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Heinz-Herbert Fiebig
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Journal Articles

Abstract 4708: Potency and selectivity of ERBB2-targeting antibody drug conjugates in vitro

Anne-Lise Peille, Kaja Holtorf, Pablo Anton Garcia, Nadine Obier, Daniel Feger, Thomas Metz, Sebastian Dempe, Heinz-Herbert Fiebig, Jan Ehlert, Vincent Vuaroqueaux
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4708.
https://doi.org/10.1158/1538-7445.AM2024-4708
Published: 22 March 2024
View article titled, Abstract 4708: Potency and selectivity of ERBB2-targeting antibody drug conjugates in vitro
Journal Articles

Abstract 4689: 4HF CancerDataMiner platform accelerates target discovery and evaluation

Heinz-Herbert Fiebig, Anne-Lise Peille, Mirko Schmitz, Vincent Vuaroqueaux, Thomas Metz
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4689.
https://doi.org/10.1158/1538-7445.AM2024-4689
Published: 22 March 2024
View article titled, Abstract 4689: 4HF CancerDataMiner platform accelerates target discovery and evaluation
Journal Articles

Abstract 4895: Introduction of a platform for preclinical profiling of drug conjugates: a case study with sacituzumab govitecan

Vincent Vuaroqueaux, Nadine Obier, Anne-Lise Peille, Daniel Feger, Katharina Schaich, Thomas Metz, Sebastian Dempe, Heinz-Herbert Fiebig, Jan Erik Ehlert
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4895.
https://doi.org/10.1158/1538-7445.AM2023-4895
Published: 04 April 2023
View article titled, Abstract 4895: Introduction of a platform for preclinical profiling of drug conjugates: a case study with sacituzumab govitecan
Journal Articles

Abstract 1132: A systems biology approach combining ProLiFiler and Cancer Data Miner for an enhanced preclinical characterization of the WEE-1 inhibitor Adavosertib

Vincent Vuaroqueaux, Daniel Feger, Anne-Lise Peille, Oliver Siedentopf, Sadhana Panzade, Sarah Ulrich, Sebastian Dempe, Heinz-Herbert Fiebig, Jan Erik Ehlert
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1132.
https://doi.org/10.1158/1538-7445.AM2022-1132
Published: 15 June 2022
View article titled, Abstract 1132: A systems biology approach combining ProLiFiler and Cancer Data Miner for an enhanced preclinical characterization of the WEE-1 inhibitor Adavosertib
Journal Articles

Abstract LB107: Identification of a promising renal cell carcinoma target using a unique in silico approach

Alexandra Musch, Anne-Lise Peille, Hoor Al Hasani, Heinz-Herbert Fiebig, Vincent Vuaroqueaux
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB107.
https://doi.org/10.1158/1538-7445.AM2021-LB107
Published: 01 July 2021
View article titled, Abstract LB107: Identification of a promising renal cell carcinoma target using a unique in silico approach
Journal Articles

Abstract 2879: MACC1 overexpression in colorectal cancer is driven by chromosomal instability and is associated with molecular subtype

Vincent Vuaroqueaux, Hoor Al-Hasani, Dennis Kobelt, Thomas Risch, Susen Burock, Marie-Laure Yaspo, Heinz-Herbert Fiebig, Ulrike Stein
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2879.
https://doi.org/10.1158/1538-7445.AM2021-2879
Published: 01 July 2021
View article titled, Abstract 2879: MACC1 overexpression in colorectal cancer is driven by chromosomal instability and is associated with molecular subtype
Journal Articles

Abstract 1027: ProLiFiler and Cancer Data Miner, combined platforms for preclinical investigation to scrutinize impact of inhibitors on the KRAS, PI3K and MDM2 signaling pathways

Vincent Vuaroqueaux, Daniel Feger, Hoor Al-Hasani, Oliver Siedentopf, Anne-Lise Peille, Sarah Ulrich, Sebastian Dempe, Heinz-Herbert Fiebig, Jan Erik Ehlert
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1027.
https://doi.org/10.1158/1538-7445.AM2021-1027
Published: 01 July 2021
View article titled, Abstract 1027: ProLiFiler and Cancer Data Miner, combined platforms for preclinical investigation to scrutinize impact of inhibitors on the KRAS, PI3K and MDM2 signaling pathways
Journal Articles

