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Journal Articles

Abstract 3229: IACS-16559, a CBP/P300 bromodomain inhibitor for the treatment of specific AML subsets

Ciro Zanca, Michael Soth, Guang Gao, Jason Gay, Ningping Feng, Christopher Bristow, Kang Le, Quanyun Xu, Phuong Nguyen, Yongying Jiang, Teresa Perry, Faika Mseeh, Paul Leonard, Jason Cross, Virginia Giuliani, Joe Marszalek, Philip Jones, Tim Heffernan
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3229.
https://doi.org/10.1158/1538-7445.AM2024-3229
Published: 22 March 2024
View article titled, Abstract 3229: IACS-16559, a CBP/P300 bromodomain inhibitor for the treatment of specific AML subsets
Journal Articles

Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib

Yuting Sun, Brooke A. Meyers, Barbara Czako, Paul Leonard, Faika Mseeh, Angela L. Harris, Qi Wu, Sarah Johnson, Connor A. Parker, Jason B. Cross, Maria Emilia Di Francesco, Benjamin J. Bivona, Christopher A. Bristow, Jason P. Burke, Caroline C. Carrillo, Christopher L. Carroll, Qing Chang, Ningping Feng, Guang Gao, Sonal Gera, Virginia Giuliani, Justin K. Huang, Yongying Jiang, Zhijun Kang, Jeffrey J. Kovacs, Chiu-Yi Liu, Anastasia M. Lopez, Xiaoyan Ma, Pijus K. Mandal, Timothy McAfoos, Meredith A. Miller, Robert A. Mullinax, Michael Peoples, Vandhana Ramamoorthy, Sahil Seth, Nakia D. Spencer, Erika Suzuki, Christopher C. Williams, Simon S. Yu, Andy M. Zuniga, Giulio F. Draetta, Joseph R. Marszalek, Timothy P. Heffernan, Nancy E. Kohl, Philip Jones
Journal: Cancer Research
Series: Author Choice
Cancer Res (2020) 80 (21): 4840–4853.
https://doi.org/10.1158/0008-5472.CAN-20-1634
Published: 03 November 2020
View article titled, Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib
Open the PDF for Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib in another window
Includes: Supplementary data
Journal Articles

Abstract 277: Inhibition of protein arginine methylation alters RNA metabolism and DNA damage response providing a new therapeutic strategy in pancreatic ductal adenocarcinoma

Virginia Giuliani, Alessandro Carugo, Meredith Miller, Lionel Sanz, Chiu-Yi Liu, Christopher A Bristow, Erika Suzuki, Caleb A Class, Stella R. Hartono, Guang Gao, Ningping Feng, Jason P Gay, Bhavatarini Vangamudi, Joseph R Marszalek, Jeffrey Kovacs, Maria Emilia Di Francesco, Frederic Chedin, Philip Jones, Giulio Draetta, Timothy Heffernan
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 277.
https://doi.org/10.1158/1538-7445.AM2019-277
Published: 01 July 2019
View article titled, Abstract 277: Inhibition of protein arginine methylation alters RNA metabolism and DNA damage response providing a new therapeutic strategy in pancreatic ductal adenocarcinoma
Journal Articles

Abstract 3016: Identification of protein arginine methyltransferase 1 as novel epigenetic vulnerability in KRAS/p53 mutant PDAC primary patient models

Virginia Giuliani, Bhavatarini Vangamudi, Erika Suzuki, Meredith Miller, Chiu-Yi Liu, Alessandro Carugo, Christopher Bristow, Guang Gao, Jing Han, Yuting Sun, Ningping Feng, Edward Chang, Joseph Marszalek, Jeffrey Kovacs, Maria Emilia Di Francesco, Carlo Toniatti, Timothy Heffernan, Philip Jones, Giulio Draetta
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3016.
https://doi.org/10.1158/1538-7445.AM2017-3016
Published: 01 July 2017
View article titled, Abstract 3016: Identification of protein arginine methyltransferase 1 as novel epigenetic vulnerability in KRAS/p53 mutant PDAC primary patient models
Journal Articles

Gain of Glucose-Independent Growth upon Metastasis of Breast Cancer Cells to the Brain

Jinyu Chen, Ho-Jeong Lee, Xuefeng Wu, Lei Huo, Sun-Jin Kim, Lei Xu, Yan Wang, Junqing He, Lakshmi R. Bollu, Guang Gao, Fei Su, James Briggs, Xiaojing Liu, Tamar Melman, John M. Asara, Isaiah J. Fidler, Lewis C. Cantley, Jason W. Locasale, Zhang Weihua
Journal: Cancer Research
Cancer Res (2015) 75 (3): 554–565.
https://doi.org/10.1158/0008-5472.CAN-14-2268
Published: 01 February 2015
View article titled, Gain of Glucose-Independent Growth upon Metastasis of Breast Cancer Cells to the Brain
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Includes: Supplementary data
Journal Articles

Intracellular ATP Levels Are a Pivotal Determinant of Chemoresistance in Colon Cancer Cells

Yunfei Zhou, Federico Tozzi, Jinyu Chen, Fan Fan, Ling Xia, Jinrong Wang, Guang Gao, Aijun Zhang, Xuefeng Xia, Heather Brasher, William Widger, Lee M. Ellis, Zhang Weihua
Journal: Cancer Research
Cancer Res (2012) 72 (1): 304–314.
https://doi.org/10.1158/0008-5472.CAN-11-1674
Published: 02 January 2012
View article titled, Intracellular ATP Levels Are a Pivotal Determinant of Chemoresistance in Colon Cancer Cells
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Includes: Supplementary data
Journal Articles

Antigen-specific CD4+ T-Cell Help Is Required to Activate a Memory CD8+ T Cell to a Fully Functional Tumor Killer Cell

Feng Guang Gao, Vithagna Khammanivong, Wen Jun Liu, Graham R. Leggatt, Ian H. Frazer, Germain J. P. Fernando
Journal: Cancer Research
Cancer Res (2002) 62 (22): 6438–6441.
Published: 15 November 2002
View article titled, Antigen-specific CD4<sup>+</sup> T-Cell Help Is Required to Activate a Memory CD8<sup>+</sup> T Cell to a Fully Functional Tumor Killer Cell
Open the PDF for Antigen-specific CD4<sup>+</sup> T-Cell Help Is Required to Activate a Memory CD8<sup>+</sup> T Cell to a Fully Functional Tumor Killer Cell in another window