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Gregory H. Bird
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Journal Articles

Abstract 2867: MDM2 and MDM4 are therapeutic vulnerabilities in malignant rhabdoid tumors

Thomas P. Howard, Taylor E. Arnoff, Melinda R. Song, Andrew O. Giacomelli, Xiaofeng Wang, Andrew L. Hong, Neekesh V. Dharia, Su Wang, Francisca Vazquez, Minh-Tam Pham, Ann M. Morgan, Franziska Wachter, Gregory H. Bird, Guillaume Kugener, Elaine M. Oberlick, Matthew G. Rees, Hong Tiv, Justin H. Hwang, Katherine H. Walsh, April Cook, John M. Krill-Burger, Aviad Tsherniak, Prafulla C. Gokhale, Peter J. Park, Kimberly Stegmaier, Loren D. Walensky, William C. Hahn, Charles W. Roberts
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2867.
https://doi.org/10.1158/1538-7445.AM2019-2867
Published: 01 July 2019
View article titled, Abstract 2867: MDM2 and MDM4 are therapeutic vulnerabilities in malignant rhabdoid tumors
Journal Articles

MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors

Thomas P. Howard, Taylor E. Arnoff, Melinda R. Song, Andrew O. Giacomelli, Xiaofeng Wang, Andrew L. Hong, Neekesh V. Dharia, Su Wang, Francisca Vazquez, Minh-Tam Pham, Ann M. Morgan, Franziska Wachter, Gregory H. Bird, Guillaume Kugener, Elaine M. Oberlick, Matthew G. Rees, Hong L. Tiv, Justin H. Hwang, Katherine H. Walsh, April Cook, John M. Krill-Burger, Aviad Tsherniak, Prafulla C. Gokhale, Peter J. Park, Kimberly Stegmaier, Loren D. Walensky, William C. Hahn, Charles W.M. Roberts
Journal: Cancer Research
Cancer Res (2019) 79 (9): 2404–2414.
https://doi.org/10.1158/0008-5472.CAN-18-3066
Published: 01 May 2019
View article titled, MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors
Open the PDF for MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors in another window
Includes: Supplementary data
Journal Articles

Abstract 1901: Structural basis for selective therapeutic targeting of BFL-1 in cancer by a covalent stapled peptide inhibitor

Edward P. Harvey, Hyuk-Soo Seo, Rachel M. Guerra, Gregory H. Bird, Sirano Dhe-Paganon, Loren D. Walensky
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1901.
https://doi.org/10.1158/1538-7445.AM2018-1901
Published: 01 July 2018
View article titled, Abstract 1901: Structural basis for selective therapeutic targeting of BFL-1 in cancer by a covalent stapled peptide inhibitor
Journal Articles

Abstract 2024: Reactivating apoptosis in BFL-1/A1 driven cancer with cysteine-reactive stapled peptide inhibitors

Rachel M. Guerra, Annissa J. Huhn, Edward P. Harvey, Gregory H. Bird, Loren D. Walensky
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2024.
https://doi.org/10.1158/1538-7445.AM2017-2024
Published: 01 July 2017
View article titled, Abstract 2024: Reactivating apoptosis in BFL-1/A1 driven cancer with cysteine-reactive stapled peptide inhibitors
Journal Articles

Abstract 3553: A novel allosteric mechanism for molecular inhibition of anti-apoptotic MCL-1

Susan Lee, Thomas E. Wales, Catherine Gallagher, Daniel T. Cohen, Silvia Escudero, James Luccarelli, Annissa J. Huhn, Nicole A. Cohen, Gregory H. Bird, John R. Engen, Loren D. Walensky
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3553.
https://doi.org/10.1158/1538-7445.AM2016-3553
Published: 15 July 2016
View article titled, Abstract 3553: A novel allosteric mechanism for molecular inhibition of anti-apoptotic MCL-1
Journal Articles

Abstract 3845: A novel selectivity determinant informs the development of next-generation stapled peptide inhibitors of anti-apoptotic BFL-1/A1

Annissa J. Huhn, Rachel M. Guerra, Gregory H. Bird, Loren D. Walensky
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3845.
https://doi.org/10.1158/1538-7445.AM2016-3845
Published: 15 July 2016
View article titled, Abstract 3845: A novel selectivity determinant informs the development of next-generation stapled peptide inhibitors of anti-apoptotic BFL-1/A1
Journal Articles

Abstract 2597: Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices

Elizaveta Leshchiner, Joseph Bellairs, Gregory H. Bird, Kwadwo Opoku-Nsiah, Marina Godes, Lored D. Walensky
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2597.
https://doi.org/10.1158/1538-7445.AM2014-2597
Published: 01 October 2014
View article titled, Abstract 2597: Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices
Journal Articles

Abstract 2954: A noncanonical mechanism for BCL-2 inhibition of pro-apoptotic BAX

Lauren A. Barclay, Susan Lee, Michelle L. Stewart, Craig R. Braun, Gregory H. Bird, Loren D. Walensky
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2954.
https://doi.org/10.1158/1538-7445.AM2014-2954
Published: 01 October 2014
View article titled, Abstract 2954: A noncanonical mechanism for BCL-2 inhibition of pro-apoptotic BAX
Journal Articles

Abstract 4611: Multimodal activation of apoptosis by a hydrocarbon-stapled PUMA BH3 helix.

Amanda L. Edwards, Evripidis Gavathiotis, James L. LaBelle, Craig R. Braun, Kwadwo Opoku-Nsiah, Gregory H. Bird, Loren D. Walensky
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4611.
https://doi.org/10.1158/1538-7445.AM2013-4611
Published: 15 April 2013
View article titled, Abstract 4611: Multimodal activation of apoptosis by a hydrocarbon-stapled PUMA BH3 helix.
Journal Articles

Abstract 1775: Therapeutic reactivation of cell death in refractory hematologic cancers using a broad spectrum BIM BH3 death helix

James L. LaBelle, Samuel G. Katz, Gregory H. Bird, Evripidis Gavathiotis, Michelle L. Stewart, Jill K. Fisher, Marina Godes, Loren D. Walensky
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 1775.
https://doi.org/10.1158/1538-7445.AM2011-1775
Published: 15 April 2011
View article titled, Abstract 1775: Therapeutic reactivation of cell death in refractory hematologic cancers using a broad spectrum BIM BH3 death helix
Journal Articles

Abstract LB-241: Photoreactive stapled peptides for target discovery in cancer

Craig R. Braun, Julian Mintseris, Evripidis Gavathiotis, Gregory H. Bird, Steven P. Gygi, Loren D. Walensky
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): LB-241.
https://doi.org/10.1158/1538-7445.AM2011-LB-241
Published: 15 April 2011
View article titled, Abstract LB-241: Photoreactive stapled peptides for target discovery in cancer
Journal Articles

Abstract 4871: Photoreactive stapled peptides to capture cancer proteins and define their sites of interaction

Craig R. Braun, Julian Mintseris, Evripidis Gavathiotis, Gregory H. Bird, Steven P. Gygi, Loren D. Walensky
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4871.
https://doi.org/10.1158/1538-7445.AM2011-4871
Published: 15 April 2011
View article titled, Abstract 4871: Photoreactive stapled peptides to capture cancer proteins and define their sites of interaction