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Journal Articles

Aberrant FGFR Tyrosine Kinase Signaling Enhances the Warburg Effect by Reprogramming LDH Isoform Expression and Activity in Prostate Cancer

Junchen Liu, Guo Chen, Zezhen Liu, Shaoyou Liu, Zhiduan Cai, Pan You, Yuepeng Ke, Li Lai, Yun Huang, Hongchang Gao, Liangcai Zhao, Helene Pelicano, Peng Huang, Wallace L. McKeehan, Chin-Lee Wu, Cong Wang, Weide Zhong, Fen Wang

Cancer Res (2018) 78 (16): 4459–4470.

https://doi.org/10.1158/0008-5472.CAN-17-3226

Published: 14 August 2018

View articletitled, Aberrant FGFR Tyrosine Kinase Signaling Enhances the Warburg Effect by Reprogramming LDH Isoform Expression and Activity in Prostate Cancer

Includes: Supplementary data

Journal Articles

Abstract 4408: Metabolic alterations induced by ibrutinib in CLL cells as a basis for drug combinations to enhance ibrutinib therapeutic activity

Helene Pelicano, Li Feng, William G. Wierda, Michael J. Keating, Peng Huang

Cancer Res (2017) 77 (13_Supplement): 4408.

https://doi.org/10.1158/1538-7445.AM2017-4408

Published: 01 July 2017

View articletitled, Abstract 4408: Metabolic alterations induced by ibrutinib in CLL cells as a basis for drug combinations to enhance ibrutinib therapeutic activity

Journal Articles

Abstract 2697: A novel therapeutic strategy to effectively kill CLL cells in stromal microenvironment by targeting lipid metabolism

Panpan Liu, Jinyun Liu, Marcia A. Ogasawara, Helene Pelicano, Ruihua Xu, Michael J. Keating, Peng Huang

Cancer Res (2014) 74 (19_Supplement): 2697.

https://doi.org/10.1158/1538-7445.AM2014-2697

Published: 01 October 2014

View articletitled, Abstract 2697: A novel therapeutic strategy to effectively kill CLL cells in stromal microenvironment by targeting lipid metabolism

Journal Articles

Abstract 3072: Characterization of TCL1-Tg:p53-/- mice that resemble human chronic lymphocytic leukemia with 17p-deletion: alterations in p53→Mir30→EZH2 axis.

Jinyun Liu, Marcia A. Ogasawara, Gang Chen, Helene Pelicano, Peng Huang

Cancer Res (2013) 73 (8_Supplement): 3072.

https://doi.org/10.1158/1538-7445.AM2013-3072

Published: 15 April 2013

View articletitled, Abstract 3072: Characterization of TCL1-Tg:p53-/- mice that resemble human chronic lymphocytic leukemia with 17p-deletion: alterations in p53→Mir30→EZH2 axis.

Journal Articles

Abstract LB-106: A novel TCL1-Tg:p53^−/− mouse model of human CLL

Jinyun Liu, Gang Chen, Li Feng, Wan Zhang, Helene Pelicano, Weiqing Lu, Hesham Amin, Michael Keating, Carlo M. Croce, Peng Huang

Cancer Res (2012) 72 (8_Supplement): LB-106.

https://doi.org/10.1158/1538-7445.AM2012-LB-106

Published: 15 April 2012

View articletitled, Abstract LB-106: A novel TCL1-Tg:p53−/− mouse model of human CLL

Journal Articles

Abstract LB-107: Targeting the glycolytic pathway as an effective therapeutic approach for triple-negative breast cancer

Helene Pelicano, Wan Zhang, Naima Hammoudi, Lajos Pusztai, Jiale Dai, Peng Huang

Cancer Res (2010) 70 (8_Supplement): LB-107.

https://doi.org/10.1158/1538-7445.AM10-LB-107

Published: 15 April 2010

View articletitled, Abstract LB-107: Targeting the glycolytic pathway as an effective therapeutic approach for triple-negative breast cancer

Journal Articles

Mitochondrial Dysfunction and Reactive Oxygen Species Imbalance Promote Breast Cancer Cell Motility through a CXCL14-Mediated Mechanism

Helene Pelicano, Weiqin Lu, Yan Zhou, Wan Zhang, Zhao Chen, Yumin Hu, Peng Huang

Cancer Res (2009) 69 (6): 2375–2383.

https://doi.org/10.1158/0008-5472.CAN-08-3359

Published: 17 March 2009

View articletitled, Mitochondrial Dysfunction and Reactive Oxygen Species Imbalance Promote Breast Cancer Cell Motility through a CXCL14-Mediated Mechanism

Includes: Supplementary data

Journal Articles

Mitochondrial dysfunction leads to NADPH oxidase (NOX) activation and sensitization of cancer cells to NOX inhibitor

Weiqin Lu, Zhao Chen, Helene pelicano, Li Feng, Peng Huang

Cancer Res (2008) 68 (9_Supplement): 4343.

