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Giovanni Capranico
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Journal Articles

Abstract 3367: R-loop type determines the orientation of transcription-replication conflicts attenuated by transcription factor IIS

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Renée C. Duardo, Jessica Marinello, Marco Russo, Sara Morelli, Simona Pepe, Federico Guerra, Belen Gomez-González, Andrés Aguilera, Giovanni Capranico
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3367.
https://doi.org/10.1158/1538-7445.AM2024-3367
Published: 22 March 2024
View articletitled, Abstract 3367: R-loop type determines the orientation of transcription-replication conflicts attenuated by transcription factor IIS
Journal Articles

Abstract 1234: G4 binders as potential immunostimulatory compounds for cancer therapy

Free
Marco Russo, Giulia Miglietta, Giovanni Capranico
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1234.
https://doi.org/10.1158/1538-7445.AM2021-1234
Published: 01 July 2021
View articletitled, Abstract 1234: G4 binders as potential immunostimulatory compounds for cancer therapy
Journal Articles

Abstract 4838: R loop-driven genome instability by G-quadruplex binders in BRCA2-silenced human cancer cells

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Alessio De Magis, Stefano Giustino Manzo, Marco Russo, Olivier Sordet, Rita Morigi, Giovanni Capranico
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4838.
https://doi.org/10.1158/1538-7445.AM2018-4838
Published: 01 July 2018
View articletitled, Abstract 4838: R loop-driven genome instability by G-quadruplex binders in BRCA2-silenced human cancer cells
Journal Articles

Abstract 510: Topoisomerase IIβ silencing increases R loops at specific genomic loci associated with an increase of γH2AX and cell cycle progression delay in human cancer cells

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Maria Delcuratolo, Jessica Marinello, Giovanni Capranico
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 510.
https://doi.org/10.1158/1538-7445.AM2017-510
Published: 01 July 2017
View articletitled, Abstract 510: Topoisomerase IIβ silencing increases R loops at specific genomic loci associated with an increase of γH2AX and cell cycle progression delay in human cancer cells
Journal Articles

Abstract 2243: Gene expression signature of aneuploidy in acute myeloid leukemia

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Giorgia Simonetti, Antonella Padella, Viviana Guadagnuolo, Cristina Papayannidis, Francesca Volpato, Emanuela Ottaviani, Serena Formica, Annalisa Astolfi, Ilaria Iacobucci, Giovanni Capranico, Daniel Remondini, Giovanni Martinelli
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2243.
https://doi.org/10.1158/1538-7445.AM2014-2243
Published: 01 October 2014
View articletitled, Abstract 2243: Gene expression signature of aneuploidy in acute myeloid leukemia
Journal Articles

Abstract 637: Antisense transcripts and R-loops caused by DNA topoisomerase I inhibition by camptothecin at human active CpG island promoters.

Free
Jessica Marinello, Giovanni Chillemi, Susana Bueno, Stefano G. Manzo, Giovanni Capranico
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 637.
https://doi.org/10.1158/1538-7445.AM2013-637
Published: 15 April 2013
View articletitled, Abstract 637: Antisense transcripts and R-loops caused by DNA topoisomerase I inhibition by camptothecin at human active CpG island promoters.
Journal Articles

Natural Product Triptolide Mediates Cancer Cell Death by Triggering CDK7-Dependent Degradation of RNA Polymerase II

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Stefano Giustino Manzo, Zhao-Li Zhou, Ying-Qing Wang, Jessica Marinello, Jin-Xue He, Yuan-Chao Li, Jian Ding, Giovanni Capranico, Ze-Hong Miao
Journal: Cancer Research
Cancer Res (2012) 72 (20): 5363–5373.
https://doi.org/10.1158/0008-5472.CAN-12-1006
Published: 14 October 2012
View articletitled, Natural Product Triptolide Mediates Cancer Cell Death by Triggering CDK7-Dependent Degradation of RNA Polymerase II
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Includes: Supplementary data
Journal Articles

Abstract 1180: Activation of antisense transcription by Top1cc in human colon cancer cells

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Jessica Marinello, Davide Bertozzi, Susana Bueno, Raffaella Iurlaro, Olivier Sordet, Giovanni Chillemi, Giovanni Capranico
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 1180.
https://doi.org/10.1158/1538-7445.AM2011-1180
Published: 15 April 2011
View articletitled, Abstract 1180: Activation of antisense transcription by Top1cc in human colon cancer cells
Journal Articles

Abstract 2143: High-Resolution Molecular Karyotyping of Chronic Myeloid Leukemia Patients in Blast Crisis by 6.0 SNP-Arrays Identifies Focal Copy Number Alterations Affecting the Whole Sequence or Specific Exons of Oncogenes and Tumor Suppressor Genes

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Alessandra Gnani, Simona Soverini, Sabrina Colarossi, Fausto Castagnetti, Annalisa Astolfi, Serena Formica, Francesca Palandri, Ilaria Iacobucci, Gabriele Gugliotta, Angela Poerio, Marilina Amabile, Giulia Marzocchi, Nicoletta Testoni, Elisabetta Abruzzese, Gianantonio Rosti, Giovanni Capranico, Michele Baccarani, Giovanni Martinelli
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2143.
https://doi.org/10.1158/1538-7445.AM10-2143
Published: 15 April 2010
View articletitled, Abstract 2143: High-Resolution Molecular Karyotyping of Chronic Myeloid Leukemia Patients in Blast Crisis by 6.0 SNP-Arrays Identifies Focal Copy Number Alterations Affecting the Whole Sequence or Specific Exons of Oncogenes and Tumor Suppressor Genes
Journal Articles

Abstract #3753: Induction of a novel long antisense RNA from the human HIF-1\#945; locus may contribute to HIF-1\#945; regulation and inhibition by camptothecins in cancer cells.

