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Journal Articles

Abstract 1778: NR2F2 mediates cell growth and endocrine resistance in NF1 loss, ER+ breast cancer

Free
Yanyan Cai, Peihua Zhao, Fan Wu, Hong Shao, Pedram Razavi, Guotai Xu, Maurizio Scaltriti, Sarat Chandarlapaty
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1778.
https://doi.org/10.1158/1538-7445.AM2022-1778
Published: 15 June 2022
View articletitled, Abstract 1778: NR2F2 mediates cell growth and endocrine resistance in NF1 loss, ER+ breast cancer
Journal Articles

Cell Line–Specific Network Models of ER+ Breast Cancer Identify Potential PI3Kα Inhibitor Resistance Mechanisms and Drug Combinations

Free
Jorge Gómez Tejeda Zañudo, Pingping Mao, Clara Alcon, Kailey Kowalski, Gabriela N. Johnson, Guotai Xu, Jose Baselga, Maurizio Scaltriti, Anthony Letai, Joan Montero, Réka Albert, Nikhil Wagle
Journal: Cancer Research
Cancer Res (2021) 81 (17): 4603–4617.
https://doi.org/10.1158/0008-5472.CAN-21-1208
Published: 01 September 2021
View articletitled, Cell Line–Specific Network Models of ER+ Breast Cancer Identify Potential PI3Kα Inhibitor Resistance Mechanisms and Drug Combinations
Open the PDF for Cell Line–Specific Network Models of ER+ Breast Cancer Identify Potential PI3Kα Inhibitor Resistance Mechanisms and Drug Combinations in another window
Includes: Supplementary data
Journal Articles

Abstract NG05: Epigenetic mechanisms of endocrine therapy response in breast cancer

Free
Eneda Toska, Guotai Xu, Amaia Arruabarrena-Aristorena, Maurizio Scaltriti
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): NG05.
https://doi.org/10.1158/1538-7445.AM2021-NG05
Published: 01 July 2021
View articletitled, Abstract NG05: Epigenetic mechanisms of endocrine therapy response in breast cancer
Journal Articles

Genomic Alterations in PIK3CA-Mutated Breast Cancer Result in mTORC1 Activation and Limit the Sensitivity to PI3Kα Inhibitors

Free
Yanyan Cai, Guotai Xu, Fan Wu, Flavia Michelini, Carmen Chan, Xuan Qu, Pier Selenica, Erik Ladewig, Pau Castel, Yuanming Cheng, Alison Zhao, Komal Jhaveri, Eneda Toska, Marta Jimenez, Alexandra Jacquet, Alicia Tran-Dien, Fabrice Andre, Sarat Chandarlapaty, Jorge S. Reis-Filho, Pedram Razavi, Maurizio Scaltriti
Journal: Cancer Research
Cancer Res (2021) 81 (9): 2470–2480.
https://doi.org/10.1158/0008-5472.CAN-20-3232
Published: 01 May 2021
View articletitled, Genomic Alterations in PIK3CA-Mutated Breast Cancer Result in mTORC1 Activation and Limit the Sensitivity to PI3Kα Inhibitors
Open the PDF for Genomic Alterations in PIK3CA-Mutated Breast Cancer Result in mTORC1 Activation and Limit the Sensitivity to PI3Kα Inhibitors in another window
Includes: Supplementary data
Journal Articles

Abstract NG16: Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors

Free
Neil Vasan, Pedram Razavi, Jared L. Johnson, Hong Shao, Hardik Shah, Alesia Antoine, Erik Ladewig, Alexander Gorelick, Ting-Yu Lin, Eneda Toska, Guotai Xu, Abiha Kazmi, Matthew T. Chang, Barry S. Taylor, Maura N. Dickler, Komal Jhaveri, Sarat Chandarlapaty, Raul Rabadan, Ed Reznik, Melissa L. Smith, Robert Sebra, Frauke Schimmoller, Timothy R. Wilson, Lori S. Friedman, Lewis C. Cantley, Maurizio Scaltriti, Jose Baselga
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): NG16.
https://doi.org/10.1158/1538-7445.AM2020-NG16
Published: 15 August 2020
View articletitled, Abstract NG16: Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors
Journal Articles

Abstract P3-03-01: Double PIK3CA mutations in cis drive oncogene addiction and enhance sensitivity to PI3K alpha inhibitors in breast cancer

