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Henrik Edgren
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Journal Articles

Abstract 2276: Efficient curation and ontology mapping of clinical and phenotypic data

Henrik Edgren, Beatriz Mano, Maria Laaksonen
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2276.
DOI: https://doi.org/10.1158/1538-7445.AM2018-2276
Published: 01 July 2018
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Journal Articles

Abstract 2596: MediSapiens Explorer Technology Platform - Integrated Solution for big biomedical data

Henrik Edgren, MediSapiens bioinformatics and development teams
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2596.
DOI: https://doi.org/10.1158/1538-7445.AM2017-2596
Published: 01 July 2017
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Journal Articles

Abstract 4505: Pan-cancer analysis of fusion gene druggability and neoantigen potential

Henrik Edgren, Anja Ruusulehto, Kalle Ojala, Maria Laaksonen
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4505.
DOI: https://doi.org/10.1158/1538-7445.AM2016-4505
Published: 15 July 2016
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Journal Articles

Abstract 2378: Responses of AML patients to tailored drug regimens: monitoring cancer subclones by ultra-deep resequencing

Poojitha N Ojamies, Mika Kontro, Henrik Edgren, Pekka Ellonen, Sonja Lagstrom, Henrikki Almusa, Timo Miettinen, Samuli Eldfors, David Tamborero, Krister Wennerberg, Caroline Heckman, Kimmo Porkka, Maija Wolf, Olli Kallioniemi
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2378.
DOI: https://doi.org/10.1158/1538-7445.AM2016-2378
Published: 15 July 2016
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Journal Articles

Abstract 4793: Rapid pan-cancer identification of previously unidentified fusion genes to enable novel targeted therapeutics

Henrik Edgren, Kalle Ojala, Anja Ruusulehto, Gopi Ganji
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4793.
DOI: https://doi.org/10.1158/1538-7445.AM2015-4793
Published: 01 August 2015
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Journal Articles

Abstract 982: Analysis of clonal evolution of leukemia in vivo following novel targeted treatments

Naga Poojitha Ojamies, Mika Kontro, Henrik Edgren, Samuli Eldfors, Pekka Ellonen, Tea Pemovska, Langstrom Sonja, Henrikki Almusa, Maija Lepisto, Tero Aittokallio, Krister Wennerberg, Caroline Heckman, Kimmo Porkka, Olli Kallioniemi
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 982.
DOI: https://doi.org/10.1158/1538-7445.AM2014-982
Published: 01 October 2014
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Journal Articles

Abstract 65: Comprehensive ex vivo drug sensitivity testing combined with in depth molecular profiling of AML patients cells provides individualized treatment strategies and reveals mechanisms of drug resistance.

Krister Wennerberg, Tea Pemovska, Mika Kontro, Bhagwan Yadav, Evgeny Kulesskiy, Henrik Edgren, Samuli Eldfors, Riikka Karjalainen, Naga Poojitha Kota Venkata, Anna Lehto, Muntasir Mamun Majumder, Disha Malani, Astrid Murumägi, Laura Turunen, Jonathan Knowles, Tero Aittokallio, Caroline Heckman, Kimmo Porkka, Olli Kallioniemi
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 65.
DOI: https://doi.org/10.1158/1538-7445.AM2013-65
Published: 15 April 2013
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Journal Articles

Abstract 2107: Identification of alternative compounds by drug screening of HER2 positive breast cancer cell lines.

Sandra Nyberg, Vesa Hongisto, Dagim Shiferaw Tadele, Henrik Edgren, Suvi-Katri Leivonen, Olli Kallioniemi, Gunhild Mari Mælandsmo, Merja Perälä, Anne-Lise Børresen-Dale, Kristine Kleivi Sahlberg
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2107.
DOI: https://doi.org/10.1158/1538-7445.AM2013-2107
Published: 15 April 2013
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Journal Articles

Abstract 3164: Somatic mutation analysis pipeline for exome-sequencing data identifies oncogenic STAT3 mutations in T-LGL leukemia.

