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Journal Articles

Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface

Jessica Koach, Jessica K. Holien, Hassina Massudi, Daniel R. Carter, Olivia C. Ciampa, Mika Herath, Taylor Lim, Janith A. Seneviratne, Giorgio Milazzo, Jayne E. Murray, Joshua A. McCarroll, Bing Liu, Chelsea Mayoh, Bryce Keenan, Brendan W. Stevenson, Michael A. Gorman, Jessica L. Bell, Larissa Doughty, Stefan Hüttelmaier, Andre Oberthuer, Matthias Fischer, Andrew J. Gifford, Tao Liu, Xiaoling Zhang, Shizhen Zhu, W. Clay Gustafson, Michelle Haber, Murray D. Norris, Jamie I. Fletcher, Giovanni Perini, Michael W. Parker, Belamy B. Cheung, Glenn M. Marshall
Journal: Cancer Research
Series: Author Choice
Cancer Res (2019) 79 (21): 5652–5667.
https://doi.org/10.1158/0008-5472.CAN-19-1112
Published: 01 November 2019
View articletitled, Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface
Open the PDF for Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface in another window
Includes: Supplementary data
Journal Articles

Abstract 2616: A novel iron-chelating agent reduces MYC transcription via E2F gene family regulation

Emanuele Valli, Chengyuan Xue, Leanna Cheung, Laura Gamble, Ruby Pandher, Simone Di Giacomo, Catherine Burkhart, Natalia Fedtsova, Francesca Ferrucci, Sergei Makarov, Thomas Telfer, Rachel Codd, David Scott, Giovanni Perini, Andrei Osterman, Andrei Gudkov, Murray Norris, Michelle Haber
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2616.
https://doi.org/10.1158/1538-7445.AM2019-2616
Published: 01 July 2019
View articletitled, Abstract 2616: A novel iron-chelating agent reduces MYC transcription via E2F gene family regulation
Journal Articles

Abstract 2453: Eradication of neuroblastoma by suppressing the expression of a single noncoding RNA

Andrew E. Tee, Pei Y. Liu, Giorgio Milazzo, Kate M. Hannan, Jesper Maag, Nenad Bartonicek, Renhua Song, Chen C. Jiang, Xu D. Zhang, Murray D. Norris, Michelle Haber, Glenn M. Marshall, Jinyan Li, Jo Vandesompele, John S. Mattick, Pieter Mestdagh, Giovanni Perini, Ross D. Hannan, Marcel E. Dinger, Tao Liu
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2453.
https://doi.org/10.1158/1538-7445.AM2018-2453
Published: 01 July 2018
View articletitled, Abstract 2453: Eradication of neuroblastoma by suppressing the expression of a single noncoding RNA
Journal Articles

Abstract LB-080: The histone methyltransferase DOT1L promotes neuroblastoma by regulating gene transcription

Matthew Wong, Andrew Tee, Giorgio Milazzo, Jessica Bell, Stefan Hüttelmaier, Patsie Polly, Giovanni Perini, Christopher J. Scarlett, Tao Liu
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): LB-080.
https://doi.org/10.1158/1538-7445.AM2017-LB-080
Published: 01 July 2017
View articletitled, Abstract LB-080: The histone methyltransferase DOT1L promotes neuroblastoma by regulating gene transcription
Journal Articles

The Histone Methyltransferase DOT1L Promotes Neuroblastoma by Regulating Gene Transcription

Matthew Wong, Andrew E.L. Tee, Giorgio Milazzo, Jessica L. Bell, Rebecca C. Poulos, Bernard Atmadibrata, Yuting Sun, Duohui Jing, Nicholas Ho, Dora Ling, Pei Yan Liu, Xu Dong Zhang, Stefan Hüttelmaier, Jason W.H. Wong, Jenny Wang, Patsie Polly, Giovanni Perini, Christopher J. Scarlett, Tao Liu
Journal: Cancer Research
Cancer Res (2017) 77 (9): 2522–2533.
https://doi.org/10.1158/0008-5472.CAN-16-1663
Published: 30 April 2017
View articletitled, The Histone Methyltransferase DOT1L Promotes Neuroblastoma by Regulating Gene Transcription
Open the PDF for The Histone Methyltransferase DOT1L Promotes Neuroblastoma by Regulating Gene Transcription in another window
Includes: Supplementary data
Journal Articles