Free
Laura Baranello, Davide Bertozzi, Yves Pommier, Giovanni Capranico
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 3753.
Published: 01 May 2009
View articletitled, Abstract #3753: Induction of a novel long antisense RNA from the human HIF-1\#945; locus may contribute to HIF-1\#945; regulation and inhibition by camptothecins in cancer cells.
Journal Articles

DNA topoisomerase I (Top1) can regulate the coupling of RNA polymerase II (RNAP) pausing at promoter-proximal sites and transcript maturation in human cells.

Free
Maria Vittoria Fogli, Laura Baranello, Francesca Ferri, Yves Pommier, Giovanni Capranico
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 789.
Published: 01 May 2007
View articletitled, DNA topoisomerase I (Top1) can regulate the coupling of RNA polymerase II (RNAP) pausing at promoter-proximal sites and transcript maturation in human cells.
Journal Articles

Rapid and specific disassembly of RNA polymerase II from transcribed chromatin regions after topoisomerase I poison treatments of human cancer cells

Free
Andriy Khobta, Francesca Ferri, Rossella Rossi, Alessandra Motecucco, Giovanni Capranico
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 563.
Published: 01 May 2005
View articletitled, Rapid and specific disassembly of RNA polymerase II from transcribed chromatin regions after topoisomerase I poison treatments of human cancer cells
Journal Articles

Specific Histone Patterns and Acetylase/Deacetylase Activity at the Breakpoint-Cluster Region of the Human MLL Gene

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Andriy Khobta, Carmelo Carlo-Stella, Giovanni Capranico
Journal: Cancer Research
Cancer Res (2004) 64 (8): 2656–2662.
https://doi.org/10.1158/0008-5472.CAN-03-1126
Published: 15 April 2004
View articletitled, Specific Histone Patterns and Acetylase/Deacetylase Activity at the Breakpoint-Cluster Region of the Human MLL Gene
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Journal Articles

Mapping and dynamics of DNA topoisomerase I recruitment at a transcribed human gene locus

Free
Andriy Khobta, Francesca Ferri, Giovanni Capranico
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 216–217.
Published: 01 April 2004
View articletitled, Mapping and dynamics of DNA topoisomerase I recruitment at a transcribed human gene locus
Journal Articles

Significant effects of DNA topoisomerase I on global gene expression profiles in S. cerevisiae

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Luca Lotito, Alessandra Russo, Duccio Cavaliere, Giovanni Capranico
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 609.
Published: 01 April 2004
View articletitled, Significant effects of DNA topoisomerase I on global gene expression profiles in S. cerevisiae
Journal Articles

In Vivo Site Specificity and Human Isoenzyme Selectivity of Two Topoisomerase II-poisoning Anthracyclines

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Monica Binaschi, Rosalba Farinosi, M. Evelina Borgnetto, Giovanni Capranico
Journal: Cancer Research
Cancer Res (2000) 60 (14): 3770–3776.
Published: 15 July 2000
View articletitled, In Vivo Site Specificity and Human Isoenzyme Selectivity of Two Topoisomerase II-poisoning Anthracyclines
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Journal Articles

Tethering a Type IB Topoisomerase to a DNA Site by Enzyme Fusion to a Heterologous Site-selective DNA-binding Protein Domain

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Giovanni Luca Beretta, Monica Binaschi, Emanuela Zagni, Luisa Capuani, Giovanni Capranico
Journal: Cancer Research
Cancer Res (1999) 59 (15): 3689–3697.
Published: 01 August 1999
View articletitled, Tethering a Type IB Topoisomerase to a DNA Site by Enzyme Fusion to a Heterologous Site-selective DNA-binding Protein Domain
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Journal Articles

Human DNA Topoisomerase IIα-dependent DNA Cleavage and Yeast Cell Killing by Anthracycline Analogues

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Monica Binaschi, Rosalba Farinosi, Caroline A. Austin, L. Mark Fisher, Franco Zunino, Giovanni Capranico
Journal: Cancer Research
Cancer Res (1998) 58 (9): 1886–1892.
Published: 01 May 1998
View articletitled, Human DNA Topoisomerase IIα-dependent DNA Cleavage and Yeast Cell Killing by Anthracycline Analogues
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Journal Articles

Irreversible and Reversible Topoisomerase II DNA Cleavage Stimulated by Clerocidin: Sequence Specificity and Structural Drug Determinants

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Monica Binaschi, Giuseppe Zagotto, Manlio Palumbo, Franco Zunino, Rosalba Farinosi, Giovanni Capranico
Journal: Cancer Research
Cancer Res (1997) 57 (9): 1710–1716.
Published: 01 May 1997
View articletitled, Irreversible and Reversible Topoisomerase II DNA Cleavage Stimulated by Clerocidin: Sequence Specificity and Structural Drug Determinants
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Journal Articles

Drug-specific Sites of Topoisomerase II DNA Cleavage in Drosophila Chromatin: Heterogeneous Localization and Reversibility

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Maria E. Borgnetto, Franco Zunino, Stella Tinelli, Emmanuel Käs, Giovanni Capranico
Journal: Cancer Research
Cancer Res (1996) 56 (8): 1855–1862.
Published: 01 April 1996
View articletitled, Drug-specific Sites of Topoisomerase II DNA Cleavage in Drosophila Chromatin: Heterogeneous Localization and Reversibility
Open the PDF for Drug-specific Sites of Topoisomerase II DNA Cleavage in Drosophila Chromatin: Heterogeneous Localization and Reversibility in another window