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Giovanni Tonon
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Journal Articles

Abstract 3994: N glycosylation inhibition hinders immunosuppressive tumor microenvironment cells improving CAR T cell efficacy

Camilla Sirini, Beatrice Greco, Chiara Balestrieri, Barbara Camisa, Laura Falcone, Rita El Khoury, Oronzina Botrugno, Giulio Giovannoni, Giovanni Tonon, Emanuela Brunetto, Maria Giulia Cangi, Federica Pedica, Alice Bergamini, Fabio Ciceri, Chiara Bonini, Monica Casucci
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3994.
https://doi.org/10.1158/1538-7445.AM2024-3994
Published: 22 March 2024
View article titled, Abstract 3994: N glycosylation inhibition hinders immunosuppressive tumor microenvironment cells improving CAR T cell efficacy
Journal Articles

Abstract 3596: Metabolic reprogramming of the tumor microenvironment to enhance the functionality of TCR-edited T cell in colorectal cancer and liver metastases

Alessia Potenza, Chiara Balestrieri, Martina Spiga, Luca Albarello, Federica Pedica, Arianna Ferrari, Oronza A. Botrugno, Barbara Camisa, Elena Tiziano, Camilla Sirini, Monica Casucci, Chiara Iozzi, Danilo Abbati, Ugo Elmore, Giulia Di Lullo, Giulia Casorati, Claudio Doglioni, Giovanni Tonon, Paolo Dellabona, Riccardo Rosati, Luca Aldrighetti, Paolo Monti, Eliana Ruggiero, Chiara Bonini
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3596.
https://doi.org/10.1158/1538-7445.AM2024-3596
Published: 22 March 2024
View article titled, Abstract 3596: Metabolic reprogramming of the tumor microenvironment to enhance the functionality of TCR-edited T cell in colorectal cancer and liver metastases
Journal Articles

Preexisting Immunity Drives the Response to Neoadjuvant Chemotherapy in Esophageal Adenocarcinoma

Giuseppina Arbore, Luca Albarello, Gabriele Bucci, Marco Punta, Andrea Cossu, Lorella Fanti, Aurora Maurizio, Francesco Di Mauro, Vito Bilello, Gianluigi Arrigoni, Silvia Bonfiglio, Donatella Biancolini, Francesco Puccetti, Ugo Elmore, Luca Vago, Stefano Cascinu, Giovanni Tonon, Riccardo Rosati, Giulia Casorati, Paolo Dellabona
Journal: Cancer Research
Cancer Res (2023) 83 (17): 2873–2888.
https://doi.org/10.1158/0008-5472.CAN-23-0356
Published: 01 September 2023
View article titled, Preexisting Immunity Drives the Response to Neoadjuvant Chemotherapy in Esophageal Adenocarcinoma
Open the PDF for Preexisting Immunity Drives the Response to Neoadjuvant Chemotherapy in Esophageal Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 902: Harnessing CD39 for the treatment of colorectal cancer and liver metastases by engineered T cells

Alessia Potenza, Chiara Balestrieri, Luca Albarello, Federica Pedica, Martina Spiga, Francesco Manfredi, Beatrice C. Cianciotti, Claudia De Lalla, Lorena Stasi, Elena Tassi, Silvia Bonfiglio, Giulia M. Scotti, Miriam Redegalli, Donatella Biancolini, Danilo Abbati, Fabio Simeoni, Dejan Lazarevic, Ugo Elmore, Guido Fiorentini, Giulia Di Lullo, Giulia Casorati, Claudio Doglioni, Giovanni Tonon, Paolo Dellabona, Riccardo Rosati, Luca Aldrighetti, Eliana Ruggiero, Chiara Bonini
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 902.
https://doi.org/10.1158/1538-7445.AM2023-902
Published: 04 April 2023
View article titled, Abstract 902: Harnessing CD39 for the treatment of colorectal cancer and liver metastases by engineered T cells
Journal Articles

Abstract 3297: IFNalpha by in vivo-engineered macrophages abates liver metastases and triggers counter regulatory responses limiting efficacy

