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Henry S. Friedman
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Journal Articles

Abstract 4924: Alternative lengthening of telomeres is associated with hypersensitivity to topoisomerase 1 inhibition in glioblastoma xenograft models

Stephen T. Keir, Heng Liu, Justin T. Low, Christopher J. Pirozzi, Nathan Reynolds, Eric S. Lipp, Annick Desjardins, Henry S. Friedman, Mustafa Khasraw, Darell D. Bigner, David M. Ashley, Matthew S. Waitkus
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4924.
https://doi.org/10.1158/1538-7445.AM2023-4924
Published: 04 April 2023
View article titled, Abstract 4924: Alternative lengthening of telomeres is associated with hypersensitivity to topoisomerase 1 inhibition in glioblastoma xenograft models
Journal Articles

MTAP Loss Promotes Stemness in Glioblastoma and Confers Unique Susceptibility to Purine Starvation

Landon J. Hansen, Ran Sun, Rui Yang, Simranjit X. Singh, Lee H. Chen, Christopher J. Pirozzi, Casey J. Moure, Carlee Hemphill, Austin B. Carpenter, Patrick Healy, Ryan C. Ruger, Chin-Pu J. Chen, Paula K. Greer, Fangping Zhao, Ivan Spasojevic, Carole Grenier, Zhiqing Huang, Susan K. Murphy, Roger E. McLendon, Henry S. Friedman, Allan H. Friedman, James E. Herndon, II, John H. Sampson, Stephen T. Keir, Darell D. Bigner, Hai Yan, Yiping He
Journal: Cancer Research
Cancer Res (2019) 79 (13): 3383–3394.
https://doi.org/10.1158/0008-5472.CAN-18-1010
Published: 01 July 2019
View article titled, MTAP Loss Promotes Stemness in Glioblastoma and Confers Unique Susceptibility to Purine Starvation
Open the PDF for MTAP Loss Promotes Stemness in Glioblastoma and Confers Unique Susceptibility to Purine Starvation in another window
Includes: Supplementary data
Journal Articles

Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities

Matthew S. Waitkus, Christopher J. Pirozzi, Casey J. Moure, Bill H. Diplas, Landon J. Hansen, Austin B. Carpenter, Rui Yang, Zhaohui Wang, Brian O. Ingram, Edward D. Karoly, Robert P. Mohney, Ivan Spasojevic, Roger E. McLendon, Henry S. Friedman, Yiping He, Darell D. Bigner, Hai Yan
Journal: Cancer Research
Cancer Res (2018) 78 (1): 36–50.
https://doi.org/10.1158/0008-5472.CAN-17-1352
Published: 02 January 2018
View article titled, Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1<sup>R132H</sup>-Induced Metabolic Liabilities
Open the PDF for Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1<sup>R132H</sup>-Induced Metabolic Liabilities in another window
Includes: Supplementary data
Journal Articles

Dendritic Cells Enhance Polyfunctionality of Adoptively Transferred T Cells That Target Cytomegalovirus in Glioblastoma

Elizabeth A. Reap, Carter M. Suryadevara, Kristen A. Batich, Luis Sanchez-Perez, Gary E. Archer, Robert J. Schmittling, Pamela K. Norberg, James E. Herndon, II, Patrick Healy, Kendra L. Congdon, Patrick C. Gedeon, Olivia C. Campbell, Adam M. Swartz, Katherine A. Riccione, John S. Yi, Mohammed K. Hossain-Ibrahim, Anirudh Saraswathula, Smita K. Nair, Anastasie M. Dunn-Pirio, Taylor M. Broome, Kent J. Weinhold, Annick Desjardins, Gordana Vlahovic, Roger E. McLendon, Allan H. Friedman, Henry S. Friedman, Darell D. Bigner, Peter E. Fecci, Duane A. Mitchell, John H. Sampson
Journal: Cancer Research
Series: Author Choice
Cancer Res (2018) 78 (1): 256–264.
https://doi.org/10.1158/0008-5472.CAN-17-0469
Published: 02 January 2018
View article titled, Dendritic Cells Enhance Polyfunctionality of Adoptively Transferred T Cells That Target Cytomegalovirus in Glioblastoma
Open the PDF for Dendritic Cells Enhance Polyfunctionality of Adoptively Transferred T Cells That Target Cytomegalovirus in Glioblastoma in another window
Includes: Supplementary data
Journal Articles

Abstract 2435A: Identification and treatment data of xenografts representing TCGA-defined glioblastoma subtypes

Stephen T. Keir, B. Ahmed Rasheed, Katherine A. Hoadley, Martin A. Roskoski, Danuta Gasinski, Madan M. Kwatra, Henry S. Friedman, Darell D. Bigner
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2435A.
https://doi.org/10.1158/1538-7445.AM2015-2435A
Published: 01 August 2015
View article titled, Abstract 2435A: Identification and treatment data of xenografts representing TCGA-defined glioblastoma subtypes
Journal Articles

