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Journal Articles

Abstract 6006: The discovery and development of a CD3 agonistic single domain antibody to accelerate the development of CD3 T cell engager multi-specific antibodies

Yu Liang, Yingyu Li, Yi Zhou, Cheng Luo, Xin Wang, Yang Xin, Shishuai Shao, Tingting Yang, Mingzhu Shao, Jin Chen, Ziyu Chen, Sujuan Hong, Hai Huang, Cheng Chen, Hui Wang, Miaomiao Song, Yuanxin Zhang, Shuai Yang, Xiaojie Tu, Sujuan Wang, Li Chen
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6006.
https://doi.org/10.1158/1538-7445.AM2025-6006
Published: 21 April 2025
View articletitled, Abstract 6006: The discovery and development of a CD3 agonistic single domain antibody to accelerate the development of CD3 T cell engager multi-specific antibodies
Journal Articles

JMJD6 Rewires ATF4-Dependent Glutathione Metabolism to Confer Ferroptosis Resistance in SPOP-Mutated Prostate Cancer

Chuanjie Zhang, Jiawei Ding, Kiat Shenq Lim, Wenjie Zhou, Wenyu Miao, Siqi Wu, Hanqing Liu, Da Huang, Chufeng Chen, Hongchao He, Jun Xiao, Dan-feng Xu, Yan Shen, Hai Huang, Yi Gao
Journal: Cancer Research
Cancer Res (2025) 85 (8): 1496–1513.
https://doi.org/10.1158/0008-5472.CAN-23-2796
Published: 15 April 2025
View articletitled, JMJD6 Rewires ATF4-Dependent Glutathione Metabolism to Confer Ferroptosis Resistance in SPOP-Mutated Prostate Cancer
Open the PDF for JMJD6 Rewires ATF4-Dependent Glutathione Metabolism to Confer Ferroptosis Resistance in SPOP-Mutated Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Chromatin Helicase CHD6 Establishes Proinflammatory Enhancers and Is a Synthetic Lethal Target in FH-Deficient Renal Cell Carcinoma

Juan Jin, Jun Luo, Xiaodong Jin, Kiat Shenq Lim, Yang He, Jiawei Ding, Yan Shen, Yuchen Hou, Hanqing Liu, Xiaoyu Zhu, Jing Zhao, Wenjie Zhou, Hai Huang, Yi Gao, Jun Xiao, Hongchao He, Qunyi Li, Lianxin Liu, Li Chen, Qiang He, Chuanjie Zhang
Journal: Cancer Research
Cancer Res (2025) 85 (4): 675–691.
https://doi.org/10.1158/0008-5472.CAN-24-0787
Published: 17 February 2025
View articletitled, Chromatin Helicase CHD6 Establishes Proinflammatory Enhancers and Is a Synthetic Lethal Target in FH-Deficient Renal Cell Carcinoma
Open the PDF for Chromatin Helicase CHD6 Establishes Proinflammatory Enhancers and Is a Synthetic Lethal Target in FH-Deficient Renal Cell Carcinoma in another window
Includes: Supplementary data
Journal Articles

JMJD6 Rewires ATF4-Dependent Glutathione Metabolism to Confer Ferroptosis Resistance in SPOP-Mutated Prostate Cancer

Chuanjie Zhang, Jiawei Ding, Kiat Shenq Lim, Wenjie Zhou, Wenyu Miao, Siqi Wu, Hanqing Liu, Da Huang, Chufeng Chen, Hongchao He, Jun Xiao, Dan-feng Xu, Yan Shen, Hai Huang, Yi Gao
Journal: Cancer Research
Cancer Res (2025)
https://doi.org/10.1158/0008-5472.CAN-23-2796
Published: 04 February 2025
View articletitled, JMJD6 Rewires ATF4-Dependent Glutathione Metabolism to Confer Ferroptosis Resistance in SPOP-Mutated Prostate Cancer
Open the PDF for JMJD6 Rewires ATF4-Dependent Glutathione Metabolism to Confer Ferroptosis Resistance in SPOP-Mutated Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 2109: Preoperative exercise therapy attenuates the progression of liver metastases following surgical stress by inducing Kupffer cells-mediated anti-tumor trained immunity

Hongji Zhang, Xiang Cheng, Chengli Shen, Meihong Deng, Allan Tsung, Hai Huang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2109.
https://doi.org/10.1158/1538-7445.AM2022-2109
Published: 15 June 2022
View articletitled, Abstract 2109: Preoperative exercise therapy attenuates the progression of liver metastases following surgical stress by inducing Kupffer cells-mediated anti-tumor trained immunity
Journal Articles

Abstract 5203: Discovery and development of SLD2435, a novel humanized IgG1 bispecific antibody simultaneously targeting human TIGIT and PVRIG for cancer immunotherapy