Thomas Kerzel, Stefano Beretta, Eloise Scamardella, Chiara Balestrieri, Tamara Canu, Federica Pedica, Rossana Norata, Lucia Sergi Sergi, Marco Genua, Ostuni Renato, Anna Kajaste-Rudnitski, Antonio Esposito, Masanobu Oshima, Giovanni Tonon, Francesca Sanvito, Mario Leonardo Squadrito, Luigi Naldini
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3297.
https://doi.org/10.1158/1538-7445.AM2022-3297
Published: 15 June 2022
View article titled, Abstract 3297: IFNalpha by <em>in vivo</em>-engineered macrophages abates liver metastases and triggers counter regulatory responses limiting efficacy
Journal Articles

FAM46C and FNDC3A Are Multiple Myeloma Tumor Suppressors That Act in Concert to Impair Clearing of Protein Aggregates and Autophagy

Nicola Manfrini, Marilena Mancino, Annarita Miluzio, Stefania Oliveto, Matteo Balestra, Piera Calamita, Roberta Alfieri, Riccardo L. Rossi, Marco Sassoè-Pognetto, Chiara Salio, Alessandro Cuomo, Tiziana Bonaldi, Marcello Manfredi, Emilio Marengo, Elia Ranzato, Simona Martinotti, Davide Cittaro, Giovanni Tonon, Stefano Biffo
Journal: Cancer Research
Cancer Res (2020) 80 (21): 4693–4706.
https://doi.org/10.1158/0008-5472.CAN-20-1357
Published: 03 November 2020
View article titled, FAM46C and FNDC3A Are Multiple Myeloma Tumor Suppressors That Act in Concert to Impair Clearing of Protein Aggregates and Autophagy
Open the PDF for FAM46C and FNDC3A Are Multiple Myeloma Tumor Suppressors That Act in Concert to Impair Clearing of Protein Aggregates and Autophagy in another window
Includes: Supplementary data
Journal Articles

Abstract 2912: The AP-1 transcription factor JunB promotes multiple myeloma cell proliferation, survival and drug resistance in the bone marrow microenvironment

Fengjuan Fan, Sonia Vallet, Muhammad Hasan Bashari, Mostafa Jarahian, Eugenio Morelli, Dirk Hose, Latifa Bakiri, Claudia Ball, Hanno Glimm, Martin Sattler, Hartmut Goldschmidt, Giovanni Tonon, Pierfrancesco Tassone, Erwin F. Wagner, Dirk Jäger, Klaus Podar
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2912.
https://doi.org/10.1158/1538-7445.AM2016-2912
Published: 15 July 2016
View article titled, Abstract 2912: The AP-1 transcription factor JunB promotes multiple myeloma cell proliferation, survival and drug resistance in the bone marrow microenvironment
Journal Articles

Chromogranin A Is Preferentially Cleaved into Proangiogenic Peptides in the Bone Marrow of Multiple Myeloma Patients

Mimma Bianco, Anna Maria Gasparri, Barbara Colombo, Flavio Curnis, Stefania Girlanda, Maurilio Ponzoni, Maria Teresa Sabrina Bertilaccio, Arianna Calcinotto, Angelina Sacchi, Elisabetta Ferrero, Marina Ferrarini, Marta Chesi, P. Leif Bergsagel, Matteo Bellone, Giovanni Tonon, Fabio Ciceri, Magda Marcatti, Federico Caligaris-Cappio, Angelo Corti
Journal: Cancer Research
Cancer Res (2016) 76 (7): 1781–1791.
https://doi.org/10.1158/0008-5472.CAN-15-1637
Published: 31 March 2016
View article titled, Chromogranin A Is Preferentially Cleaved into Proangiogenic Peptides in the Bone Marrow of Multiple Myeloma Patients
Open the PDF for Chromogranin A Is Preferentially Cleaved into Proangiogenic Peptides in the Bone Marrow of Multiple Myeloma Patients in another window
Includes: Supplementary data
Journal Articles

Abstract 3383: JunB/AP-1 controls MM cell proliferation, survival and drug resistance in the bone marrow microenvironment

Fengjuan Fan, Sonia Vallet, Martin Sattler, Giovanni Tonon, Muhammad Hasan Bashari, Latifa Bakiri, Hartmut Goldschmidt, Erwin F. Wagner, Dirk Jaeger, Klaus Podar
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3383.
https://doi.org/10.1158/1538-7445.AM2014-3383
Published: 01 October 2014
View article titled, Abstract 3383: JunB/AP-1 controls MM cell proliferation, survival and drug resistance in the bone marrow microenvironment
Journal Articles

Abstract 1734: Drug- induced generation of Mcl-1128-350 fragment triggers apoptosis in multiple myeloma cells through upregulation of c-Jun.

