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H. Phillip Koeffler
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Journal Articles

Targeting RNA Exonuclease XRN1 Potentiates Efficacy of Cancer Immunotherapy

Xue-Bin Ran, Ling-Wen Ding, Qiao-Yang Sun, Henry Yang, Jonathan W. Said, Lao Zhentang, Vikas Madan, Pushkar Dakle, Jin-Fen Xiao, Xinyi Loh, Ying Li, Liang Xu, Xiao-Qiang Xiang, Ling-Zhi Wang, Boon Cher Goh, De-Chen Lin, Wee Joo Chng, Soo-Yong Tan, Sudhakar Jha, H. Phillip Koeffler
Journal: Cancer Research
Cancer Res (2023) 83 (6): 922–938.
https://doi.org/10.1158/0008-5472.CAN-21-3052
Published: 15 March 2023
View article titled, Targeting RNA Exonuclease XRN1 Potentiates Efficacy of Cancer Immunotherapy
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Includes: Supplementary data
Journal Articles

PINK1-Mediated Mitophagy Promotes Oxidative Phosphorylation and Redox Homeostasis to Induce Drug-Tolerant Persister Cancer Cells

Yun Li, Hengxing Chen, Xuan Xie, Bing Yang, Xiaojuan Wang, Jingyuan Zhang, Tian Qiao, Jiao Guan, Yuntan Qiu, Yong-Xin Huang, Duanqing Tian, Xinyi Yao, Daning Lu, H. Phillip Koeffler, Yin Zhang, Dong Yin
Journal: Cancer Research
Cancer Res (2023) 83 (3): 398–413.
https://doi.org/10.1158/0008-5472.CAN-22-2370
Published: 03 February 2023
View article titled, PINK1-Mediated Mitophagy Promotes Oxidative Phosphorylation and Redox Homeostasis to Induce Drug-Tolerant Persister Cancer Cells
Open the PDF for PINK1-Mediated Mitophagy Promotes Oxidative Phosphorylation and Redox Homeostasis to Induce Drug-Tolerant Persister Cancer Cells in another window
Includes: Supplementary data
Journal Articles

A Transcriptional Regulatory Loop of Master Regulator Transcription Factors, PPARG, and Fatty Acid Synthesis Promotes Esophageal Adenocarcinoma

Sai Ma, Bo Zhou, Qian Yang, Yunzhi Pan, Wei Yang, Stephen J. Freedland, Ling-Wen Ding, Michael R. Freeman, Joshua J. Breunig, Neil A. Bhowmick, Jian Pan, H. Phillip Koeffler, De-Chen Lin
Journal: Cancer Research
Series: Author Choice
Cancer Res (2021) 81 (5): 1216–1229.
https://doi.org/10.1158/0008-5472.CAN-20-0652
Published: 01 March 2021
View article titled, A Transcriptional Regulatory Loop of Master Regulator Transcription Factors, PPARG, and Fatty Acid Synthesis Promotes Esophageal Adenocarcinoma
Open the PDF for A Transcriptional Regulatory Loop of Master Regulator Transcription Factors, PPARG, and Fatty Acid Synthesis Promotes Esophageal Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 4670: TIP60 regulates alternative splicing of Integrin subunit alpha 6

Shreshtha Sailesh Bhatia, H. Phillip Koeffler, Sudhakar Jha
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4670.
https://doi.org/10.1158/1538-7445.AM2020-4670
Published: 15 August 2020
View article titled, Abstract 4670: TIP60 regulates alternative splicing of Integrin subunit alpha 6
Journal Articles

Abstract 72: PARK2 enhances chemosensitivity of antimicrotubule drugs in breast cancer via promoting degradation of BCL-2

Hengxing Chen, Yun Li, Yu Li, Zhen Chen, Limin Xie, Wenjia Li, Yuanxin Zhu, Daning Lu, Xue Hong, H. Phillip Koeffler, Wenjing Wu, Kaishun Hu, Dong Yin
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 72.
https://doi.org/10.1158/1538-7445.AM2020-72
Published: 15 August 2020
View article titled, Abstract 72: PARK2 enhances chemosensitivity of antimicrotubule drugs in breast cancer via promoting degradation of BCL-2
Journal Articles

