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Journal Articles

Mutant PP2A Induces IGFBP2 Secretion to Promote Development of High-Grade Uterine Cancer

Terrance J. Haanen, Sophie Boock, Catherine G. Callahan, Irene Peris, Kaitlin P. Zawacki, Brynne Raines, Charles A. Nino, Brian Tran, Alexis Harold, Gabrielle Hodges Onishi, Matthew Hinderman, Amanda Dowdican, Wei Huang, Derek J. Taylor, Sarah E. Taylor, Mark W. Jackson, Analisa DiFeo, Caitlin M. O'Connor, Goutham Narla

Cancer Res (2024)

https://doi.org/10.1158/0008-5472.CAN-24-1263

Published: 12 November 2024

View article titled, Mutant PP2A Induces IGFBP2 Secretion to Promote Development of High-Grade Uterine Cancer

Includes: Supplementary data

Journal Articles

Abstract 4717: Small molecule modulation of PP2A selectively induces oncogenic cytotoxicity through chronic and irreversible integrated stress response

Rita A. Avelar, Riya Gupta, Grace Carvette, Felipe da Veiga Leprevost, Jose Colina, Jessica Teitel, Goutham Narla, Analisa DiFeo

Cancer Res (2024) 84 (6_Supplement): 4717.

https://doi.org/10.1158/1538-7445.AM2024-4717

Published: 22 March 2024

View article titled, Abstract 4717: Small molecule modulation of PP2A selectively induces oncogenic cytotoxicity through chronic and irreversible integrated stress response

Journal Articles

Abstract C080: Decoding the MYC-PDAC nexus: Unveiling the impact of PP2A-C subunit methylation on tumor onset and advancement

Vidhi Shah, Alexander Smith, Gabriel Cohn, Motoyuki Tsuda, Goutham Narla, Jonathan Brody, Brett Sheppard, Rosalie Sears

Cancer Res (2024) 84 (2_Supplement): C080.

https://doi.org/10.1158/1538-7445.PANCA2023-C080

Published: 16 January 2024

View article titled, Abstract C080: Decoding the MYC-PDAC nexus: Unveiling the impact of PP2A-C subunit methylation on tumor onset and advancement

Journal Articles

Abstract B064: The role of PP2A-B56α in KRAS-mediated pancreatic tumorigenesis

Samantha L Tinsley, Rebecca A. Shelley, Gagan K. Mall, Ella Rose D. Chianis, Mary C. Thoma, Marina Pasca di Magliano, Goutham Narla, Rosalie C. Sears, Brittany L. Allen-Petersen

Cancer Res (2022) 82 (22_Supplement): B064.

https://doi.org/10.1158/1538-7445.PANCA22-B064

Published: 15 November 2022

View article titled, Abstract B064: The role of PP2A-B56α in KRAS-mediated pancreatic tumorigenesis

Journal Articles

Abstract 3341: Synthetic lethality by targeting ribonucleotide reductase in PP2A deficient uterine serous carcinoma

Caitlin M. O'Connor, Sarah E. Taylor, Kathryn M. Miller, Lauren Hurst, Terrance J. Haanen, Tahra K. Suhan, Kaitlin P. Zawacki, Fallon K. Noto, Jonida Trako, Arathi Mohan, Jaya Sangodkar, Dmitriy Zamarin, Analisa DiFeo, Goutham Narla

Cancer Res (2022) 82 (12_Supplement): 3341.

https://doi.org/10.1158/1538-7445.AM2022-3341

Published: 15 June 2022

View article titled, Abstract 3341: Synthetic lethality by targeting ribonucleotide reductase in PP2A deficient uterine serous carcinoma

Journal Articles

Abstract 3340: Small molecule mediated stabilization of PP2A modulates the homologous recombination pathway and potentiates DNA damage-induced cell death

Rita A. Avelar, Amy Armstrong, Goutham Narla, Analisa DiFeo

Cancer Res (2022) 82 (12_Supplement): 3340.

https://doi.org/10.1158/1538-7445.AM2022-3340

Published: 15 June 2022

View article titled, Abstract 3340: Small molecule mediated stabilization of PP2A modulates the homologous recombination pathway and potentiates DNA damage-induced cell death

Journal Articles

Targeting Ribonucleotide Reductase Induces Synthetic Lethality in PP2A-Deficient Uterine Serous Carcinoma

Cancer Res (2022) 82 (4): 721–733.

https://doi.org/10.1158/0008-5472.CAN-21-1987

Published: 15 February 2022

View article titled, Targeting Ribonucleotide Reductase Induces Synthetic Lethality in PP2A-Deficient Uterine Serous Carcinoma

Includes: Supplementary data

Journal Articles

CIP2A Interacts with TopBP1 and Drives Basal-Like Breast Cancer Tumorigenesis

Cancer Res (2021) 81 (16): 4319–4331.

https://doi.org/10.1158/0008-5472.CAN-20-3651

Published: 15 August 2021

View article titled, CIP2A Interacts with TopBP1 and Drives Basal-Like Breast Cancer Tumorigenesis

