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Journal Articles

Abstract C029: Window-of-opportunity trial of metastatic pancreatic cancer reveals potential mechanisms of response to targeting RAS/MEK signaling

Motoyuki Tsuda, Colin Daniel, Xiaoyan Wang, Carl Peltz, Hayley Zimmny, Alexander Smith, John Muschler, Xi Li, Tugba Yildiran Ozmen, Furkan Ozmen, Dove Keith, Christopher Corless, Koei Chin, Jonathan Brody, Charles Lopez, Gordon Mills, Rosalie Sears
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): C029.
https://doi.org/10.1158/1538-7445.PANCREATIC24-C029
Published: 15 September 2024
View article titled, Abstract C029: Window-of-opportunity trial of metastatic pancreatic cancer reveals potential mechanisms of response to targeting RAS/MEK signaling
Journal Articles

Abstract PS03-04: Tumor immune microenvironment modulates resistance to estrogen suppression in ER+ breast cancer

Fabiana Napolitano, Yunguan Wang, Dhivya Sudhan, Paula Gonzalez-Ericsson, Luigi Formisano, Lei Guo, M Rosario Chica-Parrado, Chang-Ching Lin, Kyung-Min Lee, Hongli Ma, Nathaniel Evans, Alberto Servetto, Saurabh Mendiratta, Spencer Barnes, Yisheng Fang, Lin Xu, Justin Balko, Gordon Mills, Marilyne Labrie, Ariella Hanker, Carlos Arteaga
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PS03-04.
https://doi.org/10.1158/1538-7445.SABCS23-PS03-04
Published: 02 May 2024
View article titled, Abstract PS03-04: Tumor immune microenvironment modulates resistance to estrogen suppression in ER+ breast cancer
Journal Articles

Abstract LB247: TCPAplus: An LLM-empowered chatbot for analyzing a large protein expression atlas of human cancers

Wei Liu, Jun Liu, Yitao Tang, Chaozhong Liu, Meiyi Song, Zhenlin Ju, Shweth V. Kumar, Yiling Lu, Rehan Akbani, Gordon Mills, Han Liang
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB247.
https://doi.org/10.1158/1538-7445.AM2024-LB247
Published: 05 April 2024
View article titled, Abstract LB247: TCPAplus: An LLM-empowered chatbot for analyzing a large protein expression atlas of human cancers
Journal Articles

Abstract 583: Spatiotemporal analyses of longitudinal specimens reveal mechanisms of response and resistance to immune checkpoint blockade in metastatic melanoma

Gao Zhang, Lisa Coussens, Meenhard Herlyn, Keith T. Flaherty, Genevieve Boland, Gordon Mills
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 583.
https://doi.org/10.1158/1538-7445.AM2024-583
Published: 22 March 2024
View article titled, Abstract 583: Spatiotemporal analyses of longitudinal specimens reveal mechanisms of response and resistance to immune checkpoint blockade in metastatic melanoma
Journal Articles

Abstract 2504: Determining tumour homologous recombination repair status in PDX and clinical samples using automated RAD51 scoring

Jack Robertson, Jack Ashton, Gemma N. Jones, Gordon Mills, Tugba Y. Ozmen, Matthew J. Rames, Soonyoung Park, Paul Waring, Natalia Lukashchuk, Elizabeth Harrington
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2504.
https://doi.org/10.1158/1538-7445.AM2024-2504
Published: 22 March 2024
View article titled, Abstract 2504: Determining tumour homologous recombination repair status in PDX and clinical samples using automated RAD51 scoring
Journal Articles

Abstract 2499: Window-of-opportunity trial of metastatic pancreatic cancer reveals potential mechanisms of response to targeting RAS signaling

Motoyuki Tsuda, Colin Daniel, Xiaoyan Wang, Carl Pelz, Hayley Zimny, Alexander Smith, John Muschler, Xi Li, Tugba Yildiran Ozmen, Furkan Ozmen, Dove Keith, Christopher Corless, Koei Chin, Jonathan Brody, Charles Lopez, Gordon Mills, Rosalie Sears
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2499.
https://doi.org/10.1158/1538-7445.AM2024-2499
Published: 22 March 2024
View article titled, Abstract 2499: Window-of-opportunity trial of metastatic pancreatic cancer reveals potential mechanisms of response to targeting RAS signaling
Journal Articles

Abstract B003: Advancing biomarker discovery using a novel window of opportunity (WOO) trial for pancreatic ductal adenocarcinoma: Trial updates

