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Journal Articles

The Novel Tubulin-Targeting Agent Pyrrolo-1,5-Benzoxazepine-15 Induces Apoptosis in Poor Prognostic Subgroups of Chronic Lymphocytic Leukemia

Anthony M. McElligott, Elaina N. Maginn, Lisa M. Greene, Siobhan McGuckin, Amjad Hayat, Paul V. Browne, Stefania Butini, Giuseppe Campiani, Mark A. Catherwood, Elisabeth Vandenberghe, D. Clive Williams, Daniela M. Zisterer, Mark Lawler

Cancer Res (2009) 69 (21): 8366–8375.

DOI: https://doi.org/10.1158/0008-5472.CAN-09-0131

Published: 28 October 2009

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Includes: Supplementary data

Journal Articles

Paclitaxel Directly Binds to Bcl-2 and Functionally Mimics Activity of Nur77

Cristiano Ferlini, Lucia Cicchillitti, Giuseppina Raspaglio, Silvia Bartollino, Samanta Cimitan, Carlo Bertucci, Simona Mozzetti, Daniela Gallo, Marco Persico, Caterina Fattorusso, Giuseppe Campiani, Giovanni Scambia

Cancer Res (2009) 69 (17): 6906–6914.

DOI: https://doi.org/10.1158/0008-5472.CAN-09-0540

Published: 31 August 2009

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Includes: Supplementary data

Journal Articles

Abstract #5568: A novel tubulin depolymerization agent, PBOX-15, induces caspase-8 and JNK activation dependent apoptosis in CLL cells, including those isolated from patients with poor prognostic indicators

Anthony McElligott, Elaina Maginn, Lisa Greene, Amjad Hayat, Paul Browne, Giuseppe Campiani, Elisabeth Vandenberghe, D. Williams, Daniela Zisterer, Mark Lawler

Cancer Res (2009) 69 (9_Supplement): 5568.

Published: 01 May 2009

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Journal Articles

Pyrrolo-1,5-benzoxazepine (PBOX)-15, a novel tubulin depolymerization agent, induces apoptosis of multiple myeloma cells in vitro

Elaina Maginn, Anthony McElligott, Giuseppe Campiani, D Clive Williams, Daniela Zisterer, Paul Browne, Mark Lawler

Cancer Res (2007) 67 (9_Supplement): 1420.

Published: 01 May 2007

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Journal Articles

A novel microtubule depolymerization agent, PBOX-15, induces apoptosis in non-proliferating chronic lymphocytic leukemia cells ex vivo.

Anthony McElligott, Elaina Maginn, Lisa Greene, Elisabeth Vandenberghe, Amjad Hayat, Paul Browne, Giuseppe Campiani, D. Williams, Daniela Zisterer, Mark Lawler

Cancer Res (2007) 67 (9_Supplement): 1443.

Published: 01 May 2007

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Journal Articles

Pyrrolo-1,5-benzoxazapine (PBOX)-15 potently induces apoptosis in childhood acute lymphoblastic leukaemia and regulates cytokine gene expression

Joanne Lysaght, Giuseppe Campiani, Clive Williams, Daniela Zisterer, Owen Smith, Mark Lawler

Cancer Res (2007) 67 (9_Supplement): 1919.

Published: 01 May 2007

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Journal Articles

Pyrrolo-1,5-benzoxazepines induce apoptosis in chronic B-lymphoid malignancies

Anthony M. McElligott, Elaina N. Maginn, Lisa M. Greene, Elizabeth Vandenberghe, Amjad Hayat, Margaret M. McGee, Giuseppe Campiani, Paul V. Browne, D. Clive Williams, Daniela M. Zisterer, Mark P. Lawler

Cancer Res (2006) 66 (8_Supplement): 899.

Published: 15 April 2006

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Journal Articles

The paradox of Bcl-2: How does paclitaxel convert Bcl-2 function from antiapoptotic to proapoptotic?

Cristiano Ferlini, Samanta Cimitan, Giuseppina Raspaglio, Lucia Cicchillitti, Carlo Bertucci, Giuseppe Campiani, Caterina Fattorusso, Marco Persico, Carla Manzotti, Antonella Riva, Giovanni Scambia

Cancer Res (2005) 65 (9_Supplement): 398–399.

Published: 01 May 2005

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Journal Articles

The Seco-Taxane IDN5390 Is Able to Target Class III β-Tubulin and to Overcome Paclitaxel Resistance

Cristiano Ferlini, Giuseppina Raspaglio, Simona Mozzetti, Lucia Cicchillitti, Flavia Filippetti, Daniela Gallo, Caterina Fattorusso, Giuseppe Campiani, Giovanni Scambia

Cancer Res (2005) 65 (6): 2397–2405.

DOI: https://doi.org/10.1158/0008-5472.CAN-04-3065

Published: 21 March 2005

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NARROW

The Novel Tubulin-Targeting Agent Pyrrolo-1,5-Benzoxazepine-15 Induces Apoptosis in Poor Prognostic Subgroups of Chronic Lymphocytic Leukemia

Paclitaxel Directly Binds to Bcl-2 and Functionally Mimics Activity of Nur77

Abstract #5568: A novel tubulin depolymerization agent, PBOX-15, induces caspase-8 and JNK activation dependent apoptosis in CLL cells, including those isolated from patients with poor prognostic indicators

Pyrrolo-1,5-benzoxazepine (PBOX)-15, a novel tubulin depolymerization agent, induces apoptosis of multiple myeloma cells in vitro

A novel microtubule depolymerization agent, PBOX-15, induces apoptosis in non-proliferating chronic lymphocytic leukemia cells ex vivo.

Pyrrolo-1,5-benzoxazapine (PBOX)-15 potently induces apoptosis in childhood acute lymphoblastic leukaemia and regulates cytokine gene expression

Pyrrolo-1,5-benzoxazepines induce apoptosis in chronic B-lymphoid malignancies

The paradox of Bcl-2: How does paclitaxel convert Bcl-2 function from antiapoptotic to proapoptotic?

The Seco-Taxane IDN5390 Is Able to Target Class III β-Tubulin and to Overcome Paclitaxel Resistance

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