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Heinrich Kovar
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Journal Articles

Abstract 234: ITCC-P4: Genomic profiling and analyses of pediatric patient tumor and patient-derived xenograft (PDX) models for high throughput in vivo testing

Apurva Gopisetty, Aniello Federico, Didier Surdez, Yasmine Iddir, Sakina Zaidi, Alexandra Saint-Charles, Joshua Waterfall, Elnaz Saberi-Ansari, Justyna Wierzbinska, Andreas Schlicker, Norman Mack, Benjamin Schwalm, Christopher Previti, Lena Weiser, Ivo Buchhalter, Anna-Lisa Böttcher, Martin Sill, Robert Autry, Frank Estermann, David Jones, Richard Volckmann, Danny Zwijnenburg, Angelika Eggert, Olaf Heidenreich, Fatima Iradier, Irmela Jeremias, Heinrich Kovar, Jan-Henning Klusmann, Klaus-Michael Debatin, Simon Bomken, Petra Hamerlik, Maureen Hattersley, Olaf Witt, Louis Chesler, Alan Mackay, Johannes Gojo, Stefano Cairo, Julia Schueler, Johannes Schulte, Birgit Geoerger, Jan J. Molenaar, David J. Shields, Hubert N. Caron, Gilles Vassal, Louis F. Stancato, Stefan M. Pfister, Natalie Jaeger, Jan Koster, Marcel Kool, Gudrun Schleiermacher
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 234.
https://doi.org/10.1158/1538-7445.AM2023-234
Published: 04 April 2023
View article titled, Abstract 234: ITCC-P4: Genomic profiling and analyses of pediatric patient tumor and patient-derived xenograft (PDX) models for high throughput <em>in vivo</em> testing
Journal Articles

Abstract 3571: The ITCC-P4 sustainable platform of fully characterized PDXs supports the preclinical proof-of-concept drug testing of high-risk pediatric tumor models

Aniello Federico, Apurva Gopisetty, Didier Surdez, Yasmine Iddir, Alexandra Saint-Charles, Justyna Wierzbinska, Andreas Schlicker, Richard Volckmann, Danny Zwijnenburg, Sara Colombetti, Olaf Heidenreich, Fatima Iradier, Heinrich Kovar, Jan-Henning Klusmann, Klaus-Michael Debatin, Simon Bomken, Christina Guttke, Maureen M. Hattersley, Frédéric Colland, Ashley Strougo, María José Guillén, Louis Chesler, Chris Jones, Maria Eugénia Marques da Costa, Katia Scotlandi, Massimo Moro, Beat Schäfer, Marco Wachtel, Johannes Gojo, Walter Berger, Ángel Montero Carcaboso, Dennis Gürgen, Jens Hoffmann, Emilie Indersie, Stefano Cairo, Julia Schueler, Nicole Huebener, Johannes H. Schulte, Jan J. Molenaar, Birgit Geoerger, David J. Shields, Hubert N. Caron, Gilles Vassal, Lou F. Stancato, Lou F. Stancato, Stefan M. Pfister, Natalie Jäger, Jan Koster, Marcel Kool, Gudrun Schleiermacher
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3571.
https://doi.org/10.1158/1538-7445.AM2023-3571
Published: 04 April 2023
View article titled, Abstract 3571: The ITCC-P4 sustainable platform of fully characterized PDXs supports the preclinical proof-of-concept drug testing of high-risk pediatric tumor models
Journal Articles

Abstract 1467: A novel screening model to identify EWS::FLI1 regulators and their consequences on Ewing sarcoma plasticity

Veveeyan Suresh, Valerie Fock, Beat Schäfer, Heinrich Kovar
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1467.
https://doi.org/10.1158/1538-7445.AM2023-1467
Published: 04 April 2023
View article titled, Abstract 1467: A novel screening model to identify EWS::FLI1 regulators and their consequences on Ewing sarcoma plasticity
Journal Articles

Abstract 6245: 3D-models of pediatric bone sarcomas for personalized therapeutic screening

