Drug Distribution, and Increased P-Glycoprotein Expression in Cultured SW-1573 Human Lung Tumor Cells
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Journal Articles

Pharmacokinetics of 5-Fluorouracil Assessed with a Sensitive Mass Spectrometric Method in Patients on a Dose Escalation Schedule

Cees J. van Groeningen, Herbert M. Pinedo, Jozef Heddes, Robert M. Kok, Adrianus P.J.M. de Jong, Evert Wattel, Godefridus J. Peters, Jan Lankelma
Journal: Cancer Research
Cancer Res (1988) 48 (23): 6956–6961.
Published: 01 December 1988
View article titled, Pharmacokinetics of 5-Fluorouracil Assessed with a Sensitive Mass Spectrometric Method in Patients on a Dose Escalation Schedule
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Journal Articles

Effect of Endogenous Glutathione, Superoxide Dismutases, Catalase, and Glutathione Peroxidase on Adriamycin Tolerance of Chinese Hamster Ovary Cells

Hiskias G. Keizer, Johan van Rijn, Herbert M. Pinedo, Hans Joenje
Journal: Cancer Research
Cancer Res (1988) 48 (16): 4493–4497.
Published: 01 August 1988
View article titled, Effect of Endogenous Glutathione, Superoxide Dismutases, Catalase, and Glutathione Peroxidase on Adriamycin Tolerance of Chinese Hamster Ovary Cells
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Journal Articles

Comparative Pharmacokinetics of Cisplatin and Three Analogues in Mice and Humans

Maaike B. van Hennik, Wim J. F. van der Vijgh, Ina Klein, Frits Elferink, Jan B. Vermorken, Benjamin Winograd, Herbert M. Pinedo
Journal: Cancer Research
Cancer Res (1987) 47 (23): 6297–6301.
Published: 01 December 1987
View article titled, Comparative Pharmacokinetics of Cisplatin and Three Analogues in Mice and Humans
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