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Guillermo Garcia-Manero
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Journal Articles

Abstract 7172: Comprehensive whole genome sequencing (WGS) assay provides diagnostic insight into clinically relevant genomic alterations across myeloid malignancies

Free
Robert Huether, Derick Hoskinson, Pavana Anur, Raul Torres, Karl R. Beutner, Kristiyana Kaneva, Yan Yang, Kelly A. Potts, Andrew Frazier, Iris Braunstein, Brett M. Mahon, Michael A. Thompson, Kate Sasser, Halla Nimeiri, Lewis J. Kraft, Francisco M. De La Vega, Guillermo Garcia-Manero
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 7172.
https://doi.org/10.1158/1538-7445.AM2025-7172
Published: 21 April 2025
View article titled, Abstract 7172: Comprehensive whole genome sequencing (WGS) assay provides diagnostic insight into clinically relevant genomic alterations across myeloid malignancies
Journal Articles

Abstract CT060: Phase 1 study of azacitidine in combination with evorpacept for higher-risk myelodysplastic syndrome (MDS)

Free
Guillermo Garcia-Manero, Bart L. Scott, Ashwin Kishtagari, Srinivasa R. Sanikommu, Aref Al-Kali, Je-Hwan Lee, Juan M. Bergua Burgues, Maria Diez-Campelo, Harry P. Erba, Carmen Garcia-Hernandez, Guillermo Sanz Santillana, Casey O'Connell, Jun-Ho Jang, Dong-Yeop Shin, Hamid Sayar, Mayank Rao, Richard S. Schwartz, Grace An, Feng Jin, Alison J. Forgie, Athanasios C. Tsiatis, Jessica K. Altman
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT060.
https://doi.org/10.1158/1538-7445.AM2024-CT060
Published: 05 April 2024
View article titled, Abstract CT060: Phase 1 study of azacitidine in combination with evorpacept for higher-risk myelodysplastic syndrome (MDS)
Journal Articles

Abstract 3400: Single-cell proteogenomics analysis of AML samples treated with decitabine and venetoclax reveals divergent treatment escape mechanisms

Free
Yi June Kim, Zongrui Li, Abhishek Maiti, Tomoyuki Tanaka, Hidetaka Uryu, Ken Furudate, Kala Hayes, Naval Daver, Naveen Pemmaraju, Tapan M. Kadia, Farhad Ravandi, Nicholas J. Short, Maro Ohanian, Gautam Borthakur, Nitin Jain, Ghayas C. Issa, Lucia Masarova, Steven M. Kornblau, William G. Wierda, Sanam Loghavi, Sa A. Wang, Guillermo Garcia-Manero, Hagop Kantarjian, Courtney D. DiNardo, Marina Y. Konopleva, Koichi Takahashi
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3400.
https://doi.org/10.1158/1538-7445.AM2024-3400
Published: 22 March 2024
View article titled, Abstract 3400: Single-cell proteogenomics analysis of AML samples treated with decitabine and venetoclax reveals divergent treatment escape mechanisms
Journal Articles

Abstract 2725: The single-cell atlas of driver mutations in acute myeloid leukemia

Free
Kiyomi Morita, Feng Wang, Katharina Jahn, Yuanqing Yan, Robert Durruthy-Durruthy, Anup Parikh, Jairo Matthews, Latasha Little, Curtis Gumbs, Jianhua Zhang, Xingzhi Song, Erika Thompson, Keyur Patel, Carlos Bueso-Ramos, Courtney DiNardo, Farhad Ravandi, Elias Jabbour, Michael Andreeff, Jorge Cortes, Marina Konopleva, Guillermo Garcia-Manero, Hagop Kantarjian, Dennis J. Eastburn, P Andrew Futreal, Niko Beerenwinkel, Koichi Takahashi
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2725.
https://doi.org/10.1158/1538-7445.AM2019-2725
Published: 01 July 2019
View article titled, Abstract 2725: The single-cell atlas of driver mutations in acute myeloid leukemia
Journal Articles

Abstract LB-222: Polyfunctionality determined by single-cell proteomics of bone marrow-derived CD4 T cells from patients with acute myeloid leukemia identifies patients responding to anti-PD-1-based therapy and discovers profound T cell defect in mutant TP53 disease

Free
Naval Daver, Hagop Kantarjian, Sean Mackay, Brianna Flynn, Sreyashi Basu, Guillermo Garcia-Manero, Mansour Alfayez, Marina Konopleva, Jairo Matthews, Steven Kornblau, Ellias Jabbour, Jing Zhou, Michael Andreeff
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-222.
https://doi.org/10.1158/1538-7445.AM2019-LB-222
Published: 01 July 2019
View article titled, Abstract LB-222: Polyfunctionality determined by single-cell proteomics of bone marrow-derived CD4 T cells from patients with acute myeloid leukemia identifies patients responding to anti-PD-1-based therapy and discovers profound T cell defect in mutant TP53 disease
Journal Articles

Abstract CT068: Phase Ib/II combination study of APR-246 and azacitidine (AZA) in patients with TP53 mutant myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML)