Abstract 2664: Eradication of neuroblastoma by suppressing the expression of a single long noncoding RNA

Andrew E. Tee, Pei Y. Liu, Giorgio Milazzo, Jo Vandesompele, Glenn M. Marshall, Giovanni Perini, Pieter Mestdagh, Marcel Dinger, Tao Liu
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2664.
https://doi.org/10.1158/1538-7445.AM2016-2664
Published: 15 July 2016
View articletitled, Abstract 2664: Eradication of neuroblastoma by suppressing the expression of a single long noncoding RNA
Journal Articles

Abstract 2450: MYCN and TFAP4 promote neuroblastoma malignancy by cooperating in the regulation a subset of target genes involved in cancer cell growth and metastasis

Chengyuan Xue, Denise M. Yu, Samuele Gherardi, Jessica Koach, Giorgio Milazzo, Laura Gamble, Bing Liu, Amanda Russell, Tao Liu, Belamy B. Cheung, Glenn M. Marshall, Giovanni Perini, Michelle Haber, Murray D. Norris
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2450.
https://doi.org/10.1158/1538-7445.AM2016-2450
Published: 15 July 2016
View articletitled, Abstract 2450: MYCN and TFAP4 promote neuroblastoma malignancy by cooperating in the regulation a subset of target genes involved in cancer cell growth and metastasis
Journal Articles

MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin

Rosemary O'Brien, Sieu L. Tran, Michelle F. Maritz, Bing Liu, Cheng Fei Kong, Stefania Purgato, Chen Yang, Jayne Murray, Amanda J. Russell, Claudia L. Flemming, Georg von Jonquieres, Hilda A. Pickett, Wendy B. London, Michelle Haber, Preethi H. Gunaratne, Murray D. Norris, Giovanni Perini, Jamie I. Fletcher, Karen L. MacKenzie
Journal: Cancer Research
Cancer Res (2016) 76 (12): 3604–3617.
https://doi.org/10.1158/0008-5472.CAN-15-0879
Published: 14 June 2016
View articletitled, MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin
Open the PDF for MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin in another window
Includes: Supplementary data
Journal Articles

WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma

Yuting Sun, Jessica L. Bell, Daniel Carter, Samuele Gherardi, Rebecca C. Poulos, Giorgio Milazzo, Jason W.H. Wong, Rima Al-Awar, Andrew E. Tee, Pei Y. Liu, Bing Liu, Bernard Atmadibrata, Matthew Wong, Toby Trahair, Quan Zhao, Jason M. Shohet, Ygal Haupt, Johannes H. Schulte, Peter J. Brown, Cheryl H. Arrowsmith, Masoud Vedadi, Karen L. MacKenzie, Stefan Hüttelmaier, Giovanni Perini, Glenn M. Marshall, Antony Braithwaite, Tao Liu
Journal: Cancer Research
Cancer Res (2015) 75 (23): 5143–5154.
https://doi.org/10.1158/0008-5472.CAN-15-0423
Published: 30 November 2015
View articletitled, WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma
Open the PDF for WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma in another window
Includes: Supplementary data
Journal Articles

Abstract 488: High DKC1 expression supports neuroblastoma tumor cell proliferation and is strongly associated with poor patient outcomes

Rosemary O'Brien, Michelle F. Maritz, Cheng Fei Kong, Stefania Purgato, Bing Liu, Chen Yang, Amanda Russell, Jayne Murray, Claudia Flemming, Michelle Haber, Giovanni Perini, Murray D. Norris, Jamie I. Fletcher, Karen L. Mackenzie
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 488.
https://doi.org/10.1158/1538-7445.AM2015-488
Published: 01 August 2015
View articletitled, Abstract 488: High DKC1 expression supports neuroblastoma tumor cell proliferation and is strongly associated with poor patient outcomes
Journal Articles

Abstract 3808: MYCN coordinately regulates the entire polyamine gene pathway to drive polyamine biosynthesis in neuroblastoma, with expression of every synthetic and catabolic polyamine pathway gene being highly prognostic of clinical outcome.

