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Journal Articles

p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade

David P. Molkentine, Jessica M. Molkentine, Kathleen A. Bridges, David R. Valdecanas, Annika Dhawan, Reshub Bahri, Andrew J. Hefner, Manish Kumar, Liangpeng Yang, Mohamed Abdelhakiem, Phillip M. Pifer, Vlad Sandulache, Aakash Sheth, Beth M. Beadle, Howard D. Thames, Kathryn A. Mason, Curtis R. Pickering, Raymond E. Meyn, Heath D. Skinner

Cancer Res (2022) 82 (5): 916–928.

https://doi.org/10.1158/0008-5472.CAN-21-2101

Published: 01 March 2022

View article titled, p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade

Includes: Supplementary data

Journal Articles

Abstract 6185: In vivo screening in HPV positive and HPV negative head and neck squamous cell carcinoma

Mohamed K. Abdelhakiem, Liangpeng Yang, Tongxin Xie, Manish Kumar, David Molkentine, Aakash Sheth, Mitchell Frederick, Jeffrey Myers, Curtis R. Pickering, Heath D. Skinner

Cancer Res (2020) 80 (16_Supplement): 6185.

https://doi.org/10.1158/1538-7445.AM2020-6185

Published: 15 August 2020

View article titled, Abstract 6185: In vivo screening in HPV positive and HPV negative head and neck squamous cell carcinoma

Journal Articles

Abstract 2925: Targeting histone acetyltransferase (HAT) function for synthetic cytotoxicity in CREBBP/EP300 mutant tumors

Curtis Pickering, Manish Kumar, Kathleen Bridges, Tongxin Xie, David Molkentine, Aakash Sheth, Liang Yang, Mitchell Frederick, Tim Heffernan, Sahil Seth, Jeffrey Myers, Heath D. Skinner

Cancer Res (2019) 79 (13_Supplement): 2925.

https://doi.org/10.1158/1538-7445.AM2019-2925

Published: 01 July 2019

View article titled, Abstract 2925: Targeting histone acetyltransferase (HAT) function for synthetic cytotoxicity in CREBBP/EP300 mutant tumors

Journal Articles

Abstract 2919: p16 modulates a novel ubiquitin signaling cascade which regulates radioresponse and offers clinically relevant therapeutic targets in squamous cell carcinoma

David Molkentine, Kathleen Bridges, Aakash Sheth, David Valdecanas, Curtis Pickering, Heath D. Skinner

Cancer Res (2019) 79 (13_Supplement): 2919.

https://doi.org/10.1158/1538-7445.AM2019-2919

Published: 01 July 2019

View article titled, Abstract 2919: p16 modulates a novel ubiquitin signaling cascade which regulates radioresponse and offers clinically relevant therapeutic targets in squamous cell carcinoma

Journal Articles

Abstract 456: Circulating tumor cells and cfDNA changes during radiotherapy in patients with head and neck cancer

Sweet Ping Ng, Carolyn S. Hall, Salyna Meas, Vanessa N. Sarli, Houda Bahig, Baher Elgohari, Amy Moreno, Heath D. Skinner, Adam S. Garden, David I. Rosenthal, William H. Morrison, Jack Phan, G Brandon Gunn, Steven J. Frank, Clifton D. Fuller, Anthony Lucci

Cancer Res (2019) 79 (13_Supplement): 456.

https://doi.org/10.1158/1538-7445.AM2019-456

Published: 01 July 2019

View article titled, Abstract 456: Circulating tumor cells and cfDNA changes during radiotherapy in patients with head and neck cancer

Journal Articles

Abstract 978: In vivo shRNA screening identifies synthetic cytotoxicity in CREBBP/EP300 mutant head and neck cancer

Manish Kumar, Kathleen Bridges, David Molkentine, Liangpeng Yang, Aakash Sheth, Raymond Meyn, Mitchell Frederick, Jeffrey Myers, Curtis Pickering, Heath D. Skinner

Cancer Res (2018) 78 (13_Supplement): 978.

https://doi.org/10.1158/1538-7445.AM2018-978

Published: 01 July 2018

View article titled, Abstract 978: In vivo shRNA screening identifies synthetic cytotoxicity in CREBBP/EP300 mutant head and neck cancer

Journal Articles

Abstract 1652: P16INK4a over-expression sensitizes HPV(-) HNSCC to radiation through down-regulation of USP7

