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Harriet Kluger
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Journal Articles

Abstract 489: Association between immune-mediated adverse events and survival in patients with metastatic non-small cell lung cancer treated with durvalumab and tremelimumab

Agnish Dey, Matthew Austin, Harriet Kluger, Nataliya Trunova, Helen Mann, Norah Shire, Diansong Zhou, Ganesh Mugundu
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 489.
https://doi.org/10.1158/1538-7445.AM2021-489
Published: 01 July 2021
View article titled, Abstract 489: Association between immune-mediated adverse events and survival in patients with metastatic non-small cell lung cancer treated with durvalumab and tremelimumab
Journal Articles

Abstract CT235: A Phase 2, multicenter study of autologous tumor infiltrating lymphocytes (TIL, LN 144/LN-145/LN-145-S1) in patients with solid tumors

Scott Gettinger, Harriet Kluger, Adam Schoenfeld, Allison Betof-Warner, Kai He, Ammar Sukari, Bernard Doger de Speville Uribe, Sylvia Lee, Simon Haefliger, Zelanna Goldberg, Alex Cacovean, Rana Fiaz, Guang Chen, Madan Jagasia, Friedrich Graf Finckenstein, Maria Fardis, Antonio Jimeno
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): CT235.
https://doi.org/10.1158/1538-7445.AM2021-CT235
Published: 01 July 2021
View article titled, Abstract CT235: A Phase 2, multicenter study of autologous tumor infiltrating lymphocytes (TIL, LN 144/LN-145/LN-145-S1) in patients with solid tumors
Journal Articles

Abstract LB027: Tracking and decoding the antigen specificity of peripherally derived T cells that infiltrate into solid tumors in patients treated with an autologous T cell therapy, PRIME IL-15 (RPTR-147)

John David Pajerowski, William Gordon, Phil Bardwell, Christine McInnis, Ji Young Hwang, Tabasum Huseni, Parul Agnihotri, Josh Francis, Christina Tarr, Florian Renoux, Sebastian Heer, Nastassja Cerreghetti-Terraneo, Marisa Loi, Erika Hamilton, Sarah Nikiforow, George Blumenschein, Mihaela Christea, Keren Osman, Anthony Shields, Harriet Kluger, Franz-Josef Obermair, Daniel Pregibon, Jan Kisielow, Anthony Coyle, Mojca Skoberne
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB027.
https://doi.org/10.1158/1538-7445.AM2021-LB027
Published: 01 July 2021
View article titled, Abstract LB027: Tracking and decoding the antigen specificity of peripherally derived T cells that infiltrate into solid tumors in patients treated with an autologous T cell therapy, PRIME IL-15 (RPTR-147)
Journal Articles

Abstract 3095: Combination of spatial protein data with bulk transcriptional profiling of the same cohort shows relationships between RNA and protein and facilitates combined predictive signatures

Ioannis A. Vathiotis, Jason Reeves, Maria Toki, Pok Fai Wong, Harriet Kluger, Thazin Nwe Aung, Konstantinos N. Syrigos, Sarah Warren, David L. Rimm
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3095.
https://doi.org/10.1158/1538-7445.AM2020-3095
Published: 15 August 2020
View article titled, Abstract 3095: Combination of spatial protein data with bulk transcriptional profiling of the same cohort shows relationships between RNA and protein and facilitates combined predictive signatures
Journal Articles

Abstract 2001: Biomarker discovery in immunotherapy-treated melanoma patients with imaging mass cytometry

Sandra Martinez-Morilla, Franz Villarroel-Espindola, Pok Fai Wong, Harriet Kluger, Maria Toki, Thazin New Aung, Vasiliki Pelekanou, Brian Bourke-Martin, David L. Rimm
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 2001.
https://doi.org/10.1158/1538-7445.AM2020-2001
Published: 15 August 2020
View article titled, Abstract 2001: Biomarker discovery in immunotherapy-treated melanoma patients with imaging mass cytometry
Journal Articles

Abstract CT249: A phase 1b study of nivolumab in patients with autoimmune disorders and advanced malignancies (AIM-NIVO)

Ecaterina E. Ileana Dumbrava, Maria Suarez-Almazor, Jeane Painter, Tanner M. Johanns, Michael L. Dougan, Laura Cappelli, Yinghong Wang, Clifton Bingham, Sarthak Gupta, Blake M. Warner, Osama Rahma, Jarushka Naidoo, Patrick A. Ott, David A. Hafler, Harriet Kluger, Arezou Khosroshahi, Rafeh Naqash, Lorinda Chung, Tamiko R. Katsumoto, Shivaani Kummar, Hussein Tawbi, Elad Sharon
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): CT249.
https://doi.org/10.1158/1538-7445.AM2020-CT249
Published: 15 August 2020
View article titled, Abstract CT249: A phase 1b study of nivolumab in patients with autoimmune disorders and advanced malignancies (AIM-NIVO)
Journal Articles

Abstract CT089: Phase Ib/II of CD40 agonistic antibody APX005M in combination with nivolumab (nivo) in subjects with metastatic melanoma (M) or non-small cell lung cancer (NSCLC)