Samuli Eldfors, Hanna LM Rajala, Pekka Ellonen, Emma I. Andersson, Sonja Lagström, Henrikki Almusa, Henrik Edgren, Maija Lepistö, Pirkko Mattila, Jonathan Knowles, Janna Saarela, Kimmo Porkka, Olli Kallioniemi, Satu Mustjoki, Caroline A. Heckman
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3164.
DOI: https://doi.org/10.1158/1538-7445.AM2013-3164
Published: 15 April 2013
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Journal Articles

A Single-Nucleotide Substitution Mutator Phenotype Revealed by Exome Sequencing of Human Colon Adenomas

Sergey I. Nikolaev, Sotirios K. Sotiriou, Ioannis S. Pateras, Federico Santoni, Stavros Sougioultzis, Henrik Edgren, Henrikki Almusa, Daniel Robyr, Michel Guipponi, Janna Saarela, Vassilis G. Gorgoulis, Stylianos E. Antonarakis, Thanos D. Halazonetis
Journal: Cancer Research
Cancer Res (2012) 72 (23): 6279–6289.
DOI: https://doi.org/10.1158/0008-5472.CAN-12-3869
Published: 29 November 2012
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Includes: Supplementary data
Journal Articles

Abstract 3188: Development of a cancer pharmacopeia-wide ex-vivo drug sensitivity and resistance testing (DSRT) platform for AML: Towards individually optimized therapy and improved understanding of drug resistance patterns

Disha Malani, Tea Pemovska, Mika Kontro, Astrid Murumägi, Evgeny Kulesskiy, Bhagwan Yadav, Maxim Bespalov, Samuli Eldfors, Erkki Elonen, Riikka Karjalainen, Jonathan KC Knowles, Muntasir Mamun Majumder, John Patrick Mpindi, Henrik Edgren, Agnieszka Szwajda, Naga Poojitha Kota Venkata, Laura Turunen, Satu Mustjoki, Maija Wolf, Tero Aittokallio, Caroline A. Heckman, Kimmo Porkka, Krister Wennerberg, Olli Kallioniemi
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3188.
DOI: https://doi.org/10.1158/1538-7445.AM2012-3188
Published: 15 April 2012
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Journal Articles

Abstract 3175: Genomic and transcriptomic data integration in chronic myelomonocytic leukemia reveals a novel fusion gene involving onco-miR-125b-2

Muntasir M. Majumder, Mika Kontro, Henrik Edgren, Daniel Nicorici, Alun Parsons, Riikka Karjalainen, Samuli Eldfors, Pirkko Mattila, Maija Lepistö, Pekka Ellonen, Henrikki Almusa, Hannele Rintala, Jonathan K c Knowles, Janna Saarela, Krister Wennerberg, Satu Mustjoki, Maija Wolf, Olli Kallioniemi, Kimmo Porkka, Caroline A. Heckman
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3175.
DOI: https://doi.org/10.1158/1538-7445.AM2012-3175
Published: 15 April 2012
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Journal Articles

Abstract 4580: Personalized treatment selection for therapy-resistant AML by integrating ex-vivo drug sensitivity and resistance testing (DSRT) as well as serial genomic, transcriptomic and phosphoproteomic profiling

Naga Poojitha Kota Venkata, Mika Kontro, Henrik Edgren, Samuli Eldfors, Tea Pemovska, Evgeny Kulesskiy, Muntasir Mamun Majumder, Astrid Murumägi, Daniel Nicorici, Henrikki Almusa, Pirkko Mattila, Pekka Ellonen, Maija Lepistö, John Patrick Mpindi, Riikka Karjalainen, Alun Parsons, Jonathan K.C Knowles, Janna Saarela, Maija Wolf, Krister Wennerberg, Caroline A. Heckman, Kimmo Porkka, Olli Kallioniemi
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4580.
DOI: https://doi.org/10.1158/1538-7445.AM2012-4580
Published: 15 April 2012
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Journal Articles

Abstract 895: Quantitative drug sensitivity and resistance testing (DSRT) of primary ex vivo AML blasts highlights mTOR and MEK as potential key molecular driver signals of therapeutic significance

Tea Pemovska, Evgeny Kylesskiy, Mika Kontro, Agnieszka Szwajda, Riikka Karjalainen, Muntasir M. Majumder, Disha Malani, Maxim M. Bespalov, Samuli Eldfors, Erkki Elonen, Jonathan Knowles, Astrid Murumägi, John P. Mpindi, Henrik Edgren, Naga Poojitha Kota Venkata, Laura Turunen, Satu Mustjoki, Maija Wolf, Bhagwan Yadav, Tero Aittokallio, Caroline A. Heckman, Kimmo Porkka, Olli Kallioniemi, Krister Wennerberg
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 895.
DOI: https://doi.org/10.1158/1538-7445.AM2012-895
Published: 15 April 2012
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Journal Articles

