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Journal Articles

Abstract CT050: Zongertinib in patients with pretreated HER2-mutant advanced NSCLC: Beamion LUNG-1

Free
John V. Heymach, Gerrina Ruiter, Myung-Ju Ahn, Nicolas Girard, Egbert Smit, David Planchard, Yi-Long Wu, Byoung Chul Cho, Noboru Yamamoto, Joshua K. Sabari, Yanqiu Zhao, Hai-Yan Tu, Kiyotaka Yoh, Ernest Nadal, Behbood Sadrolhefazi, Maren Rohrbacher, Ute von Wangenheim, Sabina Eigenbrod-Giese, Jon Zugazagoitia
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): CT050.
https://doi.org/10.1158/1538-7445.AM2025-CT050
Published: 22 May 2025
View articletitled, Abstract CT050: Zongertinib in patients with pretreated HER2-mutant advanced NSCLC: Beamion LUNG-1
Journal Articles

Abstract 3422: Targeted optimized interferon alpha demonstrates improved safety and efficacy in tumors with low PD-L1 expression

Free
Kristopher Steward, Wuyi Wang, Yanmei Sun, Chengwei Shang, Chun Yang, Tom Boone, Hai Yan
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3422.
https://doi.org/10.1158/1538-7445.AM2025-3422
Published: 21 April 2025
View articletitled, Abstract 3422: Targeted optimized interferon alpha demonstrates improved safety and efficacy in tumors with low PD-L1 expression
Journal Articles

Osimertinib Covalently Binds to CD34 and Eliminates Myeloid Leukemia Stem/Progenitor Cells

Open Access
Li Xia, Jie-Yang Liu, Meng-Ying Yang, Xue-Hong Zhang, Yue Jiang, Qian-Qian Yin, Chen-Hui Luo, Hong-Chen Liu, Zhi-Jie Kang, Cheng-Tao Zhang, Bei-Bei Gao, Ai-Wu Zhou, Hai-Yan Cai, Edmund K. Waller, Jin-Song Yan, Ying Lu
Journal: Cancer Research
Cancer Res (2024) 84 (3): 479–492.
https://doi.org/10.1158/0008-5472.CAN-23-1632
Published: 01 February 2024
View articletitled, Osimertinib Covalently Binds to CD34 and Eliminates Myeloid Leukemia Stem/Progenitor Cells
Open the PDF for Osimertinib Covalently Binds to CD34 and Eliminates Myeloid Leukemia Stem/Progenitor Cells in another window
Includes: Supplementary data
Journal Articles

Abstract CT203: Updated data from the Phase I Beamion Lung 1 trial of the HER2 tyrosine kinase inhibitor (TKI), BI 1810631, as monotherapy in patients (pts) with advanced/metastatic solid tumors with HER2 aberrations

Free
John Heymach, Frans Opdam, Minal Barve, Hai-Yan Tu, Yi-Long Wu, Neil Gibson, Behbood Sadrolhefazi, Josep Serra, Kiyotaka Yoh, Noboru Yamamoto
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT203.
https://doi.org/10.1158/1538-7445.AM2023-CT203
Published: 14 April 2023
View articletitled, Abstract CT203: Updated data from the Phase I Beamion Lung 1 trial of the HER2 tyrosine kinase inhibitor (TKI), BI 1810631, as monotherapy in patients (pts) with advanced/metastatic solid tumors with HER2 aberrations
Journal Articles

Abstract 5853: (R)-2-hydroxyglutarate inhibits KDM5 histone lysine demethylases to drive tumorigenesis in IDH-mutant cancers

Free
Kathryn E. Gunn, Matti Myllykoski, John Cao, Bofu Huang, Betty Rouaisnel, Bill Diplas, Michael M. Levitt, Ryan Looper, John G. Doench, Keith L. Ligon, Harley I. Kornblum, Hai Yan, Samuel McBrayer, Lucy A. Godley, Peppi Koivunen, Julie-Aurore Losman
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5853.
https://doi.org/10.1158/1538-7445.AM2022-5853
Published: 15 June 2022
View articletitled, Abstract 5853: (R)-2-hydroxyglutarate inhibits KDM5 histone lysine demethylases to drive tumorigenesis in IDH-mutant cancers
Journal Articles

Abstract 2103: Distinct methylation patterns correlate with unique clinical and genomic profiles of brainstem gliomas

Free
Lee H. Chen, Changcun Pan, Sizhen Wang, Hai Yan, Liwei Zhang
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2103.
https://doi.org/10.1158/1538-7445.AM2021-2103
Published: 01 July 2021
View articletitled, Abstract 2103: Distinct methylation patterns correlate with unique clinical and genomic profiles of brainstem gliomas
Journal Articles

Abstract 535: Molecular profiling of brainstem gliomas by liquid biopsy

Free
Changcun Pan, Tian Li, Liping Jiang, Hai Yan, Liwei Zhang
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 535.
https://doi.org/10.1158/1538-7445.AM2021-535
Published: 01 July 2021
View articletitled, Abstract 535: Molecular profiling of brainstem gliomas by liquid biopsy
Journal Articles

