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Gregory P. Adams
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Journal Articles

Abstract CT255: ELU-FRα-1: a study to evaluate ELU001 in patients with solid tumors that overexpress folate receptor alpha (FRα)

Free
Wen Wee Ma, Anthony Tolcher, Cesar A. Perez, Douglass Orr, Erika Hamilton, Yujie Zhao, Yonina Murciano-Goroff, Carey Anders, Gregory P. Adams, Catherine W. Reddick, Eliel Bayever
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT255.
https://doi.org/10.1158/1538-7445.AM2023-CT255
Published: 14 April 2023
View articletitled, Abstract CT255: ELU-FRα-1: a study to evaluate ELU001 in patients with solid tumors that overexpress folate receptor alpha (FRα)
Journal Articles

Abstract 837: Preclinical development of ELU001: A folate receptor alpha (FRα)-targeted C’Dot drug conjugate (CDC) for the treatment of brain metastases

Free
Gregory P. Adams, Tin Khor, Feng Chen, Kai Ma, Marion Scocca, Aranapakam Venkatesan, Cathy Reddick, Mary Hilgart, Thomas Gardinier, Fei Wu, Melik Turker, Peiming Chen, Vaibhav Patel, Eliel Bayever
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 837.
https://doi.org/10.1158/1538-7445.AM2023-837
Published: 04 April 2023
View articletitled, Abstract 837: Preclinical development of ELU001: A folate receptor alpha (FRα)-targeted C’Dot drug conjugate (CDC) for the treatment of brain metastases
Journal Articles

Abstract 1077: Stability and safety evaluation of ELU001, a targeted C’Dot drug conjugate for the potential treatment of folate receptor alpha-overexpressing cancers

Free
Gregory P. Adams, Kai Ma, Feng Chen, Marion Scocca, Aranapakam Venkatesan, Cathy Reddick, Mary Hilgart, Thomas Gardinier, Fei Wu, Melik Turker, Peiming Chen, Tin Khor, Vaibhav Patel, Eliel Bayever
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1077.
https://doi.org/10.1158/1538-7445.AM2022-1077
Published: 15 June 2022
View articletitled, Abstract 1077: Stability and safety evaluation of ELU001, a targeted C’Dot drug conjugate for the potential treatment of folate receptor alpha-overexpressing cancers
Journal Articles

Abstract 1075: Therapeutic targeting of CBFA2T3-GLIS2 infant AML with ELU001 - folate receptor alpha-directed C’Dot-drug-conjugate

Free
Quy Le, Feng Chen, Thao Tang, Cynthia Nourigat McKay, Fei Wu, Melik Turker, Thomas Gardinier, Vaibhav Patel, Aranapakam Venkatesan, Tin Khor, Kai Ma, Gregory P. Adams, Soheil Meshinchi
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1075.
https://doi.org/10.1158/1538-7445.AM2022-1075
Published: 15 June 2022
View articletitled, Abstract 1075: Therapeutic targeting of CBFA2T3-GLIS2 infant AML with ELU001 - folate receptor alpha-directed C’Dot-drug-conjugate
Journal Articles

Abstract 2388: In vitro assessment of tumor associated I.O. markers in cancer cell lines following Vicinium treatment

Free
Shilpa Chooniedass, Rachelle L. Dillon, Arjune Premsukh, Glen C. MacDonald, Jeannick Cizeau, Gregory P. Adams
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2388.
https://doi.org/10.1158/1538-7445.AM2019-2388
Published: 01 July 2019
View articletitled, Abstract 2388: In vitro assessment of tumor associated I.O. markers in cancer cell lines following Vicinium treatment
Journal Articles

Abstract 5770: Engineering and characterization of anti-PSMA humabody-deBouganin fusion proteins

Free
Jeannick Cizeau, Shilpa Chooniedass, Rachelle L. Dillon, Arjune Premsukh, Gregory P. Adams, Glen C. MacDonald, Normann Goodwin, Lorraine Thompson, Bethan Archer
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5770.
https://doi.org/10.1158/1538-7445.AM2018-5770
Published: 01 July 2018
View articletitled, Abstract 5770: Engineering and characterization of anti-PSMA humabody-deBouganin fusion proteins
Journal Articles

Abstract 2788: VB6-845d tumor cell killing elicits biologic features of immunogenic cell death