Xiaofeng Zhao, Yayuan Fu, Xiaoqing Liu, Fengli Shan, Zhenna Gao, Mengyu Wang, Huiming Xu, Hai Huang, Yang Liu, Wenqing Yang, Zhuoxiao Cao, Renhong Tang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5203.
https://doi.org/10.1158/1538-7445.AM2022-5203
Published: 15 June 2022
View articletitled, Abstract 5203: Discovery and development of SLD2435, a novel humanized IgG1 bispecific antibody simultaneously targeting human TIGIT and PVRIG for cancer immunotherapy
Journal Articles

Abstract 2544: Preoperative exercise inhibits hepatic metastasis by suppressing PMN-MDSC formation of NETs

Xiang Cheng, Hongji Zhang, Allan Tsung, Hai Huang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2544.
https://doi.org/10.1158/1538-7445.AM2022-2544
Published: 15 June 2022
View articletitled, Abstract 2544: Preoperative exercise inhibits hepatic metastasis by suppressing PMN-MDSC formation of NETs
Journal Articles

Abstract 2981: Establishment and validation of humanized murine modeling platforms to facilitate immuno-oncology research

Yang Liu, Hai Huang, Danni Hao, Ran Pang, Mi Ye, Guojing Wu, Wenjing Li, Liting Xue, Zhenchuan Miao, Ming Yin, Wenqing Yang
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2981.
https://doi.org/10.1158/1538-7445.AM2021-2981
Published: 01 July 2021
View articletitled, Abstract 2981: Establishment and validation of humanized murine modeling platforms to facilitate immuno-oncology research
Journal Articles

Platelet TLR4-ERK5 Axis Facilitates NET-Mediated Capturing of Circulating Tumor Cells and Distant Metastasis after Surgical Stress

Jinghua Ren, Jiayi He, Hongji Zhang, Yujia Xia, Zhiwei Hu, Patricia Loughran, Timothy Billiar, Hai Huang, Allan Tsung
Journal: Cancer Research
Cancer Res (2021) 81 (9): 2373–2385.
https://doi.org/10.1158/0008-5472.CAN-20-3222
Published: 01 May 2021
View articletitled, Platelet TLR4-ERK5 Axis Facilitates NET-Mediated Capturing of Circulating Tumor Cells and Distant Metastasis after Surgical Stress
Open the PDF for Platelet TLR4-ERK5 Axis Facilitates NET-Mediated Capturing of Circulating Tumor Cells and Distant Metastasis after Surgical Stress in another window
Includes: Multimedia, Supplementary data
Journal Articles

Neutrophil Extracellular Traps Drive Mitochondrial Homeostasis in Tumors to Augment Growth

Hamza O. Yazdani, Eva Roy, Alexander J. Comerci, Dirk J. van der Windt, Hongji Zhang, Hai Huang, Patricia Loughran, Sruti Shiva, David A. Geller, David L. Bartlett, Allan Tsung, Tai Sheng, Richard L. Simmons, Samer Tohme
Journal: Cancer Research
Cancer Res (2019) 79 (21): 5626–5639.
https://doi.org/10.1158/0008-5472.CAN-19-0800
Published: 01 November 2019
View articletitled, Neutrophil Extracellular Traps Drive Mitochondrial Homeostasis in Tumors to Augment Growth
Open the PDF for Neutrophil Extracellular Traps Drive Mitochondrial Homeostasis in Tumors to Augment Growth in another window
Includes: Supplementary data
Journal Articles

Glutamate Decarboxylase 65 Signals through the Androgen Receptor to Promote Castration Resistance in Prostate Cancer

Yi Gao, Lu Chen, ZunGuo Du, WenChao Gao, ZhengMing Wu, XiuJuan Liu, Hai Huang, DanFeng Xu, QingQuan Li
Journal: Cancer Research
Cancer Res (2019) 79 (18): 4638–4649.
https://doi.org/10.1158/0008-5472.CAN-19-0700
Published: 13 September 2019
View articletitled, Glutamate Decarboxylase 65 Signals through the Androgen Receptor to Promote Castration Resistance in Prostate Cancer
Open the PDF for Glutamate Decarboxylase 65 Signals through the Androgen Receptor to Promote Castration Resistance in Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 2959: Deoxysappanchalcone inhibits cell growth by regulation of TOPK signaling pathway in colon cancer

Ran Zhao, Hai Huang, Bu Young Choi, Mengqiu Song, Fanxiang Yin, Xiaorong Fu, Hanyong Chen, Jung Hyun Shim, Mee-Hyun Lee, Zigang Dong
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2959.
https://doi.org/10.1158/1538-7445.AM2019-2959
Published: 01 July 2019
View articletitled, Abstract 2959: Deoxysappanchalcone inhibits cell growth by regulation of TOPK signaling pathway in colon cancer
Journal Articles

Abstract 131: Neutrophil extracellular trap mediate mitochondrial biogenesis in cancer cells to promote growth of metastases

Hamza Yazdani, Samer Tohme, Eva Roy, Patricia Loughran, Dirk Vander Windth, Hai Huang, Allan Tsung
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 131.
https://doi.org/10.1158/1538-7445.AM2018-131
Published: 01 July 2018
View articletitled, Abstract 131: Neutrophil extracellular trap mediate mitochondrial biogenesis in cancer cells to promote growth of metastases
Journal Articles

