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Journal Articles

Abstract 4771: The oncogenic kinase Bcr-Abl regulates splicing of Bcl-x trough a quaternary complex coordinated by Nck-beta and Sam68 adapter proteins

Valentina Rosso, Monica Pradotto, Sonia Carturan, Francesca Arruga, Giuseppe Saglio, Daniela Cilloni, Enrico Bracco

Cancer Res (2011) 71 (8_Supplement): 4771.

https://doi.org/10.1158/1538-7445.AM2011-4771

Published: 15 April 2011

View article titled, Abstract 4771: The oncogenic kinase Bcr-Abl regulates splicing of Bcl-x trough a quaternary complex coordinated by Nck-beta and Sam68 adapter proteins

Journal Articles

Abstract 5448: Pharmacogenetics of drug transporters may be useful to identify chronic myeloid leukemia patients who are less likely to achieve molecular responses to imatinib: Implications for treatment optimization in the era of new tyrosine kinase inhibitors

Simona Soverini, Sabrina Angelini, Matt Barnett, Gloria Ravegnini, Fabrizio Pane, Timothy P. Hughes, Deborah White, Dong-Wook Kim, Giuseppe Saglio, Gianantonio Rosti, Richard Woodman, Richard Woodman, Patrizia Hrelia, Guido Biasco, Michele Baccarani, Giovanni Martinelli

Cancer Res (2011) 71 (8_Supplement): 5448.

https://doi.org/10.1158/1538-7445.AM2011-5448

Published: 15 April 2011

View article titled, Abstract 5448: Pharmacogenetics of drug transporters may be useful to identify chronic myeloid leukemia patients who are less likely to achieve molecular responses to imatinib: Implications for treatment optimization in the era of new tyrosine kinase inhibitors

Journal Articles

Abstract 651: Whole transcriptome sequencing of Philadelphia positive acute lymphoblastic leukemia (ALL) by RNA-seq: an exhaustive overview of novel point mutations, gene expression and alternative splicing profiles

Cancer Res (2010) 70 (8_Supplement): 651.

https://doi.org/10.1158/1538-7445.AM10-651

Published: 15 April 2010

View article titled, Abstract 651: Whole transcriptome sequencing of Philadelphia positive acute lymphoblastic leukemia (ALL) by RNA-seq: an exhaustive overview of novel point mutations, gene expression and alternative splicing profiles

Journal Articles

Abstract 656: High-resolution molecular allelokaryotyping identifies novel genomic alterations in acute promyelocytic leukemia (APL)

Ilaria Iacobucci, Emanuela Ottaviani, Viviana Guadagnuolo, Annalisa Lonetti, Nicoletta Testoni, Cristina Papayannidis, Stefania Paolini, Daniela Cilloni, Francesca Messa, Anna Candoni, Francesca Arruga, Giuseppe Saglio, Michela Rondoni, Fabrizio Pane, Hasan Syed Khizer, Michele Baccarani, Francesco Lo Coco, Giovanni Martinelli

Cancer Res (2010) 70 (8_Supplement): 656.

https://doi.org/10.1158/1538-7445.AM10-656

Published: 15 April 2010

View article titled, Abstract 656: High-resolution molecular allelokaryotyping identifies novel genomic alterations in acute promyelocytic leukemia (APL)

Journal Articles

Abstract 1805: Improving on Imatinib for targeted therapy of chronic myeloid leukemia: First line treatment with Nilotinib 800 mg daily results in unprecedentedly high rate of rapid, “deep” and stable molecular responses - Results of a phase 2 trial of the GIMEMA CML working party

Cancer Res (2010) 70 (8_Supplement): 1805.

https://doi.org/10.1158/1538-7445.AM10-1805

Published: 15 April 2010

View article titled, Abstract 1805: Improving on Imatinib for targeted therapy of chronic myeloid leukemia: First line treatment with Nilotinib 800 mg daily results in unprecedentedly high rate of rapid, “deep” and stable molecular responses - Results of a phase 2 trial of the GIMEMA CML working party

