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Journal Articles

Abstract 5586: Hijacking mutant E3 ligase for targeted protein degradation: Discovery of cancer-specific PROTACs for the treatment of FBXW7 R465C driven cancers

Hailong Zhang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5586.
https://doi.org/10.1158/1538-7445.AM2024-5586
Published: 22 March 2024
View articletitled, Abstract 5586: Hijacking mutant E3 ligase for targeted protein degradation: Discovery of cancer-specific PROTACs for the treatment of FBXW7 R465C driven cancers
Journal Articles

Abstract 4962: Discovery of cancer-specific E3 ligase ligands for targeted protein degradation

Zhaofu Wang, Lynette Zhang, Zhen Chang, Mengxi Zhao, Guobin Li, Fang Qin, Shichao Ma, Yunfeng Li, Zhongguo Zhang, Xinghao Wang, Ying Kong, Shidi Lou, Sheng Chen, Lanzhen Liu, Shuaijie Xu, Hailong Zhang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4962.
https://doi.org/10.1158/1538-7445.AM2023-4962
Published: 04 April 2023
View articletitled, Abstract 4962: Discovery of cancer-specific E3 ligase ligands for targeted protein degradation
Journal Articles

Abstract 6271: Discovery of BR1733 for the treatment of SWI/SNF deficient or highly vascularized solid tumor

Xinghao Wang, Shichao Ma, Min (Bella) Xie, Lele Wang, Yajun Wang, Song Zhang, Sheng Chen, Lynette Zhang, Yongqi Zhou, Mengxi Zhao, Dandan Li, Guobin Li, Xiao Fan, Hailong Zhang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6271.
https://doi.org/10.1158/1538-7445.AM2023-6271
Published: 04 April 2023
View articletitled, Abstract 6271: Discovery of BR1733 for the treatment of SWI/SNF deficient or highly vascularized solid tumor
Journal Articles

Abstract B013: Suppression of TET1 expression down-regulates p16 and contributes to the resistance of SWI/SNF LOF tumors to PRC2 inhibition

Hailong Zhang
Journal: Cancer Research
Cancer Res (2022) 82 (23_Supplement_2): B013.
https://doi.org/10.1158/1538-7445.CancEpi22-B013
Published: 01 December 2022
View articletitled, Abstract B013: Suppression of TET1 expression down-regulates p16 and contributes to the resistance of SWI/SNF LOF tumors to PRC2 inhibition
Journal Articles

Abstract B031: PRC2 inhibitor suppresses angiogenesis in Hepatocellular carcinoma (HCC) by up-regulation of anti-angiogenic factors vasohibin1 (VASH1) and tissue inhibitor of metalloproteinases 3 (TIMP-3)

Hailong Zhang
Journal: Cancer Research
Cancer Res (2022) 82 (23_Supplement_2): B031.
https://doi.org/10.1158/1538-7445.CancEpi22-B031
Published: 01 December 2022
View articletitled, Abstract B031: PRC2 inhibitor suppresses angiogenesis in Hepatocellular carcinoma (HCC) by up-regulation of anti-angiogenic factors vasohibin1 (VASH1) and tissue inhibitor of metalloproteinases 3 (TIMP-3)
Journal Articles

An Allosteric PRC2 Inhibitor Targeting EED Suppresses Tumor Progression by Modulating the Immune Response

Hongping Dong, Shaojun Liu, Xuejie Zhang, Sheng Chen, Lijing Kang, Yanni Chen, Shichao Ma, Xianlei Fu, Yanchao Liu, Hailong Zhang, Bin Zou
Journal: Cancer Research
Series: Author Choice
Cancer Res (2019) 79 (21): 5587–5596.
https://doi.org/10.1158/0008-5472.CAN-19-0428
Published: 01 November 2019
View articletitled, An Allosteric PRC2 Inhibitor Targeting EED Suppresses Tumor Progression by Modulating the Immune Response
Open the PDF for An Allosteric PRC2 Inhibitor Targeting EED Suppresses Tumor Progression by Modulating the Immune Response in another window
Includes: Supplementary data
Journal Articles

Abstract 3471: Mutual regulation of MDM4 and TOP2A in cancer cell proliferation

Tao Liu, Hailong Zhang, Sha Yi, Lubing Gu, Muxiang Zhou
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3471.
https://doi.org/10.1158/1538-7445.AM2019-3471
Published: 01 July 2019
View articletitled, Abstract 3471: Mutual regulation of MDM4 and TOP2A in cancer cell proliferation
Journal Articles

Abstract LB-288: An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED

Wei Qi, Kehao Zhao, Justin Gu, Ying Huang, Youzhen Wang, Hailong Zhang, Man Zhang, Jeff Zhang, Zhengtian Yu, Ling Li, Lin Teng, Shannon Chuai, Chao Zhang, Mengxi Zhao, HoMan Chan, Zijun Chen, Douglas Fang, Fei Qi, Leying Feng, Lijian Feng, Yuan Gao, Hui Ge, Xinjian Ge, Andreas Lingel, Guobin Li, Ying Lin, Yueqin Liu, Fangjun Luo, Minlong Shi, Long Wang, Zhaofu Wang, Yanyan Yu, Jue Zeng, Chenhui Zeng, Lijun Zhang, Qiong Zhang, Shaolian Zhou, Counde Oyang, Peter Atadja, En Li
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): LB-288.
https://doi.org/10.1158/1538-7445.AM2017-LB-288
Published: 01 July 2017
View articletitled, Abstract LB-288: An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED
Journal Articles

NSD2 Is Recruited through Its PHD Domain to Oncogenic Gene Loci to Drive Multiple Myeloma

Zheng Huang, Haiping Wu, Shannon Chuai, Fiona Xu, Feng Yan, Nathan Englund, Zhaofu Wang, Hailong Zhang, Ming Fang, Youzhen Wang, Justin Gu, Man Zhang, Teddy Yang, Kehao Zhao, Yanyan Yu, Jingquan Dai, Wei Yi, Shaolian Zhou, Qian Li, Jing Wu, Jun Liu, Xu Wu, Homan Chan, Chris Lu, Peter Atadja, En Li, Yan Wang, Min Hu
Journal: Cancer Research
Cancer Res (2013) 73 (20): 6277–6288.
https://doi.org/10.1158/0008-5472.CAN-13-1000
Published: 14 October 2013
View articletitled, NSD2 Is Recruited through Its PHD Domain to Oncogenic Gene Loci to Drive Multiple Myeloma
Open the PDF for NSD2 Is Recruited through Its PHD Domain to Oncogenic Gene Loci to Drive Multiple Myeloma in another window
Includes: Supplementary data
Journal Articles

Abstract 3162: MDM2 regulates MYCN mRNA stabilization and translation in human neuroblastoma cells

Hailong Zhang, Lubing Gu, Jiansha Li, Jing He, Muxiang Zhou
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3162.
https://doi.org/10.1158/1538-7445.AM10-3162
Published: 15 April 2010
View articletitled, Abstract 3162: MDM2 regulates MYCN mRNA stabilization and translation in human neuroblastoma cells
Journal Articles

Abstract 1202: MDM2 and its interaction with MYCN in neuroblastoma survival

Jing He, Lubing Gu, Jiansha Li, Hailong Zhang, Muxiang Zhou
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1202.
https://doi.org/10.1158/1538-7445.AM10-1202
Published: 15 April 2010
View articletitled, Abstract 1202: MDM2 and its interaction with MYCN in neuroblastoma survival