Fengjuan Fan, Giovanni Tonon, Martin Sattler, Hartmut Goldschmidt, Joseph Opferman, Kenneth C. Anderson, Dirk Jäger, Klaus Podar
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1734.
https://doi.org/10.1158/1538-7445.AM2013-1734
Published: 15 April 2013
View article titled, Abstract 1734: Drug- induced generation of Mcl-1<sup>128-350</sup> fragment triggers apoptosis in multiple myeloma cells through upregulation of c-Jun.
Journal Articles

Abstract 3169: Lentiviral vector-based insertional mutagenesis identifies new clinically relevant liver cancer genes.

Marco Ranzani, Daniela Cesana, Cynthia C. Bartholomä, Francesca Sanvito, Michela Riba, Mauro Pala, Fabrizio Benedicenti, Pierangela Gallina, Stefano Annunziato, Lucia Sergi Sergi, Stefania Merella, Alessandro Bulfone, Claudio Doglioni, Christof von Kalle, Yoon Jun Kim, Manfred Schmidt, Elia Stupka, Giovanni Tonon, Luigi Naldini, Eugenio Montini
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3169.
https://doi.org/10.1158/1538-7445.AM2013-3169
Published: 15 April 2013
View article titled, Abstract 3169: Lentiviral vector-based insertional mutagenesis identifies new clinically relevant liver cancer genes.
Journal Articles

Abstract 104: New liver cancer genes identified by lentiviral vector-based insertional mutagenesis in mice are associated to differential survival in hepatocellular carcinoma patients

Marco Ranzani, Daniela Cesana, Cynthia C. Bartholomae, Francesca Sanvito, Mauro Pala, Fabrizio Benedicenti, Pierangela Gallina, Lucia Sergi Sergi, Stefania Merella, Alessandro Bulfone, Claudio Doglioni, Christof von Kalle, Yoon Jun Kim, Manfred Schmidt, Giovanni Tonon, Luigi Naldini, Eugenio Montini
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 104.
https://doi.org/10.1158/1538-7445.AM2012-104
Published: 15 April 2012
View article titled, Abstract 104: New liver cancer genes identified by lentiviral vector-based insertional mutagenesis in mice are associated to differential survival in hepatocellular carcinoma patients
Journal Articles

Abstract 4982: Identification of new human liver cancer genes by a novel lentiviral vector-based insertional mutagenesis approach in three mouse models of hepatocarcinogenesis

Marco Ranzani, Daniela Cesana, Cynthia Bartholomae, Francesca Sanvito, Mauro Pala, Fabrizio Benedicenti, Lucia Sergi Sergi, Alessandro Bulfone, Claudio Doglioni, Christof von Kalle, Manfred Schmidt, Giovanni Tonon, Luigi Naldini, Eugenio Montini
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4982.
https://doi.org/10.1158/1538-7445.AM2011-4982
Published: 15 April 2011
View article titled, Abstract 4982: Identification of new human liver cancer genes by a novel lentiviral vector-based insertional mutagenesis approach in three mouse models of hepatocarcinogenesis
Journal Articles

Targeting Angiogenesis via a c-Myc/Hypoxia-Inducible Factor-1α–Dependent Pathway in Multiple Myeloma

Jing Zhang, Martin Sattler, Giovanni Tonon, Clemens Grabher, Samir Lababidi, Alexander Zimmerhackl, Marc S. Raab, Sonia Vallet, Yiming Zhou, Marie-Astrid Cartron, Teru Hideshima, Yu-Tzu Tai, Dharminder Chauhan, Kenneth C. Anderson, Klaus Podar
Journal: Cancer Research
Cancer Res (2009) 69 (12): 5082–5090.
https://doi.org/10.1158/0008-5472.CAN-08-4603
Published: 15 June 2009
View article titled, Targeting Angiogenesis via a c-Myc/Hypoxia-Inducible Factor-1α–Dependent Pathway in Multiple Myeloma
Open the PDF for Targeting Angiogenesis via a c-Myc/Hypoxia-Inducible Factor-1α–Dependent Pathway in Multiple Myeloma in another window
Includes: Supplementary data
Journal Articles