Published: 01 May 2008

View articletitled, Mitochondrial dysfunction leads to NADPH oxidase (NOX) activation and sensitization of cancer cells to NOX inhibitor

Journal Articles

CXCL14: A new molecular link between ROS and malignant behavior in breast cancer cells

Helene Pelicano, Weigin lu, Zhao Chen, Yumin Hu, Peng Huang

Cancer Res (2007) 67 (9_Supplement): LB-271.

Published: 01 May 2007

View articletitled, CXCL14: A new molecular link between ROS and malignant behavior in breast cancer cells

Journal Articles

PEITC: a natural compound effective in killing primary leukemia cells and overcoming drug resistance

Dunyaporn Trachootham, Hui Zhang, Zhao Chen, Li Feng, Min Du, Helene Pelicano, Michael Keating, Peng Huang

Cancer Res (2007) 67 (9_Supplement): 1842.

Published: 01 May 2007

View articletitled, PEITC: a natural compound effective in killing primary leukemia cells and overcoming drug resistance

Journal Articles

Mitochondrial respiratory defects lead to significant alterations in cellular redox states and drug sensitivity

Weiqin Lu, Helene Pelicano, zhao chen, li feng, Peng Huang

Cancer Res (2007) 67 (9_Supplement): LB-115.

Published: 01 May 2007

View articletitled, Mitochondrial respiratory defects lead to significant alterations in cellular redox states and drug sensitivity

Journal Articles

Novel Action of Paclitaxel against Cancer Cells: Bystander Effect Mediated by Reactive Oxygen Species

Jérôme Alexandre, Yumin Hu, Weiqin Lu, Helene Pelicano, Peng Huang

Cancer Res (2007) 67 (8): 3512–3517.

https://doi.org/10.1158/0008-5472.CAN-06-3914

Published: 17 April 2007

View articletitled, Novel Action of Paclitaxel against Cancer Cells: Bystander Effect Mediated by Reactive Oxygen Species

Journal Articles

Inducible expression of dominant negative DNA polymerase gamma(POLGdn) in human cells: characterizations and applications

Weiqin Lu, Li Feng, Helene Pelicano, Zhao Chen, Geetha Achanta, Hui Zhang, Peng Huang

Cancer Res (2006) 66 (8_Supplement): 25.

Published: 15 April 2006

View articletitled, Inducible expression of dominant negative DNA polymerase gamma(POLGdn) in human cells: characterizations and applications

Journal Articles

A novel mechanism of action of methyl-2-cyano-3,12 dioxoolean-1,9 diene-28-oate (CDDO-Me): Direct permeabilization of the inner mitochondrial membrane to inhibit electron transport and induce apoptosis

Ismael Samudio, Marina Konopleva, Helene Pelicano, Peng Huang, Olga Frolova, William Bornmann, Yun-Ming Ying, Randall Evans, Michael Andreeff

Cancer Res (2006) 66 (8_Supplement): 1102–1103.

Published: 15 April 2006

View articletitled, A novel mechanism of action of methyl-2-cyano-3,12 dioxoolean-1,9 diene-28-oate (CDDO-Me): Direct permeabilization of the inner mitochondrial membrane to inhibit electron transport and induce apoptosis

Journal Articles

Selective killing of oncogenic transformed cells through ROS-mediated mechanism by β-phenylethyl isothiocyanates

Dunyaporn Trachootham, Yan Zhou, Helene Pelicano, Paul Chiao, Jin-Song Liu, Peng Huang

Cancer Res (2006) 66 (8_Supplement): 323.

Published: 15 April 2006

View articletitled, Selective killing of oncogenic transformed cells through ROS-mediated mechanism by β-phenylethyl isothiocyanates

Journal Articles

Alterations of ROS generation and drug sensitivity in Ras-transformed pancreatic cells

Yumin Hu, Helene Pelicano, Paul J. Chiao, Peng Huang, Ming-Sound Tsao

Cancer Res (2006) 66 (8_Supplement): 831.

Published: 15 April 2006

View articletitled, Alterations of ROS generation and drug sensitivity in Ras-transformed pancreatic cells

Journal Articles

Preferential induction of apoptosis in malignant cells by β-Phenetyl isothiocyanates (PEITC): Implication of ROS stress in cancer therapeutics

Dunyaporn Trachootham, Helene Pelicano, Jinsong Liu, Peng Huang

Cancer Res (2005) 65 (9_Supplement): 1172–1173.

