1-20 of 34
Giulio F. Draetta
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Abstract 646: Unravelling the mechanisms of resistance and hyperprogression of renal medullary carcinoma to immune checkpoint therapy

Free
Jing Qian, Melinda Soeung, Xinmiao Yan, Kai Yu, Ciro Zanca, Li Zhang, Ziheng Chen, Luigi Perelli, Jianfeng Chen, Rebecca Slack Tidwell, Hania Khan, Fei Duan, Menuka Karki, Rong He, Courtney N. Le, Truong N.A. Lam, Nirjar Bhattacharya, Mariah N. Williams, David H. Peng, Rutvi Shah, I-Lin Ho, Ningping Feng, Niki Millward Zacharias, Rahul Anil Sheth, Tharakeswara K. Bathala, Priya Rao, Najat C. Daw, Durga N. Tripathi, Cheryl L. Walker, Ruiping Wang, Minghao Dang, Enyu Dai, Fuduan Peng, Yunhe Liu, Akshaya S. Jadhav, Wenhua Lang, Claudio A. Arrechedera, Leticia Campos Clemente, Hsinyi Lu, Cara L. Haymaker, Ignacio I. Wistuba, Andrew Futreal, Andrea Viale, Timothy Heffernan, Giulio F. Draetta, Nazir M. Tannir, Jianjun Gao, Linghua Wang, Giannicola Genovese, Pavlos Msaouel
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 646.
https://doi.org/10.1158/1538-7445.AM2025-646
Published: 21 April 2025
View articletitled, Abstract 646: Unravelling the mechanisms of resistance and hyperprogression of renal medullary carcinoma to immune checkpoint therapy
Journal Articles

Abstract 2702: Hyperprogression due to myeloid mimicry in renal medullary carcinoma treated with nivolumab plus ipilimumab

Free
Melinda Soeung, Xinmiao Yan, Li Zhang, Luigi Perelli, Jianfeng Chen, Becky Slack Tidwell, Hania Khan, Courtney N. Le, Truong N. Lam, Nirjar Bhattacharya, Rutvi Shah, I-Lin Ho, Ziheng Chen, Sebastian R. Lundgren, Ningping Feng, Ciro Zanca, Menuka Karki, Niki Marie Zacharias Millward, Rong He, Rahul A. Sheth, Bathala K. Tharakeswara, Priya Rao, Najat C. Daw, Durga N. Tripathi, Cheryl L. Walker, Guangchun Han, Yanshuo Chu, Ruiping Wang, Minghao Dang, Enyu Dai, Fuduan Peng, Yunhe Liu, Akshaya S. Jadhav, Wenhua Lang, Claudio A. Arrechedera, Leticia Campos Clemente, Edwin R. Parra-Cuentas, Hsinyi Lu, Cara Haymaker, Ignacio I. Wistuba, Andrew Futreal, Timothy Heffernan, Andrea Viale, Giulio F. Draetta, Nizar M. Tannir, Jianjun Gao, Linghua Wang, Giannicola Genovese, Pavlos Msaouel
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2702.
https://doi.org/10.1158/1538-7445.AM2024-2702
Published: 22 March 2024
View articletitled, Abstract 2702: Hyperprogression due to myeloid mimicry in renal medullary carcinoma treated with nivolumab plus ipilimumab
Journal Articles

Abstract 1758: Chromosome 3 copy number loss alone drives tumor evolution to aggressive disease in uveal melanoma

Free
Sanjana Srinivasan, Johnathon Rose, Rosalba Minelli, Christopher Terranova, Parth Shah, Joseph R. Daniele, Michael Peoples, Meng He, Chiu-Yi Liu, Jason Gay, Melinda Soeung, Sanjay Soni, Fangyang Wang, Christopher Bristow, Khalida Wani, Luigi Perelli, Dmitry Loza, Ningping Feng, Maxime Tarabichi, Peter Van Loo, Andrew Futreal, Scott Woodman, Alexander Lazar, Christopher P. Vellano, Joseph Marszalek, Giulio F. Draetta, Timothy Heffernan, Alessandro Carugo, Giannicola Genovese, Virginia Giuliani
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1758.
https://doi.org/10.1158/1538-7445.AM2024-1758
Published: 22 March 2024
View articletitled, Abstract 1758: Chromosome 3 copy number loss alone drives tumor evolution to aggressive disease in uveal melanoma
Journal Articles

