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Journal Articles

Modeling Resistance and Recurrence Patterns of Combined Targeted–Chemoradiotherapy Predicts Benefit of Shorter Induction Period

David M. McClatchy, Henning Willers, Aaron N. Hata, Zofia Piotrowska, Lecia V. Sequist, Harald Paganetti, Clemens Grassberger

Cancer Res (2020) 80 (22): 5121–5133.

https://doi.org/10.1158/0008-5472.CAN-19-3883

Published: 13 November 2020

View articletitled, Modeling Resistance and Recurrence Patterns of Combined Targeted–Chemoradiotherapy Predicts Benefit of Shorter Induction Period

Includes: Supplementary data

Journal Articles

Patient-Specific Tumor Growth Trajectories Determine Persistent and Resistant Cancer Cell Populations during Treatment with Targeted Therapies

Clemens Grassberger, David McClatchy, III, Changran Geng, Sophia C. Kamran, Florian Fintelmann, Yosef E. Maruvka, Zofia Piotrowska, Henning Willers, Lecia V. Sequist, Aaron N. Hata, Harald Paganetti

Cancer Res (2019) 79 (14): 3776–3788.

https://doi.org/10.1158/0008-5472.CAN-18-3652

Published: 15 July 2019

View articletitled, Patient-Specific Tumor Growth Trajectories Determine Persistent and Resistant Cancer Cell Populations during Treatment with Targeted Therapies

Includes: Supplementary data

Journal Articles

Abstract SY24-01: Genomic biomarkers for radiation resistance and targeted radiosensitizers

Henning Willers

Cancer Res (2018) 78 (13_Supplement): SY24-01.

https://doi.org/10.1158/1538-7445.AM2018-SY24-01

Published: 01 July 2018

View articletitled, Abstract SY24-01: Genomic biomarkers for radiation resistance and targeted radiosensitizers

Journal Articles

Abstract 4756: A SPP1-EGFR pathway links stem-like properties of KRAS-mutated lung cancer to radiation resistance

Meng Wang, Jing Han, Lynnette Marcar, Josh Black, Qi Liu, Xiangyong Li, Kshithija Nagulapalli, Lecia V. Sequist, Raymond H. Mak, Cyril H. Benes, Theodore S. Hong, Kristin Gurtner, Mechthild Krause, Michael Baumann, Jing X. Kang, Johnathan R. Whetstine, Henning Willers

Cancer Res (2017) 77 (13_Supplement): 4756.

https://doi.org/10.1158/1538-7445.AM2017-4756

Published: 01 July 2017

View articletitled, Abstract 4756: A SPP1-EGFR pathway links stem-like properties of KRAS-mutated lung cancer to radiation resistance

Journal Articles

Radiation Resistance in KRAS-Mutated Lung Cancer Is Enabled by Stem-like Properties Mediated by an Osteopontin–EGFR Pathway

Cancer Res (2017) 77 (8): 2018–2028.

https://doi.org/10.1158/0008-5472.CAN-16-0808

Published: 13 April 2017

View articletitled, Radiation Resistance in KRAS-Mutated Lung Cancer Is Enabled by Stem-like Properties Mediated by an Osteopontin–EGFR Pathway

Includes: Supplementary data

Journal Articles

Abstract LB-209: Chromatin condensation in KRAS-mutant lung cancer as a therapeutic target: challenging the paradigm of associating KRAS mutation with EGFR inhibitor resistance

Meng Wang, Ashley M. Kern, Marieke Hülskötter, Patricia Greninger, Anurag Singh, Yunfeng Pan, Dipanjan Chowdhury, Mechthild Krause, Michael Baumann, Cyril H. Benes, Jason A. Efstathiou, Jeff Settleman, Henning Willers

Cancer Res (2014) 74 (19_Supplement): LB-209.

https://doi.org/10.1158/1538-7445.AM2014-LB-209

Published: 01 October 2014

View articletitled, Abstract LB-209: Chromatin condensation in KRAS-mutant lung cancer as a therapeutic target: challenging the paradigm of associating KRAS mutation with EGFR inhibitor resistance

Journal Articles

EGFR-Mediated Chromatin Condensation Protects KRAS-Mutant Cancer Cells against Ionizing Radiation

Cancer Res (2014) 74 (10): 2825–2834.

https://doi.org/10.1158/0008-5472.CAN-13-3157

Published: 14 May 2014

View articletitled, EGFR-Mediated Chromatin Condensation Protects KRAS-Mutant Cancer Cells against Ionizing Radiation

Includes: Supplementary data

Journal Articles

EGFR-Activating Mutations Correlate with a Fanconi Anemia–like Cellular Phenotype That Includes PARP Inhibitor Sensitivity

Heike N. Pfäffle, Meng Wang, Liliana Gheorghiu, Natalie Ferraiolo, Patricia Greninger, Kerstin Borgmann, Jeffrey Settleman, Cyril H. Benes, Lecia V. Sequist, Lee Zou, Henning Willers

Cancer Res (2013) 73 (20): 6254–6263.