Harriet Kluger, Sarah A. Weiss, Anthony J. Olszanski, Lynn Schuchter, Gerald P. Linette, Linda Garland, Nicholas O. Iannotti, Melissa Johnson, Emin Avsar, Minu K. Srivastava, Ovid C. Trifan, Martin J. Edelman
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): CT089.
https://doi.org/10.1158/1538-7445.AM2019-CT089
Published: 01 July 2019
View article titled, Abstract CT089: Phase Ib/II of CD40 agonistic antibody APX005M in combination with nivolumab (nivo) in subjects with metastatic melanoma (M) or non-small cell lung cancer (NSCLC)
Journal Articles

Abstract 3621: High-plex immune marker spatial profiling quantitation by NanoString Digital Spatial Profiling technology and quantitative immunofluorescence

Maria I. Toki, Pok Fai Wong, Harriet Kluger, Yuting Liu, Chris Merritt, Giang Ong, Sarah Warren, Joseph M. Beechem, David L. Rimm
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3621.
https://doi.org/10.1158/1538-7445.AM2018-3621
Published: 01 July 2018
View article titled, Abstract 3621: High-plex immune marker spatial profiling quantitation by NanoString Digital Spatial Profiling technology and quantitative immunofluorescence
Journal Articles

Abstract CT169: A phase II, multicenter study to assess the efficacy and safety of autologous tumor infiltrating lymphocytes (LN-144) for treatment of patients with metastatic melanoma

Amod Sarnaik, Brendan Curti, Diwakar Davar, Omid Hamid, Jose Lutzky, Melissa Wilson, Harriet Kluger, Jason Chesney, Kevin Kim, Giao Phan, Sajeve Thomas, Eric Whitman, Bente Larsen, Sam Suzuki, Nancy Samberg, Igor Gorbatchevsky, Maria Fardis, John M. Kirkwood
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): CT169.
https://doi.org/10.1158/1538-7445.AM2018-CT169
Published: 01 July 2018
View article titled, Abstract CT169: A phase II, multicenter study to assess the efficacy and safety of autologous tumor infiltrating lymphocytes (LN-144) for treatment of patients with metastatic melanoma
Journal Articles

Abstract CT003: Activity of the ERK1/2 inhibitor ulixertinib (BVD-523) in patients with BRAF and NRAS mutant melanoma

Ryan J. Sullivan, Filip Janku, Bob T. Li, Deborah Wong, Jeffrey Sosman, Vicki Keedy, Elizabeth Buchbinder, Anthony Tolcher, Anna Varghese, David M. Hyman, Keith T. Flaherty, Antoni Ribas, Richard Carvajal, Andrea Wang-Gillam, Harriet Kluger, Manish Patel, Peter Langecker, Mary Varterasian, Dean Welsch, Jeffrey Infante
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): CT003.
https://doi.org/10.1158/1538-7445.AM2017-CT003
Published: 01 July 2017
View article titled, Abstract CT003: Activity of the ERK1/2 inhibitor ulixertinib (BVD-523) in patients with <em>BRAF</em> and <em>NRAS</em> mutant melanoma
Journal Articles

Abstract CT096: Clinical activity, immune and viral correlates of PD-1 blockade with pembrolizumab as first systemic therapy in patients with advanced Merkel cell carcinoma

Paul Nghiem, Shailender Bhatia, Evan Lipson, Ragini Kudchadkar, Natalie Miller, Adil Daud, Steven Fling, Philip Friedlander, Harriet Kluger, Holbrook Kohrt, Lisa Lundgren, Kim Margolin, Thomas Olencki, Sunil Reddy, Erica Shantha, William Sharfman, Elad Sharon, Michi Shinohara, John Thompson, Jennifer Yearley, Suzanne Topalian, Martin Cheever
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): CT096.
https://doi.org/10.1158/1538-7445.AM2016-CT096
Published: 15 July 2016
View article titled, Abstract CT096: Clinical activity, immune and viral correlates of PD-1 blockade with pembrolizumab as first systemic therapy in patients with advanced Merkel cell carcinoma
Journal Articles

Abstract CT023: Phase I results from the combination of an immune-activating anti-CD27 antibody (varlilumab) in combination with PD-1 blockade (nivolumab): activation across multiple immune pathways without untoward immune-related adverse events

Rachel E. Sanborn, Michael J. Pishvain, Margaret K. Callahan, Naiyer Rizvi, Harriet Kluger, Michael Yellin, Tracey Rawls, Laura Vitale, Abdel Halim, Tom Davis, Tibor Keler
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): CT023.
https://doi.org/10.1158/1538-7445.AM2016-CT023
Published: 15 July 2016
View article titled, Abstract CT023: Phase I results from the combination of an immune-activating anti-CD27 antibody (varlilumab) in combination with PD-1 blockade (nivolumab): activation across multiple immune pathways without untoward immune-related adverse events
Journal Articles

Abstract CT001: Durable, long-term survival in previously treated patients with advanced melanoma (MEL) who received nivolumab (NIVO) monotherapy in a phase I trial