Abstract 4304: Chromosome 3 dosage-loss informs on the unique biology underlying ultra high-risk uveal melanoma

Free
Johnathon Lynn Rose, Sanjana Srinivasan, Meng He, Rosalba Minelli, Chiu-Yi Liu, Christopher Terranova, Jason Gay, Joseph R. Daniele, Loza Dmitriy, Michael Peoples, Melinda Soeung, Vandhana Ramamoorthy, Parth Shah, Sanjay Soni, Christopher Bristow, Fangyang Wang, Anastasia Lopez, Charles Deckard, Brooke Meyers, Luigi Perelli, Khalida Wani, Ningping Feng, Christopher P. Vellano, Joe Marszalek, Alexander J. Lazar, Andrew Futreal, Giulio F. Draetta, Scott E. Woodman, Timothy Heffernan, Giannicola Genovese, Alessandro Carugo, Virginia Giuliani
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4304.
https://doi.org/10.1158/1538-7445.AM2024-4304
Published: 22 March 2024
View articletitled, Abstract 4304: Chromosome 3 dosage-loss informs on the unique biology underlying ultra high-risk uveal melanoma
Journal Articles

Abstract 92: Deploying spatial transcriptomics to inform intratumoral heterogeneity in late-stage uveal melanoma leveraging advanced preclinical modeling and clinical samples

Free
Sanjana Srinivasan, Johnathon Rose, Joseph R. Daniele, Michael Peoples, Meng He, Rosalba Minelli, Chiu-Yi Liu, Jason Gay, Melinda Soeung, Khalida Wani, Luigi Perelli, Dmitriy Loza, Ningping Feng, Christopher P. Vellano, Joseph Marszalek, Giulio F. Draetta, P. Andrew Futreal, Scott E. Woodman, Alexander J. Lazar, Timothy Heffernan, Alessandro Carugo, Giannicola Genovese, Virginia Giuliani
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 92.
https://doi.org/10.1158/1538-7445.AM2023-92
Published: 04 April 2023
View articletitled, Abstract 92: Deploying spatial transcriptomics to inform intratumoral heterogeneity in late-stage uveal melanoma leveraging advanced preclinical modeling and clinical samples
Journal Articles

Abstract 77: Recapitulating metastatic colorectal cancer in somatic mutation models for investigating the tumor immune microenvironment in minimal residual disease

Free
Alaa M. Mohamed, Melinda Soeung, Jumanah Alshenaifi, Natalie Fowlkes, Ganiraju Manyam, Jennifer Davis, Amanda Anderson, Will Norton, Angela K. Deem, Sisi Gao, Isha Khanduri, Christopher Bistow, Federica Carbone, Stefania Napolitano, Justin Huang, Dipen M. Maru, David G. Menter, Giulio F. Draetta, Giannicola Genovese, Scott Kopetz
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 77.
https://doi.org/10.1158/1538-7445.AM2023-77
Published: 04 April 2023
View articletitled, Abstract 77: Recapitulating metastatic colorectal cancer in somatic mutation models for investigating the tumor immune microenvironment in minimal residual disease
Journal Articles

Abstract 303: DPY30 loss leads to DNA re-replication and immunoediting in pancreatic ductal adenocarcinoma

Free
Francesca Citron, Luigi Perelli, Yanshuo Chu, Sanjana Srinivasan, I-Lin Ho, Er-Yen Yen, Rutvi Shah, Sergio Attanasio, Luis Castillo Montanez, Mauro Di Pilato, Shan Jiang, Wantong Yao, Sisi Gao, Angela Deem, Giannicola Genovese, Linghua Wang, Virginia Giuliani, Andrea Viale, Giulio F. Draetta
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 303.
https://doi.org/10.1158/1538-7445.AM2023-303
Published: 04 April 2023
View articletitled, Abstract 303: DPY30 loss leads to DNA re-replication and immunoediting in pancreatic ductal adenocarcinoma
Journal Articles

Abstract 94: Advanced preclinical modeling reveals unique monosomy 3 associated biology in late-stage uveal melanoma

