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Journal Articles

Abstract B004: Promoter methylation gains in aging and cancer are independent of replication

Sara-Jayne Thursby, Zhicheng Jin, Nibedita Patel, Yong Tao, Yuba Bhandari, Daniel Petkovich, Shangzhi Lu, Lijing Yang, Tza-Huei Wang, Thomas R. Pisanic, II, Stephen B Baylin, Hariharan Easwaran
Journal: Cancer Research
Cancer Res (2025) 85 (3_Supplement): B004.
https://doi.org/10.1158/1538-7445.DNAMETHYLATION-B004
Published: 01 February 2025
View article titled, Abstract B004: Promoter methylation gains in aging and cancer are independent of replication
Journal Articles

Abstract 230: Deep learning embedding-based segmentation for morphological analysis in organoids

Akash Sureshkumar, Shilpa Bisht, Hariharan Easwaran
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 230.
https://doi.org/10.1158/1538-7445.AM2024-230
Published: 22 March 2024
View article titled, Abstract 230: Deep learning embedding-based segmentation for morphological analysis in organoids
Journal Articles

Abstract 3666: Multi-cancer early detection using metrics of DNA methylation based epigenetic instability

Sara-Jayne Thursby, Zhicheng Jin, Steve B. Baylin, Malcolm Brock, Thomas Pisanic, Hariharan Easwaran
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3666.
https://doi.org/10.1158/1538-7445.AM2024-3666
Published: 22 March 2024
View article titled, Abstract 3666: Multi-cancer early detection using metrics of DNA methylation based epigenetic instability
Journal Articles

Abstract 1463: Characterizing inflammation-induced epigenetic and transcriptomic alterations driving NSCLC using lung organoid models

Na Wang, Kara Lombardo, Raksha Padaki, Ray-Whay Chiu Yen, Malcolm V. Brock, Leslie Cope, Hariharan Easwaran, Stephen B. Baylin, Michelle Vaz
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1463.
https://doi.org/10.1158/1538-7445.AM2024-1463
Published: 22 March 2024
View article titled, Abstract 1463: Characterizing inflammation-induced epigenetic and transcriptomic alterations driving NSCLC using lung organoid models
Journal Articles

Abstract LB046: Characterizing the role of inflammation-induced epigenetic alterations in modulating the immune microenvironment during lung cancer initiation

Na Wang, Ray-Whay Chiu Yen, Hamza Khan, Malcolm V. Brock, Hariharan Easwaran, Stephen B. Baylin, Michelle Vaz
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB046.
https://doi.org/10.1158/1538-7445.AM2023-LB046
Published: 14 April 2023
View article titled, Abstract LB046: Characterizing the role of inflammation-induced epigenetic alterations in modulating the immune microenvironment during lung cancer initiation
Journal Articles

Abstract A012: Transcription factor expression repertoire basis for epigenetic and transcriptional subtypes of colorectal cancers

Yuba R. Bhandari, Vinod Krishna, Rachael Powers, Sehej Parmar, Sara-Jayne Thursby, Ekta Gupta, Ozlem Kulak, Prashanth Gokare, Joke Reumers, Liesbeth Van Wesenbeeck, Kurtis E. Bachman, Stephen B. Baylin, Hariharan Easwaran
Journal: Cancer Research
Cancer Res (2022) 82 (23_Supplement_2): A012.
https://doi.org/10.1158/1538-7445.CancEpi22-A012
Published: 01 December 2022
View article titled, Abstract A012: Transcription factor expression repertoire basis for epigenetic and transcriptional subtypes of colorectal cancers
Journal Articles

Abstract A008: DNA methyltransferase 3A promotes inflammation-associated gastric cancer growth and presents a therapy target for gastric cancer

Anne Huber, Christine Dijkstra, Yuba Bhandari, Hariharan Easwaran, Stephen Baylin, Matthias Ernst, Moritz Eissmann
Journal: Cancer Research
Cancer Res (2022) 82 (23_Supplement_2): A008.
https://doi.org/10.1158/1538-7445.CancEpi22-A008
Published: 01 December 2022
View article titled, Abstract A008: DNA methyltransferase 3A promotes inflammation-associated gastric cancer growth and presents a therapy target for gastric cancer
Journal Articles

