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Hartmut Juhl
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Journal Articles

Abstract 6775: Combination of spatial transcriptomics and multiplex IHC as valuable multi-omics tool for biomarker discovery

Nicole Kerstedt, Monika Schoeppler, Bita Motamedi-Baniassad, Antonia Hirt, Julia Ploetzky, Mirja Kastein, Laura Thoms, Malik Khenkhar, Hartmut Juhl, Kerstin A. David
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6775.
https://doi.org/10.1158/1538-7445.AM2023-6775
Published: 04 April 2023
View article titled, Abstract 6775: Combination of spatial transcriptomics and multiplex IHC as valuable multi-omics tool for biomarker discovery
Journal Articles

Abstract 2705: Spatial transcriptomics - a valuable tool to visualize compound effect in precision cut cancer tissue slices (PCCTS)

Nicole Kerstedt, Nicole Grabinski, Kristina Bernoth, Monika Schoeppler, Bita Motamedi-Baniassad, Jana Krueger, Moiken Petersen, Hartmut Juhl, Kerstin A. David
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2705.
https://doi.org/10.1158/1538-7445.AM2021-2705
Published: 01 July 2021
View article titled, Abstract 2705: Spatial transcriptomics - a valuable tool to visualize compound effect in precision cut cancer tissue slices (PCCTS)
Journal Articles

Abstract 6587: Proteogenomic characterization of colorectal cancer using the IndivuType multiomics database

Margarita Krawczyk, Jonathan Woodsmith, Marcel Nutsoa, Thomas Corwin, Silvia von der Heyde, Vincent Piras, Mark Whittaker, Alex Hergovich, Peter Frommolt, Hartmut Juhl
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6587.
https://doi.org/10.1158/1538-7445.AM2020-6587
Published: 15 August 2020
View article titled, Abstract 6587: Proteogenomic characterization of colorectal cancer using the IndivuType multiomics database
Journal Articles

Abstract 4572: Cross-validation between anti-CD3/CD8/FOXP3/pan-Cytokeratin fluorescent multiplex IHC and chromogenic single IHC by digital image analysis for quantifying tumor-infiltrating lymphocytes in colorectal cancer patient samples

Daniel Biljes, Philipp Layer, Nickels Winkler, Nadine Fändrich-Dursun, Hartmut Juhl, Bernd Gromoll, Malik Khenkhar, Philipp C. Uhlig
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4572.
https://doi.org/10.1158/1538-7445.AM2019-4572
Published: 01 July 2019
View article titled, Abstract 4572: Cross-validation between anti-CD3/CD8/FOXP3/pan-Cytokeratin fluorescent multiplex IHC and chromogenic single IHC by digital image analysis for quantifying tumor-infiltrating lymphocytes in colorectal cancer patient samples
Journal Articles

Abstract 2128: Simple Western Size (SWS) in combination with precision cut cancer tissue slices: An excellent patient-derived platform to support drug development

Nicole Grabinski, Kristina Bernoth, Mirja Piller, Moiken Petersen, Jana Krüger, Olivia Timm, Hartmut Juhl, Kerstin A. David
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2128.
https://doi.org/10.1158/1538-7445.AM2019-2128
Published: 01 July 2019
View article titled, Abstract 2128: Simple Western Size (SWS) in combination with precision cut cancer tissue slices: An excellent patient-derived platform to support drug development
Journal Articles

Abstract 1711: Immunoprofiling of precision-cut cancer tissue slices (PCCTS) as a tool for cancer immunotherapy

Nicole Grabinski, Kristina Bernoth, Aljoscha Leusmann, Carolin Fleischhauer-Biermann, Dorte Wendt, Mirja Piller, Moiken Petersen, Nicole Lange, Anna Tiedemann, Monika Schoeppler, Hartmut Juhl, Gerd Helftenbein, Andrea Miegel, Frank Schnieders, Kerstin David
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1711.
https://doi.org/10.1158/1538-7445.AM2018-1711
Published: 01 July 2018
View article titled, Abstract 1711: Immunoprofiling of precision-cut cancer tissue slices (PCCTS) as a tool for cancer immunotherapy
Journal Articles

Abstract 5686: Utilization of fluorescent multiplex IHC and digital image analysis for studying LAG-3, CD3 and CD8 positive TIL subsets in NSCLC tissue

Malik Khenkhar, Daniel Biljes, Nickels Winkler, Philipp C. Uhlig, Hartmut Juhl, Alison L. Bigley, Lorcan Sherry
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5686.
https://doi.org/10.1158/1538-7445.AM2018-5686
Published: 01 July 2018
View article titled, Abstract 5686: Utilization of fluorescent multiplex IHC and digital image analysis for studying LAG-3, CD3 and CD8 positive TIL subsets in NSCLC tissue
Journal Articles

Abstract 4830: Precision cut cancer tissues slices as human model for the testing of immuno-modulatory compounds

Kristina Bernoth, Florian T. Unger, Moiken Petersen, Mirja Piller, Jana Krüger, Nicole Grabinski, Hartmut Juhl, Kerstin A. David
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4830.
https://doi.org/10.1158/1538-7445.AM2017-4830
Published: 01 July 2017
View article titled, Abstract 4830: Precision cut cancer tissues slices as human model for the testing of immuno-modulatory compounds
Journal Articles

Abstract 3989: Analysis of minute amounts of clinical biospecimen for the AXL receptor expression using real-time PCR and Simple Western size technology

Florian T. Unger, Kristina Bernoth, Nicole Lange, Hartmut Juhl, Kerstin A. David
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3989.
https://doi.org/10.1158/1538-7445.AM2016-3989
Published: 15 July 2016
View article titled, Abstract 3989: Analysis of minute amounts of clinical biospecimen for the AXL receptor expression using real-time PCR and Simple Western size technology
Journal Articles

