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Gina M. DeNicola
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Journal Articles

PHGDH Induction by MAPK Is Essential for Melanoma Formation and Creates an Actionable Metabolic Vulnerability

Neel Jasani, Xiaonan Xu, Benjamin Posorske, Yumi Kim, Kaizhen Wang, Olga Vera, Kenneth Y. Tsai, Gina M. DeNicola, Florian A. Karreth
Journal: Cancer Research
Cancer Res (2025) 85 (2): 314–328.
https://doi.org/10.1158/0008-5472.CAN-24-2471
Published: 15 January 2025
View articletitled, PHGDH Induction by MAPK Is Essential for Melanoma Formation and Creates an Actionable Metabolic Vulnerability
Open the PDF for PHGDH Induction by MAPK Is Essential for Melanoma Formation and Creates an Actionable Metabolic Vulnerability in another window
Includes: Supplementary data
Journal Articles

Correction: Comprehensive Metabolic Tracing Reveals the Origin and Catabolism of Cysteine in Mammalian Tissues and Tumors

Sang Jun Yoon, Joseph A. Combs, Aimee Falzone, Nicolas Prieto-Farigua, Samantha Caldwell, Hayley D. Ackerman, Elsa R. Flores, Gina M. DeNicola
Journal: Cancer Research
Cancer Res (2024) 84 (8): 1372.
https://doi.org/10.1158/0008-5472.CAN-24-0459
Published: 15 April 2024
View articletitled, Correction: Comprehensive Metabolic Tracing Reveals the Origin and Catabolism of Cysteine in Mammalian Tissues and Tumors
Open the PDF for Correction: Comprehensive Metabolic Tracing Reveals the Origin and Catabolism of Cysteine in Mammalian Tissues and Tumors in another window
Journal Articles

Abstract LB292: Glutathione supports lipid abundance in vivo

Gloria Asantewaa, Emily T. Tuttle, Nathan P. Ward, Yun P. Kang, Yumi Kim, Madeline Kavanagh, Aaron R. Huber, Joshua Munger, Benjamin Cravatt, Calvin L. Cole, Gina M. DeNicola, Isaac S. Harris
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB292.
https://doi.org/10.1158/1538-7445.AM2024-LB292
Published: 05 April 2024
View articletitled, Abstract LB292: Glutathione supports lipid abundance in vivo
Journal Articles

Abstract 3495: Multi-omic landscape of squamous cell lung cancer

Isis Y. Narvaez-Bandera, Ashley Lui, Eric Welsh, Dalia Ercan, Vanessa Rubio, Hayley Ackerman, Guohui Li, Lancia Darville, Min Liu, Bin Fang, Steven Eschrich, Brooke Fridley, John Koomen, Eric Haura, Gina M. DeNicola, Elsa Flores, Paul Stewart
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3495.
https://doi.org/10.1158/1538-7445.AM2024-3495
Published: 22 March 2024
View articletitled, Abstract 3495: Multi-omic landscape of squamous cell lung cancer
Journal Articles

Abstract 2516: Influence of pre-treatment nutrition and inflammation on immunotherapy response in non-small cell lung cancer

Lary A. Robinson, Youngchul Kim, Acadia Buro, Stephanie R. Hogue, Alexis Bailey, Gina M. DeNicola, Christine Pierce, Mark Umbarger, Doratha A. Byrd
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2516.
https://doi.org/10.1158/1538-7445.AM2024-2516
Published: 22 March 2024
View articletitled, Abstract 2516: Influence of pre-treatment nutrition and inflammation on immunotherapy response in non-small cell lung cancer
Journal Articles

Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression

Janine M. DeBlasi, Aimee Falzone, Samantha Caldwell, Nicolas Prieto-Farigua, Justin R. Prigge, Edward E. Schmidt, Iok In Christine Chio, Florian A. Karreth, Gina M. DeNicola
Journal: Cancer Research
Cancer Res (2023) 83 (12): 1953–1967.
https://doi.org/10.1158/0008-5472.CAN-22-3848
Published: 15 June 2023
View articletitled, Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression
Open the PDF for Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression in another window
Includes: Supplementary data
Journal Articles

Comprehensive Metabolic Tracing Reveals the Origin and Catabolism of Cysteine in Mammalian Tissues and Tumors

Sang Jun Yoon, Joseph A. Combs, Aimee Falzone, Nicolas Prieto-Farigua, Samantha Caldwell, Hayley D. Ackerman, Elsa R. Flores, Gina M. DeNicola
Journal: Cancer Research
Cancer Res (2023) 83 (9): 1426–1442.
https://doi.org/10.1158/0008-5472.CAN-22-3000
Published: 02 May 2023
View articletitled, Comprehensive Metabolic Tracing Reveals the Origin and Catabolism of Cysteine in Mammalian Tissues and Tumors
Open the PDF for Comprehensive Metabolic Tracing Reveals the Origin and Catabolism of Cysteine in Mammalian Tissues and Tumors in another window
Includes: Supplementary data
Journal Articles