Charles D. Lopez, Adel Kardosh, Emerson Chen, Guillame Pegna, Alexander Guimaraes, Bryan Foster, Brian Brinkerhoff, Shaun M. Goodyear, Erin Taber, Brindha Rajagopalan, Johnson Vo, Kiara Siex, Brett Johnson, Danielle Galipeau, Dove Keith, Brett Sheppard, Brody Jonathan, Rosalie Sears, Gordon Mills
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): B003.
https://doi.org/10.1158/1538-7445.PANCA2023-B003
Published: 16 January 2024
View article titled, Abstract B003: Advancing biomarker discovery using a novel window of opportunity (WOO) trial for pancreatic ductal adenocarcinoma: Trial updates
Journal Articles

Abstract LB178: Cell free RNA for prediction of PDAC in de novo symptomatic patients presenting for EUS-FNA

Travis Moore, Elias Spiliotopolous, Rowan Callahan, Ward Kirschbaum, Hyun Ji Kim, Dove Keith, Aaron Grossberg, Paul T. Spellman, Gordon Mills, Rosalie C. Sears, Terry Morgan, Thuy Ngo
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB178.
https://doi.org/10.1158/1538-7445.AM2023-LB178
Published: 14 April 2023
View article titled, Abstract LB178: Cell free RNA for prediction of PDAC in de novo symptomatic patients presenting for EUS-FNA
Journal Articles

Abstract 2276: Spatiotemporal analysis of metastatic melanoma reveals mechanisms of resistance to immune checkpoint blockade

Shiyou Wei, Jinho Lee, Marilyne Labrie, Courtney Betts, Lunxu Liu, Lisa Coussens, Meenhard Herlyn, Genevieve Boland, Gordon Mills, Gao Zhang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2276.
https://doi.org/10.1158/1538-7445.AM2023-2276
Published: 04 April 2023
View article titled, Abstract 2276: Spatiotemporal analysis of metastatic melanoma reveals mechanisms of resistance to immune checkpoint blockade
Journal Articles

Abstract 1759: Targeting adaptation to cancer treatment by drug combinations

Augustin Luna, Heping Wang, Gonghong Yan, Xubin Li, Ozgun Babur, Gordon Mills B. Mills, Chris Sander, Anil Korkut
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1759.
https://doi.org/10.1158/1538-7445.AM2023-1759
Published: 04 April 2023
View article titled, Abstract 1759: Targeting adaptation to cancer treatment by drug combinations
Journal Articles

Abstract 2153: Cyclin E1 protein overexpression sensitizes ovarian cancer cells to ZN-c3, a novel, selective and oral bioavailable inhibitor of Wee1

Jianhui Ma, Wen Liu, Heekyung Chung, Hooman Izadi, Petrus DeJong, Olivier Harismendy, Jia li, Fernando Doñate, Ahmed Samatar, Mark Lackner, Laure Escoubet, Kevin Bunker, Daehwan Kim, Nathan Jameson, Tugba Yildiran Ozmen, Kangjin Jeong, Dong Zhang, Wen-An Pan, Gordon Mills
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2153.
https://doi.org/10.1158/1538-7445.AM2023-2153
Published: 04 April 2023
View article titled, Abstract 2153: Cyclin E1 protein overexpression sensitizes ovarian cancer cells to ZN-c3, a novel, selective and oral bioavailable inhibitor of Wee1
Journal Articles

Abstract 5641: Single cell spatial molecular imaging of 76-plex proteins in clinical cancer samples in response to personalized treatment

Zachary R. Lewis, Brian Birditt, Emily Brown, Kan Chantranuvatana, Brian Filanoski, Chris Corless, Tiên Phan-Everson, Gary Geiss, Tyler Hether, Evie Hobbs, Brett Johnson, Taylor Kelley, Charles Lopez, Rhonda Meredith, Anastasiya Olson, Giang Ong, Mithra Korukonda, Erin Piazza, Jason Reeves, Alyssa Rosenbloom, Kiara Siex, Hye Son Yi, Edward Zhao, Joseph M. Beechem, Gordon Mills
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5641.
https://doi.org/10.1158/1538-7445.AM2023-5641
Published: 04 April 2023
View article titled, Abstract 5641: Single cell spatial molecular imaging of 76-plex proteins in clinical cancer samples in response to personalized treatment
Journal Articles

Abstract 5627: Spatial protein profiling by cyclic immunofluorescence to interpret and improve bulk tumor-based predictor of response to chemotherapy with bevacizumab in neoadjuvant breast cancer treatment

Mads Haugland Haugen, David Kilburn, Hongli Ma, Cameron Watson, Allison Creason, Dong Zhang, Maria Aa Dahle, Ole Christian Lingjaerde, Marianne L. Smebye, Oeystein Garred, Mette S. Foersund, Mai T. Nguyen, Gunhild M. Maelandsmo, Gordon Mills, Olav Engebraaten
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5627.
https://doi.org/10.1158/1538-7445.AM2023-5627
Published: 04 April 2023
View article titled, Abstract 5627: Spatial protein profiling by cyclic immunofluorescence to interpret and improve bulk tumor-based predictor of response to chemotherapy with bevacizumab in neoadjuvant breast cancer treatment
Journal Articles