Free
David A. Sallman, Amy DeZern, Kendra Sweet, David P. Steensma, Thomas Cluzeau, Mikkael Sekeres, Guillermo Garcia-Manero, Gail Roboz, Amy McLemore, Kathy McGraw, John Puskas, Ling Zhang, Chirag Bhagat, Armin Graber, Najla H. Al Ali, Eric Padron, Roger Tell, Jeffrey E. Lancet, Pierre Fenaux, Alan F. List, Rami S. Komrokji
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): CT068.
https://doi.org/10.1158/1538-7445.AM2018-CT068
Published: 01 July 2018
View article titled, Abstract CT068: Phase Ib/II combination study of APR-246 and azacitidine (AZA) in patients with TP53 mutant myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML)
Journal Articles

Abstract 2776: Genetic correlations with clinical response to ASTX727 in patients with myelodysplastic syndromes (MDS)

Free
Haley E. Ramsey, Shilin Zhao, Yaomin Xu, Olatoyosi Otoyosi, Philip Amrein, Amy Dezern, Laura Michaelis, David P. Steensma, Stefan Faderl, Guillermo Garcia-Manero, James Lowder, Pietro Taverna, Michael R. Savona
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2776.
https://doi.org/10.1158/1538-7445.AM2017-2776
Published: 01 July 2017
View article titled, Abstract 2776: Genetic correlations with clinical response to ASTX727 in patients with myelodysplastic syndromes (MDS)
Journal Articles

Abstract 5033: Clonal origin of therapy-related myeloid neoplasms

Free
Koichi Takahashi, Feng Wang, Hagop Kantarjian, Doss Denaha, Erika Thompson, Curtis Gumbs, Keyur Patel, Sattva Neelapu, Yan Wang, Zachary Bohannan, Courtney DiNardo, Farhad Ravandi, Zeev Estrov, Simona Colla, Jianhua Zhang, Xifeng Wu, Guillermo Garcia-Manero, Andrew Futreal
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 5033.
https://doi.org/10.1158/1538-7445.AM2016-5033
Published: 15 July 2016
View article titled, Abstract 5033: Clonal origin of therapy-related myeloid neoplasms
Journal Articles

Abstract 3205: Defining the immune checkpoint landscape of acute myeloid leukemia (AML)

Free
Naval Daver, Sreyashi Basu, Guillermo Garcia-Manero, Jorge Cortes, Farhad Ravandi, Steven Kornblau, Marina Konopleva, Michael Andreeff, Gautam Borthakur, Nitin Jain, William Wierda, Srdan Verstovsek, Peter Ruvolo, Tapan Kadia, Jairo Matthews, Wilmer Flores, Hui Yang, Carlos Bueso-Ramos, Narmeen Somani, Jorge Blando, James Allison, Hagop Kantarjian, Padmanee Sharma
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3205.
https://doi.org/10.1158/1538-7445.AM2016-3205
Published: 15 July 2016
View article titled, Abstract 3205: Defining the immune checkpoint landscape of acute myeloid leukemia (AML)
Journal Articles

Abstract CT307: Phase I/II study of vosaroxin and decitabine in older patients (pts) with acute myeloid leukemia (AML) and high risk myelodysplastic syndrome (MDS)

Free
Naval Daver, Hagop M. Kantarjian, Guillermo Garcia - Manero, Naveen Pemmaraju, Tapan Kadia, Courtney DiNardo, Nitin Jain, Gautum Borthakur, Jorge Cortes, Craig Adam, Farhad Ravandi
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): CT307.
https://doi.org/10.1158/1538-7445.AM2014-CT307
Published: 01 October 2014
View article titled, Abstract CT307: Phase I/II study of vosaroxin and decitabine in older patients (pts) with acute myeloid leukemia (AML) and high risk myelodysplastic syndrome (MDS)
Journal Articles

Abstract 592: Preclinical evaluation of the PARP inhibitor veliparib (ABT-888) in combination with cytotoxic chemotherapy in acute myeloid leukemia.

Free
Tapan Kadia, Sara McCay, Hui Yang, Irene Ganan-Gomez, Yue Wei, Guillermo Garcia-Manero
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 592.
https://doi.org/10.1158/1538-7445.AM2013-592
Published: 15 April 2013
View article titled, Abstract 592: Preclinical evaluation of the PARP inhibitor veliparib (ABT-888) in combination with cytotoxic chemotherapy in acute myeloid leukemia.
Journal Articles

Abstract 4800: Genome-wide CHIP-Seq analysis of histone methylation reveals modulators of NF-κB signaling and the histone demethylase JMJD3 as implicated in disease progression in myelodysplastic syndrome (MDS)

Free
Yue Wei, Rui Chen, Carlos Bueso-Ramos, Hui Yang, Guillermo Garcia-Manero
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4800.
https://doi.org/10.1158/1538-7445.AM10-4800
Published: 15 April 2010
View article titled, Abstract 4800: Genome-wide CHIP-Seq analysis of histone methylation reveals modulators of NF-κB signaling and the histone demethylase JMJD3 as implicated in disease progression in myelodysplastic syndrome (MDS)
Journal Articles