Lineage-Specific Epigenomic and Genomic Activation of Oncogene HNF4A Promotes Gastrointestinal Adenocarcinomas

Jian Pan, Tiago C. Silva, Nicole Gull, Qian Yang, Jasmine T. Plummer, Stephanie Chen, Kenji Daigo, Takao Hamakubo, Sigal Gery, Ling-Wen Ding, Yan-Yi Jiang, Shaoyan Hu, Li-Yan Xu, En-Min Li, Yanbing Ding, Samuel J. Klempner, Simon A. Gayther, Benjamin P. Berman, H. Phillip Koeffler, De-Chen Lin
Journal: Cancer Research
Series: Author Choice
Cancer Res (2020) 80 (13): 2722–2736.
https://doi.org/10.1158/0008-5472.CAN-20-0390
Published: 02 July 2020
View article titled, Lineage-Specific Epigenomic and Genomic Activation of Oncogene HNF4A Promotes Gastrointestinal Adenocarcinomas
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Includes: Supplementary data
Journal Articles

RNA-Binding Protein ZFP36L1 Suppresses Hypoxia and Cell-Cycle Signaling

Xin-Yi Loh, Qiao-Yang Sun, Ling-Wen Ding, Anand Mayakonda, Nachiyappan Venkatachalam, Mei-Shi Yeo, Tiago C. Silva, Jin-Fen Xiao, Ngan B. Doan, Jonathan W. Said, Xue-Bin Ran, Si-Qin Zhou, Pushkar Dakle, Pavithra Shyamsunder, Angele Pei-Fern Koh, Ruby Yun-Ju Huang, Benjamin P. Berman, Soo-Yong Tan, Henry Yang, De-Chen Lin, H. Phillip Koeffler
Journal: Cancer Research
Cancer Res (2020) 80 (2): 219–233.
https://doi.org/10.1158/0008-5472.CAN-18-2796
Published: 15 January 2020
View article titled, RNA-Binding Protein <em>ZFP36L1</em> Suppresses Hypoxia and Cell-Cycle Signaling
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Includes: Supplementary data
Journal Articles

Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma

Jiang Yuan, Yan-Yi Jiang, Anand Mayakonda, Moli Huang, Ling-Wen Ding, Han Lin, Fenggang Yu, Yanan Lu, Thomas Kwok Seng Loh, Marilynn Chow, Samantha Savage, Jeffrey W. Tyner, De-Chen Lin, H. Phillip Koeffler
Journal: Cancer Research
Cancer Res (2017) 77 (23): 6614–6626.
https://doi.org/10.1158/0008-5472.CAN-17-1143
Published: 30 November 2017
View article titled, Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma
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Includes: Supplementary data
Journal Articles

Abstract 2450: Mutational profiling of MLL-PTD acute myeloid leukemia

Lingwen Ding, Qiaoyang Sun, Kar-Tong Tan, Wenwen Chien, Anand Mayakonda, Dechen Lin, Xinyi Loh, Jinfen Xiao, Manja Meggendorfer, Tamara Alpermann, Manoj Garg, Su-Lin Lim, Vikas Madan, Norimichi Hattori, Yasunobu Nagata, Satoru Miyano, Allen Yeoh Eng Juh, Hsin-An Hou, Yan-Yi Jiang, Yan-Yi Jiang, Sumiko Takao, Li-Zhen Liu, Siew-Zhuan Tan, Siew-Zhuan Tan, Michael Lill, Mutsumi Hayashi, Akitoshi Kinoshita, Hagop M. Kantarjian, Steven M. Kornblau, Seishi Ogawa, Torsten Haferlach, Henry Yang, H. Phillip Koeffler
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2450.
https://doi.org/10.1158/1538-7445.AM2017-2450
Published: 01 July 2017
View article titled, Abstract 2450: Mutational profiling of MLL-PTD acute myeloid leukemia
Journal Articles

