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Giorgia Zadra
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Journal Articles

Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer

Open Access
Nadia Boufaied, Paolo Chetta, Tarek Hallal, Stefano Cacciatore, Daniela Lalli, Carole Luthold, Kevin Homsy, Eddie L. Imada, Sudeepa Syamala, Cornelia Photopoulos, Anna Di Matteo, Anna de Polo, Alessandra Maria Storaci, Ying Huang, Francesca Giunchi, Patricia A. Sheridan, Gregory Michelotti, Quang-De Nguyen, Xin Zhao, Yang Liu, Elai Davicioni, Daniel E. Spratt, Simone Sabbioneda, Giovanni Maga, Lorelei A. Mucci, Claudia Ghigna, Luigi Marchionni, Lisa M. Butler, Leigh Ellis, François Bordeleau, Massimo Loda, Valentina Vaira, David P. Labbé, Giorgia Zadra
Journal: Cancer Research
Cancer Res (2024) 84 (11): 1834–1855.
https://doi.org/10.1158/0008-5472.CAN-23-0519
Published: 04 June 2024
View articletitled, Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Open the PDF for Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 1513: FASN inhibition-induced BRCAness as a therapeutic option for castration-resistant prostate cancer (CRPC)

Free
Caroline Fidalgo Ribeiro, Silvia D. Rodrigues, Debora C. Bastos, Hubert Pakula, Giorgia Zadra, Marco Foiani, Massimo Loda
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1513.
https://doi.org/10.1158/1538-7445.AM2022-1513
Published: 15 June 2022
View articletitled, Abstract 1513: FASN inhibition-induced BRCAness as a therapeutic option for castration-resistant prostate cancer (CRPC)
Journal Articles

ELOVL5 Is a Critical and Targetable Fatty Acid Elongase in Prostate Cancer

Free
Margaret M. Centenera, Julia S. Scott, Jelle Machiels, Zeyad D. Nassar, Deanna C. Miller, Irene Zinonos, Jonas Dehairs, Ingrid J.G. Burvenich, Giorgia Zadra, Paolo M. Chetta, Clyde Bango, Emma Evergren, Natalie K. Ryan, Joanna L. Gillis, Chui Yan Mah, Terence Tieu, Adrienne R. Hanson, Ryan Carelli, Katarzyna Bloch, Vasilios Panagopoulos, Etienne Waelkens, Rita Derua, Elizabeth D. Williams, Andreas Evdokiou, Anna Cifuentes-Rius, Nicolas H. Voelcker, Ian G. Mills, Wayne D. Tilley, Andrew M. Scott, Massimo Loda, Luke A. Selth, Johannes V. Swinnen, Lisa M. Butler
Journal: Cancer Research
Cancer Res (2021) 81 (7): 1704–1718.
https://doi.org/10.1158/0008-5472.CAN-20-2511
Published: 01 April 2021
View articletitled, ELOVL5 Is a Critical and Targetable Fatty Acid Elongase in Prostate Cancer
Open the PDF for ELOVL5 Is a Critical and Targetable Fatty Acid Elongase in Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 3591: Genetic and pharmacological inhibition of fatty acid synthase (FASN) attenuates prostate cancer driven by Pten loss

Free
Caroline F. Ribeiro, Débora C. Bastos, Hubert Pakula, Thomas Ahearn, Jéssica Nascimento, John S. Clohessy, Lorelei Mucci, Silvio M. Zanata, Giorgia Zadra, Massimo Loda
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3591.
https://doi.org/10.1158/1538-7445.AM2019-3591
Published: 01 July 2019
View articletitled, Abstract 3591: Genetic and pharmacological inhibition of fatty acid synthase (FASN) attenuates prostate cancer driven by Pten loss
Journal Articles

Abstract 2748: The role of TMPRSS2_ERG fusions in modulating tumor microenvironment in prostate cancer

Free
Hubert Pakula, Caroline F. Ribeiro, Giuseppe N. Fanelli, Rory Kirchner, Sudeepa Syamala, Basudev Chowdhury, Giorgia Zadra, Paolo Chetta, Zhe Li, Massimo Loda
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2748.
https://doi.org/10.1158/1538-7445.AM2019-2748
Published: 01 July 2019
View articletitled, Abstract 2748: The role of TMPRSS2_ERG fusions in modulating tumor microenvironment in prostate cancer
Journal Articles

Abstract 1851: Novel roles of DNA-PK in metabolic regulation in prostate cancer

Free
Emanuela Dylgjeri, Jonathan Goodwin, Ayesha Shafi, Vishal Kothari, Giorgia Zadra, Erin Seifert, Felix Feng, Karen Knudsen
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1851.
https://doi.org/10.1158/1538-7445.AM2019-1851
Published: 01 July 2019
View articletitled, Abstract 1851: Novel roles of DNA-PK in metabolic regulation in prostate cancer
Journal Articles