Free
Neil Vasan, Pedram Razavi, Jared L Johnson, Hong Shao, Timothy Wilson, Frauke Schimmoller, Hardik Shah, Alesia Antoine, Erik Ladewig, Alexander Gorelick, Ting-Yu Lin, Eneda Toska, Guotai Xu, Abiha Kazmi, Matthew T Chang, Barry S. Taylor, Maura N. Dickler, Komal Jhaveri, Sarat Chandarlapaty, Raul Rabadan, Ed Reznik, Melissa L Smith, Robert Sebra, Lori Friedman, Lewis C Cantley, Maurizio Scaltriti, José Baselga
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P3-03-01.
https://doi.org/10.1158/1538-7445.SABCS19-P3-03-01
Published: 15 February 2020
View articletitled, Abstract P3-03-01: Double PIK3CA mutations in cis drive oncogene addiction and enhance sensitivity to PI3K alpha inhibitors in breast cancer
Journal Articles

Abstract 675: Network modeling of drug resistance mechanisms and drug combinations in breast cancer

Free
Jorge Gómez Tejeda Zañudo, Pingping Mao, Joan Montero, Guotai Xu, Kailey J. Kowalski, Gabriela N. Johnson, José Baselga, Maurizio Scaltriti, Anthony G. Letai, Nikhil Wagle, Reka Albert
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 675.
https://doi.org/10.1158/1538-7445.AM2019-675
Published: 01 July 2019
View articletitled, Abstract 675: Network modeling of drug resistance mechanisms and drug combinations in breast cancer
Journal Articles

Abstract 949: ARID1A is a critical regulator of luminal identity and therapeutic response in estrogen receptor-positive breast cancer

Free
Eneda Toska, Guotai Xu, Sagar Chhangawala, Emiliano Cocco, Pedram Razavi, Jordan Otto, Yanyan Cai, Carmen Chan, Drew R. D' Avino, Clayton Collings, Ross L. Levine, Maurizo Scaltriti, Jorge S. Reis-Filho, Cigall Kadoch, Christina Leslie, Jose Baselga
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 949.
https://doi.org/10.1158/1538-7445.AM2019-949
Published: 01 July 2019
View articletitled, Abstract 949: ARID1A is a critical regulator of luminal identity and therapeutic response in estrogen receptor-positive breast cancer
Journal Articles

Abstract 3917: Double PIK3CA mutations in cis enhance oncogene activation and sensitivity to PI3K alpha inhibitors in breast cancer

Free
Neil Vasan, Pedram Razavi, Jared Johnson, Hong Shao, Hardik Shah, Alesia Antoine, Erik Ladewig, Alexander Gorelick, Eneda Toska, Guotai Xu, Abiha Kazmi, Matthew T. Chang, Barry S. Taylor, Maura N. Dickler, Komal Jhaveri, Raul Rabadan, Ed Reznik, Melissa L. Smith, Robert Sebra, Lewis C. Cantley, Maurizio Scaltriti, Jose Baselga
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3917.
https://doi.org/10.1158/1538-7445.AM2019-3917
Published: 01 July 2019
View articletitled, Abstract 3917: Double PIK3CA mutations in cis enhance oncogene activation and sensitivity to PI3K alpha inhibitors in breast cancer
Journal Articles

BRCA2-Deficient Sarcomatoid Mammary Tumors Exhibit Multidrug Resistance

Free
Janneke E. Jaspers, Wendy Sol, Ariena Kersbergen, Andreas Schlicker, Charlotte Guyader, Guotai Xu, Lodewyk Wessels, Piet Borst, Jos Jonkers, Sven Rottenberg
Journal: Cancer Research
Series: Author Choice
Cancer Res (2015) 75 (4): 732–741.
https://doi.org/10.1158/0008-5472.CAN-14-0839
Published: 15 February 2015
View articletitled, BRCA2-Deficient Sarcomatoid Mammary Tumors Exhibit Multidrug Resistance
Open the PDF for BRCA2-Deficient Sarcomatoid Mammary Tumors Exhibit Multidrug Resistance in another window
Includes: Supplementary data
Journal Articles

Abstract LB-392: Loss of Rev7 causes PARP inhibitor resistance in BRCA1;p53-deficient mouse mammary tumor cells

Free
Guotai Xu, Peter Bouwman, Janneke Jaspers, Mark Pieterse, Ariena Kersbergen, Jos Jonkers, Piet Borst, Sven Rottenberg
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): LB-392.
https://doi.org/10.1158/1538-7445.AM2012-LB-392
Published: 15 April 2012
View articletitled, Abstract LB-392: Loss of Rev7 causes PARP inhibitor resistance in BRCA1;p53-deficient mouse mammary tumor cells