Abstract 2062: Pre-analytical conditions strongly influence molecular pattern in clinical biospecimen

Florian T. Unger, Nicole Lange, Philipp Uhlig, Hartmut Juhl, Kerstin A. David
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2062.
https://doi.org/10.1158/1538-7445.AM2015-2062
Published: 01 August 2015
View article titled, Abstract 2062: Pre-analytical conditions strongly influence molecular pattern in clinical biospecimen
Journal Articles

Abstract 913: Differences in basal isoform phosphorylation of signaling proteins between normal and tumor tissue in different cancer types detected by the NanoPro™1000 technology

Florian T. Unger, Jana Krueger, Janina Schaller, Rebecca Giese, Cordula Dede, Alexandra Samsen, Hartmut Juhl, Kerstin A. David
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 913.
https://doi.org/10.1158/1538-7445.AM2014-913
Published: 01 October 2014
View article titled, Abstract 913: Differences in basal isoform phosphorylation of signaling proteins between normal and tumor tissue in different cancer types detected by the NanoPro™1000 technology
Journal Articles

Abstract 2408: Comparison of ERK, AKT and MEK isoform phosphorylations between primary and corresponding metastatic colorectal carcinoma lesions using the NanoPro1000 technology.

Florian T. Unger, Jana Krueger, Janina Schaller, Cordula Dede, Alexandra Samsen, Hartmut Juhl, Kerstin A. David
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2408.
https://doi.org/10.1158/1538-7445.AM2013-2408
Published: 15 April 2013
View article titled, Abstract 2408: Comparison of ERK, AKT and MEK isoform phosphorylations between primary and corresponding metastatic colorectal carcinoma lesions using the NanoPro1000 technology.
Journal Articles

Abstract 3605: Effects of antibody-mediated EGF-receptor inhibition on ERK 1/2 isoform phosphorylation in organoid cultures

Florian T. Unger, Cordula Rosenbrock, Jana Krueger, Janina Schaller, Birgit Rabe, Hartmut Juhl, Kerstin A. David
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3605.
https://doi.org/10.1158/1538-7445.AM2012-3605
Published: 15 April 2012
View article titled, Abstract 3605: Effects of antibody-mediated EGF-receptor inhibition on ERK 1/2 isoform phosphorylation in organoid cultures
Journal Articles

Abstract 3177: Early detection biomarker for colorectal malignancies identified by a novel comparative proteomic workflow

Florian T. Unger, Markus Meyer, Monika Spörl, Agnieszka Harasym, Katja Pursche, Hartmut Juhl, Kerstin A. David
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 3177.
https://doi.org/10.1158/1538-7445.AM2011-3177
Published: 15 April 2011
View article titled, Abstract 3177: Early detection biomarker for colorectal malignancies identified by a novel comparative proteomic workflow
Journal Articles

Abstract 4577: Comparative proteomic biomarker screening in laser microdissected tissues from colon adenoma and cancer

Markus Meyer, Monika Spörl, Agnieszka Harasym, Jörg Spangenberg, Florian Unger, Hartmut Juhl, Kerstin A. David
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4577.
https://doi.org/10.1158/1538-7445.AM10-4577
Published: 15 April 2010
View article titled, Abstract 4577: Comparative proteomic biomarker screening in laser microdissected tissues from colon adenoma and cancer
Journal Articles

Abstract 2706: Discovery of predictive biomarkers based on differential chemosensitivity of colorectal cell lines

Florian T. Unger, Markus Meyer, Agnieszka Harasym, Jörg Spangenberg, Kevin Sullivan, Hartmut Juhl, Kerstin A. David
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2706.
https://doi.org/10.1158/1538-7445.AM10-2706
Published: 15 April 2010
View article titled, Abstract 2706: Discovery of predictive biomarkers based on differential chemosensitivity of colorectal cell lines
Journal Articles

The NCI biospecimen research network: the influence of warm ischemic time on gene expression profiles for colon cancer

Dang Hien, Helen Moore, Audrey Player, Yonghong Wang, Ernie Kawasaki, Kerstin David, Joerg Spangenberg, Hartmut Juhl, Jim Vaught, Anna Barker, John Gillespie, Carolyn Compton
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 1756.
Published: 01 May 2008
View article titled, The NCI biospecimen research network: the influence of warm ischemic time on gene expression profiles for colon cancer
Journal Articles

Multifunctional molecular analysis of common cancer drug responses in short-term cultivated primary epithelial cells

Annika Sprussel, Jana Kruger, Jana Hennesen, Jorg Spangenberg, Hartmut Juhl, Kerstin David
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 1547.
Published: 01 May 2008
View article titled, Multifunctional molecular analysis of common cancer drug responses in short-term cultivated primary epithelial cells
Journal Articles

Impact of short-term primary cell cultivation on gene expression profiles of colorectal tumor cells

Annika Sprussel, Jorg Spangenberg, Heinz Joachim List, Carsten Zornig, Arnulf Dorner, Hartmut Juhl, Kerstin David
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 4699.
Published: 01 May 2007
View article titled, Impact of short-term primary cell cultivation on gene expression profiles of colorectal tumor cells
Journal Articles

Detection and quantification of mutations in the plasma of patients with colorectal tumors.

Frank Diehl, Meng Li, Devin Dressman, Hartmut Juhl, Kenneth W. Kinzler, Bert Vogelstein
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1347.
Published: 15 April 2006
View article titled, Detection and quantification of mutations in the plasma of patients with colorectal tumors.