David Molkentine, Li Wang, Kathleen Bridges, Kathy Mason, Raymond Meyn, Heath D. Skinner

Cancer Res (2016) 76 (14_Supplement): 1652.

https://doi.org/10.1158/1538-7445.AM2016-1652

Published: 15 July 2016

View article titled, Abstract 1652: P16INK4a over-expression sensitizes HPV(-) HNSCC to radiation through down-regulation of USP7

Journal Articles

Abstract 1661: TRIP12 as a mediator of human papillomavirus/p16-related radiation enhancement effects

Li Wang, Peijing Zhang, David Molkentine, Jessica Molkentine, Uma Raju, David Valdecanas, Ramesh Tailor, Howard Thames, Thomas Buchholz, Junjie Chen, Li Ma, Kathy Mason, Raymond Meyn, Heath D. Skinner

Cancer Res (2016) 76 (14_Supplement): 1661.

https://doi.org/10.1158/1538-7445.AM2016-1661

Published: 15 July 2016

View article titled, Abstract 1661: TRIP12 as a mediator of human papillomavirus/p16-related radiation enhancement effects

Journal Articles

Abstract CT075: Tumor mutation status will predict metabolic response to metformin in lung cancer treated with stereotactic body radiation therapy (SBRT)

Heath D. Skinner, Thomas Guerrero, Brian Hobbs, Laurence Court, Paige L. Nitsch, John Heymach

Cancer Res (2016) 76 (14_Supplement): CT075.

https://doi.org/10.1158/1538-7445.AM2016-CT075

Published: 15 July 2016

View article titled, Abstract CT075: Tumor mutation status will predict metabolic response to metformin in lung cancer treated with stereotactic body radiation therapy (SBRT)

Journal Articles

Abstract 3441: Proteomic profiling identifies PTK2/FAK as a targetable marker of radioresistance in head and neck cancer

Heath D. Skinner, Uma Giri, John S. Yordy, Michael D. Story, Jing Wang, Lauren A. Byers, Michelle D. Williams, Adel K. El-Naggar, Sang H. Woo, Liang P. Yang, You Fan, Curtis R. Pickering, Jeffrey N. Myers, John V. Heymach

Cancer Res (2015) 75 (15_Supplement): 3441.

https://doi.org/10.1158/1538-7445.AM2015-3441

Published: 01 August 2015

View article titled, Abstract 3441: Proteomic profiling identifies PTK2/FAK as a targetable marker of radioresistance in head and neck cancer

Journal Articles

Evolutionary Action Score of TP53 Coding Variants Is Predictive of Platinum Response in Head and Neck Cancer Patients

Cancer Res (2015) 75 (7): 1205–1215.

https://doi.org/10.1158/0008-5472.CAN-14-2729

Published: 31 March 2015

View article titled, Evolutionary Action Score of TP53 Coding Variants Is Predictive of Platinum Response in Head and Neck Cancer Patients

Includes: Supplementary data

Journal Articles

Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer

Cancer Res (2015) 75 (7): 1527–1536.

https://doi.org/10.1158/0008-5472.CAN-14-2735

Published: 31 March 2015

View article titled, Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer

Includes: Supplementary data

Journal Articles

Abstract A28: Phase I trial of radiotherapy with concurrent bevacizumab, erlotinib, and capecitabine for locally advanced pancreatic cancer (LAPC).

Heath D. Skinner, Christopher H. Crane, Sunil Krishnan, Milind M. Javle, Robert A. Wolff, Jason B. Fleming, Marilyn V. Clemons, Mark F. Munsell, Marc E. Delclos, Prajnan Das

Cancer Res (2012) 72 (14_Supplement): A28.

https://doi.org/10.1158/1538-7445.PANCA2012-A28

Published: 03 April 2014

View article titled, Abstract A28: Phase I trial of radiotherapy with concurrent bevacizumab, erlotinib, and capecitabine for locally advanced pancreatic cancer (LAPC).

Journal Articles

Abstract 77: Genetic variations in the stem cell pathway predict for toxicity following radiotherapy in lung cancer.

Heath D. Skinner, Xia Pu, Joe Chang, Charles Lu, Ritsuko Komaki, Xifeng Wu

Cancer Res (2013) 73 (8_Supplement): 77.

https://doi.org/10.1158/1538-7445.AM2013-77

Published: 15 April 2013

View article titled, Abstract 77: Genetic variations in the stem cell pathway predict for toxicity following radiotherapy in lung cancer.

