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Journal Articles

HSP90 Mediates IFNγ-Induced Adaptive Resistance to Anti-PD-1 Immunotherapy

Ke Liu, Jun Huang, Jiao Liu, Changfeng Li, Guido Kroemer, Daolin Tang, Rui Kang

Cancer Res (2022) 82 (10): 2003–2018.

DOI: https://doi.org/10.1158/0008-5472.CAN-21-3917

Published: 16 May 2022

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Includes: Supplementary data

Journal Articles

Immune Checkpoint Blockade, Immunogenic Chemotherapy or IFN-α Blockade Boost the Local and Abscopal Effects of Oncolytic Virotherapy

Laetitia Fend, Takahiro Yamazaki, Christelle Remy, Catherine Fahrner, Murielle Gantzer, Virginie Nourtier, Xavier Préville, Eric Quéméneur, Oliver Kepp, Julien Adam, Aurélien Marabelle, Jonathan M. Pitt, Guido Kroemer, Laurence Zitvogel

Cancer Res (2017) 77 (15): 4146–4157.

DOI: https://doi.org/10.1158/0008-5472.CAN-16-2165

Published: 01 August 2017

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Includes: Supplementary data

Journal Articles

Abstract 5128: Induction of immunogenic cell death and tumor regression in murine animal models by a novel cytolytic compound, LTX-401

Cancer Res (2017) 77 (13_Supplement): 5128.

DOI: https://doi.org/10.1158/1538-7445.AM2017-5128

Published: 01 July 2017

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Journal Articles

Abstract CT108: A phase I dose escalation study of intra-tumoral LTX-315 as monotherapy or in combination with either ipilimumab or pembrolizumab in patients with transdermally accessible tumors (NCT01986426)

Jean-Francois Baurain, Ahmad Awada, Paal F. Brunsvig, Rebecca Kristeleit, Delphine Loirat, Dag Eirik Jøssang, Laurence Zitvogel, Guido Kroemer, Aurilièn Marabelle, Øystein Rekdal, Baldur Sveinbjørnsson, Hedda Wold, Berit Nicolaisen, Andrew Saunders, James Spicer

Cancer Res (2017) 77 (13_Supplement): CT108.

DOI: https://doi.org/10.1158/1538-7445.AM2017-CT108

Published: 01 July 2017

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Journal Articles

Abstract 4309: Mode of action of LTX315-induced cell death

HENG ZHOU, Allan Sauvat, Sylvère Durand, Sabrina Forveille, Takahiro Yamazaki, Sylvie Souquere, Valentina Sica, Øystein Rekdal, Oliver Kepp, Guido Kroemer

Cancer Res (2017) 77 (13_Supplement): 4309.

DOI: https://doi.org/10.1158/1538-7445.AM2017-4309

Published: 01 July 2017

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Journal Articles

Abstract 4563: Local and abscopal effects in oncolytic virotherapy are boosted by immune checkpoint blockade, immunogenic chemotherapy, or IFNAR blockade

Laetitia Fend, Takahiro Yamazaki, Xavier Préville, Eric Quéméneur, Oliver Kepp, Julien Adam, Aurélien Marabelle, Jonathan Pitt, Guido Kroemer, Laurence Zitvogel

Cancer Res (2017) 77 (13_Supplement): 4563.

DOI: https://doi.org/10.1158/1538-7445.AM2017-4563

Published: 01 July 2017

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Journal Articles

Fine-Tuning Cancer Immunotherapy: Optimizing the Gut Microbiome

Jonathan M. Pitt, Marie Vétizou, Nadine Waldschmitt, Guido Kroemer, Mathias Chamaillard, Ivo Gomperts Boneca, Laurence Zitvogel

Cancer Res (2016) 76 (16): 4602–4607.

DOI: https://doi.org/10.1158/0008-5472.CAN-16-0448

Published: 14 August 2016

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Journal Articles

Abstract 2326: LTX-315, an oncolytic peptide, increases anticancer immunity mediated by CTLA4 blockade in an interleukin-2 receptor beta-chain-dependent manner

Takahiro Yamazaki, Marie Vetizou, Camila Flores, Aurelien Marabelle, Baldur Sveinbjørnsson, Øystein Rekdal, Guido Kroemer, Laurence Zitvogel

Cancer Res (2016) 76 (14_Supplement): 2326.

