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Gordon B. Mills
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Journal Articles

Abstract LB414: Novel ALK/PIK3CA cooperativity in head and neck squamous cell carcinoma (HNSCC) progression

Lan Wang, Helen Hoi-Yin Chan, Angel Yee Lok Fung, Yuen-Keng Ng, Patrick Kwok-Shing Ng, Yuxiong Su, Jason Ying Kuen Chan, Peony Hiu Yan Poon, Thomas Chun Kit Yeung, Chi Man Tsang, Hoi-Lam Ngan, Wenying Piao, Yuchen Liu, Jack Nimitz Smith, Tin Yu Samuel Law, Ee Ling Kong, Melissa Sue Ann Chan, Chun Ho Law, Sze-Man Chan, Zoey Wing Yee Liu, Joshua Chung-Hymn Ng, Gordon B. Mills, Vivian W.Y. Lui
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB414.
https://doi.org/10.1158/1538-7445.AM2024-LB414
Published: 05 April 2024
View article titled, Abstract LB414: Novel <em>ALK/PIK3CA</em> cooperativity in head and neck squamous cell carcinoma (HNSCC) progression
Journal Articles

Abstract CT203: Multi-omic analysis of serial biopsies to inform biomarkers of sensitivity to olaparib and durvalumab in patients with metastatic BRCA-wildtype triple negative breast cancer (mTNBC)

Zahi I. Mitri, Allison L. Creason, Jayne M. Stommel, Daniel Bottomly, Jeong Youn Lim, SMMART Clinical Trials Program, Christopher L. Corless, Shannon McWeeney, Gordon B. Mills
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT203.
https://doi.org/10.1158/1538-7445.AM2024-CT203
Published: 05 April 2024
View article titled, Abstract CT203: Multi-omic analysis of serial biopsies to inform biomarkers of sensitivity to olaparib and durvalumab in patients with metastatic <em>BRCA</em>-wildtype triple negative breast cancer (mTNBC)
Journal Articles

Abstract 3344: Widespread BRCA1/2-independent homologous recombination defects are caused by alterations in RNA binding proteins

Babita Kaundal, Daniel J. McGrail, Yang Li, Roger S. Smith, Bin Feng, Hui Dai, Limei Hu, Briana Dennehey, Sharad Awasthi, Marc L. Mendillo, Anil K. Sood, Gordon B. Mills, Shiaw-Yih Lin, S. Stephen Yi, Nidhi Sahni
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3344.
https://doi.org/10.1158/1538-7445.AM2024-3344
Published: 22 March 2024
View article titled, Abstract 3344: Widespread <em>BRCA1/2</em>-independent homologous recombination defects are caused by alterations in RNA binding proteins
Journal Articles

Abstract 3997: PARP inhibitors plus anlotinib as bridging therapy for TGFβ-insensitive CAR-T cell therapy targeting MSLN and CD19 in advanced ovarian cancer

Huayi Li, Minghua Xiang, Jiahao Liu, Wei Mu, Li Zhu, Xuejiao Zhao, Gordon B. Mills, Qinglei Gao, Yong Fang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3997.
https://doi.org/10.1158/1538-7445.AM2024-3997
Published: 22 March 2024
View article titled, Abstract 3997: PARP inhibitors plus anlotinib as bridging therapy for TGFβ-insensitive CAR-T cell therapy targeting MSLN and CD19 in advanced ovarian cancer
Journal Articles

Abstract 5280: Minimizes T cells DNA damage induced by PARP inhibitors and enhances its anti-tumor efficacy

Jiahao Liu, Xiaofei Jiao, Wei Mu, Huayi Li, Li Zhu, Xuejiao Zhao, Gordon B. Mills, Qinglei Gao, Yong Fang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5280.
https://doi.org/10.1158/1538-7445.AM2024-5280
Published: 22 March 2024
View article titled, Abstract 5280: Minimizes T cells DNA damage induced by PARP inhibitors and enhances its anti-tumor efficacy
Journal Articles

