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Abstract 6245: 3D-models of pediatric bone sarcomas for personalized therapeutic screening

Branka Radic Sarikas, Mathias Ilg, Marica Markovic, Caterina Sturtzel, Eva Scheuringer, Justine Zulini, Martin Metzelder, Florian Halbritter, Martin Distel, Didier Surdez, Olivier Delattre, Aleksandr Ovsianikov, Heinrich Kovar

Cancer Res (2022) 82 (12_Supplement): 6245.

DOI: https://doi.org/10.1158/1538-7445.AM2022-6245

Published: 15 June 2022

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Abstract 1669: Transient IGF1 exposure stably reprograms EWS-FLI1 immortalized embryonal limb-derived mesenchymal stem cell-like cells to full transformation

Rahil Noorizadeh, Florian Halbritter, Barbara Sax, Wolfgang Mikulits, Richard Moriggl, Heinrich Kovar

Cancer Res (2022) 82 (12_Supplement): 1669.

DOI: https://doi.org/10.1158/1538-7445.AM2022-1669

Published: 15 June 2022

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Abstract B40: EWS-FLI1 orchestrates Ewing sarcoma plasticity through a post-translational modification cascade regulating FOXM1 stability

Jozef Ban, Dave Aryee, Lisa Bierbaumer, Heinrich Kovar

Cancer Res (2020) 80 (14_Supplement): B40.

DOI: https://doi.org/10.1158/1538-7445.PEDCA19-B40

Published: 15 July 2020

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Abstract B28: A cross-species enhancer activity analysis approach to identify the Ewing sarcoma cell of origin

Sarah Grissenberger, Anna Poetsch, Monika Heinzl, Luisa Morelli, Nathan Sheffield, Niko Popitsch, Heinrich Kovar, Martin Distel

Cancer Res (2020) 80 (14_Supplement): B28.

DOI: https://doi.org/10.1158/1538-7445.PEDCA19-B28

Published: 15 July 2020

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Journal Articles

Abstract 1049: Targeting YAP/TAZ pathway inhibits Ewing sarcoma metastasis

Lisa Bierbaumer, Anna M. Katschnig, Branka Radic-Sarikas, Jeffrey R. Petro, Karin Mühlbacher, Dave N. Aryee, Anna R. Pötsch, Sandra Högler, Lukas Kenner, Aykut Uren, Heinrich Kovar

Cancer Res (2019) 79 (13_Supplement): 1049.

DOI: https://doi.org/10.1158/1538-7445.AM2019-1049

Published: 01 July 2019

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Abstract A02: Targeting EWS-FLI1 dose-dependent epithelial-to-mesenchymal transition

Anna M. Katschnig, Maximilian O. Kauer, Raphaela Schwentner, Eleni M. Tomazou, Dave N.T. Aryee, Heinrich Kovar

Cancer Res (2018) 78 (19_Supplement): A02.

DOI: https://doi.org/10.1158/1538-7445.PEDCA17-A02

Published: 01 October 2018

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Abstract A13: Genome-wide association study identifies multiple new loci associated with Ewing sarcoma susceptibility

Mitchell J. Machiela, Thomas G.P. Grünewald, Didier Surdez, Stephanie Reynaud, Olivier Mirabeau, Eric Karlins, Rebeca Alba Rubio, Sakina Zaidi, Sandrine Grossetete-Lalami, Stelly Ballet, Eve Lapouble, Valérie Laurence, Jean Michon, Gaelle Pierron, Heinrich Kovar, Nathalie Gaspar, Udo Kontny, Anna González-Neira, Piero Picci, Javier Alonso, Ana Patino-Garcia, Nadège Corradini, Neal D. Freedman, Nathaniel Rothman, Casey L. Dagnall, Laurie Burdett, Kristine Jones, Michelle Manning, Kathleen Wyatt, Weiyin Zhou, Meredith Yeager, David G. Cox, Robert N. Hoover, Javed Khan, Gregory T. Armstrong, Wendy M. Leisenring, Smita Bhatia, Leslie L. Robison, Uta Dirksen, Markus Metzler, Wolfgang Hartmann, Konstantin Strauch, Thomas Kirchner, Andreas E. Kulozik, Lindsay M. Morton, Lisa Mirabello, Margaret A. Tucker, Franck Tirode, Stephen Chanock, Olivier Delattre

Cancer Res (2018) 78 (19_Supplement): A13.