Journal Articles

Abstract 1600: Molecular Characterization of PAX5 alterations in Adult BCR-ABL1-Positive Acute Lymphoblastic Leukemia (ALL)

Annalisa Lonetti, Ilaria Iacobucci, Cristina Papayannidis, Anna Ferrari, Viviana Guadagnuolo, Daniela Cilloni, Francesca Messa, Stefania Paolini, Sabina Chiaretti, Simona Soverini, Giuseppe Saglio, Fabrizio Pane, Michele Baccarani, Robin Foà, Giovanni Martinelli

Cancer Res (2010) 70 (8_Supplement): 1600.

https://doi.org/10.1158/1538-7445.AM10-1600

Published: 15 April 2010

View article titled, Abstract 1600: Molecular Characterization of PAX5 alterations in Adult BCR-ABL1-Positive Acute Lymphoblastic Leukemia (ALL)

Journal Articles

Abstract 251: Disabled gene is involved in CML progression and its expression level at diagnosis can predict major molecular response (MMR) to imatinib therapy

Cancer Res (2010) 70 (8_Supplement): 251.

https://doi.org/10.1158/1538-7445.AM10-251

Published: 15 April 2010

View article titled, Abstract 251: Disabled gene is involved in CML progression and its expression level at diagnosis can predict major molecular response (MMR) to imatinib therapy

Journal Articles

Abstract 246: Genome-wide screening for dominant modifiers in Drosophila identified new genes involved in BCR-ABL signaling and chronic myeloid leukemia (CML) progression

Monica Pradotto, Francesca Messa, Francesca Arruga, Roberto Bernardoni, Enrico Bracco, Chiara Maffè, Emanuela Messa, Sonia Carturan, Chiara Zanone, Elisabetta Greco, Ilaria Iacobucci, Elisabetta Signorino, Valentina Gaidano, Antonia Rotolo, Giovanni Martinelli, Michele Baccarani, Giuseppe Saglio, Daniela Cilloni

Cancer Res (2010) 70 (8_Supplement): 246.

https://doi.org/10.1158/1538-7445.AM10-246

Published: 15 April 2010

View article titled, Abstract 246: Genome-wide screening for dominant modifiers in Drosophila identified new genes involved in BCR-ABL signaling and chronic myeloid leukemia (CML) progression

Journal Articles

Abstract #1287: IKZF1 (Ikaros) Deletions are a frequent event in BCR-ABL1 Positive Acute Lymphoblastic Leukemia (ALL) and are associated with an impaired B-cell differentiation and poor outcome: A GIMEMA ALL Working Party Report

Cancer Res (2009) 69 (9_Supplement): 1287.

Published: 01 May 2009

View article titled, Abstract #1287: IKZF1 (Ikaros) Deletions are a frequent event in BCR-ABL1 Positive Acute Lymphoblastic Leukemia (ALL) and are associated with an impaired B-cell differentiation and poor outcome: A GIMEMA ALL Working Party Report

Journal Articles

Abstract #743: RASGRP1/APTX ratio is a strong biomarker which predicts response to therapy with Tipifarnib plus Bortezomib in elderly patients with Acute Myeloid Leukemia (AML)

Cancer Res (2009) 69 (9_Supplement): 743.

Published: 01 May 2009

View article titled, Abstract #743: RASGRP1/APTX ratio is a strong biomarker which predicts response to therapy with Tipifarnib plus Bortezomib in elderly patients with Acute Myeloid Leukemia (AML)

Journal Articles

Abstract #3597: A phase I study of Tipifarnib and Bortezomib in the treatment of poor risk adult acute myeloid leukemia (AML)

Cristina Papayannidis, Stefania Paolini, Barbara Lama, Emanuela Ottaviani, Federica Salmi, Ilaria Iacobucci, Antonio Curti, Daniela Cilloni, Sarah Parisi, Giuseppe Saglio, Renato Fanin, Fortunato Morabito, Maria Pantaleo, Pier Luigi Lollini, Michele Baccarani, Giovanni Martinelli

Cancer Res (2009) 69 (9_Supplement): 3597.