Abstract 12: Distinct Nrf2 signaling thresholds mediate lung tumor initiation and progression

Janine M. DeBlasi, Aimee Falzone, Samantha Caldwell, Yun Pyo Kang, Nicolas Prieto-Farigua, Justin R. Prigge, Edward E. Schmidt, Iok In Christine Chio, Florian A. Karreth, Gina M. DeNicola
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 12.
https://doi.org/10.1158/1538-7445.AM2023-12
Published: 04 April 2023
View articletitled, Abstract 12: Distinct Nrf2 signaling thresholds mediate lung tumor initiation and progression
Journal Articles

Abstract 309: ATM phosphorylation of NRF2 promotes DNA damage repair

Cheyenne A. Schneider, Tin-Yu Lin, Aimee Falzone, Samantha Caldwell, Jared L. Johnson, Gina M. DeNicola
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 309.
https://doi.org/10.1158/1538-7445.AM2023-309
Published: 04 April 2023
View articletitled, Abstract 309: ATM phosphorylation of NRF2 promotes DNA damage repair
Journal Articles

Abstract 2161: Quinolinic acid phosphoribosyl transferase (QPRT) is an essential liability of non-small cell lung cancer

Hossein Kashfi, Nathan Ward, Didem Ilter, Stanislav Drapela, Aimee Falzone, Stephen Gardell, Gina M. DeNicola, Ana P. Gomes
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2161.
https://doi.org/10.1158/1538-7445.AM2023-2161
Published: 04 April 2023
View articletitled, Abstract 2161: Quinolinic acid phosphoribosyl transferase (QPRT) is an essential liability of non-small cell lung cancer
Journal Articles

Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer

Xiuchao Wang, Yunzhan Li, Zekun Li, Shengchen Lin, Hongwei Wang, Jianwei Sun, Chungen Lan, Liangliang Wu, Dongxiao Sun, Chongbiao Huang, Pankaj K. Singh, Nadine Hempel, Mohamed Trebak, Gina M. DeNicola, Jihui Hao, Shengyu Yang
Journal: Cancer Research
Cancer Res (2022) 82 (12): 2254–2268.
https://doi.org/10.1158/0008-5472.CAN-21-3230
Published: 15 June 2022
View articletitled, Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer
Open the PDF for Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer in another window
Includes: Multimedia, Supplementary data
Journal Articles

Abstract 2507: Does a threshold exist for NRF2 hyperactivation to block tumor progression in KRAS mutant, TP53-deficient NSCLC

Janine M. DeBlasi, Aimee Falzone, Gina M. DeNicola
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2507.
https://doi.org/10.1158/1538-7445.AM2021-2507
Published: 01 July 2021
View articletitled, Abstract 2507: Does a threshold exist for NRF2 hyperactivation to block tumor progression in KRAS mutant, TP53-deficient NSCLC
Journal Articles

Abstract PO-028: Investigating the contribution of CHAC1 to persistent mitochondrial respiratory function in NSCLC under cysteine deprivation

Nathan P. Ward, Gina M. DeNicola
Journal: Cancer Research
Cancer Res (2020) 80 (23_Supplement): PO-028.
https://doi.org/10.1158/1538-7445.EPIMETAB20-PO-028
Published: 02 December 2020
View articletitled, Abstract PO-028: Investigating the contribution of CHAC1 to persistent mitochondrial respiratory function in NSCLC under cysteine deprivation
Journal Articles

Abstract B04: NRF2 regulates serine biosynthesis in pancreatic ductal adenocarcinoma

Gina M. DeNicola, Pei-Hsuan Chen, Edouard Mullarky, Christine Chio, John M. Asara, John D. Minna, David A. Tuveson, Ralph J. DeBerardinis, Lewis C. Cantley
Journal: Cancer Research
Cancer Res (2016) 76 (24_Supplement): B04.
https://doi.org/10.1158/1538-7445.PANCA16-B04
Published: 14 December 2016
View articletitled, Abstract B04: NRF2 regulates serine biosynthesis in pancreatic ductal adenocarcinoma
Journal Articles

Abstract NG05: Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53 null tumors

Brooke M. Emerling, Jonathan B. Hurov, George Poulogiannis, Rayman Choo-Wing, Gerburg M. Wulf, Hye-Seok Shim, Katja A. Lamia, Lucia E. Rameh, Xin Yuan, Andrea Bullock, Gina M. DeNicola, Jiaxi Song, Sabina Signoretti, Lewis C. Cantley
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): NG05.
https://doi.org/10.1158/1538-7445.AM2014-NG05
Published: 01 October 2014
View articletitled, Abstract NG05: Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53 null tumors