Free
Rachelle L. Dillon, Shilpa Chooniedass, Arjune Premsukh, Glen C. MacDonald, Jeannick Cizeau, Gregory P. Adams
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2788.
https://doi.org/10.1158/1538-7445.AM2018-2788
Published: 01 July 2018
View articletitled, Abstract 2788: VB6-845d tumor cell killing elicits biologic features of immunogenic cell death
Journal Articles

Abstract 79: Trastuzumab and C6.5 diabody armed with deBouganin overcome drug resistance to ADCs comprised of anti-microtubule agents

Free
Shilpa Chooniedass, Rachelle L. Dillon, Arjune Premsukh, Gregory P. Adams, Glen C. MacDonald, Jeannick Cizeau
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 79.
https://doi.org/10.1158/1538-7445.AM2017-79
Published: 01 July 2017
View articletitled, Abstract 79: Trastuzumab and C6.5 diabody armed with deBouganin overcome drug resistance to ADCs comprised of anti-microtubule agents
Journal Articles

Abstract 2963: VB7-756: a Her2-specific diabody armed with deBouganin, a plant toxin with a distinct MOA

Free
Shilpa Chooniedass, Rachelle L. Dillon, Arjune Premsukh, Joycelyn Entwistle, Gregory P. Adams, Peter J. Hudson, Glen C. MacDonald, Jeannick Cizeau
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2963.
https://doi.org/10.1158/1538-7445.AM2016-2963
Published: 15 July 2016
View articletitled, Abstract 2963: VB7-756: a Her2-specific diabody armed with deBouganin, a plant toxin with a distinct MOA
Journal Articles

Abstract 2961: deBouganin conjugated to trastuzumab overcomes multiple mechanisms of T-DM1 drug resistance

Free
Rachelle L. Dillon, Shilpa Chooniedass, Arjune Premsukh, Gregory P. Adams, Joycelyn Entwistle, Glen C. MacDonald, Jeannick Cizeau
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2961.
https://doi.org/10.1158/1538-7445.AM2016-2961
Published: 15 July 2016
View articletitled, Abstract 2961: deBouganin conjugated to trastuzumab overcomes multiple mechanisms of T-DM1 drug resistance
Journal Articles

Abstract 4300: Receptor occupancy and tumor penetration by antibodies, peptides, and antibody fragments: Molecular simulation of imaging assessment

Free
Kelly D. Orcutt, Gregory P. Adams, Anna M. Wu, Matthew Silva, Jack Hoppin, Catey Harwell, Manabu Matsumura, Masakatsu Kotsuma, Daniel Freeman, Archie Tse, Jonathan Greenberg, Andrew Scott, Robert A. Beckman
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4300.
https://doi.org/10.1158/1538-7445.AM2014-4300
Published: 01 October 2014
View articletitled, Abstract 4300: Receptor occupancy and tumor penetration by antibodies, peptides, and antibody fragments: Molecular simulation of imaging assessment
Journal Articles

Influence of Affinity and Antigen Internalization on the Uptake and Penetration of Anti-HER2 Antibodies in Solid Tumors

Free
Stephen I. Rudnick, Jianlong Lou, Calvin C. Shaller, Yong Tang, Andres J.P. Klein-Szanto, Louis M. Weiner, James D. Marks, Gregory P. Adams
Journal: Cancer Research
Cancer Res (2011) 71 (6): 2250–2259.
https://doi.org/10.1158/0008-5472.CAN-10-2277
Published: 14 March 2011
View articletitled, Influence of Affinity and Antigen Internalization on the Uptake and Penetration of Anti-HER2 Antibodies in Solid Tumors
Open the PDF for Influence of Affinity and Antigen Internalization on the Uptake and Penetration of Anti-HER2 Antibodies in Solid Tumors in another window
Includes: Supplementary data
Journal Articles

Abstract 2437: Engineered human monoclonal antibodies targeting the Müllerian inhibiting substance type II receptor for ovarian cancer therapy

Free
Tatiana A. Karakasheva, Heidi H. Simmons, Stephen I. Rudnick, Matthew K. Robinson, Gregory P. Adams
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2437.
https://doi.org/10.1158/1538-7445.AM10-2437
Published: 15 April 2010
View articletitled, Abstract 2437: Engineered human monoclonal antibodies targeting the Müllerian inhibiting substance type II receptor for ovarian cancer therapy
Journal Articles

Abstract 2580: Single-chain antibody based immunotoxins targeting Her2/neu: design optimization and impact of affinity on antitumor effects