Abstract 5279: Sequential treatment with PARPi and WEE1i minimizes T cell DNA damage and enhances its immune response

Xiaofei Jiao, Jiahao Liu, Wei Mu, Li Zhu, Xuejiao Zhao, Gordon B. Mills, Qinglei Gao, Yong Fang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5279.
https://doi.org/10.1158/1538-7445.AM2024-5279
Published: 22 March 2024
View article titled, Abstract 5279: Sequential treatment with PARPi and WEE1i minimizes T cell DNA damage and enhances its immune response
Journal Articles

Abstract A064: Study of molecular pathways involved in the development of ovarian cancer brain metastases

Korina Mouzakitis, Nathan McMahon, Hongli Ma, Gordon B. Mills, Tanja Pejovic, Marilyne Labrie
Journal: Cancer Research
Cancer Res (2024) 84 (5_Supplement_2): A064.
https://doi.org/10.1158/1538-7445.OVARIAN23-A064
Published: 04 March 2024
View article titled, Abstract A064: Study of molecular pathways involved in the development of ovarian cancer brain metastases
Journal Articles

Abstract C087: Window-of-opportunity trial of metastatic pancreatic cancer reveals mechanisms of response to targeting RAS signaling

Motoyuki Tsuda, Colin J. Daniel, Carl Pelz, Sam Sivagnanam, Dove Keith, Christopher L. Corless, Koei Chin, Lisa M. Coussens, Jonathan R. Brody, Charles D. Lopez, Gordon B. Mills, Rosalie C. Sears
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): C087.
https://doi.org/10.1158/1538-7445.PANCA2023-C087
Published: 16 January 2024
View article titled, Abstract C087: Window-of-opportunity trial of metastatic pancreatic cancer reveals mechanisms of response to targeting RAS signaling
Journal Articles

Abstract B018: RNR inhibitors enhance chemotherapeutic activity in pancreatic cancer cells through altering replication stress

Soon Young Park, Kang Jing Jeong, Alfonso Poire, Isabel English, Jonathan R. Brody, Rosalie C. Sears, Gordon B. Mills
Journal: Cancer Research
Cancer Res (2024) 84 (1_Supplement): B018.
https://doi.org/10.1158/1538-7445.DNAREPAIR24-B018
Published: 09 January 2024
View article titled, Abstract B018: RNR inhibitors enhance chemotherapeutic activity in pancreatic cancer cells through altering replication stress
Journal Articles

Abstract 6618: Longitudinal, multimodal profiling of metastatic ER+ breast cancer on CDK4/6 inhibitor therapy

Allison L. Creason, Julian Egger, Cameron Watson, Shamilene Sivagnanam, Jia-Ren Lin, Koei Chin, Peter K. Sorger, Lisa M. Coussens, Zahi I. Mitri, Joe W. Gray, Gordon B. Mills, Jeremy Goecks
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6618.
https://doi.org/10.1158/1538-7445.AM2023-6618
Published: 04 April 2023
View article titled, Abstract 6618: Longitudinal, multimodal profiling of metastatic ER+ breast cancer on CDK4/6 inhibitor therapy
Journal Articles

Abstract 4916: Spatial analysis of local drug induced changes in tumor microenvironment predicts effective treatment combinations in breast cancer

Zuzana Tatarova, Dylan C. Blumberg, Gordon B. Mills, Lisa M. Coussens, Oliver Jonas, Joe W. Gray
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4916.
https://doi.org/10.1158/1538-7445.AM2023-4916
Published: 04 April 2023
View article titled, Abstract 4916: Spatial analysis of local drug induced changes in tumor microenvironment predicts effective treatment combinations in breast cancer
Journal Articles

Abstract 5610: [18F]FluorThanatrace ([18F]FTT) PET Imaging of PARP-inhibitor drug-target engagement as a biomarker of response in ovarian cancer