Abstract 3702: A lineage-specific lncRNA driven by Foxa1 associated super enhancer promotes tumor growth through interacting YBX1

Free
Yin Zhang, Yong-xin Huang, Dan-lan Wang, Hai-yan Yan, Yin Dong
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3702.
https://doi.org/10.1158/1538-7445.AM2020-3702
Published: 15 August 2020
View articletitled, Abstract 3702: A lineage-specific lncRNA driven by Foxa1 associated super enhancer promotes tumor growth through interacting YBX1
Journal Articles

Abstract 709: The utility of plasma ctDNA for detection of KRAS G12C and other mutations in lung cancers

Free
Yonina R. Murciano-Goroff, Kathryn C. Arbour, Michael D. Offin, Hai-Yan Y. Tu, Emily S. Lebow, Tristan S. Shaffer, Caterina Bertucci, Syed A. Hosseini, Kavita Garg, Lee P. Lim, Mark Li, Jason C. Chang, Jorge S. Reis-Filho, Pedram Razavi, James M. Isbell, Gregory J. Riely, David M. Hyman, Piro Lito, Bob T. Li
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 709.
https://doi.org/10.1158/1538-7445.AM2020-709
Published: 15 August 2020
View articletitled, Abstract 709: The utility of plasma ctDNA for detection of KRAS G12C and other mutations in lung cancers
Journal Articles

Abstract 5821: The role of SMARCAL1 loss-of-function mutations in glioblastoma telomere maintenance

Free
Heng Liu, Cheng Xu, Lee H. Chen, Bill H. Diplas, Jinjie Ling, Paula K. Greer, Martin Roskoski, Stephen T. Keir, David M. Ashley, Hai Yan, Matthew S. Waitkus
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5821.
https://doi.org/10.1158/1538-7445.AM2020-5821
Published: 15 August 2020
View articletitled, Abstract 5821: The role of SMARCAL1 loss-of-function mutations in glioblastoma telomere maintenance
Journal Articles

ARRB1-Promoted NOTCH1 Degradation Is Suppressed by OncomiR miR-223 in T-cell Acute Lymphoblastic Leukemia

Available to Purchase
Yi Shu, Yi Wang, Wen-Qiong Lv, Dan-Yi Peng, Juan Li, Hang Zhang, Guang-Jie Jiang, Bi-Jie Yang, Shan Liu, Jia Zhang, Yan-Hua Chen, Shi Tang, Ke-Xing Wan, Jun-Tao Yuan, Wei Guo, Guo Fu, Xin-Kun Qi, Zhi-Dai Liu, Hai-Yan Liu, Chao Yang, Ling-Huan Zhang, Fang-Jie Liu, Jie Yu, Peng-Hui Zhang, Bin Qu, Hui Zhao, Tong-Chuan He, Lin Zou
Journal: Cancer Research
Cancer Res (2020) 80 (5): 988–998.
https://doi.org/10.1158/0008-5472.CAN-19-1471
Published: 02 March 2020
View articletitled, ARRB1-Promoted NOTCH1 Degradation Is Suppressed by OncomiR miR-223 in T-cell Acute Lymphoblastic Leukemia
Open the PDF for ARRB1-Promoted NOTCH1 Degradation Is Suppressed by OncomiR miR-223 in T-cell Acute Lymphoblastic Leukemia in another window
Includes: Supplementary data
Journal Articles

Genome-Wide CRISPR-Cas9 Screen Reveals Selective Vulnerability of ATRX-Mutant Cancers to WEE1 Inhibition

Available to Purchase
Junbo Liang, Hong Zhao, Bill H. Diplas, Song Liu, Jianmei Liu, Dingding Wang, Yan Lu, Qing Zhu, Jiayu Wu, Wenjia Wang, Hai Yan, Yi-Xin Zeng, Xiaoyue Wang, Yuchen Jiao
Journal: Cancer Research
Cancer Res (2020) 80 (3): 510–523.
https://doi.org/10.1158/0008-5472.CAN-18-3374
Published: 03 February 2020
View articletitled, Genome-Wide CRISPR-Cas9 Screen Reveals Selective Vulnerability of ATRX-Mutant Cancers to WEE1 Inhibition
Open the PDF for Genome-Wide CRISPR-Cas9 Screen Reveals Selective Vulnerability of ATRX-Mutant Cancers to WEE1 Inhibition in another window
Includes: Supplementary data
Journal Articles

MTAP Loss Promotes Stemness in Glioblastoma and Confers Unique Susceptibility to Purine Starvation