Induction of an anti-angiogenesis factor, Thrombospondin 1 (TSP-1), by a novel histone deacetylase inhibitor, MGCD0103, in human cancer cells in vitro and in vivo

Free
Jianhong Liu, Claire Bonfils, Marja Dubay, Hannah Nguyen, Guillermo Garcia-Manero, Allen Yang, Selina Luger, Robert Martell, Jeffrey Besterman, Zuomei Li
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 739.
Published: 01 May 2008
View article titled, Induction of an anti-angiogenesis factor, Thrombospondin 1 (TSP-1), by a novel histone deacetylase inhibitor, MGCD0103, in human cancer cells in vitro and in vivo
Journal Articles

The dual ABL/SRC inhibitors dasatinib, SKI-606, and INNO-406 are potent inhibitors of T cell acute lymphoblastic leukemia cell lines expressing the NUP214-ABL1 fusion kinase

Free
Alfonso Quintas-Cardama, Taghi Manshouri, Weigang Tong, Hagop Kantarjian, Jorge Cortes, Guillermo Garcia-Manero
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 1825.
Published: 01 May 2007
View article titled, The dual ABL/SRC inhibitors dasatinib, SKI-606, and INNO-406 are potent inhibitors of T cell acute lymphoblastic leukemia cell lines expressing the NUP214-ABL1 fusion kinase
Journal Articles

Global gene methylation profiling of CLL patients and its implication in therapy

Free
Wei-gang Tong, Shang-Qing Kuang, William Wierda, Guillermo Garcia-Manero
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 1112.
Published: 01 May 2007
View article titled, Global gene methylation profiling of CLL patients and its implication in therapy
Journal Articles

Identification of novel differentially methylated markers in adult acute lymphocytic leukemias

Free
Shao-Qing Kuang, Hui Yang, Jaroslav Jelinek, Weigang Tong, Jean-Pierre Issa, Guillermo Garcia-Manero
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 1131.
Published: 01 May 2007
View article titled, Identification of novel differentially methylated markers in adult acute lymphocytic leukemias
Journal Articles

RIL, a LIM Gene on 5q31, Is Silenced by Methylation in Cancer and Sensitizes Cancer Cells to Apoptosis

Free
Yanis A. Boumber, Yutaka Kondo, Xuqi Chen, Lanlan Shen, Vazganush Gharibyan, Kazuo Konishi, Elihu Estey, Hagop Kantarjian, Guillermo Garcia-Manero, Jean-Pierre J. Issa
Journal: Cancer Research
Cancer Res (2007) 67 (5): 1997–2005.
https://doi.org/10.1158/0008-5472.CAN-06-3093
Published: 01 March 2007
View article titled, RIL, a LIM Gene on 5q31, Is Silenced by Methylation in Cancer and Sensitizes Cancer Cells to Apoptosis
Open the PDF for RIL, a LIM Gene on 5q31, Is Silenced by Methylation in Cancer and Sensitizes Cancer Cells to Apoptosis in another window
Includes: Supplementary data
Journal Articles

DNA Methylation Changes after 5-Aza-2′-Deoxycytidine Therapy in Patients with Leukemia

Free
Allen S. Yang, Ketan D. Doshi, Sang-Woon Choi, Joel B. Mason, Rajan K. Mannari, Vazganush Gharybian, Rene Luna, Asif Rashid, Lanlan Shen, Marcos R.H. Estecio, Hagop M. Kantarjian, Guillermo Garcia-Manero, Jean-Pierre J. Issa
Journal: Cancer Research
Cancer Res (2006) 66 (10): 5495–5503.
https://doi.org/10.1158/0008-5472.CAN-05-2385
Published: 16 May 2006
View article titled, DNA Methylation Changes after 5-Aza-2′-Deoxycytidine Therapy in Patients with Leukemia
Open the PDF for DNA Methylation Changes after 5-Aza-2′-Deoxycytidine Therapy in Patients with Leukemia in another window
Includes: Supplementary data
Journal Articles

Expression analysis of the p15INK4B and p21Cip/WAF genes in patients with MDS treated with decitabine

Free
Yasuhiro Oki, Hagop M. Kantarjian, Jan Davis, Farhad Ravandi, Srdan Verstovsek, Jorge E. Cortes, Guillermo Garcia-Manero, Jean-Pierre Issa
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 540.
Published: 15 April 2006
View article titled, Expression analysis of the p15INK4B and p21Cip/WAF genes in patients with MDS treated with decitabine
Journal Articles

Switch from a one-allele to two-allele mutation of the deoxycytidine kinase gene causes resistance to 5-aza-2’-deoxycytidine in the HL 60 cell line

Free
Taichun Qin, Sr, Jaroslav Jelinek, Sr, Emile Youssef, Sr, Guillermo Garcia-Manero, Sr, Jean-Pierre Issa, Sr
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 382.
Published: 15 April 2006
View article titled, Switch from a one-allele to two-allele mutation of the deoxycytidine kinase gene causes resistance to 5-aza-2’-deoxycytidine in the HL 60 cell line