Includes: Supplementary data

Journal Articles

Abstract 937: The PP2A activation using a small molecule agonist triggers apoptosis by releasing mitochondrial permeability transition pores in multi-drug resistant leukemic B cells

Kallesh D. Jayappa, Caroline Farrington, Vicki L. Gordon, Shekhar Saha, Christopher Morris, Krista M. Isaac, Timothy P. Bender, Michael E. Williams, Craig A. Portell, Goutham Narla, Michael J. Weber

Cancer Res (2021) 81 (13_Supplement): 937.

https://doi.org/10.1158/1538-7445.AM2021-937

Published: 01 July 2021

View article titled, Abstract 937: The PP2A activation using a small molecule agonist triggers apoptosis by releasing mitochondrial permeability transition pores in multi-drug resistant leukemic B cells

Journal Articles

Abstract 2949: Sprague-Dawley Rag2 null Il2rgamma null SRG rat (OncoRat®) has enhanced tumor microenvironment in human prostate cancer xenografts

Diane Begemann, Bisoye Towobola Adedeji, Valeriya Steffey, Sam Moody, Goutham Narla, Fallon Noto

Cancer Res (2021) 81 (13_Supplement): 2949.

https://doi.org/10.1158/1538-7445.AM2021-2949

Published: 01 July 2021

View article titled, Abstract 2949: Sprague-Dawley Rag2 null Il2rgamma null SRG rat (OncoRat®) has enhanced tumor microenvironment in human prostate cancer xenografts

Journal Articles

Abstract PR-008: The role of PP2A-B56α in acinar-to-ductal metaplasia and initiation of pancreatic ductal adenocarcinoma

Samantha L. Tinsley, Rebecca A. Shelley, Mary C. Thoma, Goutham Narla, Rosalie C. Sears, Brittany A. Allen-Petersen

Cancer Res (2020) 80 (22_Supplement): PR-008.

https://doi.org/10.1158/1538-7445.PANCA20-PR-008

Published: 13 November 2020

View article titled, Abstract PR-008: The role of PP2A-B56α in acinar-to-ductal metaplasia and initiation of pancreatic ductal adenocarcinoma

Journal Articles

Abstract 2981: Biased activation of PP2A through selective heterotrimer binding and stabilization

Daniel Leonard, Wei Huang, Sudeh Izadmehr, Caitlin M. O'Connor, Danica D. Wiredja, Zhizhi Wang, Nilesh Zaware, Daniela M. Schlatzer, Stefan Schuchner, Janna Kiselar, Yinghua Chen, Nikhil Vasireddi, Abbey L. Perl, Matthew D. Glasky, Wenqing Xu, David L. Brautigan, Egon Ogris, Derek J. Taylor, Goutham Narla

Cancer Res (2020) 80 (16_Supplement): 2981.

https://doi.org/10.1158/1538-7445.AM2020-2981

Published: 15 August 2020

View article titled, Abstract 2981: Biased activation of PP2A through selective heterotrimer binding and stabilization

Journal Articles

Abstract 3403: Drugging the undruggable: Lessons learned from protein phosphatase 2A

Derek Taylor, Goutham Narla

Cancer Res (2020) 80 (16_Supplement): 3403.

https://doi.org/10.1158/1538-7445.AM2020-3403

Published: 15 August 2020

View article titled, Abstract 3403: Drugging the undruggable: Lessons learned from protein phosphatase 2A

Journal Articles

Abstract 6133: Rats support cancer studies

Bisoye Towobola Adedeji, Noto K. Fallon, Sam Moody, Valeriya Steffey, Chris Brenzel, Jack Crawford, Tseten Yeshi Jamling, Goutham Narla

Cancer Res (2020) 80 (16_Supplement): 6133.

https://doi.org/10.1158/1538-7445.AM2020-6133

Published: 15 August 2020

View article titled, Abstract 6133: Rats support cancer studies

Journal Articles

A Genome-Wide Pooled shRNA Screen Identifies PPP2R2A as a Predictive Biomarker for the Response to ATR and CHK1 Inhibitors

Zhaojun Qiu, Pengyan Fa, Tao Liu, Chandra B. Prasad, Shanhuai Ma, Zhipeng Hong, Ernest R. Chan, Hongbing Wang, Zaibo Li, Kai He, Qi-En Wang, Terence M. Williams, Chunhong Yan, Steven T. Sizemore, Goutham Narla, Junran Zhang

Cancer Res (2020) 80 (16): 3305–3318.

https://doi.org/10.1158/0008-5472.CAN-20-0057

Published: 14 August 2020

View article titled, A Genome-Wide Pooled shRNA Screen Identifies PPP2R2A as a Predictive Biomarker for the Response to ATR and CHK1 Inhibitors

Includes: Supplementary data

Journal Articles

The Highly Recurrent PP2A Aα-Subunit Mutation P179R Alters Protein Structure and Impairs PP2A Enzyme Function to Promote Endometrial Tumorigenesis

Cancer Res (2019) 79 (16): 4242–4257.

https://doi.org/10.1158/0008-5472.CAN-19-0218

Published: 15 August 2019

View article titled, The Highly Recurrent PP2A Aα-Subunit Mutation P179R Alters Protein Structure and Impairs PP2A Enzyme Function to Promote Endometrial Tumorigenesis