Free
Johnathon L. Rose, Sanjana Srinivasan, Meng He, Rosalba Minelli, Chiu-Yi Liu, Jason Gay, Joseph R. Daniele, Michael Peoples, Melinda Soeung, Vandhana Ramamoorthy, Anastasia Lopez, Charles Deckard, Brooke Meyers, Edoardo Del Poggetto, Daniel Zamler, Justin Huang, Luigi Perelli, Khalida Wani, Christopher Bristow, Ningping Feng, Christopher P. Vellano, Joe Marszalek, Alexander J. Lazar, Andrew Futreal, Giulio F. Draetta, Scott E. Woodman, Timothy Heffernan, Giannicola Genovese, Alessandro Carugo, Virginia Giuliani
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 94.
https://doi.org/10.1158/1538-7445.AM2023-94
Published: 04 April 2023
View articletitled, Abstract 94: Advanced preclinical modeling reveals unique monosomy 3 associated biology in late-stage uveal melanoma
Journal Articles

Abstract 5750: The mutational landscape of ultraconserved elements in human cancers

Free
Recep Bayraktar, Yitao Tang, Mihnea P. Dragomir, Linda Fabris, Giulio F. Draetta, Han Liang, George A. Calin
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5750.
https://doi.org/10.1158/1538-7445.AM2023-5750
Published: 04 April 2023
View articletitled, Abstract 5750: The mutational landscape of ultraconserved elements in human cancers
Journal Articles

Abstract 2611: The NEDD8 pathway as a therapeutic target in HER2-amplified colorectal cancer

Free
Federica Invrea, Alessandro Carugo, Sabrina Arena, Alberto Bardelli, Giulio F. Draetta, Enzo Medico
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2611.
https://doi.org/10.1158/1538-7445.AM2022-2611
Published: 15 June 2022
View articletitled, Abstract 2611: The NEDD8 pathway as a therapeutic target in HER2-amplified colorectal cancer
Journal Articles

Oxidative Phosphorylation Is a Metabolic Vulnerability in Chemotherapy-Resistant Triple-Negative Breast Cancer

Open Access
Kurt W. Evans, Erkan Yuca, Stephen S. Scott, Ming Zhao, Natalia Paez Arango, Christian X. Cruz Pico, Turcin Saridogan, Maryam Shariati, Caleb A. Class, Christopher A. Bristow, Christopher P. Vellano, Xiaofeng Zheng, Ana Maria Gonzalez-Angulo, Xiaoping Su, Coya Tapia, Ken Chen, Argun Akcakanat, Bora Lim, Debu Tripathy, Timothy A. Yap, Maria Emilia Di Francesco, Giulio F. Draetta, Philip Jones, Timothy P. Heffernan, Joseph R. Marszalek, Funda Meric-Bernstam
Journal: Cancer Research
Cancer Res (2021) 81 (21): 5572–5581.
https://doi.org/10.1158/0008-5472.CAN-20-3242
Published: 01 November 2021
View articletitled, Oxidative Phosphorylation Is a Metabolic Vulnerability in Chemotherapy-Resistant Triple-Negative Breast Cancer
Open the PDF for Oxidative Phosphorylation Is a Metabolic Vulnerability in Chemotherapy-Resistant Triple-Negative Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract PD9-05: A tiered algorithm using mid-therapy ultrasound (US) response assessment and a novel gene expression signature (GES) improves the prediction of pathologic complete response (pCR) to neoadjuvant therapy (NAT) in triple-negative breast cancer (TNBC): Results from the ARTEMIS trial (NCT02276443)

Free
Sahil Seth, Gaiane M Rauch, Beatriz Adrada, Helen Piwnica-Worms, Lei Hou, Alastair M Thompson, William F Symmans, Bora Lim, Jason White, Giulio F Draetta, Andrew Futreal, Jeffrey Chang, Stacy Moulder
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PD9-05.
https://doi.org/10.1158/1538-7445.SABCS20-PD9-05
Published: 15 February 2021
View articletitled, Abstract PD9-05: A tiered algorithm using mid-therapy ultrasound (US) response assessment and a novel gene expression signature (GES) improves the prediction of pathologic complete response (pCR) to neoadjuvant therapy (NAT) in triple-negative breast cancer (TNBC): Results from the ARTEMIS trial (NCT02276443)
Journal Articles