Abstract LB-064: The discovery of novel small molecular CXCR2 antagonist by using ligand-based pharmacophore model

Wen-Hai Huang, Zhi-Long Wang, Jin-Xin Che, Hai-Chao Sheng, Feng Huang, Yong-Zhou Hu, You-Hong Hu, Xin Xie, Xiao-Wu Dong
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-064.
https://doi.org/10.1158/1538-7445.AM2018-LB-064
Published: 01 July 2018
View articletitled, Abstract LB-064: The discovery of novel small molecular CXCR2 antagonist by using ligand-based pharmacophore model
Journal Articles

Abstract 2021: Ablation of caspase-7 promotes solar-simulated light-induced mouse skin carcinogenesis through upregulation of keratin-17

Mee-Hyun Lee, Do Young Lim, Sung Young Lee, Jung Hyun Shim, Xuejiao Liu, Ran Zhao, Hai Huang, G.Timothy Bowden, Young-Joon Surh, Yong-Yeon Cho, Ann M. Bode, Zigang Dong
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2021.
https://doi.org/10.1158/1538-7445.AM2017-2021
Published: 01 July 2017
View articletitled, Abstract 2021: Ablation of caspase-7 promotes solar-simulated light-induced mouse skin carcinogenesis through upregulation of keratin-17
Journal Articles

Abstract 2940: TH17: mediators of metastatic growth acceleration after surgery

Vikas Sud, Samer Tohme, Dirk J. van der Windt, Hai Huang, Allan Tsung
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2940.
https://doi.org/10.1158/1538-7445.AM2017-2940
Published: 01 July 2017
View articletitled, Abstract 2940: TH17: mediators of metastatic growth acceleration after surgery
Journal Articles

Spermidine Prolongs Lifespan and Prevents Liver Fibrosis and Hepatocellular Carcinoma by Activating MAP1S-Mediated Autophagy

Fei Yue, Wenjiao Li, Jing Zou, Xianhan Jiang, Guibin Xu, Hai Huang, Leyuan Liu
Journal: Cancer Research
Cancer Res (2017) 77 (11): 2938–2951.
https://doi.org/10.1158/0008-5472.CAN-16-3462
Published: 31 May 2017
View articletitled, Spermidine Prolongs Lifespan and Prevents Liver Fibrosis and Hepatocellular Carcinoma by Activating MAP1S-Mediated Autophagy
Open the PDF for Spermidine Prolongs Lifespan and Prevents Liver Fibrosis and Hepatocellular Carcinoma by Activating MAP1S-Mediated Autophagy in another window
Journal Articles

Abstract A30: The role of neutrophil extracellular traps in promoting metastatic cancer following surgical stress

Samer Tohme, Hai Huang, Alexis Chidi, Richard Simmons, Allan Tsung
Journal: Cancer Research
Cancer Res (2016) 76 (7_Supplement): A30.
https://doi.org/10.1158/1538-7445.TUMMET15-A30
Published: 26 May 2016
View articletitled, Abstract A30: The role of neutrophil extracellular traps in promoting metastatic cancer following surgical stress
Journal Articles

Neutrophil Extracellular Traps Promote the Development and Progression of Liver Metastases after Surgical Stress

Samer Tohme, Hamza O. Yazdani, Ahmed B. Al-Khafaji, Alexis P. Chidi, Patricia Loughran, Kerri Mowen, Yanming Wang, Richard L. Simmons, Hai Huang, Allan Tsung
Journal: Cancer Research
Cancer Res (2016) 76 (6): 1367–1380.
https://doi.org/10.1158/0008-5472.CAN-15-1591
Published: 14 March 2016
View articletitled, Neutrophil Extracellular Traps Promote the Development and Progression of Liver Metastases after Surgical Stress
Open the PDF for Neutrophil Extracellular Traps Promote the Development and Progression of Liver Metastases after Surgical Stress in another window
Includes: Supplementary data
Journal Articles

High-Mobility Group Box 1 Promotes Hepatocellular Carcinoma Progression through miR-21–Mediated Matrix Metalloproteinase Activity

Man Chen, Yao Liu, Patrick Varley, Ying Chang, Xing-xing He, Hai Huang, Daolin Tang, Michael T. Lotze, Jusheng Lin, Allan Tsung
Journal: Cancer Research
Cancer Res (2015) 75 (8): 1645–1656.
https://doi.org/10.1158/0008-5472.CAN-14-2147
Published: 14 April 2015
View articletitled, High-Mobility Group Box 1 Promotes Hepatocellular Carcinoma Progression through miR-21–Mediated Matrix Metalloproteinase Activity
Open the PDF for High-Mobility Group Box 1 Promotes Hepatocellular Carcinoma Progression through miR-21–Mediated Matrix Metalloproteinase Activity in another window
Includes: Supplementary data