Abstract 2107: Transcription factor repertoire basis for epigenetic and consensus molecular subtypes of colorectal cancer

Yuba Bhandari, Rachael Powers, Sehej Parmar, Vinod Krishna, Kurtis E. Bachman, Steve Baylin, Hariharan Easwaran
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2107.
https://doi.org/10.1158/1538-7445.AM2021-2107
Published: 01 July 2021
View article titled, Abstract 2107: Transcription factor repertoire basis for epigenetic and consensus molecular subtypes of colorectal cancer
Journal Articles

Abstract A36: Organoid models for deciphering roles of the evolving landscape of epigenetic heterogeneity during aging in cancer development

Yong Tao, Byunghak Kang, Daniel Petkovich, Steve Baylin, Hariharan Easwaran
Journal: Cancer Research
Cancer Res (2020) 80 (11_Supplement): A36.
https://doi.org/10.1158/1538-7445.CAMODELS2020-A36
Published: 02 June 2020
View article titled, Abstract A36: Organoid models for deciphering roles of the evolving landscape of epigenetic heterogeneity during aging in cancer development
Journal Articles

Abstract 947: Defining UHRF1 domains that support maintenance of human colon cancer DNA methylation and tumorigenicity

Xiangqian Kong, Jie Chen, Wenbing Xie, Stephen M. Brown, Yi Cai, Kaichun Wu, Daiming Fan, Yongzhan Nie, Yong Tao, Ray-Whay Chiu Yen, Hariharan Easwaran, Michael J. Topper, Scott B. Rothbart, Limin Xia, Stephen B. Baylin
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 947.
https://doi.org/10.1158/1538-7445.AM2019-947
Published: 01 July 2019
View article titled, Abstract 947: Defining UHRF1 domains that support maintenance of human colon cancer DNA methylation and tumorigenicity
Journal Articles

A KDM5 Inhibitor Increases Global H3K4 Trimethylation Occupancy and Enhances the Biological Efficacy of 5-Aza-2′-Deoxycytidine

Benjamin R. Leadem, Ioannis Kagiampakis, Catherine Wilson, Tommy K. Cheung, David Arnott, Patrick Trojer, Marie Classon, Hariharan Easwaran, Stephen B. Baylin
Journal: Cancer Research
Cancer Res (2018) 78 (5): 1127–1139.
https://doi.org/10.1158/0008-5472.CAN-17-1453
Published: 28 February 2018
View article titled, A KDM5 Inhibitor Increases Global H3K4 Trimethylation Occupancy and Enhances the Biological Efficacy of 5-Aza-2′-Deoxycytidine
Open the PDF for A KDM5 Inhibitor Increases Global H3K4 Trimethylation Occupancy and Enhances the Biological Efficacy of 5-Aza-2′-Deoxycytidine in another window
Includes: Supplementary data
Journal Articles

Abstract 4273: Oncogenic BRAFV600E drives stem cell niche factors-independent growth and tumorigenic transformation in colon organoids

Byunghak Kang, Julie In, Nicholas Zachos, David Huso, Shinji Maegawa, Jean-Pierre Issa, Hariharan Easwaran, Stephen B. Baylin
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4273.
https://doi.org/10.1158/1538-7445.AM2016-4273
Published: 15 July 2016
View article titled, Abstract 4273: Oncogenic BRAFV600E drives stem cell niche factors-independent growth and tumorigenic transformation in colon organoids
Journal Articles

Abstract 2773: Chronic cigarette smoke exposure of bronchial epithelial cells induces progressive epigenomic changes leading to transformation

Michelle P. Vaz, Stephen Y. Hwang, Ashwini Patil, Jillian Phallen, Lauren Murphy, Cynthia A. Zahnow, Victor E. Velculescu, Hariharan Easwaran, Stephen B. Baylin
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2773.
https://doi.org/10.1158/1538-7445.AM2016-2773
Published: 15 July 2016
View article titled, Abstract 2773: Chronic cigarette smoke exposure of bronchial epithelial cells induces progressive epigenomic changes leading to transformation
Journal Articles

Abstract B18: Chronic cigarette smoke exposure of bronchial epithelial cells induces progressive epigenomic changes leading to early steps of transformation