Loss of ARID1A Promotes Epithelial–Mesenchymal Transition and Sensitizes Pancreatic Tumors to Proteotoxic Stress

Free
Hideo Tomihara, Federica Carbone, Luigi Perelli, Justin K. Huang, Melinda Soeung, Johnathon L. Rose, Frederick S. Robinson, Yonathan Lissanu Deribe, Ningping Feng, Mitsunobu Takeda, Akira Inoue, Edoardo Del Poggetto, Angela K. Deem, Anirban Maitra, Pavlos Msaouel, Nizar M. Tannir, Giulio F. Draetta, Andrea Viale, Timothy P. Heffernan, Christopher A. Bristow, Alessandro Carugo, Giannicola Genovese
Journal: Cancer Research
Series: Author Choice
Cancer Res (2021) 81 (2): 332–343.
https://doi.org/10.1158/0008-5472.CAN-19-3922
Published: 15 January 2021
View articletitled, Loss of ARID1A Promotes Epithelial–Mesenchymal Transition and Sensitizes Pancreatic Tumors to Proteotoxic Stress
Open the PDF for Loss of ARID1A Promotes Epithelial–Mesenchymal Transition and Sensitizes Pancreatic Tumors to Proteotoxic Stress in another window
Includes: Supplementary data
Journal Articles

Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib

Free
Yuting Sun, Brooke A. Meyers, Barbara Czako, Paul Leonard, Faika Mseeh, Angela L. Harris, Qi Wu, Sarah Johnson, Connor A. Parker, Jason B. Cross, Maria Emilia Di Francesco, Benjamin J. Bivona, Christopher A. Bristow, Jason P. Burke, Caroline C. Carrillo, Christopher L. Carroll, Qing Chang, Ningping Feng, Guang Gao, Sonal Gera, Virginia Giuliani, Justin K. Huang, Yongying Jiang, Zhijun Kang, Jeffrey J. Kovacs, Chiu-Yi Liu, Anastasia M. Lopez, Xiaoyan Ma, Pijus K. Mandal, Timothy McAfoos, Meredith A. Miller, Robert A. Mullinax, Michael Peoples, Vandhana Ramamoorthy, Sahil Seth, Nakia D. Spencer, Erika Suzuki, Christopher C. Williams, Simon S. Yu, Andy M. Zuniga, Giulio F. Draetta, Joseph R. Marszalek, Timothy P. Heffernan, Nancy E. Kohl, Philip Jones
Journal: Cancer Research
Series: Author Choice
Cancer Res (2020) 80 (21): 4840–4853.
https://doi.org/10.1158/0008-5472.CAN-20-1634
Published: 03 November 2020
View articletitled, Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib
Open the PDF for Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib in another window
Includes: Supplementary data
Journal Articles

Abstract 1935: The NEDD8 and EGFR pathways are independent therapeutic targets in colorectal cancer

Free
Federica Invrea, Alessandro Carugo, Consalvo Petti, Cristopher Bristow, Michael Peoples, Carlotta Cancelliere, Alessia Corrado, Alberto Bardelli, Claudio Isella, Giulio F. Draetta, Enzo Medico
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1935.
https://doi.org/10.1158/1538-7445.AM2020-1935
Published: 15 August 2020
View articletitled, Abstract 1935: The NEDD8 and EGFR pathways are independent therapeutic targets in colorectal cancer
Journal Articles

Abstract 1497: Longitudinal response and selection under neoadjuvant systemic therapy (NAST) in triple-negative breast cancer (TNBC): Profiling results from a randomized trial (ARTEMIS; NCT02276443)

Free
Sahil Seth, Lei Huo, Gaiane M. Rauch, Beatriz Adrada, Helen Piwnica-Worms, Bora Lim, Alastair M. Thompson, Elizabeth A. Mittendorf, Timothy Heffernan, Jennifer K. Litton, William F. Symmans, Giulio F. Draetta, Andrew P. Futreal, Jeffrey T. Chang, Stacy L. Moulder
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1497.
https://doi.org/10.1158/1538-7445.AM2020-1497
Published: 15 August 2020
View articletitled, Abstract 1497: Longitudinal response and selection under neoadjuvant systemic therapy (NAST) in triple-negative breast cancer (TNBC): Profiling results from a randomized trial (ARTEMIS; NCT02276443)
Journal Articles