DOI: https://doi.org/10.1158/1538-7445.AM2016-2326

Published: 15 July 2016

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Journal Articles

Impact of Pattern Recognition Receptors on the Prognosis of Breast Cancer Patients Undergoing Adjuvant Chemotherapy

Erika Vacchelli, David P. Enot, Federico Pietrocola, Laurence Zitvogel, Guido Kroemer

Cancer Res (2016) 76 (11): 3122–3126.

DOI: https://doi.org/10.1158/0008-5472.CAN-16-0294

Published: 31 May 2016

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Journal Articles

Calreticulin Expression in Human Non–Small Cell Lung Cancers Correlates with Increased Accumulation of Antitumor Immune Cells and Favorable Prognosis

Jitka Fucikova, Etienne Becht, Kristina Iribarren, Jeremy Goc, Romain Remark, Diane Damotte, Marco Alifano, Priyanka Devi, Jerome Biton, Claire Germain, Audrey Lupo, Wolf Herve Fridman, Marie-Caroline Dieu-Nosjean, Guido Kroemer, Catherine Sautès-Fridman, Isabelle Cremer

Cancer Res (2016) 76 (7): 1746–1756.

DOI: https://doi.org/10.1158/0008-5472.CAN-15-1142

Published: 31 March 2016

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Journal Articles

STAT3 Inhibition Enhances the Therapeutic Efficacy of Immunogenic Chemotherapy by Stimulating Type 1 Interferon Production by Cancer Cells

Heng Yang, Takahiro Yamazaki, Federico Pietrocola, Heng Zhou, Laurence Zitvogel, Yuting Ma, Guido Kroemer

Cancer Res (2015) 75 (18): 3812–3822.

DOI: https://doi.org/10.1158/0008-5472.CAN-15-1122

Published: 14 September 2015

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Includes: Supplementary data

Journal Articles

Abstract 4691: Overactivation of poly (ADP-ribose) polymerase (PARP) in localised non-small cell lung cancer (NSCLC) predicts dismal prognosis

Judith Michels, Aïcha Goubar, Julien Adam, Lorenzo Galluzzi, Ken André Olaussen, Angélique Robin, Philippe Girard, Isabelle Kremer, Maria Castedo, Jean-Charles Soria, Guido Kroemer

Cancer Res (2014) 74 (19_Supplement): 4691.

DOI: https://doi.org/10.1158/1538-7445.AM2014-4691

Published: 01 October 2014

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Journal Articles

CCL2/CCR2-Dependent Recruitment of Functional Antigen-Presenting Cells into Tumors upon Chemotherapy

Yuting Ma, Stephen R. Mattarollo, Sandy Adjemian, Heng Yang, Laetitia Aymeric, Dalil Hannani, João Paulo Portela Catani, Helene Duret, Michele W.L. Teng, Oliver Kepp, Yidan Wang, Antonella Sistigu, Joachim L. Schultze, Gautier Stoll, Lorenzo Galluzzi, Laurence Zitvogel, Mark J. Smyth, Guido Kroemer

Cancer Res (2014) 74 (2): 436–445.

DOI: https://doi.org/10.1158/0008-5472.CAN-13-1265

Published: 16 January 2014

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Includes: Supplementary data

Journal Articles

Immune Infiltrates Are Prognostic Factors in Localized Gastrointestinal Stromal Tumors

Cancer Res (2013) 73 (12): 3499–3510.

DOI: https://doi.org/10.1158/0008-5472.CAN-13-0371

Published: 13 June 2013

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Includes: Supplementary data

Journal Articles

Abstract 706: Novel MPS1 inhibitors with potential anticancer activity.

Antje Wengner, Mohamed Jemaà, Lorenzo Galluzzi, Oliver Kepp, Michael Brands, Marcus Koppitz, Volker Schulze, Gerhard Siemeister, Dominik Mumberg, Karl Ziegelbauer, Maria Castedo, Ilio Vitale, Guido Kroemer

Cancer Res (2013) 73 (8_Supplement): 706.

DOI: https://doi.org/10.1158/1538-7445.AM2013-706

Published: 15 April 2013

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Journal Articles

Abstract SY28-03: Targeting tetraploidy for cancer therapy by pharmacological and immunological strategies.

Guido Kroemer, Laura Senovilla, Laurence Zitvogel, Maria Castedo

Cancer Res (2013) 73 (8_Supplement): SY28-03.