Sarah B. Gitto, Austin R. Pantel, Mehran Makvandi, Hyoung Kim, Sergey Medvedev, Joanna K. Weeks, Drew A. Torigian, Chia-Ju Hsieh, Benjamin Ferman, Nawar A. Latif, Janos L. Tanyi, Lainie P. Martin, Shannon M. Lanzo, Fang Liu, Quy Cao, Gordon B. Mills, Robert K. Doot, David A. Mankoff, Robert H. Mach, Lilie L. Lin, Fiona Simpkins
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5610.
https://doi.org/10.1158/1538-7445.AM2023-5610
Published: 04 April 2023
View article titled, Abstract 5610: [<sup>18</sup>F]FluorThanatrace ([<sup>18</sup>F]FTT) PET Imaging of PARP-inhibitor drug-target engagement as a biomarker of response in ovarian cancer
Journal Articles

Abstract 3445: Immune cells infiltration and activation are higher in breast cancers resistant to antiestrogen therapy

Fabiana Napolitano, Dhivya R. Sudhan, Yunguan Wang, Paula I. González-Ericsson, Luigi Formisano, Kyung-Min Lee, Chang-Ching Lin, María Rosario Chica-Parrado, Hongli Ma, Nathaniel Evans, Alberto Servetto, Saurabh Mendiratta, Spencer Barnes, Yisheng V. Fang, Justin M. Balko, Gordon B. Mills, Marilyne Labrie, Ariella B. Hanker, Carlos L. Arteaga
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3445.
https://doi.org/10.1158/1538-7445.AM2023-3445
Published: 04 April 2023
View article titled, Abstract 3445: Immune cells infiltration and activation are higher in breast cancers resistant to antiestrogen therapy
Journal Articles

Landscape of MicroRNA Regulatory Network Architecture and Functional Rerouting in Cancer

Xu Hua, Yongsheng Li, Sairahul R. Pentaparthi, Daniel J. McGrail, Raymond Zou, Li Guo, Aditya Shrawat, Kara M. Cirillo, Qing Li, Akshay Bhat, Min Xu, Dan Qi, Ashok Singh, Francis McGrath, Steven Andrews, Kyaw Lwin Aung, Jishnu Das, Yunyun Zhou, Alessia Lodi, Gordon B. Mills, S. Gail Eckhardt, Marc L. Mendillo, Stefano Tiziani, Erxi Wu, Jason H. Huang, Nidhi Sahni, S. Stephen Yi
Journal: Cancer Research
Cancer Res (2023) 83 (1): 59–73.
https://doi.org/10.1158/0008-5472.CAN-20-0371
Published: 04 January 2023
View article titled, Landscape of MicroRNA Regulatory Network Architecture and Functional Rerouting in Cancer
Open the PDF for Landscape of MicroRNA Regulatory Network Architecture and Functional Rerouting in Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 3233: Interleukin enhancer-binding factor 2 amplification controls mRNA stability and enhances DNA damage response in metastatic melanoma

Xiaoqing Zhang, Matias A. Bustos, Rebecca Gross, Romela Irene Ramos, Teh-Ling Takeshima, Gordon B. Mills, Qiang Yu, Dave S. Hoon
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3233.
https://doi.org/10.1158/1538-7445.AM2022-3233
Published: 15 June 2022
View article titled, Abstract 3233: Interleukin enhancer-binding factor 2 amplification controls mRNA stability and enhances DNA damage response in metastatic melanoma
Journal Articles

Abstract 3935: The polymeric fluoropyrimidine CF10 overcomes limitations of 5-FU in pancreatic ductal adenocarcinoma cells through increased replication stress

Roberto DiNiro, Alex O. Haber, Kang J. Jeong, Soon Y. Park, Gordon B. Mills, William H. Gmeiner, Jonathan R. Brody
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3935.
https://doi.org/10.1158/1538-7445.AM2022-3935
Published: 15 June 2022
View article titled, Abstract 3935: The polymeric fluoropyrimidine CF10 overcomes limitations of 5-FU in pancreatic ductal adenocarcinoma cells through increased replication stress
Journal Articles