Predictive Signatures Inform the Effective Repurposing of Decitabine to Treat KRAS–Dependent Pancreatic Ductal Adenocarcinoma

Free
Carla Mottini, Hideo Tomihara, Diego Carrella, Alessia Lamolinara, Manuela Iezzi, Justin K. Huang, Carla A. Amoreo, Simonetta Buglioni, Isabella Manni, Frederick S. Robinson, Rosalba Minelli, Ya'an Kang, Jason B. Fleming, Michael P. Kim, Christopher A. Bristow, Daniela Trisciuoglio, Antonella Iuliano, Donatella Del Bufalo, Diego Di Bernardo, Davide Melisi, Giulio F. Draetta, Gennaro Ciliberto, Alessandro Carugo, Luca Cardone
Journal: Cancer Research
Series: Author Choice
Cancer Res (2019) 79 (21): 5612–5625.
https://doi.org/10.1158/0008-5472.CAN-19-0187
Published: 01 November 2019
View articletitled, Predictive Signatures Inform the Effective Repurposing of Decitabine to Treat KRAS–Dependent Pancreatic Ductal Adenocarcinoma
Open the PDF for Predictive Signatures Inform the Effective Repurposing of Decitabine to Treat KRAS–Dependent Pancreatic Ductal Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract B40: Perturbation of proteostasis is lethal in SMARCB1-deficient tumors

Free
Melinda Soeung, Alessandro Carugo, Frederick Scott Robinson, Rosalba Minelli, Federica Carbone, Anirban Maitra, Andrea Viale, Charles W.M. Roberts, Nizar Tannir, Giulio F. Draetta, Giannicola Genovese
Journal: Cancer Research
Cancer Res (2018) 78 (19_Supplement): B40.
https://doi.org/10.1158/1538-7445.PEDCA17-B40
Published: 01 October 2018
View articletitled, Abstract B40: Perturbation of proteostasis is lethal in SMARCB1-deficient tumors
Journal Articles

Abstract 2856: Targeting OXPHOS with IACS-010759 to eliminate standard of care resistant tumor cells

Free
Joseph R. Marszalek, Sahil Seth, Denise Corti, Qi Zhang, Gloria V. Echeverria, Lina Han, Yuting Sun, Jennifer Molina, Sonal Gera, Edward Chang, Tin O. Khor, Mikhila Mahendra, Ningping Feng, Jason P. Gay, Timothy McAfoos, Virginia Giuliani, Xi Shi, Sabrina Jeter-Jones, Sarah Loponte, Chieh-Yuan Li, Christopher A. Bristow, Maria Emilia Di Francesco, Helen Piwnica-Worms, Marina Konopleva, Alessandro Carugo, Andrea Viale, Philip Jones, Timothy P. Heffernan, Giulio F. Draetta
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2856.
https://doi.org/10.1158/1538-7445.AM2018-2856
Published: 01 July 2018
View articletitled, Abstract 2856: Targeting OXPHOS with IACS-010759 to eliminate standard of care resistant tumor cells
Journal Articles

Abstract 1655: Discovery and development of IACS-010759, a novel inhibitor of Complex I currently in phase I studies to exploit oxidative phosphorylation dependency in acute myeloid leukemia and solid tumors

Free
Maria Emilia Di Francesco, Joseph R. Marszalek, Timothy McAfoos, Christopher L. Carroll, Zhijun Kang, Gang Liu, Jay P. Theroff, Jennifer P. Bardenhager, Madhavi L. Bandi, Jennifer R. Molina, Sonal Gera, Marina Protopopova, Yuting Sun, Mary K. Geck Do, Ningping Feng, Jason P. Gay, Florian Muller, Marina Konopleva, Funda Meric-Bernstam, Carlo Toniatti, Timothy P. Heffernan, Giulio F. Draetta, Philip Jones
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1655.
https://doi.org/10.1158/1538-7445.AM2018-1655
Published: 01 July 2018
View articletitled, Abstract 1655: Discovery and development of IACS-010759, a novel inhibitor of Complex I currently in phase I studies to exploit oxidative phosphorylation dependency in acute myeloid leukemia and solid tumors