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Harikrishna Nakshatri
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Journal Articles

Abstract 2587: Transcription factor ZEB1 controls lineage specificity of African ancestry-enriched breast stromal multilineage cells

Madhura Shirish Shukla, Maya Shraddha Krishnan, Michelle Niese, Jia Ji, Hongyu Gao, Yunlong Liu, Mark H. Kaplan, Harikrishna Nakshatri
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2587.
https://doi.org/10.1158/1538-7445.AM2025-2587
Published: 21 April 2025
View articletitled, Abstract 2587: Transcription factor ZEB1 controls lineage specificity of African ancestry-enriched breast stromal multilineage cells
Journal Articles

Abstract PO1-25-11: Deciphering biological differences between normal breast tissues in men and women using single cell sequencing and in vitro modeling

Poornima Bhat-Nakshatri, Benjamin Fischer, Aditi Khatpe, Adedeji Adebayo, Hongyu Gao, Yunlong Liu, Michele Cote, Harikrishna Nakshatri
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO1-25-11.
https://doi.org/10.1158/1538-7445.SABCS23-PO1-25-11
Published: 02 May 2024
View articletitled, Abstract PO1-25-11: Deciphering biological differences between normal breast tissues in men and women using single cell sequencing and in vitro modeling
Journal Articles

Abstract PS12-03: p53 loss enables HR+ breast cancer escape from CDK4/6 inhibitor-induced quiescence via CDK2

Rei Kudo, Anton Safonov, Edaise M. da Silva, Qing Li, Hong Shao, Marie Will, Harikrishna Nakshatri, Jorge Reis-Filho, Shom Goel, Andrew Koff, Britta Weigelt, Qamar Khan, Pedram Razavi, Sarat Chandarlapaty
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PS12-03.
https://doi.org/10.1158/1538-7445.SABCS23-PS12-03
Published: 02 May 2024
View articletitled, Abstract PS12-03: p53 loss enables HR+ breast cancer escape from CDK4/6 inhibitor-induced quiescence via CDK2
Journal Articles

Abstract 2136: Genetic ancestry dependent variability in stromal cells: An unexplored player in breast cancer disparity

Poornima Bhat-Nakshatri, Hongyu Gao, Cihat Erdogan, Yunlong Liu, Harikrishna Nakshatri
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2136.
https://doi.org/10.1158/1538-7445.AM2024-2136
Published: 22 March 2024
View articletitled, Abstract 2136: Genetic ancestry dependent variability in stromal cells: An unexplored player in breast cancer disparity
Journal Articles

Abstract 6977: ETV6 is an unexplored partner of the Chr.8 q24.3 amplicon-embedded immortalizing oncogene TONSL in tumorigenesis

Aditi S. Khatpe, Emma Doud, Amber Mosely, Kathy D. Miller, Harikrishna Nakshatri
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6977.
https://doi.org/10.1158/1538-7445.AM2024-6977
Published: 22 March 2024
View articletitled, Abstract 6977: ETV6 is an unexplored partner of the Chr.8 q24.3 amplicon-embedded immortalizing oncogene TONSL in tumorigenesis
Journal Articles

TONSL Is an Immortalizing Oncogene and a Therapeutic Target in Breast Cancer

Aditi S. Khatpe, Rebecca Dirks, Poornima Bhat-Nakshatri, Henry Mang, Katie Batic, Sarah Swiezy, Jacob Olson, Xi Rao, Yue Wang, Hiromi Tanaka, Sheng Liu, Jun Wan, Duojiao Chen, Yunlong Liu, Fang Fang, Sandra Althouse, Emily Hulsey, Maggie M. Granatir, Rebekah Addison, Constance J. Temm, George Sandusky, Audrey Lee-Gosselin, Kenneth Nephew, Kathy D. Miller, Harikrishna Nakshatri
Journal: Cancer Research
Cancer Res (2023) 83 (8): 1345–1360.
https://doi.org/10.1158/0008-5472.CAN-22-3667
Published: 14 April 2023
View articletitled, TONSL Is an Immortalizing Oncogene and a Therapeutic Target in Breast Cancer
Open the PDF for TONSL Is an Immortalizing Oncogene and a Therapeutic Target in Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 1962: Oncologic anthropology-impact of Duffy adaptive trait on breast epithelial and tumor cell biology

Poornima Bhat-Nakshatri, Brijesh Kumar, Madhura S. Shukla, Katie Batic, Henry Mang, Rana German, Anna Maria Storniolo, Harikrishna Nakshatri
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1962.
https://doi.org/10.1158/1538-7445.AM2023-1962
Published: 04 April 2023
View articletitled, Abstract 1962: Oncologic anthropology-impact of Duffy adaptive trait on breast epithelial and tumor cell biology
Journal Articles