Published: 01 May 2005

View articletitled, Preferential induction of apoptosis in malignant cells by β-Phenetyl isothiocyanates (PEITC): Implication of ROS stress in cancer therapeutics

Journal Articles

Inhibition of Glycolysis in Cancer Cells: A Novel Strategy to Overcome Drug Resistance Associated with Mitochondrial Respiratory Defect and Hypoxia

Rui-hua Xu, Helene Pelicano, Yan Zhou, Jennifer S. Carew, Li Feng, Kapil N. Bhalla, Michael J. Keating, Peng Huang

Cancer Res (2005) 65 (2): 613–621.

https://doi.org/10.1158/0008-5472.613.65.2

Published: 03 February 2005

View articletitled, Inhibition of Glycolysis in Cancer Cells: A Novel Strategy to Overcome Drug Resistance Associated with Mitochondrial Respiratory Defect and Hypoxia

Journal Articles

Role of AKT activation in drug resistance associated with malfunction of mitochondrial respiration in leukemia cells

Helene Pelicano, Ryohei Sasaki, Latha Ramdas, Li Feng, Michael J. Keating, Wei Zhang, Peng Huang

Cancer Res (2004) 64 (7_Supplement): 264.

Published: 01 April 2004

View articletitled, Role of AKT activation in drug resistance associated with malfunction of mitochondrial respiration in leukemia cells

Journal Articles

OSW-1: A novel anticancer agent with potent anticancer activity and unique mechanism of action.

Yan Zhou, Celia Garcia-Prieto, Li Feng, Helene Pelicano, Zhendong Jin, Michael J. Keating, Peng Huang

Cancer Res (2004) 64 (7_Supplement): 520.

Published: 01 April 2004

View articletitled, OSW-1: A novel anticancer agent with potent anticancer activity and unique mechanism of action.

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Aberrant FGFR Tyrosine Kinase Signaling Enhances the Warburg Effect by Reprogramming LDH Isoform Expression and Activity in Prostate Cancer

Abstract 4408: Metabolic alterations induced by ibrutinib in CLL cells as a basis for drug combinations to enhance ibrutinib therapeutic activity

Abstract 2697: A novel therapeutic strategy to effectively kill CLL cells in stromal microenvironment by targeting lipid metabolism

Abstract 3072: Characterization of TCL1-Tg:p53-/- mice that resemble human chronic lymphocytic leukemia with 17p-deletion: alterations in p53→Mir30→EZH2 axis.

Abstract LB-106: A novel TCL1-Tg:p53^−/− mouse model of human CLL

Abstract LB-107: Targeting the glycolytic pathway as an effective therapeutic approach for triple-negative breast cancer

Mitochondrial Dysfunction and Reactive Oxygen Species Imbalance Promote Breast Cancer Cell Motility through a CXCL14-Mediated Mechanism

Mitochondrial dysfunction leads to NADPH oxidase (NOX) activation and sensitization of cancer cells to NOX inhibitor

CXCL14: A new molecular link between ROS and malignant behavior in breast cancer cells

PEITC: a natural compound effective in killing primary leukemia cells and overcoming drug resistance

Mitochondrial respiratory defects lead to significant alterations in cellular redox states and drug sensitivity

Novel Action of Paclitaxel against Cancer Cells: Bystander Effect Mediated by Reactive Oxygen Species

Inducible expression of dominant negative DNA polymerase gamma(POLGdn) in human cells: characterizations and applications

A novel mechanism of action of methyl-2-cyano-3,12 dioxoolean-1,9 diene-28-oate (CDDO-Me): Direct permeabilization of the inner mitochondrial membrane to inhibit electron transport and induce apoptosis

Selective killing of oncogenic transformed cells through ROS-mediated mechanism by β-phenylethyl isothiocyanates

Alterations of ROS generation and drug sensitivity in Ras-transformed pancreatic cells

Preferential induction of apoptosis in malignant cells by β-Phenetyl isothiocyanates (PEITC): Implication of ROS stress in cancer therapeutics

Inhibition of Glycolysis in Cancer Cells: A Novel Strategy to Overcome Drug Resistance Associated with Mitochondrial Respiratory Defect and Hypoxia

Role of AKT activation in drug resistance associated with malfunction of mitochondrial respiration in leukemia cells

OSW-1: A novel anticancer agent with potent anticancer activity and unique mechanism of action.

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