Murray D. Norris, Laura D. Gamble, Jayne Murray, Stefania Purgato, Giorgio Milazzo, Lesley J. Ashton, Andrei Oberthuer, Wendy B. London, Mike D. Hogarty, Mattias Fischer, David Ziegler, Glenn M. Marshall, Giovanni Perini, Michelle Haber
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3808.
https://doi.org/10.1158/1538-7445.AM2013-3808
Published: 15 April 2013
View articletitled, Abstract 3808: MYCN coordinately regulates the entire polyamine gene pathway to drive polyamine biosynthesis in neuroblastoma, with expression of every synthetic and catabolic polyamine pathway gene being highly prognostic of clinical outcome.
Journal Articles

Abstract 789: GSTP1 expression is regulated by MycN and is a marker of poor outcome in childhood neuroblastoma

Murray D. Norris, Jamie I. Fletcher, Samuele Gherardi, Jayne Murray, Catherine Burkhart, Amanda Russell, Emanuele Valli, Andre Oberthuer, Lesley J. Ashton, Wendy B. London, Glenn M. Marshall, Giovanni Perini, Michelle Haber
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 789.
https://doi.org/10.1158/1538-7445.AM2012-789
Published: 15 April 2012
View articletitled, Abstract 789: GSTP1 expression is regulated by MycN and is a marker of poor outcome in childhood neuroblastoma
Journal Articles

N-Myc Regulates Expression of the Detoxifying Enzyme Glutathione Transferase GSTP1, a Marker of Poor Outcome in Neuroblastoma

Jamie I. Fletcher, Samuele Gherardi, Jayne Murray, Catherine A. Burkhart, Amanda Russell, Emanuele Valli, Janice Smith, André Oberthuer, Lesley J. Ashton, Wendy B. London, Glenn M. Marshall, Murray D. Norris, Giovanni Perini, Michelle Haber
Journal: Cancer Research
Cancer Res (2012) 72 (4): 845–853.
https://doi.org/10.1158/0008-5472.CAN-11-1885
Published: 14 February 2012
View articletitled, N-Myc Regulates Expression of the Detoxifying Enzyme Glutathione Transferase GSTP1, a Marker of Poor Outcome in Neuroblastoma
Open the PDF for N-Myc Regulates Expression of the Detoxifying Enzyme Glutathione Transferase GSTP1, a Marker of Poor Outcome in Neuroblastoma in another window
Includes: Supplementary data
Journal Articles

Abstract 3027: SIRT1 promotes N-Myc oncogenesis stabilizing N-Myc protein

Glenn M. Marshall, Pei Y. Liu, Samuele Gherardi, Christopher J. Scarlett, Antonio Bedalov, Ning Xu, Nunzio Iraci, Karen L. MacKenzie, Michelle Haber, Murray D. Norris, Andrew V. Biankin, Giovanni Perini, Tao Liu
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 3027.
https://doi.org/10.1158/1538-7445.AM2011-3027
Published: 15 April 2011
View articletitled, Abstract 3027: SIRT1 promotes N-Myc oncogenesis stabilizing N-Myc protein
Journal Articles

Abstract 954: ABCC/MRP multidrug transporters contribute to neuroblastoma biology, pathogenesis and clinical outcome, independently of any role in cytotoxic drug efflux

Murray D. Norris, Michelle J. Henderson, Antonio Porro, Marcia Munoz, Nunzio Iraci, Chengyuan Xue, Jayne Murray, Claudia Flemming, Jamie Fletcher, Samuele Gherardi, Alan Kwek, Amanda Russell, Wendy B. London, Allen B. Buxton, Lesley Ashton, Alan C. Sartorelli, Susan L. Cohn, Manfred Schwab, Glenn M. Marshall, Giovanni Perini, Michelle Haber
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 954.
https://doi.org/10.1158/1538-7445.AM2011-954
Published: 15 April 2011
View articletitled, Abstract 954: ABCC/MRP multidrug transporters contribute to neuroblastoma biology, pathogenesis and clinical outcome, independently of any role in cytotoxic drug efflux
Journal Articles