Abstract #325: CS1 promotes multiple myeloma cell adhesion, clonogenic growth, and tumorigenicity via c-maf-mediated interactions with bone marrow stromal cells

Yu-Tzu Tai, Ender Soydan, Mariateresa Fulciniti, Weihua Song, Kihyun Kim, Fangxin Hong, Xian-Feng Li, Peter Burger, Mathew J Rumizen Mathew J Rumizen, Sabikun Nahar, Klaus Podar Klaus Podar, Dharminder Chauhan, Teru Hideshima, Nikhil Munshi, Giovanni Tonon Giovanni Tonon, Ruben Carrasco, Kenneth Anderson
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 325.
Published: 01 May 2009
View article titled, Abstract #325: CS1 promotes multiple myeloma cell adhesion, clonogenic growth, and tumorigenicity via c-maf-mediated interactions with bone marrow stromal cells
Journal Articles

Abstract #3185: Targeting angiogenesis via a c-Myc/ Hif-1\#945;- dependent pathway in MM

Klaus Podar, Jing Zhang, Giovanni Tonon, Martin Sattler, Clemens Grabher, Samir Lababidi, Alexander Zimmerhackl, Marc Raab, Sonia Vallet, Yiming Zhou, Marie-Astrid Cartron, Yu-Tzu Tai, Dharminder Chauhan, Kenneth Anderson
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 3185.
Published: 01 May 2009
View article titled, Abstract #3185: Targeting angiogenesis via a c-Myc/ Hif-1\#945;- dependent pathway in MM
Journal Articles

Targeting PKC alters ER-stress and β-catenin signaling in multiple myeloma: Therapeutic implications

Marc Raab, Klaus Podar, Jing Zhang, Giovanni Tonon, Iris Breitkreutz, Johannes Fruehauf, Boris Lin, Teru Hideshima, Dharminder Chauhan, Kenneth Anderson
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2564.
Published: 01 May 2008
View article titled, Targeting PKC alters ER-stress and β-catenin signaling in multiple myeloma: Therapeutic implications
Journal Articles

The tyrophostin adaphostin (NSC680410) inhibits multiple myeloma bone marrow angiogenesis in in vitro and in vivo studies

Klaus Podar, Jing Zhang, Marc Raab, Sonia Vallet, Giovanni Tonon, Martin Sattler, Yutaka Ikeda, Teru Hideshima, Dharminder Chauhan, Kenneth Anderson
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 5529.
Published: 01 May 2008
View article titled, The tyrophostin adaphostin (NSC680410) inhibits multiple myeloma bone marrow angiogenesis in <em>in vitro</em> and <em>in vivo</em> studies
Journal Articles

Common and Distinct Genomic Events in Sporadic Colorectal Cancer and Diverse Cancer Types

Eric S. Martin, Giovanni Tonon, Raktim Sinha, Yonghong Xiao, Bin Feng, Alec C. Kimmelman, Alexei Protopopov, Elena Ivanova, Cameron Brennan, Kate Montgomery, Raju Kucherlapati, Gerald Bailey, Mark Redston, Lynda Chin, Ronald A. DePinho
Journal: Cancer Research
Cancer Res (2007) 67 (22): 10736–10743.
https://doi.org/10.1158/0008-5472.CAN-07-2742
Published: 15 November 2007
View article titled, Common and Distinct Genomic Events in Sporadic Colorectal Cancer and Diverse Cancer Types
Open the PDF for Common and Distinct Genomic Events in Sporadic Colorectal Cancer and Diverse Cancer Types in another window
Includes: Supplementary data
Journal Articles

Upregulation of c-Jun inhibits proliferation and induces apoptosis via caspase-triggered c-Abl cleavage in human multiple myeloma and other malignancies

Klaus Podar, Marc Raab, Giovanni Tonon, Martin Sattler, Daniela Barila, Jing Zhang, Yu-Tzu Tai, Noopur Raje, Ronald DePinho, Teru Hideshima, Dharminder Chauhan, Kenneth Anderson
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 5143.
Published: 01 May 2007
View article titled, Upregulation of c-Jun inhibits proliferation and induces apoptosis via caspase-triggered c-Abl cleavage in human multiple myeloma and other malignancies