Abstract 4188: Multitargeted tyrosine kinase inhibitor identified as potential therapeutic intervention for liposarcoma using high-throughput profiling

Deepika Kanojia, Manoj Garg, Jakki Martinez, Anand M.T., Samuel B Luty, Ngan B Doan, Jonathan W Said, Jeffrey W Tyner, H Phillip Koeffler
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4188.
https://doi.org/10.1158/1538-7445.AM2017-4188
Published: 01 July 2017
View article titled, Abstract 4188: Multitargeted tyrosine kinase inhibitor identified as potential therapeutic intervention for liposarcoma using high-throughput profiling
Journal Articles

Abstract 4494: Tumor suppressive role of ZFP36L1 by suppressing HIF1α and Cyclin D1 in bladder and breast cancer

Xin Yi Loh, Ling Wen Ding, H. Phillip Koeffler
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4494.
https://doi.org/10.1158/1538-7445.AM2017-4494
Published: 01 July 2017
View article titled, Abstract 4494: Tumor suppressive role of ZFP36L1 by suppressing HIF1α and Cyclin D1 in bladder and breast cancer
Journal Articles

Abstract 806: MGA is a potential tumor suppressor in acute myeloid leukemia

Qiaoyang Sun, Lingwen Ding, Kar-Tong Tan, Wenwen Chien, Xinyi Loh, Jinfen Xiao, Anand Mayakonda, Dechen Lin, Yanyi Jiang, Henry Yang, Sigal Gery, H. Phillip Koeffler
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 806.
https://doi.org/10.1158/1538-7445.AM2017-806
Published: 01 July 2017
View article titled, Abstract 806: MGA is a potential tumor suppressor in acute myeloid leukemia
Journal Articles

Genomic and Epigenomic Heterogeneity of Hepatocellular Carcinoma

De-Chen Lin, Anand Mayakonda, Huy Q. Dinh, Pinbo Huang, Lehang Lin, Xiaoping Liu, Ling-wen Ding, Jie Wang, Benjamin P. Berman, Er-Wei Song, Dong Yin, H. Phillip Koeffler
Journal: Cancer Research
Series: Author Choice
Cancer Res (2017) 77 (9): 2255–2265.
https://doi.org/10.1158/0008-5472.CAN-16-2822
Published: 30 April 2017
View article titled, Genomic and Epigenomic Heterogeneity of Hepatocellular Carcinoma
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Includes: Supplementary data
Journal Articles

Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia

Ling-Wen Ding, Qiao-Yang Sun, Kar-Tong Tan, Wenwen Chien, Anand Mayakonda Thippeswamy, Allen Eng Juh Yeoh, Norihiko Kawamata, Yasunobu Nagata, Jin-Fen Xiao, Xin-Yi Loh, De-Chen Lin, Manoj Garg, Yan-Yi Jiang, Liang Xu, Su-Lin Lim, Li-Zhen Liu, Vikas Madan, Masashi Sanada, Lucia Torres Fernández, Hema Preethi, Michael Lill, Hagop M. Kantarjian, Steven M. Kornblau, Satoru Miyano, Der-Cherng Liang, Seishi Ogawa, Lee-Yung Shih, Henry Yang, H. Phillip Koeffler
Journal: Cancer Research
Cancer Res (2017) 77 (2): 390–400.
https://doi.org/10.1158/0008-5472.CAN-16-1303
Published: 16 January 2017
View article titled, Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia
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Includes: Supplementary data
Journal Articles

CRM1 Inhibition Promotes Cytotoxicity in Ewing Sarcoma Cells by Repressing EWS-FLI1–Dependent IGF-1 Signaling