A SP1/MIZ1/MYCN Repression Complex Recruits HDAC1 at the TRKA and p75NTR Promoters and Affects Neuroblastoma Malignancy by Inhibiting the Cell Response to NGF

Nunzio Iraci, Daniel Diolaiti, Antonella Papa, Antonio Porro, Emanuele Valli, Samuele Gherardi, Steffi Herold, Martin Eilers, Roberto Bernardoni, Giuliano Della Valle, Giovanni Perini
Journal: Cancer Research
Cancer Res (2011) 71 (2): 404–412.
https://doi.org/10.1158/0008-5472.CAN-10-2627
Published: 13 January 2011
View articletitled, A SP1/MIZ1/MYCN Repression Complex Recruits HDAC1 at the TRKA and p75NTR Promoters and Affects Neuroblastoma Malignancy by Inhibiting the Cell Response to NGF
Open the PDF for A SP1/MIZ1/MYCN Repression Complex Recruits HDAC1 at the TRKA and p75NTR Promoters and Affects Neuroblastoma Malignancy by Inhibiting the Cell Response to NGF in another window
Includes: Supplementary data
Journal Articles

Abstract 4869: Transcriptional upregulation of histone deacetylase 2 promotes Myc-induced oncogenic effects

Glenn M. Marshall, Samuele Gherardi, Ning Xu, Zillan Neiron, Toby Trahair, Christopher Scarlett, David K. Chang, Pei Y. Liu, Kacper Jankowski, Nunzio Iraci, Michelle Haber, Murray D. Norris, Fabio Stossi, Benita S. Katzenellenbogen, Andrew V. Biankin, Giovanni Perini, Tao Liu
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4869.
https://doi.org/10.1158/1538-7445.AM10-4869
Published: 15 April 2010
View articletitled, Abstract 4869: Transcriptional upregulation of histone deacetylase 2 promotes Myc-induced oncogenic effects
Journal Articles

p53 Is a Direct Transcriptional Target of MYCN in Neuroblastoma

Lindi Chen, Nunzio Iraci, Samuele Gherardi, Laura D. Gamble, Katrina M. Wood, Giovanni Perini, John Lunec, Deborah A. Tweddle
Journal: Cancer Research
Cancer Res (2010) 70 (4): 1377–1388.
https://doi.org/10.1158/0008-5472.CAN-09-2598
Published: 14 February 2010
View articletitled, p53 Is a Direct Transcriptional Target of MYCN in Neuroblastoma
Open the PDF for p53 Is a Direct Transcriptional Target of MYCN in Neuroblastoma in another window
Includes: Supplementary data
Journal Articles

Abstract #3449: A specific transcription signature of ABC transporter genes is dictated by Myc-family oncogenes: A powerful tool to predict clinical outcome

Michelle Haber, Antonio Porro, Daniel Diolaiti, Nunzio Iraci, Michelle Henderson, Marcia Munoz, Chengyuan Xue, Claudia Flemming, Jayne Murray, Wendy London, Allen Buxton, Lesley Ashton, Susan Cohn, Manfred Schwab, Glenn Marshall, Giuliano Della Valle, Giovanni Perini, Murray Norris
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 3449.
Published: 01 May 2009
View articletitled, Abstract #3449: A specific transcription signature of ABC transporter genes is dictated by Myc-family oncogenes: A powerful tool to predict clinical outcome
Journal Articles

Abstract #3447: Evidence that p53 is a direct transcriptional target of MYCN in neuroblastoma

Lindi Chen, Nunzio Iraci, Giovanni Perini, John Lunec, Deborah Tweddle
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 3447.
Published: 01 May 2009
View articletitled, Abstract #3447: Evidence that p53 is a direct transcriptional target of MYCN in neuroblastoma