Journal Articles

Abstract 4582: Genome-wide association study of toxicity following definitive radiotherapy in non-small cell lung cancer patients.

Xia Pu, Heath D. Skinner, Yuanqing Ye, Michelle AT Hildebrandt, Joe Y. Chang, Charles Lu, Ritsuko Komaki, John D. Minna, Jack A. Roth, Xifeng Wu

Cancer Res (2013) 73 (8_Supplement): 4582.

https://doi.org/10.1158/1538-7445.AM2013-4582

Published: 15 April 2013

View article titled, Abstract 4582: Genome-wide association study of toxicity following definitive radiotherapy in non-small cell lung cancer patients.

Journal Articles

Abstract 3626: Inflammation-related genetic variants predict radiation-induced toxicity following definitive radiotherapy for non-small cell lung cancer.

Xia Pu, Liewei Wang, Michelle AT Hildebrandt, Yuanqing Ye, Joe Y. Chang, Charles Lu, Heath D. Skinner, Nifang Niu, Gregory D. Jenkins, Ritsuko Komaki, John D. Minna, Jack A. Roth, Richard M. Weinshilboum, Xifeng Wu

Cancer Res (2013) 73 (8_Supplement): 3626.

https://doi.org/10.1158/1538-7445.AM2013-3626

Published: 15 April 2013

View article titled, Abstract 3626: Inflammation-related genetic variants predict radiation-induced toxicity following definitive radiotherapy for non-small cell lung cancer.

Journal Articles

Abstract 2496: Inhibition of IL-6 signaling induces radiosensitivity in head and neck squamous cell carcinoma (HNSCC)

Heath D. Skinner, Ying-Wen Su, Thomas J. Ow, Jeffery Myers

Cancer Res (2011) 71 (8_Supplement): 2496.

https://doi.org/10.1158/1538-7445.AM2011-2496

Published: 15 April 2011

View article titled, Abstract 2496: Inhibition of IL-6 signaling induces radiosensitivity in head and neck squamous cell carcinoma (HNSCC)

Journal Articles

Stable expression of HIF-1α siRNA affects cell migration and survival in ovarian cancer cells

Heath D. Skinner, Bing-Hua Jiang

Cancer Res (2004) 64 (7_Supplement): 1190.

Published: 01 April 2004

View article titled, Stable expression of HIF-1α siRNA affects cell migration and survival in ovarian cancer cells

NARROW

p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade

Abstract 6185: In vivo screening in HPV positive and HPV negative head and neck squamous cell carcinoma

Abstract 2925: Targeting histone acetyltransferase (HAT) function for synthetic cytotoxicity in CREBBP/EP300 mutant tumors

Abstract 2919: p16 modulates a novel ubiquitin signaling cascade which regulates radioresponse and offers clinically relevant therapeutic targets in squamous cell carcinoma

Abstract 456: Circulating tumor cells and cfDNA changes during radiotherapy in patients with head and neck cancer

Abstract 978: In vivo shRNA screening identifies synthetic cytotoxicity in CREBBP/EP300 mutant head and neck cancer

Abstract 1652: P16INK4a over-expression sensitizes HPV(-) HNSCC to radiation through down-regulation of USP7

Abstract 1661: TRIP12 as a mediator of human papillomavirus/p16-related radiation enhancement effects

Abstract CT075: Tumor mutation status will predict metabolic response to metformin in lung cancer treated with stereotactic body radiation therapy (SBRT)

Abstract 3441: Proteomic profiling identifies PTK2/FAK as a targetable marker of radioresistance in head and neck cancer

Evolutionary Action Score of TP53 Coding Variants Is Predictive of Platinum Response in Head and Neck Cancer Patients

Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer

Abstract A28: Phase I trial of radiotherapy with concurrent bevacizumab, erlotinib, and capecitabine for locally advanced pancreatic cancer (LAPC).

Abstract 77: Genetic variations in the stem cell pathway predict for toxicity following radiotherapy in lung cancer.

Abstract 4582: Genome-wide association study of toxicity following definitive radiotherapy in non-small cell lung cancer patients.

Abstract 3626: Inflammation-related genetic variants predict radiation-induced toxicity following definitive radiotherapy for non-small cell lung cancer.

Abstract 2496: Inhibition of IL-6 signaling induces radiosensitivity in head and neck squamous cell carcinoma (HNSCC)

Stable expression of HIF-1α siRNA affects cell migration and survival in ovarian cancer cells

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