https://doi.org/10.1158/0008-5472.CAN-13-0044

Published: 14 October 2013

View articletitled, EGFR-Activating Mutations Correlate with a Fanconi Anemia–like Cellular Phenotype That Includes PARP Inhibitor Sensitivity

Includes: Supplementary data

Journal Articles

EGF Receptor Inhibition Radiosensitizes NSCLC Cells by Inducing Senescence in Cells Sustaining DNA Double-Strand Breaks

Meng Wang, Fabian Morsbach, David Sander, Liliana Gheorghiu, Akash Nanda, Cyril Benes, Malte Kriegs, Mechthild Krause, Ekkehard Dikomey, Michael Baumann, Jochen Dahm-Daphi, Jeffrey Settleman, Henning Willers

Cancer Res (2011) 71 (19): 6261–6269.

https://doi.org/10.1158/0008-5472.CAN-11-0213

Published: 29 September 2011

View articletitled, EGF Receptor Inhibition Radiosensitizes NSCLC Cells by Inducing Senescence in Cells Sustaining DNA Double-Strand Breaks

Includes: Supplementary data

Journal Articles

Abstract #3962: The role of activating K-RAS mutation status in predicting radiosensitization to epidermal growth factor receptor (EGFR) inhibitors in non-small cell lung cancer (NSCLC) cells

Akash Nanda, David Sander, Loreen Fournier, Anurag Singh, Lisa Kachnic, Jeffrey Settleman, Henning Willers

Cancer Res (2009) 69 (9_Supplement): 3962.

Published: 01 May 2009

View articletitled, Abstract #3962: The role of activating K-RAS mutation status in predicting radiosensitization to epidermal growth factor receptor (EGFR) inhibitors in non-small cell lung cancer (NSCLC) cells

Journal Articles

Checkpoint Kinase 2–Mediated Phosphorylation of BRCA1 Regulates the Fidelity of Nonhomologous End-Joining

Jing Zhuang, Junran Zhang, Henning Willers, Hong Wang, Jay H. Chung, Dik C. van Gent, Dennis E. Hallahan, Simon N. Powell, Fen Xia

Cancer Res (2006) 66 (3): 1401–1408.

https://doi.org/10.1158/0008-5472.CAN-05-3278

Published: 01 February 2006

View articletitled, Checkpoint Kinase 2–Mediated Phosphorylation of BRCA1 Regulates the Fidelity of Nonhomologous End-Joining

Journal Articles

Homologous recombination is independently regulated by BRCA1 and p53

Zhihui Feng, Henning Willers, Alejandro Treszezamsky, Simon Powell

Cancer Res (2005) 65 (9_Supplement): 1336.

Published: 01 May 2005

View articletitled, Homologous recombination is independently regulated by BRCA1 and p53

Journal Articles

p53 Directly Enhances Rejoining of DNA Double-Strand Breaks with Cohesive Ends in γ-Irradiated Mouse Fibroblasts

Wei Tang, Henning Willers, Simon N. Powell

Cancer Res (1999) 59 (11): 2562–2565.

Published: 01 June 1999

View articletitled, p53 Directly Enhances Rejoining of DNA Double-Strand Breaks with Cohesive Ends in γ-Irradiated Mouse Fibroblasts

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Modeling Resistance and Recurrence Patterns of Combined Targeted–Chemoradiotherapy Predicts Benefit of Shorter Induction Period

Patient-Specific Tumor Growth Trajectories Determine Persistent and Resistant Cancer Cell Populations during Treatment with Targeted Therapies

Abstract SY24-01: Genomic biomarkers for radiation resistance and targeted radiosensitizers

Abstract 4756: A SPP1-EGFR pathway links stem-like properties of KRAS-mutated lung cancer to radiation resistance

Radiation Resistance in KRAS-Mutated Lung Cancer Is Enabled by Stem-like Properties Mediated by an Osteopontin–EGFR Pathway

Abstract LB-209: Chromatin condensation in KRAS-mutant lung cancer as a therapeutic target: challenging the paradigm of associating KRAS mutation with EGFR inhibitor resistance

EGFR-Mediated Chromatin Condensation Protects KRAS-Mutant Cancer Cells against Ionizing Radiation

EGFR-Activating Mutations Correlate with a Fanconi Anemia–like Cellular Phenotype That Includes PARP Inhibitor Sensitivity

EGF Receptor Inhibition Radiosensitizes NSCLC Cells by Inducing Senescence in Cells Sustaining DNA Double-Strand Breaks

Abstract #3962: The role of activating K-RAS mutation status in predicting radiosensitization to epidermal growth factor receptor (EGFR) inhibitors in non-small cell lung cancer (NSCLC) cells

Checkpoint Kinase 2–Mediated Phosphorylation of BRCA1 Regulates the Fidelity of Nonhomologous End-Joining

Homologous recombination is independently regulated by BRCA1 and p53

p53 Directly Enhances Rejoining of DNA Double-Strand Breaks with Cohesive Ends in γ-Irradiated Mouse Fibroblasts

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