Includes: Supplementary data

Journal Articles

Abstract 1283: Targeting c-MYC and MAPK pathway to overcome pancreatic cancer drug resistance

Erika Maria Parasido, George S. Avetian, Jonathan Brody, Jordan Winter, Eric Londin, Michael Pishvaian, Eric Glasgow, Stephen Byers, Goutham Narla, Christopher Albanese

Cancer Res (2019) 79 (13_Supplement): 1283.

https://doi.org/10.1158/1538-7445.AM2019-1283

Published: 01 July 2019

View article titled, Abstract 1283: Targeting c-MYC and MAPK pathway to overcome pancreatic cancer drug resistance

Journal Articles

Abstract 1059: A case study: OncoRat is a viable patient avatar for a NSCLC patient with a Y1248H Met activating mutation

Fallon K. Noto, Bisoye Towobola Adedeji, Sam Moody, Chris Brenzel, Jack Crawford, Goutham Narla, Tseten Yeshi Jamling

Cancer Res (2019) 79 (13_Supplement): 1059.

https://doi.org/10.1158/1538-7445.AM2019-1059

Published: 01 July 2019

View article titled, Abstract 1059: A case study: OncoRat is a viable patient avatar for a NSCLC patient with a Y1248H Met activating mutation

Journal Articles

Lulling the Cancer Cell into an Eternal Sleep

Caroline C. Farrington, Goutham Narla

Cancer Res (2019) 79 (8): 1756–1757.

https://doi.org/10.1158/0008-5472.CAN-19-0853

Published: 15 April 2019

View article titled, Lulling the Cancer Cell into an Eternal Sleep

Journal Articles

Activation of PP2A and Inhibition of mTOR Synergistically Reduce MYC Signaling and Decrease Tumor Growth in Pancreatic Ductal Adenocarcinoma

Brittany L. Allen-Petersen, Tyler Risom, Zipei Feng, Zhiping Wang, Zina P. Jenny, Mary C. Thoma, Katherine R. Pelz, Jennifer P. Morton, Owen J. Sansom, Charles D. Lopez, Brett Sheppard, Dale J. Christensen, Michael Ohlmeyer, Goutham Narla, Rosalie C. Sears

Cancer Res (2019) 79 (1): 209–219.

https://doi.org/10.1158/0008-5472.CAN-18-0717

Published: 02 January 2019

View article titled, Activation of PP2A and Inhibition of mTOR Synergistically Reduce MYC Signaling and Decrease Tumor Growth in Pancreatic Ductal Adenocarcinoma

Includes: Supplementary data

NARROW

Mutant PP2A Induces IGFBP2 Secretion to Promote Development of High-Grade Uterine Cancer

Abstract 4717: Small molecule modulation of PP2A selectively induces oncogenic cytotoxicity through chronic and irreversible integrated stress response

Abstract C080: Decoding the MYC-PDAC nexus: Unveiling the impact of PP2A-C subunit methylation on tumor onset and advancement

Abstract B064: The role of PP2A-B56α in KRAS-mediated pancreatic tumorigenesis

Abstract 3341: Synthetic lethality by targeting ribonucleotide reductase in PP2A deficient uterine serous carcinoma

Abstract 3340: Small molecule mediated stabilization of PP2A modulates the homologous recombination pathway and potentiates DNA damage-induced cell death

Targeting Ribonucleotide Reductase Induces Synthetic Lethality in PP2A-Deficient Uterine Serous Carcinoma

CIP2A Interacts with TopBP1 and Drives Basal-Like Breast Cancer Tumorigenesis

Abstract 937: The PP2A activation using a small molecule agonist triggers apoptosis by releasing mitochondrial permeability transition pores in multi-drug resistant leukemic B cells

Abstract 2949: Sprague-Dawley Rag2 null Il2rgamma null SRG rat (OncoRat®) has enhanced tumor microenvironment in human prostate cancer xenografts

Abstract PR-008: The role of PP2A-B56α in acinar-to-ductal metaplasia and initiation of pancreatic ductal adenocarcinoma

Abstract 2981: Biased activation of PP2A through selective heterotrimer binding and stabilization

Abstract 3403: Drugging the undruggable: Lessons learned from protein phosphatase 2A

Abstract 6133: Rats support cancer studies

A Genome-Wide Pooled shRNA Screen Identifies PPP2R2A as a Predictive Biomarker for the Response to ATR and CHK1 Inhibitors

The Highly Recurrent PP2A Aα-Subunit Mutation P179R Alters Protein Structure and Impairs PP2A Enzyme Function to Promote Endometrial Tumorigenesis

Abstract 1283: Targeting c-MYC and MAPK pathway to overcome pancreatic cancer drug resistance

Abstract 1059: A case study: OncoRat is a viable patient avatar for a NSCLC patient with a Y1248H Met activating mutation

Lulling the Cancer Cell into an Eternal Sleep

Activation of PP2A and Inhibition of mTOR Synergistically Reduce MYC Signaling and Decrease Tumor Growth in Pancreatic Ductal Adenocarcinoma

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