Abstract 5067: Exome sequencing reveals both DNA sequence and copy number changes in AML: Potential driver changes and mechanisms of drug resistance revealed from serial samples from the same patients

Riikka Karjalainen, Samuli Eldfors, Henrik Edgren, Naga Poojitha Kota Venkata, Mika Kontro, Muntasir Mamun Majumder, Astrid Murumägi, Alun Parsons, Henrikki Almusa, Pekka Ellonen, Maija Lepistö, Pirkko Mattila, Sari Hannula, Sonja Lagström, Minna Suvela, Maija Wolf, Krister Wennerberg, Jonathan KC Knowles, Satu Mustjoki, Janna Saarela, Kimmo Porkka, Olli Kallioniemi, Caroline A. Heckman
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 5067.
DOI: https://doi.org/10.1158/1538-7445.AM2012-5067
Published: 15 April 2012
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Journal Articles

Abstract 4023: ARID1A is a candidate tumor suppressor gene in breast cancer

Catherine Chabot, Aline Mamo, Luca Cavallone, Sukru Tuzmen, Saima Hassan, Henrik Edgren, Cristiano Ferrario, Olga Aleynikova, Ewa Przybytkowska, Kristin Malcolm, Olli Kallioniemi, Patricia Tonin, Spyro Mousses, Mark Basik
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4023.
DOI: https://doi.org/10.1158/1538-7445.AM2011-4023
Published: 15 April 2011
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Abstract 4836: In vitro drug sensitivity testing along with full genome and transcriptome sequencing and phosphoproteomics: Comprehensive “next-generation” molecular oncology portrait of a sarcoma for facilitating treatment decisions

For the Individualized Medicine Collaboration, Caroline Heckman, Kari Alitalo, Leif Andersson, Peter Campbell, Henrik Edgren, Andy Futreal, Tanja Holopainen, Paul Huang, Heikki Joensuu, Olli Kallioniemi, Sara Kangaspeska, Sami Kilpinen, Jami Mandelin, Outi Monni, Astrid Murumägi, Daniel Nicorici, Arto Orpana, Merja Perälä, Maarit Sarlomo-Rikala, Mike Stratton, Forest White
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4836.
DOI: https://doi.org/10.1158/1538-7445.AM2011-4836
Published: 15 April 2011
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Abstract 3977: Systematic analysis of microRNAs targeting the androgen receptor in prostate cancer cells

Päivi Östling, Suvi-Katri Leivonen, Anna Aakula, Pekka Kohonen, Rami Mäkelä, Zandra Hagman, Anders Edsjö, Sara Kangaspeska, Henrik Edgren, Daniel Nicorici, Anders Bjartell, Yvonne Ceder, Merja Perälä, Olli Kallioniemi
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 3977.
DOI: https://doi.org/10.1158/1538-7445.AM2011-3977
Published: 15 April 2011
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Abstract 4850: Paired-end RNA-sequencing based identification of 24 novel fusion genes in breast cancer

Henrik Edgren, Astrid Murumägi, Sara Kangaspeska, Daniel Nicorici, Vesa Hongisto, Kristine Kleivi, Inga Hansine Rye, Maija Wolf, Anne-Lise Børresen-Dale, Olli Kallioniemi
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4850.
DOI: https://doi.org/10.1158/1538-7445.AM2011-4850
Published: 15 April 2011
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Journal Articles

Systematic Analysis of MicroRNAs Targeting the Androgen Receptor in Prostate Cancer Cells

Päivi Östling, Suvi-Katri Leivonen, Anna Aakula, Pekka Kohonen, Rami Mäkelä, Zandra Hagman, Anders Edsjö, Sara Kangaspeska, Henrik Edgren, Daniel Nicorici, Anders Bjartell, Yvonne Ceder, Merja Perälä, Olli Kallioniemi
Journal: Cancer Research
Cancer Res (2011) 71 (5): 1956–1967.
DOI: https://doi.org/10.1158/0008-5472.CAN-10-2421
Published: 01 March 2011
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Includes: Supplementary data