Free
Landon J. Hansen, Ran Sun, Rui Yang, Simranjit X. Singh, Lee H. Chen, Christopher J. Pirozzi, Casey J. Moure, Carlee Hemphill, Austin B. Carpenter, Patrick Healy, Ryan C. Ruger, Chin-Pu J. Chen, Paula K. Greer, Fangping Zhao, Ivan Spasojevic, Carole Grenier, Zhiqing Huang, Susan K. Murphy, Roger E. McLendon, Henry S. Friedman, Allan H. Friedman, James E. Herndon, II, John H. Sampson, Stephen T. Keir, Darell D. Bigner, Hai Yan, Yiping He
Journal: Cancer Research
Cancer Res (2019) 79 (13): 3383–3394.
https://doi.org/10.1158/0008-5472.CAN-18-1010
Published: 01 July 2019
View articletitled, MTAP Loss Promotes Stemness in Glioblastoma and Confers Unique Susceptibility to Purine Starvation
Open the PDF for MTAP Loss Promotes Stemness in Glioblastoma and Confers Unique Susceptibility to Purine Starvation in another window
Includes: Supplementary data
Journal Articles

Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities

Free
Matthew S. Waitkus, Christopher J. Pirozzi, Casey J. Moure, Bill H. Diplas, Landon J. Hansen, Austin B. Carpenter, Rui Yang, Zhaohui Wang, Brian O. Ingram, Edward D. Karoly, Robert P. Mohney, Ivan Spasojevic, Roger E. McLendon, Henry S. Friedman, Yiping He, Darell D. Bigner, Hai Yan
Journal: Cancer Research
Cancer Res (2018) 78 (1): 36–50.
https://doi.org/10.1158/0008-5472.CAN-17-1352
Published: 02 January 2018
View articletitled, Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities
Open the PDF for Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities in another window
Includes: Supplementary data
Journal Articles

Cic Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation

Free
Rui Yang, Lee H. Chen, Landon J. Hansen, Austin B. Carpenter, Casey J. Moure, Heng Liu, Christopher J. Pirozzi, Bill H. Diplas, Matthew S. Waitkus, Paula K. Greer, Huishan Zhu, Roger E. McLendon, Darell D. Bigner, Yiping He, Hai Yan
Journal: Cancer Research
Cancer Res (2017) 77 (22): 6097–6108.
https://doi.org/10.1158/0008-5472.CAN-17-1018
Published: 14 November 2017
View articletitled, Cic Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation
Open the PDF for Cic Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation in another window
Includes: Supplementary data
Journal Articles

Abstract 4213: Gold nanostar as theranostic probe for brain tumor sensitive PET-optical imaging and image-guided specific photothermal therapy

Free
Yang Liu, Austin Carpenter, Hsiangkuo Yuan, Zhengyuan Zhou, Michael Zalutsky, Ganesan Vaidyanathan, Hai Yan, Tuan Vo-Dinh
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4213.
https://doi.org/10.1158/1538-7445.AM2016-4213
Published: 15 July 2016
View articletitled, Abstract 4213: Gold nanostar as theranostic probe for brain tumor sensitive PET-optical imaging and image-guided specific photothermal therapy
Journal Articles

Abstract 5317: Photonic crystal microarray sensing of breast cancer cell line lysates

Free
Swapnajit Chakravarty, Naimei Tang, Hai Yan, Chun-ju Yang, Yi Zou, Qiang Shen, Ray Chen
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 5317.
https://doi.org/10.1158/1538-7445.AM2014-5317
Published: 01 October 2014
View articletitled, Abstract 5317: Photonic crystal microarray sensing of breast cancer cell line lysates
Journal Articles

Abstract LB-82: MLL2 maintains neoplastic cell growth and global histone H3 lysine 4 monomethylation

Free
Changcun Guo, Lee H. Chen, Yafen Huang, Chun-chi Chang, Ping Wang, Christopher J. Pirozzi, Xiaoxia Qin, Xuhui Bao, Paula K. Greer, Roger E. McLendon, Hai Yan, Stephen T. Keir, Darell D. Bigner, Yiping He
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): LB-82.
https://doi.org/10.1158/1538-7445.AM2014-LB-82
Published: 01 October 2014
View articletitled, Abstract LB-82: MLL2 maintains neoplastic cell growth and global histone H3 lysine 4 monomethylation
Journal Articles

Abstract 63: Driving brain tumorigenesis: Generation of a mutant IDH1 mouse model of progressive glioma

Free
Christopher J. Pirozzi, Catherine Y. Wang, Austin B. Carpenter, Huishan Zhu, Paula K. Greer, Roger E. McLendon, Darell D. Bigner, Yiping He, Hai Yan
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 63.
https://doi.org/10.1158/1538-7445.AM2014-63
Published: 01 October 2014
View articletitled, Abstract 63: Driving brain tumorigenesis: Generation of a mutant IDH1 mouse model of progressive glioma
Journal Articles

Abstract 838: Establishment, identification and treatment data of TCGA glioblatoma xenograft subtypes

Free
Stephen T. Keir, B Ahmed Rasheed, Katherine A. Hoadley, Martin A. Roskoski, Danuta Gasinski, Patrick J. Killela, Hai Yan, Madan M. Kwatra, Henry S. Friedman, Darell D. Bigner
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 838.
https://doi.org/10.1158/1538-7445.AM2014-838
Published: 01 October 2014
View articletitled, Abstract 838: Establishment, identification and treatment data of TCGA glioblatoma xenograft subtypes