Abstract 838: Establishment, identification and treatment data of TCGA glioblatoma xenograft subtypes

Stephen T. Keir, B Ahmed Rasheed, Katherine A. Hoadley, Martin A. Roskoski, Danuta Gasinski, Patrick J. Killela, Hai Yan, Madan M. Kwatra, Henry S. Friedman, Darell D. Bigner
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 838.
https://doi.org/10.1158/1538-7445.AM2014-838
Published: 01 October 2014
View article titled, Abstract 838: Establishment, identification and treatment data of TCGA glioblatoma xenograft subtypes
Journal Articles

Abstract 2079: Antitumoral activity of INC280 against adult glioblastoma brain tumors xenografts.

Stephen T. Keir, Martin A. Roskoski, Sabrina Wagner, Ralph Tiedt, Darell D. Bigner, Henry S. Friedman
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2079.
https://doi.org/10.1158/1538-7445.AM2013-2079
Published: 15 April 2013
View article titled, Abstract 2079: Antitumoral activity of INC280 against adult glioblastoma brain tumors xenografts.
Journal Articles

Abstract 4322: Efficacy of Sym004, a novel anti-EGFR antibody mixture, against EGFRvIII positive glioblastoma xenografts.

Stephen T. Keir, Martin A. Roskoski, Michael Kragh, Mikkel W. Pederson, Helle J. Jacobsen, Ivan D. Horak, Henry S. Friedman, Darell D. Bigner
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4322.
https://doi.org/10.1158/1538-7445.AM2013-4322
Published: 15 April 2013
View article titled, Abstract 4322: Efficacy of Sym004, a novel anti-EGFR antibody mixture, against EGFRvIII positive glioblastoma xenografts.
Journal Articles

Abstract LB-76: Mibefradil, a novel therapy for glioblastoma: An interlaced therapy approach

Stephen T. Keir, Lloyd Gray, Henry S. Friedman
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): LB-76.
https://doi.org/10.1158/1538-7445.AM2012-LB-76
Published: 15 April 2012
View article titled, Abstract LB-76: Mibefradil, a novel therapy for glioblastoma: An interlaced therapy approach
Journal Articles

Abstract 5266: Pediatric Preclinical Testing Program (PPTP) evaluation of the CDK inhibitor SCH 727965

Malcolm A. Smith, John M. Maris, Josh Courtright, Henry S. Friedman, Stephen T. Kier, Richard B. Lock, Hernan Carol, Richard Gorlick, E Anders Kolb, Min Kang, Christopher Patrick Reynolds, Christopher L. Morton, Peter J. Houghton
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5266.
https://doi.org/10.1158/1538-7445.AM10-5266
Published: 15 April 2010
View article titled, Abstract 5266: Pediatric Preclinical Testing Program (PPTP) evaluation of the CDK inhibitor SCH 727965
Journal Articles

Abstract 5265: Pediatric preclinical testing program (PPTP) stage 1 evaluation of BMS-754807 IGF-1 receptor inhibitor

Peter J. Houghton, John M. Maris, Josh Courtright, Henry S. Friedman, Stephen T. Kier, Richard B. Lock, Hernan Carol, Richard Gorlick, E Ander Kolb, Min Kang, C Patrick Reynolds, Christopher L. Morton, Malcolm A. Smith
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5265.
https://doi.org/10.1158/1538-7445.AM10-5265
Published: 15 April 2010
View article titled, Abstract 5265: Pediatric preclinical testing program (PPTP) stage 1 evaluation of BMS-754807 IGF-1 receptor inhibitor
Journal Articles

Abstract 5611: Interleukin-2 receptor α (IL-2R α/CD25)-specific antibodies eliminate regulatory T-cells (TRegs) and enhance tumor-specific immune responses

John H. Sampson, Gary E. Archer, Robert Schmittling, James E. Herndon, April D. Coan, David A. Reardon, James Verdenburgh, Annick Desjardins, Anjelika Dechkovskaia, Sharon McGehee-Norman, Denise Lally-Goss, Beth A. Perry, Allan Friedman, Henry S. Friedman, Darell D. Bigner, Duane A. Mitchell
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5611.
https://doi.org/10.1158/1538-7445.AM10-5611
Published: 15 April 2010
View article titled, Abstract 5611: Interleukin-2 receptor α (IL-2R α/CD25)-specific antibodies eliminate regulatory T-cells (TRegs) and enhance tumor-specific immune responses
Journal Articles