Abstract 1173: Identification of novel targets for the treatment of pancreatic cancer patients

Anne-Lise Peille, Alexandra Musch, Hoor Al-Hasani, Heinz-Herbert Fiebig, Vincent Vuaroqueaux
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1173.
https://doi.org/10.1158/1538-7445.AM2021-1173
Published: 01 July 2021
View article titled, Abstract 1173: Identification of novel targets for the treatment of pancreatic cancer patients
Journal Articles

Abstract 2196: Strong anti-tumor activity of MEK inhibitor GDC-0623 and determination of predictive biomarkers

Vincent Vuaroqueaux, Hoor Al Hasani, Gerhard Kelter, Hans R Hendriks, Heinz-Herbert Fiebig
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2196.
https://doi.org/10.1158/1538-7445.AM2019-2196
Published: 01 July 2019
View article titled, Abstract 2196: Strong anti-tumor activity of MEK inhibitor GDC-0623 and determination of predictive biomarkers
Journal Articles

Abstract 3074: Broad spectrum activity of the BET inhibitor GSK 1324726A in hematologic and solid cancer cell lines in-vitro and determination of associated predictive biomarkers

Heinz-Herbert Fiebig, Gerhard Kelter, Hans R Hendriks, Vincent Vuaroqueaux
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3074.
https://doi.org/10.1158/1538-7445.AM2019-3074
Published: 01 July 2019
View article titled, Abstract 3074: Broad spectrum activity of the BET inhibitor GSK 1324726A in hematologic and solid cancer cell lines <em>in-vitro</em> and determination of associated predictive biomarkers
Journal Articles

Abstract 639: Subtyping of pancreatic cancer patient-derived xenograft tumors and implications for anticancer agent testing

Peter Bronsert, Tim Kees, Bruno Zeitouni, Anne-Lise Peille, Manuel Landesfeind, Heinz-Herbert Fiebig, Simon Kuesters, Vincent Vuaroqueaux
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 639.
https://doi.org/10.1158/1538-7445.AM2016-639
Published: 15 July 2016
View article titled, Abstract 639: Subtyping of pancreatic cancer patient-derived xenograft tumors and implications for anticancer agent testing
Journal Articles

Abstract 2890: Single mouse trials, a concept using patient-derived tumor xenografts for large scale in vivo screens

Christina Gredy, Julia B. Schüler, Nina Zanella, Heinz-Herbert Fiebig, Thomas Metz
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2890.
https://doi.org/10.1158/1538-7445.AM2015-2890
Published: 01 August 2015
View article titled, Abstract 2890: Single mouse trials, a concept using patient-derived tumor xenografts for large scale in vivo screens
Journal Articles

Abstract 1705: Classification of colorectal PDX into transcriptomic subtypes associated with distinct genomic alteration profiles and in vivo response patterns to therapies

Anne-Lise Peille, Christina Gredy, Bruno Zeitouni, Armin Maier, Kerstin Klingner, Tim Kees, Julia Schüler, Thomas Metz, Heinz. Herbert Fiebig, Vincent Vuaroqueaux
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1705.
https://doi.org/10.1158/1538-7445.AM2015-1705
Published: 01 August 2015
View article titled, Abstract 1705: Classification of colorectal PDX into transcriptomic subtypes associated with distinct genomic alteration profiles and <em>in vivo</em> response patterns to therapies
Journal Articles

Abstract 4999: Signaling-associated complexes to define targetable vulnerabilities in lung cancer

Matthew Smith, Thomas Licata, Yun Bai, Guolin Zhang, Vincent Vuaroqueaux, Heinz-Herbert Fiebig, Eric B. Haura
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4999.
https://doi.org/10.1158/1538-7445.AM2015-4999
Published: 01 August 2015
View article titled, Abstract 4999: Signaling-associated complexes to define targetable vulnerabilities in lung cancer
Journal Articles