Abstract 5458: TONSL is an immortalizing oncogene of the chromosome 8q24.3 amplicon and new therapeutic target in breast cancer

Aditi S. Khatpe, Rebecca Dirks, Poornima Bhat-Nakshatri, Henry Mang, Katie Batic, Sarah Swiezy, Jacob Olson, Xi Rao, Yue Wang, Hiromi Tanaka, Sheng Liu, Jun Wan, Duojiao Chen, Yunlong Liu, Fang Fang, Sandra Althouse, Emily Hilsey, Maggie M. Granatir, Rebekah Addison, Constance J. Temm, George Sandusky, Audrey Lee-Gosselin, Kenneth Nephew Nephew, Kathy D. Miller, Harikrishna Nakshatri
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5458.
https://doi.org/10.1158/1538-7445.AM2023-5458
Published: 04 April 2023
View articletitled, Abstract 5458: TONSL is an immortalizing oncogene of the chromosome 8q24.3 amplicon and new therapeutic target in breast cancer
Journal Articles

Abstract 367: The heparan sulfate mimetic PG545 inhibits tumor growth in both male and female mouse model of pancreatic ductal adenocarcinoma (PDAC) with sex difference in the effect on cachexia

Xiaoling Zhong, Keith Dredge, John M. Chirgwin, Michael G. House, Harikrishna Nakshatri, Teresa A. Zimmers
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 367.
https://doi.org/10.1158/1538-7445.AM2023-367
Published: 04 April 2023
View articletitled, Abstract 367: The heparan sulfate mimetic PG545 inhibits tumor growth in both male and female mouse model of pancreatic ductal adenocarcinoma (PDAC) with sex difference in the effect on cachexia
Journal Articles

Abstract 3666: A human skeletal muscle stem/myotube model reveals multiple signaling targets of cancer secretome in skeletal muscle

Ruizhong Wang, Brijesh Kumar, Poornima Bhat-Nakshatri, Aditi Sanjay Khatpe, Michael P. Murphy, Kristen E. Wanczyk, Emma H. Doud, Amber L. Mosley, Yunlong Liu, Duojiao Chen, Ed Simpson, Hongyu Gao, Harikrishna Nakshatri
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3666.
https://doi.org/10.1158/1538-7445.AM2023-3666
Published: 04 April 2023
View articletitled, Abstract 3666: A human skeletal muscle stem/myotube model reveals multiple signaling targets of cancer secretome in skeletal muscle
Journal Articles

Abstract 4811: Oxygen tension - dependent differences in cancer cell kinome

Adedeji K. Adebayo, Brijesh Kumar, Christopher Davis, Steven P. Angus, Harikrishna Nakshatri
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4811.
https://doi.org/10.1158/1538-7445.AM2023-4811
Published: 04 April 2023
View articletitled, Abstract 4811: Oxygen tension - dependent differences in cancer cell kinome
Journal Articles

Abstract P2-26-08: Influence of genetic ancestry on breast stromal cells provides biologic basis for increased incidence of metaplastic breast cancer in women of African descent

Brijesh Kumar, Katie Batic, Poornima Bhat-Nakshatri, Maggie Granatir, Rebekah Addison, Megan Szymanski, Lee Ann Baldridge, Constance Temm, George Sandusky, Sandra Althouse, Anna Maria Storniolo, Harikrishna Nakshatri
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P2-26-08.
https://doi.org/10.1158/1538-7445.SABCS22-P2-26-08
Published: 01 March 2023
View articletitled, Abstract P2-26-08: Influence of genetic ancestry on breast stromal cells provides biologic basis for increased incidence of metaplastic breast cancer in women of African descent
Journal Articles

Modeling Preclinical Cancer Studies under Physioxia to Enhance Clinical Translation

Adedeji K. Adebayo, Harikrishna Nakshatri
Journal: Cancer Research
Cancer Res (2022) 82 (23): 4313–4321.
https://doi.org/10.1158/0008-5472.CAN-22-2311
Published: 02 December 2022
View articletitled, Modeling Preclinical Cancer Studies under Physioxia to Enhance Clinical Translation
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Journal Articles

Abstract 1458: Single cell resolution chromatin accessibility and transcriptomic atlas of genetic ancestry mapped healthy breast tissues