AAL881, a Novel Small Molecule Inhibitor of RAF and Vascular Endothelial Growth Factor Receptor Activities, Blocks the Growth of Malignant Glioma

Sith Sathornsumetee, Anita B. Hjelmeland, Stephen T. Keir, Roger E. McLendon, David Batt, Timothy Ramsey, Naeem Yusuff, B.K. Ahmed Rasheed, Mark W. Kieran, Andrea Laforme, Darell D. Bigner, Henry S. Friedman, Jeremy N. Rich
Journal: Cancer Research
Cancer Res (2006) 66 (17): 8722–8730.
https://doi.org/10.1158/0008-5472.CAN-06-0284
Published: 01 September 2006
View article titled, AAL881, a Novel Small Molecule Inhibitor of RAF and Vascular Endothelial Growth Factor Receptor Activities, Blocks the Growth of Malignant Glioma
Open the PDF for AAL881, a Novel Small Molecule Inhibitor of RAF and Vascular Endothelial Growth Factor Receptor Activities, Blocks the Growth of Malignant Glioma in another window
Journal Articles

O6-alkylguanine-DNA alkyltransferase (AGT) and microsatellite instability (MSI) analyses in malignant glioma

Jill A. Maxwell, Stewart P. Johnson, Roger E. McLendon, Francis Ali-Osman, Jennifer A. Quinn, Allan H. Friedman, James E. Herndon, Katja Bierau, Joseph Bigley, Darell D. Bigner, Henry S. Friedman
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1054.
Published: 15 April 2006
View article titled, O<sup>6</sup>-alkylguanine-DNA alkyltransferase (AGT) and microsatellite instability (MSI) analyses in malignant glioma
Journal Articles

Constitutive phosphorylation of Chk1 at serine 317 in a medulloblastoma cell line is sensitive to the inhibition of the phosphatidyalinositol-3-kinase-related kinase (PIKK) pathway

Bo Cui, Stewart P. Johnson, Francis Ali-Osman, Darell D. Bigner, Henry S. Friedman
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1000.
Published: 15 April 2006
View article titled, Constitutive phosphorylation of Chk1 at serine 317 in a medulloblastoma cell line is sensitive to the inhibition of the phosphatidyalinositol-3-kinase-related kinase (PIKK) pathway
Journal Articles

Evaluation of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG, KOS-1022) against Childhood Cancer Models by the Pediatric Preclinical Testing Program (PPTP)

Peter J. Houghton, John Maris, Henry S. Friedman, Stephen T. Kier, Richard B. Lock, Richard Gorlick, E. Anders Kolb, C. Patrick Reynolds, Christopher Morton, Malcolm A. Smith
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1021.
Published: 15 April 2006
View article titled, Evaluation of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG, KOS-1022) against Childhood Cancer Models by the Pediatric Preclinical Testing Program (PPTP)
Journal Articles

Characterization of membrane transport of the novel O6-alkylguanine-DNA alkyltransferase inactivator, O4-benzylfolic acid

Stewart P. Johnson, Barton A. Kamen, Robert C. Moschel, Henry S. Friedman
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 127.
Published: 15 April 2006
View article titled, Characterization of membrane transport of the novel <em>O</em><sup>6</sup>-alkylguanine-DNA alkyltransferase inactivator, <em>O</em><sup>4</sup>-benzylfolic acid
Journal Articles

Imatinib mesylate (STI-571, Gleevec®) offers combinatorial benefit with temozolomide (Temodar®) against gliomas

Jeremy N. Rich, Stephen T. Keir, Sith Sathornsumetee, David A. Reardon, David A. Reardon, Darell D. Bigner, Henry S. Friedman
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1407.
Published: 01 May 2005
View article titled, Imatinib mesylate (STI-571, Gleevec®) offers combinatorial benefit with temozolomide (Temodar®) against gliomas
Journal Articles

AAL881, a novel small molecule inhibitor of RAF and VEGFR activities, blocks growth of malignant gliomas

Sith Sathornsumetee, David Batt, Mark Kieran, Stephen Keir, Tim Ramsey, Naeem Yusuff, David Reardon, Darrell D. Bigner, Henry S. Friedman, Jeremy N. Rich
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1373–1374.
Published: 01 May 2005
View article titled, AAL881, a novel small molecule inhibitor of RAF and VEGFR activities, blocks growth of malignant gliomas
Journal Articles

Overcoming temozolomide resistance in a mismatch repair deficient malignant glioma xenograft

C. Lynn Cheng, Stewart P. Johnson, Stephen T. Keir, Francis Ali-Osman, Csaba Szabo, Andrew L. Salzman, Darell D. Bigner, Henry S. Friedman
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1182.
Published: 01 May 2005
View article titled, Overcoming temozolomide resistance in a mismatch repair deficient malignant glioma xenograft