Published: 01 May 2009

View article titled, Abstract #3597: A phase I study of Tipifarnib and Bortezomib in the treatment of poor risk adult acute myeloid leukemia (AML)

Journal Articles

Abstract #5619: Expression of different isoforms of the B-cell mutator activation-induced cytidine deaminase (AID) in BCR-ABL1-Positive Acute Lymphoblastic Leukemia (ALL) Patients

Cancer Res (2009) 69 (9_Supplement): 5619.

Published: 01 May 2009

View article titled, Abstract #5619: Expression of different isoforms of the B-cell mutator activation-induced cytidine deaminase (AID) in BCR-ABL1-Positive Acute Lymphoblastic Leukemia (ALL) Patients

Journal Articles

Abstract #5611: Identification of new genes sustaining Bcr-Abl oncogenic signalling and CML progression through a genetic tool based on human Bcr-Abl transgenic Drosophila melanogaster (Dm)

Francesca Messa, Roberto Bernardoni, Francesca Arruga, Monica Pradotto, Chiara Maffè, Enrico Bracco, Cristina Panuzzo, Emanuela Messa, Ilaria Iacobucci, Sonia Carturan, Marco Leone, Antonia Rotolo, Elisabetta Greco, Giovanni Martinelli, Michele Baccarani, Giuseppe Saglio, Daniela Cilloni

Cancer Res (2009) 69 (9_Supplement): 5611.

Published: 01 May 2009

View article titled, Abstract #5611: Identification of new genes sustaining Bcr-Abl oncogenic signalling and CML progression through a genetic tool based on human Bcr-Abl transgenic Drosophila melanogaster (Dm)

Journal Articles

Abstract #2866: EphA3 is abnormally expressed in chronic myeloprolipherative disorders and could represent a new molecular target

Francesca Arruga, Francesca Messa, Sonia Carturan, Monica Pradotto, Chiara Maffè, Marisa Pautasso, Cristina Panuzzo, Ilaria Iacobucci, Enrico Bracco, Emanuela Messa, Marco Leone, Elisabetta Greco, Antonia Rotolo, Paolo Vigneri, Giovanni Martinelli, Michele Baccarani, Martin Lackmann, Giuseppe Saglio, Daniela Cilloni

Cancer Res (2009) 69 (9_Supplement): 2866.

Published: 01 May 2009

View article titled, Abstract #2866: EphA3 is abnormally expressed in chronic myeloprolipherative disorders and could represent a new molecular target

Journal Articles

Abstract #2870: Identification of the involvement of the tyrosine kinase c-Ros in the pathogenesis of chronic myelomonocytic leukemia (CMML)

Sonia Carturan, Enrico Bracco, Chiara Maffè, Ilaria Iacobucci, Francesca Messa, Francesca Arruga, Monica Pradotto, Marisa Pautasso, Paolo Fornaciari, Emanuela Messa, Cristina Panuzzo, Marco Leone, Giovanni Martinelli, Michele Baccarani, Gianluca Gaidano, Giuseppe Saglio, Daniela Cilloni

Cancer Res (2009) 69 (9_Supplement): 2870.

Published: 01 May 2009

View article titled, Abstract #2870: Identification of the involvement of the tyrosine kinase c-Ros in the pathogenesis of chronic myelomonocytic leukemia (CMML)

Journal Articles

The Bcr-Abl kinase promotes aberrant expression of spliced oncogenic Ikaros isoforms in Philadelphia (Ph) positive acute lymphoblastic leukemia (ALL) patients treated with tyrosine kinase inhibitors

Ilaria Iacobucci, Annalisa Lonetti, Emanuela Ottaviani, Daniela Cilloni, Francesca Messa, Stefania Paolini, Cristina Papayannidis, Pier Paolo Piccaluga, Panagiota Giannoulia, Simona Soverini, Marilina Amabile, Giuseppe Saglio, Fabrizio Pane, Giorgio Berton, Anna Baruzzi, Antonella Vitale, Robin Foa, Michele Baccarani, Giovanni Martinelli

Cancer Res (2008) 68 (9_Supplement): 5515.