Abstract 2149: Biomarker-driven selection of polyADP ribose polymerase inhibitors (PARPi)-based combination therapies in patients with metastatic triple negative breast cancer (mTNBC)

Zahi I. Mitri, Evthokia A. Hobbs, Shaun M. Goodyear, Jeong Youn Lim, Joanna Pucilowska, Brett Johnson, Allison L. Creason, Courtney Betts, Lisa M. Coussens, Shannon McWeeney, Christopher L. Corless, Joe W. Gray, Gordon B. Mills
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2149.
https://doi.org/10.1158/1538-7445.AM2022-2149
Published: 15 June 2022
View article titled, Abstract 2149: Biomarker-driven selection of polyADP ribose polymerase inhibitors (PARPi)-based combination therapies in patients with metastatic triple negative breast cancer (mTNBC)
Journal Articles

Abstract P5-13-05: Multiplex spatial systems analysis of responses to spatially separate nanoliter doses of drug predicts systemic immune-modulating combination treatments in breast cancer

Zuzana Tatarova, Dylan C Blumberg, Lisa M Coussens, Gordon B Mills, Oliver Jonas, Joe W Gray
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P5-13-05.
https://doi.org/10.1158/1538-7445.SABCS21-P5-13-05
Published: 15 February 2022
View article titled, Abstract P5-13-05: Multiplex spatial systems analysis of responses to spatially separate nanoliter doses of drug predicts systemic immune-modulating combination treatments in breast cancer
Journal Articles

Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance

Jianglan Liu, Vito W. Rebecca, Andrew V. Kossenkov, Thomas Connelly, Qin Liu, Alexis Gutierrez, Min Xiao, Ling Li, Gao Zhang, Anastasia Samarkina, Delaine Zayasbazan, Jie Zhang, Chaoran Cheng, Zhi Wei, Gretchen M. Alicea, Mizuho Fukunaga-Kalabis, Clemens Krepler, Pedro Aza-Blanc, Chih-Cheng Yang, Bela Delvadia, Cynthia Tong, Ye Huang, Maya Delvadia, Alice S. Morias, Katrin Sproesser, Patricia Brafford, Joshua X. Wang, Marilda Beqiri, Rajasekharan Somasundaram, Adina Vultur, Denitsa M. Hristova, Lawrence W. Wu, Yiling Lu, Gordon B. Mills, Wei Xu, Giorgos C. Karakousis, Xiaowei Xu, Lynn M. Schuchter, Tara C. Mitchell, Ravi K. Amaravadi, Lawrence N. Kwong, Dennie T. Frederick, Genevieve M. Boland, Joseph M. Salvino, David W. Speicher, Keith T. Flaherty, Ze'ev A. Ronai, Meenhard Herlyn
Journal: Cancer Research
Cancer Res (2021) 81 (20): 5230–5241.
https://doi.org/10.1158/0008-5472.CAN-20-1496
Published: 15 October 2021
View article titled, Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance
Open the PDF for Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance in another window
Includes: Supplementary data
Journal Articles

Abstract LB010: SMMART Program: A multi-omics tumor board with a focus on breast cancer

Ben L. Kong, Brett E. Johnson, Jamie M. Keck, Souraya Mitri, Patrick Leyshock, Jayne M. Stommel, Kiara Siex, Marlana Klinger, Christina L. Zheng, Rochelle Williams-Belizaire, Shannon McWeeney, Jeremy Goecks, Annette Kolodzie, Alexander R. Guimaraes, George V. Thomas, Christopher L. Corless, Zahi I. Mitri, Joe W. Gray, Gordon B. Mills, Raymond C. Bergan
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB010.
https://doi.org/10.1158/1538-7445.AM2021-LB010
Published: 01 July 2021
View article titled, Abstract LB010: SMMART Program: A multi-omics tumor board with a focus on breast cancer