DOI: https://doi.org/10.1158/1538-7445.AM2013-SY28-03

Published: 15 April 2013

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Journal Articles

Cisplatin Resistance Associated with PARP Hyperactivation

Cancer Res (2013) 73 (7): 2271–2280.

DOI: https://doi.org/10.1158/0008-5472.CAN-12-3000

Published: 02 April 2013

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Includes: Supplementary data

Journal Articles

Expression of P2X7 Receptor Increases In Vivo Tumor Growth

Elena Adinolfi, Lizzia Raffaghello, Anna Lisa Giuliani, Luigi Cavazzini, Marina Capece, Paola Chiozzi, Giovanna Bianchi, Guido Kroemer, Vito Pistoia, Francesco Di Virgilio

Cancer Res (2012) 72 (12): 2957–2969.

DOI: https://doi.org/10.1158/0008-5472.CAN-11-1947

Published: 14 June 2012

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Includes: Supplementary data

Journal Articles

Cancer-Induced Immunosuppression: IL-18–Elicited Immunoablative NK Cells

Cancer Res (2012) 72 (11): 2757–2767.

DOI: https://doi.org/10.1158/0008-5472.CAN-11-3379

Published: 31 May 2012

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Includes: Supplementary data

Journal Articles

Abstract 3115: PARP overactivation predicts the susceptibility of human cancer cells to apoptosis induction by PARP inhibitors

Judith Michels, Ilio Vitale, Lorenzo Galluzzi, Oliver Kepp, Laura Senovilla, Ken André Olaussen, Jean-Charles Soria, Maria Castedo, Guido Kroemer

Cancer Res (2012) 72 (8_Supplement): 3115.

DOI: https://doi.org/10.1158/1538-7445.AM2012-3115

Published: 15 April 2012

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NARROW

HSP90 Mediates IFNγ-Induced Adaptive Resistance to Anti-PD-1 Immunotherapy

Immune Checkpoint Blockade, Immunogenic Chemotherapy or IFN-α Blockade Boost the Local and Abscopal Effects of Oncolytic Virotherapy

Abstract 5128: Induction of immunogenic cell death and tumor regression in murine animal models by a novel cytolytic compound, LTX-401

Abstract CT108: A phase I dose escalation study of intra-tumoral LTX-315 as monotherapy or in combination with either ipilimumab or pembrolizumab in patients with transdermally accessible tumors (NCT01986426)

Abstract 4309: Mode of action of LTX315-induced cell death

Abstract 4563: Local and abscopal effects in oncolytic virotherapy are boosted by immune checkpoint blockade, immunogenic chemotherapy, or IFNAR blockade

Fine-Tuning Cancer Immunotherapy: Optimizing the Gut Microbiome

Abstract 2326: LTX-315, an oncolytic peptide, increases anticancer immunity mediated by CTLA4 blockade in an interleukin-2 receptor beta-chain-dependent manner

Impact of Pattern Recognition Receptors on the Prognosis of Breast Cancer Patients Undergoing Adjuvant Chemotherapy

Calreticulin Expression in Human Non–Small Cell Lung Cancers Correlates with Increased Accumulation of Antitumor Immune Cells and Favorable Prognosis

STAT3 Inhibition Enhances the Therapeutic Efficacy of Immunogenic Chemotherapy by Stimulating Type 1 Interferon Production by Cancer Cells

Abstract 4691: Overactivation of poly (ADP-ribose) polymerase (PARP) in localised non-small cell lung cancer (NSCLC) predicts dismal prognosis

CCL2/CCR2-Dependent Recruitment of Functional Antigen-Presenting Cells into Tumors upon Chemotherapy

Immune Infiltrates Are Prognostic Factors in Localized Gastrointestinal Stromal Tumors

Abstract 706: Novel MPS1 inhibitors with potential anticancer activity.

Abstract SY28-03: Targeting tetraploidy for cancer therapy by pharmacological and immunological strategies.

Cisplatin Resistance Associated with PARP Hyperactivation

Expression of P2X7 Receptor Increases In Vivo Tumor Growth

Cancer-Induced Immunosuppression: IL-18–Elicited Immunoablative NK Cells

Abstract 3115: PARP overactivation predicts the susceptibility of human cancer cells to apoptosis induction by PARP inhibitors

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