Abstract 4210: Patient-derived models of human acute myeloid and lymphoid leukemia in immunocompromised mice for preclinical drug development

Eva Oswald, Kerstin Klingner, Benedikt Hammerich, Gabriele Greve, Dorothee Lenhard, Milena Pantic, Heinz-Herbert Fiebig, Michael Luebbert, Julia B. Schüler
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4210.
https://doi.org/10.1158/1538-7445.AM2015-4210
Published: 01 August 2015
View article titled, Abstract 4210: Patient-derived models of human acute myeloid and lymphoid leukemia in immunocompromised mice for preclinical drug development
Journal Articles

Abstract 1203: Whole-exome sequencing analysis across 23 histotypes of patient-derived tumor xenografts reveals their similarities with TCGA patient tumors

Frederic Foucault, Florian Kiefer, Bruno Zeitouni, Jagatheswari Virayah, Thomas Metcalfe, Vincent Vuaroqueaux, Heinz-Herbert Fiebig
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1203.
https://doi.org/10.1158/1538-7445.AM2014-1203
Published: 01 October 2014
View article titled, Abstract 1203: Whole-exome sequencing analysis across 23 histotypes of patient-derived tumor xenografts reveals their similarities with TCGA patient tumors
Journal Articles

Abstract LB-314: Whole exome sequencing analyses of gastric cancers reveal two distinct genomic alteration patterns with implications in drug sensitivity

Anne-Lise Peille, Swee-Seong Wong, Florian Kiefer, Bruno Zeitouni, Armin Maier, Frederic Foucault, Tim Kees, Vincent Vuaroqueaux, Amit Aggarwal, Christoph Reinhard, Heinz Herbert Fiebig
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): LB-314.
https://doi.org/10.1158/1538-7445.AM2014-LB-314
Published: 01 October 2014
View article titled, Abstract LB-314: Whole exome sequencing analyses of gastric cancers reveal two distinct genomic alteration patterns with implications in drug sensitivity
Journal Articles

Abstract 3699: Molecular profiling of BRAFi-resistance in melanoma cancer models using high-throughput sequencing in patient-derived xenografts

Bruno Zeitouni, Gerhard Kelter, Armin Maier, Florian Kiefer, Frederic Foucault, Anne-Lise Peille, Tim Kees, Torsten Giesemann, Vincent Vuaroqueaux, Thomas Metcalfe, Heinz-Herbert Fiebig
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3699.
https://doi.org/10.1158/1538-7445.AM2014-3699
Published: 01 October 2014
View article titled, Abstract 3699: Molecular profiling of BRAFi-resistance in melanoma cancer models using high-throughput sequencing in patient-derived xenografts
Journal Articles

Abstract 3381: Overcoming resistance to BRAF inhibitors in colon cancer and melanoma cell lines.

Gerhard Kelter, Rebekka Krumbach, Torsten Giesemann, Vincent Vuaroqueaux, Thomas Metz, Thomas Metcalfe, Heinz-Herbert Fiebig
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3381.
https://doi.org/10.1158/1538-7445.AM2013-3381
Published: 15 April 2013
View article titled, Abstract 3381: Overcoming resistance to BRAF inhibitors in colon cancer and melanoma cell lines.
Journal Articles

Abstract 2774: The molecular determinants of sensitivity to HER2 targeted therapy in Patient Derived Xenograft gastric tumor models from Caucasian and Eastern Asian patients.

Vincent Vuaroqueaux, Andreas Ackermann, Jianing Guo, Anne-Lise Peille, Rebekka Krumbach, Frederic Foucault, Thomas Metz, Heinz-Herbert Fiebig
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2774.
https://doi.org/10.1158/1538-7445.AM2013-2774
Published: 15 April 2013
View article titled, Abstract 2774: The molecular determinants of sensitivity to HER2 targeted therapy in Patient Derived Xenograft gastric tumor models from Caucasian and Eastern Asian patients.