Abstract 4952: Co-expression of pAKT and MYC is associated with aggressive disease in human prostate cancer

Free
Nelma Pértega-Gomes, Svitlana Tyekucheva, Kathryn Penney, Giorgia Zadra, Lorelei A. Mucci, Massimo Loda
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4952.
https://doi.org/10.1158/1538-7445.AM2016-4952
Published: 15 July 2016
View articletitled, Abstract 4952: Co-expression of pAKT and MYC is associated with aggressive disease in human prostate cancer
Journal Articles

Abstract 2674: High fat diet accelerates MYC-driven prostate cancer through metabolic and epigenomic rewiring

Free
David P. Labbe’, Giorgia Zadra, Meng Yang, Charles Y. Lin, Jaime M. Reyes, Stefano Cacciatore, Ericka M. Ebot, Maura B. Cotter, Amanda L. Creech, Jacob D. Jaffe, Philip W. Kantoff, James E. Bradner, Lorelei A. Mucci, Jorge E. Chavarro, Massimo Loda, Myles Brown
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2674.
https://doi.org/10.1158/1538-7445.AM2016-2674
Published: 15 July 2016
View articletitled, Abstract 2674: High fat diet accelerates MYC-driven prostate cancer through metabolic and epigenomic rewiring
Journal Articles

Abstract A10: High-fat diet enhances MYC-driven prostate cancer through epigenomic and metabolomic rewiring

Free
David P. Labbé, Giorgia Zadra, Ericka M. Ebot, Charles Y. Lin, Jaime M. Reyes, Stefano Cacciatore, Maura Cotter, Amanda L. Creech, Jacob D. Jaffe, Philip W. Kantoff, James E. Bradner, Lorelei A. Mucci, Massimo Loda, Myles Brown
Journal: Cancer Research
Cancer Res (2016) 76 (2_Supplement): A10.
https://doi.org/10.1158/1538-7445.CHROMEPI15-A10
Published: 14 January 2016
View articletitled, Abstract A10: High-fat diet enhances MYC-driven prostate cancer through epigenomic and metabolomic rewiring
Journal Articles

Abstract 4686: Identifying obesity-linked gene expression changes in prostate cancer

Free
Ericka M. Ebot, Travis Gerke, Svitlana Tyekucheva, David P. Labbé, Giorgia Zadra, Rachel S. Kelly, Michaela Bowden, Jennifer R. Rider, Kathryn M. Wilson, Neil E. Martin, Myles Brown, Matthew G. Vander Heiden, Edward L. Giovannucci, Massimo Loda, Lorelei A. Mucci
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4686.
https://doi.org/10.1158/1538-7445.AM2015-4686
Published: 01 August 2015
View articletitled, Abstract 4686: Identifying obesity-linked gene expression changes in prostate cancer
Journal Articles

AKT1 and MYC Induce Distinctive Metabolic Fingerprints in Human Prostate Cancer

Free
Carmen Priolo, Saumyadipta Pyne, Joshua Rose, Erzsébet Ravasz Regan, Giorgia Zadra, Cornelia Photopoulos, Stefano Cacciatore, Denise Schultz, Natalia Scaglia, Jonathan McDunn, Angelo M. De Marzo, Massimo Loda
Journal: Cancer Research
Series: Author Choice
Cancer Res (2014) 74 (24): 7198–7204.
https://doi.org/10.1158/0008-5472.CAN-14-1490
Published: 14 December 2014
View articletitled, AKT1 and MYC Induce Distinctive Metabolic Fingerprints in Human Prostate Cancer
Open the PDF for AKT1 and MYC Induce Distinctive Metabolic Fingerprints in Human Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract #4411: AMP-activated protein kinase (AMPK) activation reduces prostate tumor cell growth via inhibition of fatty acid synthase

Free
Giorgia Zadra, Giuseppe Fedele, Cornelia Photopoulos, Raffaella Zamponi, Carmen Priolo, Joshua Rose, Neal Birnberg, Massimo Loda
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 4411.
Published: 01 May 2009
View articletitled, Abstract #4411: AMP-activated protein kinase (AMPK) activation reduces prostate tumor cell growth via inhibition of fatty acid synthase
Journal Articles

Abstract #LB-188: Unraveling the prostate cancer metabolome: Diagnostic and therapeutic implications

Free
Carmen Priolo, Giorgia Zadra, Emanuele Palescandolo, Ewa Sicinska, Massimo Loda
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): LB-188.
Published: 01 May 2009
View articletitled, Abstract #LB-188: Unraveling the prostate cancer metabolome: Diagnostic and therapeutic implications
Journal Articles

Ex-vivo culture of normal and cancerous tissues: a tissue slice model

Free
Valentina Vaira, Giuseppe Fedele, Ester Fasoli, Giorgia Zadra, Massimo Loda, Silvano Bosari
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 398.
Published: 01 May 2008
View articletitled, Ex-vivo culture of normal and cancerous tissues: a tissue slice model