Poornima Bhat-Nakshatri, Duojiao Chen, Hongyu Gao, Yunlong Liu, Anna Maria Storniolo, Harikrishna Nakshatri
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1458.
https://doi.org/10.1158/1538-7445.AM2022-1458
Published: 15 June 2022
View articletitled, Abstract 1458: Single cell resolution chromatin accessibility and transcriptomic atlas of genetic ancestry mapped healthy breast tissues
Journal Articles

Abstract P3-14-13: Metabolic links to socioeconomic stresses uniquely affecting race in normal breast tissue at risk for breast cancer

Peggi M Angel, Yeonhee Park, Danielle A Scott, Denys Rujchanarong, Sean Brown, Richard R Drake, George E Sandusky, Harikrishna Nakshatri
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P3-14-13.
https://doi.org/10.1158/1538-7445.SABCS21-P3-14-13
Published: 15 February 2022
View articletitled, Abstract P3-14-13: Metabolic links to socioeconomic stresses uniquely affecting race in normal breast tissue at risk for breast cancer
Journal Articles

Abstract P3-07-09: Single cell transcriptomic analysis reveals the effects of BRCA1 and BRCA2 mutations on distinct signaling networks and cancer susceptibility

Harikrishna Nakshatri, Poornima Bhat-Nakshatri, Duojiao Chen, Katie Chen, Henry Mang, Christopher A Herodotou, Aditi S Khatpe, Patrick C McGuire, Xiaoling Xuei, Yunlong Liu, George Sandusky, Anna Maria Storniolo
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P3-07-09.
https://doi.org/10.1158/1538-7445.SABCS21-P3-07-09
Published: 15 February 2022
View articletitled, Abstract P3-07-09: Single cell transcriptomic analysis reveals the effects of BRCA1 and BRCA2 mutations on distinct signaling networks and cancer susceptibility
Journal Articles

Breast Cancer Cell Detection and Characterization from Breast Milk–Derived Cells

Poornima Bhat-Nakshatri, Brijesh Kumar, Ed Simpson, Kandice K. Ludwig, Mary L. Cox, Hongyu Gao, Yunlong Liu, Harikrishna Nakshatri
Journal: Cancer Research
Cancer Res (2020) 80 (21): 4828–4839.
https://doi.org/10.1158/0008-5472.CAN-20-1030
Published: 03 November 2020
View articletitled, Breast Cancer Cell Detection and Characterization from Breast Milk–Derived Cells
Open the PDF for Breast Cancer Cell Detection and Characterization from Breast Milk–Derived Cells in another window
Includes: Supplementary data
Journal Articles

Abstract 1174: PROCR+/ZEB1+/PDGFRalpha+ (PZP) multipotent cells of the breast as potential biologic mediators of breast cancer disparity

Harikrishna Nakshatri, Brijesh Kumar, Poornima Bhat-Nakshatri
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1174.
https://doi.org/10.1158/1538-7445.AM2020-1174
Published: 15 August 2020
View articletitled, Abstract 1174: PROCR+/ZEB1+/PDGFRalpha+ (PZP) multipotent cells of the breast as potential biologic mediators of breast cancer disparity
Journal Articles

Abstract 4841: Functional genome-wide screening identifies triple-negative breast cancer cell cycle-dependent vulnerability driven by genomic gain of death effector domain-containing protein

Yingjia Ni, Keon R. Schmidt, Barnes A. Werner, Jenna K. Koenig, Ian H. Guldner, Patricia M. Schnepp, Xuejuan Tan, Lan Jiang, Misha Host, Longhua Sun, Erin N. Howe, Junmin Wu, Laurie E. Littlepage, Harikrishna Nakshatri, Siyuan Zhang
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4841.
https://doi.org/10.1158/1538-7445.AM2020-4841
Published: 15 August 2020
View articletitled, Abstract 4841: Functional genome-wide screening identifies triple-negative breast cancer cell cycle-dependent vulnerability driven by genomic gain of death effector domain-containing protein
Journal Articles

Mansukhlal Chhaganlal Wani, PhD: In Memoriam (1925–2020)

Rita Ghosh, Arti Patel Varanasi, Debasis Mondal, Meghana Trivedi, Kapil Mehta, Harikrishna Nakshatri, Aniruddha Ganguly
Journal: Cancer Research
Cancer Res (2020) 80 (16): 3177–3178.
https://doi.org/10.1158/0008-5472.CAN-20-2003
Published: 14 August 2020
View articletitled, Mansukhlal Chhaganlal Wani, PhD: In Memoriam (1925–2020)
Open the PDF for Mansukhlal Chhaganlal Wani, PhD: In Memoriam (1925–2020) in another window