DOI: https://doi.org/10.1158/1538-7445.PEDCA17-A13

Published: 01 October 2018

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Journal Articles

Abstract 2970: Multiple new susceptibility loci identified in genome-wide association study of Ewing sarcoma

Mitchell J. Machiela, Thomas G. Grünewald, Didier Surdez, Stephanie Reynaud, Olivier Mirabeau, Eric Karlins, Rebeca Alba Rubio, Sakina Zaidi, Sandrine Grossetete-Lalami, Stelly Ballet, Eve Lapouble, Valérie Laurence, Jean Michon, Gaelle Pierron, Heinrich Kovar, Nathalie Gaspar, Udo Kontny, Anna González-Neira, Piero Picci, Javier Alonso, Ana Patino-Garcia, Nadège Corradini, Neal D. Freedman, Nathaniel Rothman, Casey L. Dagnall, Laurie Burdette, Kristine Jones, Michelle Manning, Kathleen Wyatt, Weiyin Zhou, Meredith Yeager, David G. Cox, Robert N. Hoover, Javed Khan, Gregory T. Armstrong, Wendy M. Leisenring, Smita Bhatia, Leslie L. Robison, Uta Dirksen, Markus Metzler, Wolfgang Hartmann, Konstantin Strauch, Thomas Kirchner, Andreas E. Kulozik, Lindsay M. Morton, Lisa Mirabello, Margaret A. Tucker, Franck Tirode, Stephen J. Chanock, Olivier Delattre

Cancer Res (2018) 78 (13_Supplement): 2970.

DOI: https://doi.org/10.1158/1538-7445.AM2018-2970

Published: 01 July 2018

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Journal Articles

Abstract 3515: Down the rabbit hole with structural effects of FK866 in primary CLL B cells

Cheryl Peltier, Eileen McMillan-Ward, Elizabeth Henson, Nabanita Chatterje, Donna Hewitt, Danielle Desautels, Matthieu Bourrier, Cornelia Mutz, Iris Gehrke, Eric Bouchard, Heinrich Kovar, Shantanu Banerji, Spencer Gibson, Sara Israels, Versha Banerji

Cancer Res (2018) 78 (13_Supplement): 3515.

DOI: https://doi.org/10.1158/1538-7445.AM2018-3515

Published: 01 July 2018

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Journal Articles

Abstract 4459: EWS-FLI1 orchestrates beta-catenin regulation by a mechanism involving post-translational KDM1A stabilization

Jozef Ban, Dave N. Aryee, Anna M. Katschnig, Raphaela Schwentner, Maximilian O. Kauer, Heinrich Kovar

Cancer Res (2018) 78 (13_Supplement): 4459.

DOI: https://doi.org/10.1158/1538-7445.AM2018-4459

Published: 01 July 2018

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Journal Articles

Abstract 3508: EWS-FLI1 represses Rho-actin signaling via MRTFB/YAP-1/TEAD perturbation in Ewing Sarcoma

Anna M. Katschnig, Maximilian O. Kauer, Raphaela Schwentner, Eleni M. Tomazou, Markus Linder, Cornelia N. Mutz, Javier Alonso, Dave N. Aryee, Heinrich Kovar

Cancer Res (2017) 77 (13_Supplement): 3508.

DOI: https://doi.org/10.1158/1538-7445.AM2017-3508

Published: 01 July 2017

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Abstract 3452: The cohesin subunit STAG1 is a hardwired genetic dependency of STAG2 mutant cancer cells

Petra Van Der Lelij, Simone Lieb, Julian Jude, Gordana Wutz, Catarina Pereira, Katrina Falkenberg, Jozef Ban, Heinrich Kovar, Todd Waldman, Francisco Real, Mark Pearson, Norbert Kraut, Jan-Michael Peters, Johannes Zuber, Mark P. Petronczki

Cancer Res (2017) 77 (13_Supplement): 3452.

DOI: https://doi.org/10.1158/1538-7445.AM2017-3452

Published: 01 July 2017

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Abstract 1045: Targeting NAMPT in Ewing's sarcoma cells

Cornelia N. Mutz, Raphaela Schwentner, Eric Bouchard, Edgard M. Mejia, Anna M. Katschnig, Maximilian O. Kauer, Dave N.T. Aryee, Antje Garten, Versha Banerji, Heinrich Kovar

Cancer Res (2016) 76 (14_Supplement): 1045.

DOI: https://doi.org/10.1158/1538-7445.AM2016-1045

Published: 15 July 2016

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Journal Articles

Abstract 1918: The role of miR17-92 in the miRegulatory landscape of Ewing sarcoma

Raphaela Schwentner, Maximilian Kauer, David Herrero-Martin, Heinrich Kovar

Cancer Res (2016) 76 (14_Supplement): 1918.

DOI: https://doi.org/10.1158/1538-7445.AM2016-1918

Published: 15 July 2016

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Abstract 973: A long noncoding RNA-regulating enhancer links Ewing sarcoma susceptibility to stress response

Dave NT Aryee, Eleni Tomazou, Maximilian Kauer, Thomas Grünewald, Franck Tirode, Olivier Delattre, Heinrich Kovar

Cancer Res (2016) 76 (14_Supplement): 973.