Michelle Vaz, Stephen Y. Hwang, Ashwini Patil, Hariharan Easwaran, Stephen B. Baylin
Journal: Cancer Research
Cancer Res (2016) 76 (2_Supplement): B18.
https://doi.org/10.1158/1538-7445.CHROMEPI15-B18
Published: 14 January 2016
View article titled, Abstract B18: Chronic cigarette smoke exposure of bronchial epithelial cells induces progressive epigenomic changes leading to early steps of transformation
Journal Articles

Abstract 2864: Acetylation regulates TET2 stability and enzymatic activity

Yang Zhang, Yi Cai, Wenbing Xie, Hariharan Easwaran, Stephen B. Baylin
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2864.
https://doi.org/10.1158/1538-7445.AM2015-2864
Published: 01 August 2015
View article titled, Abstract 2864: Acetylation regulates TET2 stability and enzymatic activity
Journal Articles

Abstract 4779: DNMT3B (a de novo DNA methyltransferase) epigenetically regulates gene expression, independent of its DNA methyltransferase activity

Khadijah A. Mitchell, Hariharan Easwaran, Stephen B. Baylin
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4779.
https://doi.org/10.1158/1538-7445.AM2014-4779
Published: 01 October 2014
View article titled, Abstract 4779: DNMT3B (a de novo DNA methyltransferase) epigenetically regulates gene expression, independent of its DNA methyltransferase activity
Journal Articles

Abstract 4619: Epigenetic therapy and sensitization of lung cancer to immunotherapy.

John Wrangle, Wei Wang, Alexander Koch, Hariharan Easwaran, Helai Mohammad, Princy Parsana, Frank Vendetti, Kristen Rodgers, Xiaoyu Pan, Kirsten Harbom, Cynthia Zahnow, Janis Taube, Julie Brahmer, Peter Jones, Suzanne Topalian, Charles Rudin, Malcolm Brock, Drew Pardoll, Stephen Baylin
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4619.
https://doi.org/10.1158/1538-7445.AM2013-4619
Published: 15 April 2013
View article titled, Abstract 4619: Epigenetic therapy and sensitization of lung cancer to immunotherapy.
Journal Articles

Abstract LB-185: Oxidative damage targets complexes containing DNA methyltransferases, SIRT1 and polycomb members to promoter CpG islands

Heather M. O'Hagan, Wei Wang, Subhojit Sen, Stella S. Lee, Eriko G. Clements, Yi Cai, Leander Van Neste, Hariharan Easwaran, Stephen B. Baylin
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): LB-185.
https://doi.org/10.1158/1538-7445.AM2011-LB-185
Published: 15 April 2011
View article titled, Abstract LB-185: Oxidative damage targets complexes containing DNA methyltransferases, SIRT1 and polycomb members to promoter CpG islands
Journal Articles

Abstract LB-174: A DNA hypermethylation module for the stem/progenitor cell signature of cancer

Hariharan Easwaran, Sarah E. Johnstone, Leander Van Neste, Joyce E. Ohm, Tim Mosbruger, Martin Aryee, Srinivasan Yegnasubramanian, William Matsui, Stephen B. Baylin
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): LB-174.
https://doi.org/10.1158/1538-7445.AM2011-LB-174
Published: 15 April 2011
View article titled, Abstract LB-174: A DNA hypermethylation module for the stem/progenitor cell signature of cancer
Journal Articles

Polycomb CBX7 Promotes Initiation of Heritable Repression of Genes Frequently Silenced with Cancer-Specific DNA Hypermethylation

Helai P. Mohammad, Yi Cai, Kelly M. McGarvey, Hariharan Easwaran, Leander Van Neste, Joyce E. Ohm, Heather M. O'Hagan, Stephen B. Baylin
Journal: Cancer Research
Cancer Res (2009) 69 (15): 6322–6330.
https://doi.org/10.1158/0008-5472.CAN-09-0065
Published: 29 July 2009
View article titled, Polycomb CBX7 Promotes Initiation of Heritable Repression of Genes Frequently Silenced with Cancer-Specific DNA Hypermethylation
Open the PDF for Polycomb CBX7 Promotes Initiation of Heritable Repression of Genes Frequently Silenced with Cancer-Specific DNA Hypermethylation in another window
Includes: Supplementary data