Branka Radic Sarikas, Mathias Ilg, Marica Markovic, Caterina Sturtzel, Eva Scheuringer, Justine Zulini, Martin Metzelder, Florian Halbritter, Martin Distel, Didier Surdez, Olivier Delattre, Aleksandr Ovsianikov, Heinrich Kovar
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6245.
https://doi.org/10.1158/1538-7445.AM2022-6245
Published: 15 June 2022
View article titled, Abstract 6245: 3D-models of pediatric bone sarcomas for personalized therapeutic screening
Journal Articles

Abstract 1669: Transient IGF1 exposure stably reprograms EWS-FLI1 immortalized embryonal limb-derived mesenchymal stem cell-like cells to full transformation

Rahil Noorizadeh, Florian Halbritter, Barbara Sax, Wolfgang Mikulits, Richard Moriggl, Heinrich Kovar
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1669.
https://doi.org/10.1158/1538-7445.AM2022-1669
Published: 15 June 2022
View article titled, Abstract 1669: Transient IGF1 exposure stably reprograms EWS-FLI1 immortalized embryonal limb-derived mesenchymal stem cell-like cells to full transformation
Journal Articles

Abstract B40: EWS-FLI1 orchestrates Ewing sarcoma plasticity through a post-translational modification cascade regulating FOXM1 stability

Jozef Ban, Dave Aryee, Lisa Bierbaumer, Heinrich Kovar
Journal: Cancer Research
Cancer Res (2020) 80 (14_Supplement): B40.
https://doi.org/10.1158/1538-7445.PEDCA19-B40
Published: 15 July 2020
View article titled, Abstract B40: EWS-FLI1 orchestrates Ewing sarcoma plasticity through a post-translational modification cascade regulating FOXM1 stability
Journal Articles

Abstract B28: A cross-species enhancer activity analysis approach to identify the Ewing sarcoma cell of origin

Sarah Grissenberger, Anna Poetsch, Monika Heinzl, Luisa Morelli, Nathan Sheffield, Niko Popitsch, Heinrich Kovar, Martin Distel
Journal: Cancer Research
Cancer Res (2020) 80 (14_Supplement): B28.
https://doi.org/10.1158/1538-7445.PEDCA19-B28
Published: 15 July 2020
View article titled, Abstract B28: A cross-species enhancer activity analysis approach to identify the Ewing sarcoma cell of origin
Journal Articles

Abstract 1049: Targeting YAP/TAZ pathway inhibits Ewing sarcoma metastasis

Lisa Bierbaumer, Anna M. Katschnig, Branka Radic-Sarikas, Jeffrey R. Petro, Karin Mühlbacher, Dave N. Aryee, Anna R. Pötsch, Sandra Högler, Lukas Kenner, Aykut Uren, Heinrich Kovar
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1049.
https://doi.org/10.1158/1538-7445.AM2019-1049
Published: 01 July 2019
View article titled, Abstract 1049: Targeting YAP/TAZ pathway inhibits Ewing sarcoma metastasis
Journal Articles

Abstract A13: Genome-wide association study identifies multiple new loci associated with Ewing sarcoma susceptibility

Mitchell J. Machiela, Thomas G.P. Grünewald, Didier Surdez, Stephanie Reynaud, Olivier Mirabeau, Eric Karlins, Rebeca Alba Rubio, Sakina Zaidi, Sandrine Grossetete-Lalami, Stelly Ballet, Eve Lapouble, Valérie Laurence, Jean Michon, Gaelle Pierron, Heinrich Kovar, Nathalie Gaspar, Udo Kontny, Anna González-Neira, Piero Picci, Javier Alonso, Ana Patino-Garcia, Nadège Corradini, Neal D. Freedman, Nathaniel Rothman, Casey L. Dagnall, Laurie Burdett, Kristine Jones, Michelle Manning, Kathleen Wyatt, Weiyin Zhou, Meredith Yeager, David G. Cox, Robert N. Hoover, Javed Khan, Gregory T. Armstrong, Wendy M. Leisenring, Smita Bhatia, Leslie L. Robison, Uta Dirksen, Markus Metzler, Wolfgang Hartmann, Konstantin Strauch, Thomas Kirchner, Andreas E. Kulozik, Lindsay M. Morton, Lisa Mirabello, Margaret A. Tucker, Franck Tirode, Stephen Chanock, Olivier Delattre
Journal: Cancer Research
Cancer Res (2018) 78 (19_Supplement): A13.
https://doi.org/10.1158/1538-7445.PEDCA17-A13
Published: 01 October 2018
View article titled, Abstract A13: Genome-wide association study identifies multiple new loci associated with Ewing sarcoma susceptibility
Journal Articles