Free
Yu Cao, James D. Marks, Walter N. Hittelman, Gregory P. Adams, Heidi H. Simmons, Lawrence H. Cheung, Michael G. Rosenblum
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2580.
https://doi.org/10.1158/1538-7445.AM10-2580
Published: 15 April 2010
View articletitled, Abstract 2580: Single-chain antibody based immunotoxins targeting Her2/neu: design optimization and impact of affinity on antitumor effects
Journal Articles

Higher affinity antibodies elicit more potent ADCC

Free
Yong Tang, Katherine Alpaugh, Jianlong Lou, Calvin Shaller, Gregory P. Adams, James D. Marks, Louis M. Weiner
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 277.
Published: 15 April 2006
View articletitled, Higher affinity antibodies elicit more potent ADCC
Journal Articles

Identification and in vitro evaluation of Müllerian inhibiting substance type II receptor (MISIIR) specific antibodies from a naïve human scFv phage library

Free
Qingan Yuan, Heidi H. Simmons, Maria Russeva, Matthew K. Robinson, Gregory P. Adams, Wayne A. Marasco
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 162.
Published: 15 April 2006
View articletitled, Identification and in vitro evaluation of Müllerian inhibiting substance type II receptor (MISIIR) specific antibodies from a naïve human scFv phage library
Journal Articles

Quantitative Immuno-Positron Emission Tomography Imaging of HER2-Positive Tumor Xenografts with an Iodine-124 Labeled Anti-HER2 Diabody

Free
Matthew K. Robinson, Mohan Doss, Calvin Shaller, Deepa Narayanan, James D. Marks, Lee P. Adler, Dinko E. González Trotter, Gregory P. Adams
Journal: Cancer Research
Cancer Res (2005) 65 (4): 1471–1478.
https://doi.org/10.1158/0008-5472.CAN-04-2008
Published: 25 February 2005
View articletitled, Quantitative Immuno-Positron Emission Tomography Imaging of HER2-Positive Tumor Xenografts with an Iodine-124 Labeled Anti-HER2 Diabody
Open the PDF for Quantitative Immuno-Positron Emission Tomography Imaging of HER2-Positive Tumor Xenografts with an Iodine-124 Labeled Anti-HER2 Diabody in another window
Journal Articles

A Single Treatment of Yttrium-90-labeled CHX-A″–C6.5 Diabody Inhibits the Growth of Established Human Tumor Xenografts in Immunodeficient Mice

Free
Gregory P. Adams, Calvin C. Shaller, Ekaterina Dadachova, Heidi H. Simmons, Eva M. Horak, Abohawariat Tesfaye, Andres J. P. Klein-Szanto, James D. Marks, Martin W. Brechbiel, Louis M. Weiner
Journal: Cancer Research
Cancer Res (2004) 64 (17): 6200–6206.
https://doi.org/10.1158/0008-5472.CAN-03-2382
Published: 01 September 2004
View articletitled, A Single Treatment of Yttrium-90-labeled CHX-A″–C6.5 Diabody Inhibits the Growth of Established Human Tumor Xenografts in Immunodeficient Mice
Open the PDF for A Single Treatment of Yttrium-90-labeled CHX-A″–C6.5 Diabody Inhibits the Growth of Established Human Tumor Xenografts in Immunodeficient Mice in another window
Journal Articles

High Affinity Restricts the Localization and Tumor Penetration of Single-Chain Fv Antibody Molecules

Free
Gregory P. Adams, Robert Schier, Adrian M. McCall, Heidi H. Simmons, Eva M. Horak, R. Katherine Alpaugh, James D. Marks, Louis M. Weiner
Journal: Cancer Research
Cancer Res (2001) 61 (12): 4750–4755.
Published: 01 June 2001
View articletitled, High Affinity Restricts the Localization and Tumor Penetration of Single-Chain Fv Antibody Molecules
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Journal Articles

Targeting of Bivalent Anti-ErbB2 Diabody Antibody Fragments to Tumor Cells Is Independent of the Intrinsic Antibody Affinity

Free
Ulrik B. Nielsen, Gregory P. Adams, Louis M. Weiner, James D. Marks
Journal: Cancer Research
Cancer Res (2000) 60 (22): 6434–6440.
Published: 15 November 2000
View articletitled, Targeting of Bivalent Anti-ErbB2 Diabody Antibody Fragments to Tumor Cells Is Independent of the Intrinsic Antibody Affinity
Open the PDF for Targeting of Bivalent Anti-ErbB2 Diabody Antibody Fragments to Tumor Cells Is Independent of the Intrinsic Antibody Affinity in another window