Abstract 3455: Transcriptional and phenotypic heterogeneity underpinning venetoclax resistance

Vakul Mohanty, Natalia Baran, Yuefan Huang, Shan He, Ramiz Iqbal, CTD2 consortium, Jeffrey Tyner, Gordon Mills, Marina Konopleva, Ken Chen
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3455.
https://doi.org/10.1158/1538-7445.AM2023-3455
Published: 04 April 2023
View article titled, Abstract 3455: Transcriptional and phenotypic heterogeneity underpinning venetoclax resistance
Journal Articles

Abstract OT3-05-01: Adaptive Multi-Drug Treatment of Evolving Cancers (AMTEC): A Phase II, Open-Label, Study of Olaparib in Combination with either Durvalumab, Selumetinib or Capivasertib, or Ceralasertib Monotherapy in Patients with Metastatic TNBC

Evthokia Hobbs, Gordon Mills, Jeong Lim, Marlana Klinger, Kiara Siex, Sidney Huszti, Annie Yang, Danielle Galipeau, Christina Zheng, Lauren Murray, Becky Goodford, Nicholas Marter-Sanders, Anastasiya Olson, Jayne Stommel, Brett Johnson, Jamie Keck, Ben Kong, Allison Solanki, Shaun Goodyear, Christopher Corless, Joe Gray, Mitri Zahi
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): OT3-05-01.
https://doi.org/10.1158/1538-7445.SABCS22-OT3-05-01
Published: 01 March 2023
View article titled, Abstract OT3-05-01: Adaptive Multi-Drug Treatment of Evolving Cancers (AMTEC): A Phase II, Open-Label, Study of Olaparib in Combination with either Durvalumab, Selumetinib or Capivasertib, or Ceralasertib Monotherapy in Patients with Metastatic TNBC
Journal Articles

Abstract 1002: Targeting adaptation to cancer treatment by drug combinations

Heping Wang, Augustin Luna, Gonghong Yan, Xubin Li, Ozgun Babur, Chris Sander, Gordon Mills
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1002.
https://doi.org/10.1158/1538-7445.AM2022-1002
Published: 15 June 2022
View article titled, Abstract 1002: Targeting adaptation to cancer treatment by drug combinations
Journal Articles

Abstract OT-16-01: A phase 1 study of abemaciclib and niraparib as neoadjuvant therapy in hormone receptor positive (HR+) HER2 negative (HER2-) breast cancer

Allen Li, Arpana Naik, Nathalie Johnson, Shaun Goodyear, Brett Johnson, Byung Park, Christopher Corless, Joe Gray, Gordon Mills, Zahi Mitri
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): OT-16-01.
https://doi.org/10.1158/1538-7445.SABCS20-OT-16-01
Published: 15 February 2021
View article titled, Abstract OT-16-01: A phase 1 study of abemaciclib and niraparib as neoadjuvant therapy in hormone receptor positive (HR+) HER2 negative (HER2-) breast cancer
Journal Articles

Abstract 5139: An atlas of perturbed functional proteomics profiles of cancer cell lines

Wei Zhao, Jun Li, Mei-Ju Chen, Rehan Akbani, Yiling Lu, Gordon Mills, Han Liang
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5139.
https://doi.org/10.1158/1538-7445.AM2020-5139
Published: 15 August 2020
View article titled, Abstract 5139: An atlas of perturbed functional proteomics profiles of cancer cell lines
Journal Articles

Abstract 1065: Comprehensive molecular and experimental characterization of ovarian clear cell carcinoma cell lines for in vivo drug development

Yasuto Kinose, Dorothy Hallberg, Kai Doberstein, Gordon Mills, Tan Ince, Victor Velculescu, Fiona Simpkins, Ronny Drapkin
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1065.
https://doi.org/10.1158/1538-7445.AM2019-1065
Published: 01 July 2019
View article titled, Abstract 1065: Comprehensive molecular and experimental characterization of ovarian clear cell carcinoma cell lines for <em>in vivo</em> drug development
Journal Articles

Abstract 1353: The clinical utility of ctDNA in colorectal cancer validated by multiregional sequencing and protein analysis

Mizunori Yaegashi, Takeshi Iwaya, Masashi Fujita, Zhenlin Ju, Doris Siwak, Kei Sato, Fumitaka Endo, Ryo Sugimoto, Tamotsu Sugai, Lance Liotta, Yiling Lu, Gordon Mills, Hidewaki Nakagawa, Satoshi Nishizuka
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1353.
https://doi.org/10.1158/1538-7445.AM2019-1353
Published: 01 July 2019
View article titled, Abstract 1353: The clinical utility of ctDNA in colorectal cancer validated by multiregional sequencing and protein analysis