Published: 01 May 2008

View article titled, The Bcr-Abl kinase promotes aberrant expression of spliced oncogenic Ikaros isoforms in Philadelphia (Ph) positive acute lymphoblastic leukemia (ALL) patients treated with tyrosine kinase inhibitors

Journal Articles

FoxO transcription factor is delocalized in CML patients by Bcr-Abl induced PI3K/AKT activation and IKK pathway and can be reactivated by Imatinib treatment

Francesca Arruga, Cristina Panuzzo, Francesca Messa, Paolo Nicoli, Emanuela Messa, Simona Soverini, Ilaria Iacobucci, Giovanni Martinelli, Michele Baccarani, Antonia Rotolo, Enrico Bracco, Thea Kalebic, Giuseppe Saglio, Daniela Cilloni

Cancer Res (2008) 68 (9_Supplement): 4397.

Published: 01 May 2008

View article titled, FoxO transcription factor is delocalized in CML patients by Bcr-Abl induced PI3K/AKT activation and IKK pathway and can be reactivated by Imatinib treatment

Journal Articles

Drosophila melanogaster (Dm): a promising genetic tool for identification of candidate genes and pathways involved in CML progression and drug testing

Francesca Messa, Francesca Arruga, Emanuela Messa, Enrico Bracco, Cristina Panuzzo, Maria Pantaleo, Ilaria Iacobucci, Giovanni Martinelli, Thea Kalebic, Michele Baccarani, Antonia Rotolo, Fabian Feiguin, Roberto Bernardoni, Giuseppe Saglio, Daniela Cilloni

Cancer Res (2008) 68 (9_Supplement): 391.

Published: 01 May 2008

View article titled, Drosophila melanogaster (Dm): a promising genetic tool for identification of candidate genes and pathways involved in CML progression and drug testing

Journal Articles

Alternative BCR/ABL Splice Variants in Philadelphia Chromosome–Positive Leukemias Result in Novel Tumor-Specific Fusion Proteins that May Represent Potential Targets for Immunotherapy Approaches

Gisella Volpe, Alessandro Cignetti, Cristina Panuzzo, Mirela Kuka, Katiuscia Vitaggio, Mara Brancaccio, Giuseppe Perrone, Monica Rinaldi, Giuseppina Prato, Milena Fava, Massimo Geuna, Marisa Pautasso, Claudia Casnici, Emanuela Signori, Giancarlo Tonon, Guido Tarone, Ornella Marelli, Vito M. Fazio, Giuseppe Saglio

Cancer Res (2007) 67 (11): 5300–5307.

https://doi.org/10.1158/0008-5472.CAN-06-3737

Published: 01 June 2007

View article titled, Alternative BCR/ABL Splice Variants in Philadelphia Chromosome–Positive Leukemias Result in Novel Tumor-Specific Fusion Proteins that May Represent Potential Targets for Immunotherapy Approaches

Journal Articles

Imatinib treatment of Philadelphia positive (Ph+) chronic myeloid leukemia (CML). For late chronic phase patients who achieve a complete cytogenetic response 5-year survival is as high as for early chronic phase patients

Ilaria Iacobucci, Giovanni Martinelli, Marilina Amabile, Angela Poerio, Simona Soverini, Fausto Castagnetti, Sabrina Colarossi, Alessandra Gnani, Nicoletta Testoni, Massimo Breccia, Elisabetta Abruzzese, Bruno Martino, Daniela Cilloni, Giuseppe Saglio, Fabrizio Pane, Gianantonio Rosti, Guido Biasco, Michele Baccarani

Cancer Res (2007) 67 (9_Supplement): 2639.