Abstract A02: Targeting EWS-FLI1 dose-dependent epithelial-to-mesenchymal transition

Anna M. Katschnig, Maximilian O. Kauer, Raphaela Schwentner, Eleni M. Tomazou, Dave N.T. Aryee, Heinrich Kovar
Journal: Cancer Research
Cancer Res (2018) 78 (19_Supplement): A02.
https://doi.org/10.1158/1538-7445.PEDCA17-A02
Published: 01 October 2018
View article titled, Abstract A02: Targeting EWS-FLI1 dose-dependent epithelial-to-mesenchymal transition
Journal Articles

Abstract 2970: Multiple new susceptibility loci identified in genome-wide association study of Ewing sarcoma

Mitchell J. Machiela, Thomas G. Grünewald, Didier Surdez, Stephanie Reynaud, Olivier Mirabeau, Eric Karlins, Rebeca Alba Rubio, Sakina Zaidi, Sandrine Grossetete-Lalami, Stelly Ballet, Eve Lapouble, Valérie Laurence, Jean Michon, Gaelle Pierron, Heinrich Kovar, Nathalie Gaspar, Udo Kontny, Anna González-Neira, Piero Picci, Javier Alonso, Ana Patino-Garcia, Nadège Corradini, Neal D. Freedman, Nathaniel Rothman, Casey L. Dagnall, Laurie Burdette, Kristine Jones, Michelle Manning, Kathleen Wyatt, Weiyin Zhou, Meredith Yeager, David G. Cox, Robert N. Hoover, Javed Khan, Gregory T. Armstrong, Wendy M. Leisenring, Smita Bhatia, Leslie L. Robison, Uta Dirksen, Markus Metzler, Wolfgang Hartmann, Konstantin Strauch, Thomas Kirchner, Andreas E. Kulozik, Lindsay M. Morton, Lisa Mirabello, Margaret A. Tucker, Franck Tirode, Stephen J. Chanock, Olivier Delattre
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2970.
https://doi.org/10.1158/1538-7445.AM2018-2970
Published: 01 July 2018
View article titled, Abstract 2970: Multiple new susceptibility loci identified in genome-wide association study of Ewing sarcoma
Journal Articles

Abstract 3515: Down the rabbit hole with structural effects of FK866 in primary CLL B cells

Cheryl Peltier, Eileen McMillan-Ward, Elizabeth Henson, Nabanita Chatterje, Donna Hewitt, Danielle Desautels, Matthieu Bourrier, Cornelia Mutz, Iris Gehrke, Eric Bouchard, Heinrich Kovar, Shantanu Banerji, Spencer Gibson, Sara Israels, Versha Banerji
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3515.
https://doi.org/10.1158/1538-7445.AM2018-3515
Published: 01 July 2018
View article titled, Abstract 3515: Down the rabbit hole with structural effects of FK866 in primary CLL B cells
Journal Articles

Abstract 4459: EWS-FLI1 orchestrates beta-catenin regulation by a mechanism involving post-translational KDM1A stabilization

Jozef Ban, Dave N. Aryee, Anna M. Katschnig, Raphaela Schwentner, Maximilian O. Kauer, Heinrich Kovar
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4459.
https://doi.org/10.1158/1538-7445.AM2018-4459
Published: 01 July 2018
View article titled, Abstract 4459: EWS-FLI1 orchestrates beta-catenin regulation by a mechanism involving post-translational KDM1A stabilization
Journal Articles

Abstract 3508: EWS-FLI1 represses Rho-actin signaling via MRTFB/YAP-1/TEAD perturbation in Ewing Sarcoma

