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Gregory Stephanopoulos
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Journal Articles

Abstract 1123: Glutaminase inhibitors suppress pyrimidine synthesis and promote DNA replication stress in VHL-deficient human renal cancer cells

Arimichi Okazaki, Paulo Gameiro, Gregory Stephanopoulos, Othon Iliopoulos
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1123.
https://doi.org/10.1158/1538-7445.AM2015-1123
Published: 01 August 2015
View article titled, Abstract 1123: Glutaminase inhibitors suppress pyrimidine synthesis and promote DNA replication stress in <em>VHL</em>-deficient human renal cancer cells
Journal Articles

Abstract NG08: Transcriptional mechanisms for autophagy regulation and metabolic reprogramming in pancreatic cancer

Rushika M. Perera, Svetlana Stoykova, Brandon N. Nicolay, Kenneth N. Ross, Julien Fitamant, Myriam Boukhali, Vikram Deshpande, Martin K. Selig, Cristina R. Ferrone, Jeff Settleman, Gregory Stephanopoulos, Nicholas J. Dyson, Roberto Zoncu, Sridhar Ramaswamy, Wilhelm Haas, Nabeel M. Bardeesy
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): NG08.
https://doi.org/10.1158/1538-7445.AM2015-NG08
Published: 01 August 2015
View article titled, Abstract NG08: Transcriptional mechanisms for autophagy regulation and metabolic reprogramming in pancreatic cancer
Journal Articles

Abstract B1: Hypoxia inducible factor (HIF) promotes reductive carboxylation by regulating citrate levels and renders VHL-deficient and hypoxic cells sensitive to glutamine deprivation

Paulo Gameiro, Ana Metelo, Rojo Pérez-Carro, Arreola Alexandra, Zongwei Wang, Kimryn W. Rathmell, Aria Olumi, Pilar López-Larrubia, Gregory Stephanopoulos, Othon Iliopoulos
Journal: Cancer Research
Cancer Res (2013) 73 (3_Supplement): B1.
https://doi.org/10.1158/1538-7445.TIM2013-B1
Published: 01 May 2014
View article titled, Abstract B1: Hypoxia inducible factor (HIF) promotes reductive carboxylation by regulating citrate levels and renders VHL-deficient and hypoxic cells sensitive to glutamine deprivation
Journal Articles

Metformin Decreases Glucose Oxidation and Increases the Dependency of Prostate Cancer Cells on Reductive Glutamine Metabolism

Sarah-Maria Fendt, Eric L. Bell, Mark A. Keibler, Shawn M. Davidson, Gregory J. Wirth, Brian Fiske, Jared R. Mayers, Matthias Schwab, Gary Bellinger, Alfredo Csibi, Akash Patnaik, Marie Jose Blouin, Lewis C. Cantley, Leonard Guarente, John Blenis, Michael N. Pollak, Aria F. Olumi, Matthew G. Vander Heiden, Gregory Stephanopoulos
Journal: Cancer Research
Cancer Res (2013) 73 (14): 4429–4438.
https://doi.org/10.1158/0008-5472.CAN-13-0080
Published: 15 July 2013
View article titled, Metformin Decreases Glucose Oxidation and Increases the Dependency of Prostate Cancer Cells on Reductive Glutamine Metabolism
Open the PDF for Metformin Decreases Glucose Oxidation and Increases the Dependency of Prostate Cancer Cells on Reductive Glutamine Metabolism in another window
Includes: Supplementary data
Journal Articles

Abstract 1881: Hypoxia Inducible Factor (HIF) promotes reductive carboxylation by regulating citrate levels and renders VHL-deficient and hypoxic cells sensitive to glutamine deprivation.

Paulo Gameiro, Ana Metelo, Rocio Pérez-Carro, Alexandra Arreolla, Rania Baker, Zongwei Wang, Aria Olumi, Kimryn Rathmell, Pilar López-Larrubia, Gregory Stephanopoulos, Othon Iliopoulos
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1881.
https://doi.org/10.1158/1538-7445.AM2013-1881
Published: 15 April 2013
View article titled, Abstract 1881: Hypoxia Inducible Factor (HIF) promotes reductive carboxylation by regulating citrate levels and renders VHL-deficient and hypoxic cells sensitive to glutamine deprivation.
Journal Articles

Abstract 3234: Metformin shifts prostate cancer metabolism towards a less malignant phenotype

Gregory J. Wirth*, Sarah-Maria Fendt*, Eric L. Bell, Mark A. Keibler, Gregory Stephanopoulos, Aria F. Olumi
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3234.
https://doi.org/10.1158/1538-7445.AM2012-3234
Published: 15 April 2012
View article titled, Abstract 3234: Metformin shifts prostate cancer metabolism towards a less malignant phenotype
Journal Articles

Abstract 1132: Regulation of the glutamine-to-lipid pathway by HIF: Reductive TCA cycle is a metabolic signature of VHL deficiency

Juanjuan Yang, Paulo A. Gameiro, Gregory Stephanopoulos, Othon Iliopoulos
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1132.
https://doi.org/10.1158/1538-7445.AM2012-1132
Published: 15 April 2012
View article titled, Abstract 1132: Regulation of the glutamine-to-lipid pathway by HIF: Reductive TCA cycle is a metabolic signature of VHL deficiency
Journal Articles

Abstract 2802: Evaluation of metabolic changes induced by loss of extracellular matrix attachment using 13C Flux analysis

Alexandra R. Grassian, Christian M. Metallo, Gregory Stephanopoulos, Joan S. Brugge
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2802.
https://doi.org/10.1158/1538-7445.AM2011-2802
Published: 15 April 2011
View article titled, Abstract 2802: Evaluation of metabolic changes induced by loss of extracellular matrix attachment using 13C Flux analysis
Journal Articles

The Phosphoinositide 3-Kinase Regulatory Subunit p85α Can Exert Tumor Suppressor Properties through Negative Regulation of Growth Factor Signaling

Cullen M. Taniguchi, Jonathon Winnay, Tatsuya Kondo, Roderick T. Bronson, Alexander R. Guimaraes, José O. Alemán, Ji Luo, Gregory Stephanopoulos, Ralph Weissleder, Lewis C. Cantley, C. Ronald Kahn
Journal: Cancer Research
Cancer Res (2010) 70 (13): 5305–5315.
https://doi.org/10.1158/0008-5472.CAN-09-3399
Published: 30 June 2010
View article titled, The Phosphoinositide 3-Kinase Regulatory Subunit p85α Can Exert Tumor Suppressor Properties through Negative Regulation of Growth Factor Signaling
Open the PDF for The Phosphoinositide 3-Kinase Regulatory Subunit p85α Can Exert Tumor Suppressor Properties through Negative Regulation of Growth Factor Signaling in another window
Includes: Supplementary data