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Journal Articles

Abstract A064: Identifying cooperating genetic events contributing to disease progression in mutant p53-driven breast cancer

Rhiannon L Morrissey, Joy M McDaniel, Dhruv Chachad, Xiaoping Su, Patty Chau, Adel El-Naggar, Guillermina Lozano

Cancer Res (2024) 84 (3_Supplement_1): A064.

https://doi.org/10.1158/1538-7445.ADVBC23-A064

Published: 01 February 2024

View article titled, Abstract A064: Identifying cooperating genetic events contributing to disease progression in mutant p53-driven breast cancer

Journal Articles

Unique Transcriptional Profiles Underlie Osteosarcomagenesis Driven by Different p53 Mutants

Dhruv Chachad, Lalit R. Patel, Carlos Vera Recio, Rasoul Pourebrahim, Elizabeth M. Whitley, Wenyi Wang, Xiaoping Su, An Xu, Dung-Fang Lee, Guillermina Lozano

Cancer Res (2023) 83 (14): 2297–2311.

https://doi.org/10.1158/0008-5472.CAN-22-3464

Published: 14 July 2023

View article titled, Unique Transcriptional Profiles Underlie Osteosarcomagenesis Driven by Different p53 Mutants

Includes: Supplementary data

Journal Articles

Abstract A042: Differences in gain-of-function and inhibitory effects amongst p53 mutants in vivo

Shunbin Xiong, Dhruv Chachad, Yun Zhang, Jovanka Gencel-Augusto, Mario Sirito, Vinod Pant, Peirong Yang, Chang Sun, Guillermina Lozano

Cancer Res (2023) 83 (2_Supplement_2): A042.

https://doi.org/10.1158/1538-7445.METASTASIS22-A042

Published: 15 January 2023

View article titled, Abstract A042: Differences in gain-of-function and inhibitory effects amongst p53 mutants in vivo

Journal Articles

p53 Activation Paradoxically Causes Liver Cancer

Michelle C. Barton, Guillermina Lozano

Cancer Res (2022) 82 (16): 2824–2825.

https://doi.org/10.1158/0008-5472.CAN-22-2065

Published: 16 August 2022

View article titled, p53 Activation Paradoxically Causes Liver Cancer

Journal Articles

Abstract 829: p53 dimers elicit tumor suppressive activities through an altered metabolic program

Jovanka Gencel-Augusto, Xiaoping Su, Guillermina Lozano

Cancer Res (2022) 82 (12_Supplement): 829.

https://doi.org/10.1158/1538-7445.AM2022-829

Published: 15 June 2022

View article titled, Abstract 829: p53 dimers elicit tumor suppressive activities through an altered metabolic program

Journal Articles

Differential Gain-of-Function Activity of Three p53 Hotspot Mutants In Vivo

Shunbin Xiong, Dhruv Chachad, Yun Zhang, Jovanka Gencel-Augusto, Mario Sirito, Vinod Pant, Peirong Yang, Chang Sun, Gilda Chau, Yuan Qi, Xiaoping Su, Elizabeth M. Whitley, Adel K. El-Naggar, Guillermina Lozano

Cancer Res (2022) 82 (10): 1926–1936.

https://doi.org/10.1158/0008-5472.CAN-21-3376

Published: 16 May 2022

View article titled, Differential Gain-of-Function Activity of Three p53 Hotspot Mutants In Vivo

Includes: Supplementary data

Journal Articles

Alterations of the Mdm2 C-Terminus Differentially Impact Its Function In Vivo

Vinod Pant, Neeraj K. Aryal, Shunbin Xiong, Gilda P. Chau, Natalie W. Fowlkes, Guillermina Lozano

Cancer Res (2022) 82 (7): 1313–1320.

https://doi.org/10.1158/0008-5472.CAN-21-2381

Published: 01 April 2022

View article titled, Alterations of the Mdm2 C-Terminus Differentially Impact Its Function In Vivo

Journal Articles

Abstract P3-05-01: Role of TRIM24 in metaplastic breast cancer and nomination of potential therapeutic targets

Vrutant Shah, Shucheng Miao, Clinton Yam, Jeffrey T Chang, Michelle Barton, Helen Piwnica-Worms, Stacy Moulder, Guillermina Lozano

Cancer Res (2022) 82 (4_Supplement): P3-05-01.