Anna M. Katschnig, Maximilian O. Kauer, Raphaela Schwentner, Eleni M. Tomazou, Markus Linder, Cornelia N. Mutz, Javier Alonso, Dave N. Aryee, Heinrich Kovar
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3508.
https://doi.org/10.1158/1538-7445.AM2017-3508
Published: 01 July 2017
View article titled, Abstract 3508: EWS-FLI1 represses Rho-actin signaling via MRTFB/YAP-1/TEAD perturbation in Ewing Sarcoma
Journal Articles

Abstract 3452: The cohesin subunit STAG1 is a hardwired genetic dependency of STAG2 mutant cancer cells

Petra Van Der Lelij, Simone Lieb, Julian Jude, Gordana Wutz, Catarina Pereira, Katrina Falkenberg, Jozef Ban, Heinrich Kovar, Todd Waldman, Francisco Real, Mark Pearson, Norbert Kraut, Jan-Michael Peters, Johannes Zuber, Mark P. Petronczki
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3452.
https://doi.org/10.1158/1538-7445.AM2017-3452
Published: 01 July 2017
View article titled, Abstract 3452: The cohesin subunit <em>STAG1</em> is a hardwired genetic dependency of <em>STAG2</em> mutant cancer cells
Journal Articles

Abstract 1918: The role of miR17-92 in the miRegulatory landscape of Ewing sarcoma

Raphaela Schwentner, Maximilian Kauer, David Herrero-Martin, Heinrich Kovar
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1918.
https://doi.org/10.1158/1538-7445.AM2016-1918
Published: 15 July 2016
View article titled, Abstract 1918: The role of miR17-92 in the miRegulatory landscape of Ewing sarcoma
Journal Articles

Abstract 2028: Transcriptional modules involving EWS-FLI1 and SRF in Ewing sarcoma

Anna M. Katschnig, Maximilian O. Kauer, Dave N t Aryee, Raphaela Schwentner, Elizabeth Lawlor, Heinrich Kovar
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2028.
https://doi.org/10.1158/1538-7445.AM2016-2028
Published: 15 July 2016
View article titled, Abstract 2028: Transcriptional modules involving EWS-FLI1 and SRF in Ewing sarcoma
Journal Articles

Abstract 1045: Targeting NAMPT in Ewing's sarcoma cells

Cornelia N. Mutz, Raphaela Schwentner, Eric Bouchard, Edgard M. Mejia, Anna M. Katschnig, Maximilian O. Kauer, Dave N.T. Aryee, Antje Garten, Versha Banerji, Heinrich Kovar
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1045.
https://doi.org/10.1158/1538-7445.AM2016-1045
Published: 15 July 2016
View article titled, Abstract 1045: Targeting NAMPT in Ewing's sarcoma cells
Journal Articles

Abstract 973: A long noncoding RNA-regulating enhancer links Ewing sarcoma susceptibility to stress response

Dave NT Aryee, Eleni Tomazou, Maximilian Kauer, Thomas Grünewald, Franck Tirode, Olivier Delattre, Heinrich Kovar
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 973.
https://doi.org/10.1158/1538-7445.AM2016-973
Published: 15 July 2016
View article titled, Abstract 973: A long noncoding RNA-regulating enhancer links Ewing sarcoma susceptibility to stress response
Journal Articles

Abstract PR13: DNA methylation mapping and computational modeling in a large Ewing sarcoma cohort identifies principles of tumor heterogeneity and their impact on clinical phenotypes

Nathan C. Sheffield, Franck Tirode, Sandrine Grossetete-Lalami, Paul Datlinger, Andreas Schönegger, Johanna Hadler, Diana Walder, Ingeborg M. Ambros, Ana Teresa Amaral, Enrique de Álava, Katharina Schallmoser, Dirk Strunk, Beate Rinner, Bernadette Liegl-Atzwanger, Berthold Huppertz, Andreas Leithner, Uta Dirksen, Peter Ambros, Olivier Delattre, Heinrich Kovar, Christoph Bock, Eleni M. Tomazou
Journal: Cancer Research
Cancer Res (2016) 76 (5_Supplement): PR13.
https://doi.org/10.1158/1538-7445.PEDCA15-PR13
Published: 04 April 2016
View article titled, Abstract PR13: DNA methylation mapping and computational modeling in a large Ewing sarcoma cohort identifies principles of tumor heterogeneity and their impact on clinical phenotypes