F. Stephen Hodi, Harriet Kluger, Mario Sznol, Richard Carvajal, Donald Lawrence, Michael Atkins, John Powderly, William Sharfman, Igor Puzanov, David Smith, Philip Leming, Evan Lipson, Janis Taube, Robert Anders, Christine Horak, Joel Jiang, David McDermott, Jeffrey Sosman, Julie Brahmer, Drew Pardoll, Suzanne Topalian
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): CT001.
https://doi.org/10.1158/1538-7445.AM2016-CT001
Published: 15 July 2016
View article titled, Abstract CT001: Durable, long-term survival in previously treated patients with advanced melanoma (MEL) who received nivolumab (NIVO) monotherapy in a phase I trial
Journal Articles

Renalase Expression by Melanoma and Tumor-Associated Macrophages Promotes Tumor Growth through a STAT3-Mediated Mechanism

Lindsay Hollander, Xiaojia Guo, Heino Velazquez, John Chang, Robert Safirstein, Harriet Kluger, Charles Cha, Gary V. Desir
Journal: Cancer Research
Series: Author Choice
Cancer Res (2016) 76 (13): 3884–3894.
https://doi.org/10.1158/0008-5472.CAN-15-1524
Published: 30 June 2016
View article titled, Renalase Expression by Melanoma and Tumor-Associated Macrophages Promotes Tumor Growth through a STAT3-Mediated Mechanism
Open the PDF for Renalase Expression by Melanoma and Tumor-Associated Macrophages Promotes Tumor Growth through a STAT3-Mediated Mechanism in another window
Includes: Supplementary data
Journal Articles

Abstract PR05: Combination therapy with anti-CTLA4 and anti-PD1 leads to distinct immunologic changes in-vivo

Rituparna Das, Rakesh Verma, Mario Sznol, Chadra Sekhar Boddupalli, Scott Gettinger, Harriet Kluger, Madhav Dhodapkar, Kavita Dhodapkar
Journal: Cancer Research
Cancer Res (2015) 75 (14_Supplement): PR05.
https://doi.org/10.1158/1538-7445.MEL2014-PR05
Published: 16 July 2015
View article titled, Abstract PR05: Combination therapy with anti-CTLA4 and anti-PD1 leads to distinct immunologic changes in-vivo
Journal Articles

Role of Chitinase 3–like-1 and Semaphorin 7a in Pulmonary Melanoma Metastasis

Bing Ma, Erica L. Herzog, Chun Geun Lee, Xueyan Peng, Chang-Min Lee, Xiaosong Chen, Sara Rockwell, Ja Seok Koo, Harriet Kluger, Roy S. Herbst, Mario Sznol, Jack A. Elias
Journal: Cancer Research
Cancer Res (2015) 75 (3): 487–496.
https://doi.org/10.1158/0008-5472.CAN-13-3339
Published: 01 February 2015
View article titled, Role of Chitinase 3–like-1 and Semaphorin 7a in Pulmonary Melanoma Metastasis
Open the PDF for Role of Chitinase 3–like-1 and Semaphorin 7a in Pulmonary Melanoma Metastasis in another window
Includes: Supplementary data
Journal Articles

Abstract 59: PDK1 in melanoma development and metastasis

Marzia Scortegagna, Chelsea Ruller, Yongmei Feng, Rossitza Lazova, Harriet Kluger, Jian-Liang Li, Surya K. De, Robert Rickert, Maurizio Pellecchia, Marcus Bosenberg, Ze'ev Ronai
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 59.
https://doi.org/10.1158/1538-7445.AM2014-59
Published: 01 October 2014
View article titled, Abstract 59: PDK1 in melanoma development and metastasis
Journal Articles

Abstract 5557: Mutation analysis of melanoma tumor samples from ECOG 2603 clinical trial

Melissa Ann Wilson, Fengmin Zhao, Richard Letrero, Kurt D'Andrea, David Rimm, John Kirkwood, Harriet Kluger, Sandra Lee, Keith Flaherty, Katherine Nathanson
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 5557.
https://doi.org/10.1158/1538-7445.AM2012-5557
Published: 15 April 2012
View article titled, Abstract 5557: Mutation analysis of melanoma tumor samples from ECOG 2603 clinical trial
Journal Articles

Identification of a melanoma prognostic model using tissue microarrays and genetic algorithms

Bonnie Gould Rothberg, Aaron Berger, Annette Molinaro, Antonio Subtil, Michael Krauthammer, William Bradley, Stephan Ariyan, Ruth Halaban, Harriet Kluger, David Rimm
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 5566.
Published: 01 May 2008
View article titled, Identification of a melanoma prognostic model using tissue microarrays and genetic algorithms
Journal Articles

Tissue expression of Uridine and Thymidine phosphorylases and NF-κB in breast cancer patients by tissue microarray

Mary McCarthy, Laxiang Wan, Amy Ziemba, Harriet Kluger, Giuseppe Pizzorno
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 4565.
Published: 01 May 2007
View article titled, Tissue expression of Uridine and Thymidine phosphorylases and NF-κB in breast cancer patients by tissue microarray