https://doi.org/10.1158/1538-7445.SABCS21-P3-05-01

Published: 15 February 2022

View article titled, Abstract P3-05-01: Role of TRIM24 in metaplastic breast cancer and nomination of potential therapeutic targets

Journal Articles

Abstract 2417: Mutant p53 and oncogenic KRAS converge on CREB1 to drive pancreatic cancer metastasis

Cancer Res (2021) 81 (13_Supplement): 2417.

https://doi.org/10.1158/1538-7445.AM2021-2417

Published: 01 July 2021

View article titled, Abstract 2417: Mutant p53 and oncogenic KRAS converge on CREB1 to drive pancreatic cancer metastasis

Journal Articles

The Common Germline TP53-R337H Mutation Is Hypomorphic and Confers Incomplete Penetrance and Late Tumor Onset in a Mouse Model

John R. Jeffers, Emilia M. Pinto, Jerold E. Rehg, Michael R. Clay, Jinling Wang, Geoffrey Neale, Richard J. Heath, Guillermina Lozano, Enzo Lalli, Bonald C. Figueiredo, Alberto S. Pappo, Carlos Rodriguez-Galindo, Wenan Chen, Stanley Pounds, Raul C. Ribeiro, Gerard P. Zambetti

Cancer Res (2021) 81 (9): 2442–2456.

https://doi.org/10.1158/0008-5472.CAN-20-1750

Published: 01 May 2021

View article titled, The Common Germline TP53-R337H Mutation Is Hypomorphic and Confers Incomplete Penetrance and Late Tumor Onset in a Mouse Model

Includes: Supplementary data

Journal Articles

Dicer1 Phosphomimetic Promotes Tumor Progression and Dissemination

Neeraj K. Aryal, Vinod Pant, Amanda R. Wasylishen, Bobbie J. Rimel, Laura Baseler, Adel K. El-Naggar, David G. Mutch, Paul J. Goodfellow, Swathi Arur, Guillermina Lozano

Cancer Res (2019) 79 (10): 2662–2668.

https://doi.org/10.1158/0008-5472.CAN-18-2460

Published: 15 May 2019

View article titled, Dicer1 Phosphomimetic Promotes Tumor Progression and Dissemination

Includes: Supplementary data

Journal Articles

Abstract A19: Phosphorylation results in nuclear translocation of Dicer protein that increases metabolism, accelerates aging, and alters tumorigenesis

Neeraj K. Aryal, Swathi Arur, Guillermina Lozano

Cancer Res (2018) 78 (10_Supplement): A19.

https://doi.org/10.1158/1538-7445.MOUSEMODELS17-A19

Published: 14 May 2018

View article titled, Abstract A19: Phosphorylation results in nuclear translocation of Dicer protein that increases metabolism, accelerates aging, and alters tumorigenesis

Journal Articles

Abstract IA08: Somatic p53 mutations drive development of triple-negative breast cancer with evolutionarily distinct metastases

Yun Zhang, Shunbin Xiong, Guillermina Lozano

Cancer Res (2018) 78 (10_Supplement): IA08.

https://doi.org/10.1158/1538-7445.MOUSEMODELS17-IA08

Published: 14 May 2018

View article titled, Abstract IA08: Somatic p53 mutations drive development of triple-negative breast cancer with evolutionarily distinct metastases

Journal Articles

Abstract 3030: Mutant p53-driven metastasis explored utilizing a traceable, conditional osteosarcoma model

Rasoul Pourebrahimabadi, Yun Zhang, Mark J. McArthur, Guillermina Lozano

Cancer Res (2017) 77 (13_Supplement): 3030.

https://doi.org/10.1158/1538-7445.AM2017-3030

Published: 01 July 2017

View article titled, Abstract 3030: Mutant p53-driven metastasis explored utilizing a traceable, conditional osteosarcoma model

Journal Articles

Abstract SY04-01: The in vivo gain-of-function activities of mutant p53

Guillermina Lozano

Cancer Res (2016) 76 (14_Supplement): SY04-01.

https://doi.org/10.1158/1538-7445.AM2016-SY04-01

Published: 15 July 2016

View article titled, Abstract SY04-01: The in vivo gain-of-function activities of mutant p53

Journal Articles

Abstract B07: Gain of function activities of p53R245W in a conditional knock-in mouse model