Haibo Sun, De-Chen Lin, Qi Cao, Xiao Guo, Helene Marijon, Zhiqiang Zhao, Sigal Gery, Liang Xu, Henry Yang, Brendan Pang, Victor Kwan Min Lee, Huey Jin Lim, Ngan Doan, Jonathan W. Said, Peiguo Chu, Anand Mayakonda, Tom Thomas, Charles Forscher, Erkan Baloglu, Sharon Shacham, Raja Rajalingam, H. Phillip Koeffler
Journal: Cancer Research
Cancer Res (2016) 76 (9): 2687–2697.
https://doi.org/10.1158/0008-5472.CAN-15-1572
Published: 01 May 2016
View article titled, CRM1 Inhibition Promotes Cytotoxicity in Ewing Sarcoma Cells by Repressing EWS-FLI1–Dependent IGF-1 Signaling
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Includes: Supplementary data
Journal Articles

Abstract A2-20: Integrative study of genomic alterations in liposarcoma

Deepika Kanojia, Manoj Garg, Yasunobu Nagata, Dhong Hyun Lee, Hans-Ulrich Klein, Christoph Bartenhagen, Anand M T, Ngan B Doan, Jonathan W Said, Henry Yang, Charles Forscher, Martin Dugas, Seishi Ogawa, H Phillip Koeffler
Journal: Cancer Research
Cancer Res (2015) 75 (22_Supplement_1): A2-20.
https://doi.org/10.1158/1538-7445.TRANSCAGEN-A2-20
Published: 15 November 2015
View article titled, Abstract A2-20: Integrative study of genomic alterations in liposarcoma
Journal Articles

Abstract 138: Novel PAK4 allosteric modulators (PAMs) provide potential therapeutic options in human gastric cancer

Wenwen Chien, Jinfen Xiao, Ling-Wen Ding, Muhammad Ikhsan B. Muzakar, Qiao-Yang Sun, Sigal Gery, William Senapedis, Sharon Shacham, Erkan Baloglu, H. Phillip Koeffler
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 138.
https://doi.org/10.1158/1538-7445.AM2015-138
Published: 01 August 2015
View article titled, Abstract 138: Novel PAK4 allosteric modulators (PAMs) provide potential therapeutic options in human gastric cancer
Journal Articles

Abstract 3939: The genomic landscape of nasopharyngeal carcinoma

DECHEN LIN, Xuan Meng, Masaharu Hazawa, Yasunobu Nagata, Ana Maria Varela, Liang Xu, Yusuke Sato, Li-Zhen Liu, Ling-Wen Ding, Arjun Sharma, Boon Cher Goh, Soo Chin Lee, Bengt Fredrik Petersson, Feng Gang Yu, Paul Macary, Min Zin Oo, Soh Ha Chan, Henry Yang, Seishi Ogawa, H. Phillip Koeffler
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3939.
https://doi.org/10.1158/1538-7445.AM2015-3939
Published: 01 August 2015
View article titled, Abstract 3939: The genomic landscape of nasopharyngeal carcinoma
Journal Articles

Genomic and Functional Analysis of the E3 Ligase PARK2 in Glioma

De-Chen Lin, Liang Xu, Ye Chen, Haiyan Yan, Masaharu Hazawa, Ngan Doan, Jonathan W. Said, Ling-Wen Ding, Li-Zhen Liu, Henry Yang, Shizhu Yu, Michael Kahn, Dong Yin, H. Phillip Koeffler
Journal: Cancer Research
Cancer Res (2015) 75 (9): 1815–1827.
https://doi.org/10.1158/0008-5472.CAN-14-1433
Published: 30 April 2015
View article titled, Genomic and Functional Analysis of the E3 Ligase PARK2 in Glioma
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Includes: Supplementary data
Journal Articles

Abstract 5542: Synergistic inhibition of growth of triple-negative breast cancer cells by co-targeting PARP and HDAC

Helene Marijon, Haibo Sun, Aimery de Gramont, Sigal Gery, H Phillip Koeffler
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 5542.
https://doi.org/10.1158/1538-7445.AM2014-5542
Published: 01 October 2014
View article titled, Abstract 5542: Synergistic inhibition of growth of triple-negative breast cancer cells by co-targeting PARP and HDAC