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Journal Articles

Abstract 1569: OXC-101 kills cancer by disturbing microtubule polymerization and inhibiting MTH1

Ulrika Warpman Berglund, Helge Gad, Kumar Sanjiv, Ann-Sofie Jemth, Oliver Mortusewics, Lars Brautigam, Juha Rantala, Thomas Helleday
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1569.
https://doi.org/10.1158/1538-7445.AM2023-1569
Published: 04 April 2023
View article titled, Abstract 1569: OXC-101 kills cancer by disturbing microtubule polymerization and inhibiting MTH1
Journal Articles

Abstract 6204: DNA-PK inhibition augment the cancer specific cytotoxicity of mitotic MTH1 inhibitor OXC-101

Akhilesh Nagesh Danda, Helge Gad, Martin Scobie, Laura Martínez-López, Nuria Pastor Carrillo, Manuel Luis Orta, Thomas Helleday, Ulrika warpman berglund, Kumar Sanjiv
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6204.
https://doi.org/10.1158/1538-7445.AM2023-6204
Published: 04 April 2023
View article titled, Abstract 6204: DNA-PK inhibition augment the cancer specific cytotoxicity of mitotic MTH1 inhibitor OXC-101
Journal Articles

MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia

Kumar Sanjiv, José Manuel Calderón-Montaño, Therese M. Pham, Tom Erkers, Viktoriia Tsuber, Ingrid Almlöf, Andreas Höglund, Yaser Heshmati, Brinton Seashore-Ludlow, Akhilesh Nagesh Danda, Helge Gad, Elisee Wiita, Camilla Göktürk, Azita Rasti, Stefanie Friedrich, Anders Centio, Montserrat Estruch, Thea Kristin Våtsveen, Nona Struyf, Torkild Visnes, Martin Scobie, Tobias Koolmeister, Martin Henriksson, Olov Wallner, Teresa Sandvall, Sören Lehmann, Kim Theilgaard-Mönch, Mathew J. Garnett, Päivi Östling, Julian Walfridsson, Thomas Helleday, Ulrika Warpman Berglund
Journal: Cancer Research
Cancer Res (2021) 81 (22): 5733–5744.
https://doi.org/10.1158/0008-5472.CAN-21-0061
Published: 15 November 2021
View article titled, MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia
Open the PDF for MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia in another window
Includes: Supplementary data
Journal Articles

NEIL3 Prevents Senescence in Hepatocellular Carcinoma by Repairing Oxidative Lesions at Telomeres during Mitosis

Zhenjun Zhao, Helge Gad, Carlos Benitez-Buelga, Kumar Sanjiv, Hua Xiangwei, He Kang, Mingxuan Feng, Zhicong Zhao, Ulrika Warpman Berglund, Qiang Xia, Thomas Helleday
Journal: Cancer Research
Cancer Res (2021) 81 (15): 4079–4093.
https://doi.org/10.1158/0008-5472.CAN-20-1028
Published: 01 August 2021
View article titled, NEIL3 Prevents Senescence in Hepatocellular Carcinoma by Repairing Oxidative Lesions at Telomeres during Mitosis
Open the PDF for NEIL3 Prevents Senescence in Hepatocellular Carcinoma by Repairing Oxidative Lesions at Telomeres during Mitosis in another window
Includes: Supplementary data
Journal Articles

MTH1 Inhibitor TH588 Disturbs Mitotic Progression and Induces Mitosis-Dependent Accumulation of Genomic 8-oxodG

Sean G. Rudd, Helge Gad, Kumar Sanjiv, Nuno Amaral, Anna Hagenkort, Petra Groth, Cecilia E. Ström, Oliver Mortusewicz, Ulrika Warpman Berglund, Thomas Helleday
Journal: Cancer Research
Cancer Res (2020) 80 (17): 3530–3541.
https://doi.org/10.1158/0008-5472.CAN-19-0883
Published: 02 September 2020
View article titled, MTH1 Inhibitor TH588 Disturbs Mitotic Progression and Induces Mitosis-Dependent Accumulation of Genomic 8-oxodG
Open the PDF for MTH1 Inhibitor TH588 Disturbs Mitotic Progression and Induces Mitosis-Dependent Accumulation of Genomic 8-oxodG in another window
Journal Articles

Abstract 105: MTH1 promotes mitotic progression to avoid oxidative DNA damage in cancer cells

Kumar Sanjiv, Helge gad, Sean G. Rudd, Oliver Mortusewicz, Ailine Stolz, Nuno Amaral, Lars Brautigham, Linda Pudelko, Christina Kaldéren, Ann-Sofie Jemth, Ingrid Almlöf, Torkild Visnes, Niklas Schultz, Johan Boström, José Manuel Calderon Montano1, Anna Hagenkort, Petra Groth, Camilla Gokturk, Tobias Koolmeister, Prasad Wakchaure, Evert Homan, Mikael Altun, Cecilia Ström, Martin Scobie, Holger Bastians, Ulrika Warpman Berglund, Thomas Helleday
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 105.
https://doi.org/10.1158/1538-7445.AM2019-105
Published: 01 July 2019
View article titled, Abstract 105: MTH1 promotes mitotic progression to avoid oxidative DNA damage in cancer cells
Journal Articles

Abstract 1260: Polymerase kappa determines the sensitivity of MTH1 inhibitors to cisplatin-resistant cell

Kumar Sanjiv, Helge Gad, Sean Rudd, Rachel Hurley, Patric Herr, José Manuel Calderón Montaño, Oliver Mortusewicz, Tobias Koolmeister, Sylvain Jaques, Estefanía Burgos Morón, Andreas Hoglund, Te-Chang Lee, Martin Scobie, Scott Kaufmann, John Weroha, Ulrika Warpman Berglund, Andrea Wahner Hendrickson, Thomas Helleday
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1260.
https://doi.org/10.1158/1538-7445.AM2016-1260
Published: 15 July 2016
View article titled, Abstract 1260: Polymerase kappa determines the sensitivity of MTH1 inhibitors to cisplatin-resistant cell
Journal Articles

Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition

Lars Bräutigam, Linda Pudelko, Ann-Sofie Jemth, Helge Gad, Mohit Narwal, Robert Gustafsson, Stella Karsten, Jordi Carreras Puigvert, Evert Homan, Carsten Berndt, Ulrika Warpman Berglund, Pål Stenmark, Thomas Helleday
Journal: Cancer Research
Cancer Res (2016) 76 (8): 2366–2375.
https://doi.org/10.1158/0008-5472.CAN-15-2380
Published: 14 April 2016
View article titled, Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition
Open the PDF for Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition in another window
Includes: Supplementary data