Shunbin Xiong, Yun Zhang, Guillermina Lozano

Cancer Res (2016) 76 (7_Supplement): B07.

https://doi.org/10.1158/1538-7445.TUMMET15-B07

Published: 26 May 2016

View article titled, Abstract B07: Gain of function activities of p53R245W in a conditional knock-in mouse model

Journal Articles

Abstract IA-3: The regulation of p53 tumor suppressing activities

Guillermina Lozano

Cancer Res (2009) 69 (23_Supplement): IA-3.

https://doi.org/10.1158/0008-5472.FBCR09-IA-3

Published: 28 October 2014

View article titled, Abstract IA-3: The regulation of p53 tumor suppressing activities

Journal Articles

Abstract SY07-03: Gain-of-function activities of mutant p53

Guillermina Lozano

Cancer Res (2014) 74 (19_Supplement): SY07-03.

https://doi.org/10.1158/1538-7445.AM2014-SY07-03

Published: 01 October 2014

View article titled, Abstract SY07-03: Gain-of-function activities of mutant p53

Journal Articles

Abstract 3917: Understanding the mechanisms driving pancreatic neuroendocrine tumorigenesis

Amanda R. Wasylishen, Guillermina Lozano

Cancer Res (2014) 74 (19_Supplement): 3917.

https://doi.org/10.1158/1538-7445.AM2014-3917

Published: 01 October 2014

View article titled, Abstract 3917: Understanding the mechanisms driving pancreatic neuroendocrine tumorigenesis

Journal Articles

Abstract 1069: Mutant p53 disrupts the role of ShcA in balancing the Smad-dependent and -independent signaling activity of TGF-β

Shu Lin, Lan Yu, Junhua Yang, Zhao Liu, Bijal Karia, Alexander J. R. Bishop, James Jackson, Guillermina Lozano, John A. Copland, Xiaoxin Mu, Beicheng Sun, Lu-Zhe Sun

Cancer Res (2012) 72 (8_Supplement): 1069.

https://doi.org/10.1158/1538-7445.AM2012-1069

Published: 15 April 2012

View article titled, Abstract 1069: Mutant p53 disrupts the role of ShcA in balancing the Smad-dependent and -independent signaling activity of TGF-β

NARROW

Abstract A064: Identifying cooperating genetic events contributing to disease progression in mutant p53-driven breast cancer

Unique Transcriptional Profiles Underlie Osteosarcomagenesis Driven by Different p53 Mutants

Abstract A042: Differences in gain-of-function and inhibitory effects amongst p53 mutants in vivo

p53 Activation Paradoxically Causes Liver Cancer

Abstract 829: p53 dimers elicit tumor suppressive activities through an altered metabolic program

Differential Gain-of-Function Activity of Three p53 Hotspot Mutants In Vivo

Alterations of the Mdm2 C-Terminus Differentially Impact Its Function In Vivo

Abstract P3-05-01: Role of TRIM24 in metaplastic breast cancer and nomination of potential therapeutic targets

Abstract 2417: Mutant p53 and oncogenic KRAS converge on CREB1 to drive pancreatic cancer metastasis

The Common Germline TP53-R337H Mutation Is Hypomorphic and Confers Incomplete Penetrance and Late Tumor Onset in a Mouse Model

Dicer1 Phosphomimetic Promotes Tumor Progression and Dissemination

Abstract A19: Phosphorylation results in nuclear translocation of Dicer protein that increases metabolism, accelerates aging, and alters tumorigenesis

Abstract IA08: Somatic p53 mutations drive development of triple-negative breast cancer with evolutionarily distinct metastases

Abstract 3030: Mutant p53-driven metastasis explored utilizing a traceable, conditional osteosarcoma model

Abstract SY04-01: The in vivo gain-of-function activities of mutant p53

Abstract B07: Gain of function activities of p53R245W in a conditional knock-in mouse model

Abstract IA-3: The regulation of p53 tumor suppressing activities

Abstract SY07-03: Gain-of-function activities of mutant p53

Abstract 3917: Understanding the mechanisms driving pancreatic neuroendocrine tumorigenesis

Abstract 1069: Mutant p53 disrupts the role of ShcA in balancing the Smad-dependent and -independent signaling activity of TGF-β

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