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Grainne Kerr
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Journal Articles

CRISPR Screening Identifies Mechanisms of Resistance to KRASG12C and SHP2 Inhibitor Combinations in Non–Small Cell Lung Cancer

Anirudh Prahallad, Andreas Weiss, Hans Voshol, Grainne Kerr, Kathleen Sprouffske, Tina Yuan, David Ruddy, Morgane Meistertzheim, Malika Kazic-Legueux, Tina Kottarathil, Michelle Piquet, Yichen Cao, Laetitia Martinuzzi-Duboc, Alexandra Buhles, Flavia Adler, Salvatore Mannino, Luca Tordella, Laurent Sansregret, Sauveur-Michel Maira, Diana Graus Porta, Carmine Fedele, Saskia M. Brachmann
Journal: Cancer Research
Cancer Res (2023) 83 (24): 4130–4141.
https://doi.org/10.1158/0008-5472.CAN-23-1127
Published: 15 December 2023
View article titled, CRISPR Screening Identifies Mechanisms of Resistance to KRAS<sup>G12C</sup> and SHP2 Inhibitor Combinations in Non–Small Cell Lung Cancer
Open the PDF for CRISPR Screening Identifies Mechanisms of Resistance to KRAS<sup>G12C</sup> and SHP2 Inhibitor Combinations in Non–Small Cell Lung Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 394: In vivo shRNA screens under treatment pressure by BRAF and MEK inhibitors to identify novel combination treatment strategies for BRAF-mutant colorectal cancer

Hyo-eun C. Bhang, Matthew T. DiMare, David P. Kodack, Lujian Tan, Grainne Kerr, Viveksagar Krishnamurthy Radhakrishna, Javad Golji, David A. Ruddy, Tina Yuan, Matthew J. Niederst, Joshua M. Korn, Diana Graus Porta, Peter S. Hammerman, Jeffrey A. Engelman, Tinya Abrams, Juliet Williams
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 394.
https://doi.org/10.1158/1538-7445.AM2019-394
Published: 01 July 2019
View article titled, Abstract 394: <em>In vivo</em> shRNA screens under treatment pressure by BRAF and MEK inhibitors to identify novel combination treatment strategies for <em>BRAF</em>-mutant colorectal cancer
Journal Articles

Dose and Schedule Determine Distinct Molecular Mechanisms Underlying the Efficacy of the p53–MDM2 Inhibitor HDM201

Sébastien Jeay, Stéphane Ferretti, Philipp Holzer, Jeanette Fuchs, Emilie A. Chapeau, Markus Wartmann, Dario Sterker, Vincent Romanet, Masato Murakami, Grainne Kerr, Eric Y. Durand, Swann Gaulis, Marta Cortes-Cros, Stephan Ruetz, Therese-Marie Stachyra, Joerg Kallen, Pascal Furet, Jens Würthner, Nelson Guerreiro, Ensar Halilovic, Astrid Jullion, Audrey Kauffmann, Emil Kuriakose, Marion Wiesmann, Michael R. Jensen, Francesco Hofmann, William R. Sellers
Journal: Cancer Research
Series: Author Choice
Cancer Res (2018) 78 (21): 6257–6267.
https://doi.org/10.1158/0008-5472.CAN-18-0338
Published: 01 November 2018
View article titled, Dose and Schedule Determine Distinct Molecular Mechanisms Underlying the Efficacy of the p53–MDM2 Inhibitor HDM201
Open the PDF for Dose and Schedule Determine Distinct Molecular Mechanisms Underlying the Efficacy of the p53–MDM2 Inhibitor HDM201 in another window
Includes: Supplementary data
Journal Articles

Abstract 361: Identification of a novel dependence on the SWI/SNF chromatin remodeling complex in uveal melanoma

Florencia Rago, Xiaoqin Xiang, Aurore Desplat, Emilie Niemezyk, David Ruddy, Grainne Kerr, Eusebio Manchado Robles, Deborah Castelletti, Zainab Jagani
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 361.
https://doi.org/10.1158/1538-7445.AM2018-361
Published: 01 July 2018
View article titled, Abstract 361: Identification of a novel dependence on the SWI/SNF chromatin remodeling complex in uveal melanoma
Journal Articles

Abstract 1007: SHP2 inhibition restores sensitivity to ALK inhibition in resistant ALK-rearranged non-small cell lung cancer (NSCLC)

Leila Dardaei, Hui Qin Wang, Paul Fordjour, Manrose Singh, Grainne Kerr, Satoshi Yoda, Jinsheng Liang, Yichen Cao, Yan Chen, Justin F. Gainor, Luc Friboulet, Ibiayi Dagogo-Jack, David T. Myers, Emma Labrot, David Ruddy, Melissa Parks, Dana Lee, Richard H. DiCecca, Susan Moody, Huaixiang Hao, Morvarid Mohseni, Matthew LaMarche, Juliet Williams, Keith Hoffmaster, Giordano Caponigro, Cyril H. Benes, Alice T. Shaw, Aaron N. Hata, Fang Li, Jeffrey A. Engelman
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1007.
https://doi.org/10.1158/1538-7445.AM2017-1007
Published: 01 July 2017
View article titled, Abstract 1007: SHP2 inhibition restores sensitivity to ALK inhibition in resistant ALK-rearranged non-small cell lung cancer (NSCLC)
Journal Articles

Abstract 3240: The Wnt secretion factor Evi/Wls/Gpr177 promotes glioma tumorigenesis

Iris Augustin, Violaine Goidts, Angelika Bongers, Grainne Kerr, Bernhard Radlwimmer, Christian Hartmann, Christel Herold-Mende, Andreas von Deimling, Guido Reifenberg, Michael Boutros
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3240.
https://doi.org/10.1158/1538-7445.AM2012-3240
Published: 15 April 2012
View article titled, Abstract 3240: The Wnt secretion factor Evi/Wls/Gpr177 promotes glioma tumorigenesis