DOI: https://doi.org/10.1158/1538-7445.AM2016-973

Published: 15 July 2016

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Abstract 2028: Transcriptional modules involving EWS-FLI1 and SRF in Ewing sarcoma

Anna M. Katschnig, Maximilian O. Kauer, Dave N t Aryee, Raphaela Schwentner, Elizabeth Lawlor, Heinrich Kovar

Cancer Res (2016) 76 (14_Supplement): 2028.

DOI: https://doi.org/10.1158/1538-7445.AM2016-2028

Published: 15 July 2016

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Journal Articles

Abstract PR13: DNA methylation mapping and computational modeling in a large Ewing sarcoma cohort identifies principles of tumor heterogeneity and their impact on clinical phenotypes

Cancer Res (2016) 76 (5_Supplement): PR13.

DOI: https://doi.org/10.1158/1538-7445.PEDCA15-PR13

Published: 04 April 2016

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Journal Articles

Abstract 2105: An EWS-FLI1/MRTF gene regulatory network in Ewing sarcoma

Anna M. Katschnig, Maximilian Kauer, Raphaela Schwentner, Dave N.T Aryee, Elizabeth Lawlor, Heinrich Kovar

Cancer Res (2015) 75 (15_Supplement): 2105.

DOI: https://doi.org/10.1158/1538-7445.AM2015-2105

Published: 01 August 2015

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Abstract 2104: Evidence for E2F/EWS-FLI1 oncoprotein synergism using systems biology

Raphaela Schwentner, Theodore Papamarkou, Maximilian Kauer, Vassilios Stathopoulos, Fan Yang, Sven Bilke, Paul S. Meltzer, Mark Girolami, Heinrich Kovar

Cancer Res (2015) 75 (15_Supplement): 2104.

DOI: https://doi.org/10.1158/1538-7445.AM2015-2104

Published: 01 August 2015

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Journal Articles

Abstract 1162: Investigating the NAD metabolome in Ewing Sarcoma

Cornelia N. Mutz, Raphaela Schwentner, Maximilian O. Kauer, Jozef Ban, Dave N. T. Aryee, Sophie Erhardt, Dietmar Fuchs, Andreas Heitger, Heinrich Kovar

Cancer Res (2015) 75 (15_Supplement): 1162.

DOI: https://doi.org/10.1158/1538-7445.AM2015-1162

Published: 01 August 2015

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NARROW

Abstract 6245: 3D-models of pediatric bone sarcomas for personalized therapeutic screening

Abstract 1669: Transient IGF1 exposure stably reprograms EWS-FLI1 immortalized embryonal limb-derived mesenchymal stem cell-like cells to full transformation

Abstract B40: EWS-FLI1 orchestrates Ewing sarcoma plasticity through a post-translational modification cascade regulating FOXM1 stability

Abstract B28: A cross-species enhancer activity analysis approach to identify the Ewing sarcoma cell of origin

Abstract 1049: Targeting YAP/TAZ pathway inhibits Ewing sarcoma metastasis

Abstract A02: Targeting EWS-FLI1 dose-dependent epithelial-to-mesenchymal transition

Abstract A13: Genome-wide association study identifies multiple new loci associated with Ewing sarcoma susceptibility

Abstract 2970: Multiple new susceptibility loci identified in genome-wide association study of Ewing sarcoma

Abstract 3515: Down the rabbit hole with structural effects of FK866 in primary CLL B cells

Abstract 4459: EWS-FLI1 orchestrates beta-catenin regulation by a mechanism involving post-translational KDM1A stabilization

Abstract 3508: EWS-FLI1 represses Rho-actin signaling via MRTFB/YAP-1/TEAD perturbation in Ewing Sarcoma

Abstract 3452: The cohesin subunit STAG1 is a hardwired genetic dependency of STAG2 mutant cancer cells

Abstract 1045: Targeting NAMPT in Ewing's sarcoma cells

Abstract 1918: The role of miR17-92 in the miRegulatory landscape of Ewing sarcoma

Abstract 973: A long noncoding RNA-regulating enhancer links Ewing sarcoma susceptibility to stress response

Abstract 2028: Transcriptional modules involving EWS-FLI1 and SRF in Ewing sarcoma

Abstract PR13: DNA methylation mapping and computational modeling in a large Ewing sarcoma cohort identifies principles of tumor heterogeneity and their impact on clinical phenotypes

Abstract 2105: An EWS-FLI1/MRTF gene regulatory network in Ewing sarcoma

Abstract 2104: Evidence for E2F/EWS-FLI1 oncoprotein synergism using systems biology

Abstract 1162: Investigating the NAD metabolome in Ewing Sarcoma

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