Published: 01 May 2007

View article titled, Imatinib treatment of Philadelphia positive (Ph+) chronic myeloid leukemia (CML). For late chronic phase patients who achieve a complete cytogenetic response 5-year survival is as high as for early chronic phase patients

NARROW

Abstract 4771: The oncogenic kinase Bcr-Abl regulates splicing of Bcl-x trough a quaternary complex coordinated by Nck-beta and Sam68 adapter proteins

Abstract 5448: Pharmacogenetics of drug transporters may be useful to identify chronic myeloid leukemia patients who are less likely to achieve molecular responses to imatinib: Implications for treatment optimization in the era of new tyrosine kinase inhibitors

Abstract 651: Whole transcriptome sequencing of Philadelphia positive acute lymphoblastic leukemia (ALL) by RNA-seq: an exhaustive overview of novel point mutations, gene expression and alternative splicing profiles

Abstract 656: High-resolution molecular allelokaryotyping identifies novel genomic alterations in acute promyelocytic leukemia (APL)

Abstract 1805: Improving on Imatinib for targeted therapy of chronic myeloid leukemia: First line treatment with Nilotinib 800 mg daily results in unprecedentedly high rate of rapid, “deep” and stable molecular responses - Results of a phase 2 trial of the GIMEMA CML working party

Abstract 1600: Molecular Characterization of PAX5 alterations in Adult BCR-ABL1-Positive Acute Lymphoblastic Leukemia (ALL)

Abstract 251: Disabled gene is involved in CML progression and its expression level at diagnosis can predict major molecular response (MMR) to imatinib therapy

Abstract 246: Genome-wide screening for dominant modifiers in Drosophila identified new genes involved in BCR-ABL signaling and chronic myeloid leukemia (CML) progression

Abstract #1287: IKZF1 (Ikaros) Deletions are a frequent event in BCR-ABL1 Positive Acute Lymphoblastic Leukemia (ALL) and are associated with an impaired B-cell differentiation and poor outcome: A GIMEMA ALL Working Party Report

Abstract #743: RASGRP1/APTX ratio is a strong biomarker which predicts response to therapy with Tipifarnib plus Bortezomib in elderly patients with Acute Myeloid Leukemia (AML)

Abstract #3597: A phase I study of Tipifarnib and Bortezomib in the treatment of poor risk adult acute myeloid leukemia (AML)

Abstract #5619: Expression of different isoforms of the B-cell mutator activation-induced cytidine deaminase (AID) in BCR-ABL1-Positive Acute Lymphoblastic Leukemia (ALL) Patients

Abstract #5611: Identification of new genes sustaining Bcr-Abl oncogenic signalling and CML progression through a genetic tool based on human Bcr-Abl transgenic Drosophila melanogaster (Dm)

Abstract #2866: EphA3 is abnormally expressed in chronic myeloprolipherative disorders and could represent a new molecular target

Abstract #2870: Identification of the involvement of the tyrosine kinase c-Ros in the pathogenesis of chronic myelomonocytic leukemia (CMML)

The Bcr-Abl kinase promotes aberrant expression of spliced oncogenic Ikaros isoforms in Philadelphia (Ph) positive acute lymphoblastic leukemia (ALL) patients treated with tyrosine kinase inhibitors

FoxO transcription factor is delocalized in CML patients by Bcr-Abl induced PI3K/AKT activation and IKK pathway and can be reactivated by Imatinib treatment

Drosophila melanogaster (Dm): a promising genetic tool for identification of candidate genes and pathways involved in CML progression and drug testing

Alternative BCR/ABL Splice Variants in Philadelphia Chromosome–Positive Leukemias Result in Novel Tumor-Specific Fusion Proteins that May Represent Potential Targets for Immunotherapy Approaches

Imatinib treatment of Philadelphia positive (Ph+) chronic myeloid leukemia (CML). For late chronic phase patients who achieve a complete cytogenetic response 5-year survival is as high as for early chronic phase patients

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