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Giampaolo Tortora
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Journal Articles

Abstract PO2-01-14: Development of Artificial Intelligence-based Machine Learning Models for Predicting Survival In Hormone-Receptor-Positive/HER2-Negative Early Breast Cancer undergoing Neoadjuvant Chemotherapy

Luca Mastrantoni, Giovanna Garufi, Noemi Maliziola, Elena Di Monte, Giorgia Arcuri, Valentina Frescura, Angelachiara Rotondi, Giulia Giordano, Luisa Carbognin, Alessandra Fabi, Ida Paris, Gianluca Franceschini, Armando Orlandi, Antonella Palazzo, Giovanni Scambia, Giampaolo Tortora, Emilio Bria
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO2-01-14.
https://doi.org/10.1158/1538-7445.SABCS23-PO2-01-14
Published: 02 May 2024
View article titled, Abstract PO2-01-14: Development of Artificial Intelligence-based Machine Learning Models for Predicting Survival In Hormone-Receptor-Positive/HER2-Negative Early Breast Cancer undergoing Neoadjuvant Chemotherapy
Journal Articles

Abstract P2-02-06: Adjuvant Denosumab treatment in early breast cancer: a systematic review and meta-analysis of randomized controlled clinical trials

Luca Mastrantoni, Giovanna Garufi, Elena Di Monte, Noemi Maliziola, Mariangela Pasqualoni, Letizia Pontolillo, Sergio Pannunzio, Maria Chiara Cannizzaro, Armando Di Bello, Alessandra Fabi, Antonella Palazzo, Emilio Bria, Giampaolo Tortora, Armando Orlandi
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P2-02-06.
https://doi.org/10.1158/1538-7445.SABCS22-P2-02-06
Published: 01 March 2023
View article titled, Abstract P2-02-06: Adjuvant Denosumab treatment in early breast cancer: a systematic review and meta-analysis of randomized controlled clinical trials
Journal Articles

Abstract P1-19-43: Palbociclib-fulvestrant (PALBO-FUL) and everolimus -exemestane (EVE-EXE) for second line hormonal treatment (HT) of metastatic breast cancer (MBC) with lobular histology: A propensity score matched analysis

Armando Orlandi, Elena Iattoni, Laura Pizzuti, Agnese Fabbri, Andrea Botticelli, Carmela Di Dio, Antonella Palazzo, Giovanna Garufi, Giulia Indellicati, Daniele Alesini, Luisa Carbognin, Ida Paris, Angela Vaccaro, Luca Moscetti, Alessandra Cassano, Patrizia Vici, Valentina Magri, Giuseppe Naso, Diana Giannarelli, Paolo Marchetti, Emilio Bria, Giampaolo Tortora
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P1-19-43.
https://doi.org/10.1158/1538-7445.SABCS19-P1-19-43
Published: 15 February 2020
View article titled, Abstract P1-19-43: Palbociclib-fulvestrant (PALBO-FUL) and everolimus -exemestane (EVE-EXE) for second line hormonal treatment (HT) of metastatic breast cancer (MBC) with lobular histology: A propensity score matched analysis
Journal Articles

A Tribute to John Mendelsohn: A Pioneer in Targeted Cancer Therapy

Rakesh Kumar, Marc Van de Vijver, Giampaolo Tortora, Fortunato Ciardiello, Tzipora Goldkorn, Wilson H. Miller, Jr, Larry Norton
Journal: Cancer Research
Cancer Res (2019) 79 (17): 4315–4323.
https://doi.org/10.1158/0008-5472.CAN-19-0989
Published: 03 September 2019
View article titled, A Tribute to John Mendelsohn: A Pioneer in Targeted Cancer Therapy
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Journal Articles

Abstract 973: MEKK3 sustains EMT and stemness in pancreatic cancer by regulating YAP and TAZ transcriptional activity

Geny Piro, Raffaela Santoro, Marco Zanotto, Carmine Carbone, Giampaolo Tortora, Davide Melisi
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 973.
https://doi.org/10.1158/1538-7445.AM2018-973
Published: 01 July 2018
View article titled, Abstract 973: MEKK3 sustains EMT and stemness in pancreatic cancer by regulating YAP and TAZ transcriptional activity
Journal Articles

Abstract 3501: Adipocytes sustain pancreatic cancer progression through a non-canonical WNT paracrine network inducing ROR2 nuclear shuttling

Carmine Carbone, Geny Piro, Raffaela Santoro, Francesca Simionato, Valeria Merz, Camilla Zecchetto, Aldo Scarpa, Giampaolo Tortora, Davide Melisi
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3501.
https://doi.org/10.1158/1538-7445.AM2018-3501
Published: 01 July 2018
View article titled, Abstract 3501: Adipocytes sustain pancreatic cancer progression through a non-canonical WNT paracrine network inducing ROR2 nuclear shuttling
Journal Articles

Abstract 3339: Modulating TAK1 expression through the inhibition of GSK3 impairs YAP/TAZ oncogenic functions in pancreatic cancer

Raffaela Santoro, Marco Zanotto, Geny Piro, Carmine Carbone, Giampaolo Tortora, Davide Melisi
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3339.
https://doi.org/10.1158/1538-7445.AM2018-3339
Published: 01 July 2018
View article titled, Abstract 3339: Modulating TAK1 expression through the inhibition of GSK3 impairs YAP/TAZ oncogenic functions in pancreatic cancer
Journal Articles

Abstract 3265: Homeobox B9 (HOXB9) sustains anti-VEGF treatment resistance in gastrointestinal tumors

Carmine Carbone, Geny Piro, Francesca Simionato, Fotios Loupakis, Chiara Cremolini, Gabriella Fontanini, Federica Di Nicolantonio, Elisa Moratti, Francesca Ligorio, Marco Zanotto, Raffaela Santoro, Maria Mihaela Mina, Aldo Scarpa, Alberto Bardelli, Giampaolo Tortora, Davide Melisi
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3265.
https://doi.org/10.1158/1538-7445.AM2016-3265
Published: 15 July 2016
View article titled, Abstract 3265: Homeobox B9 (HOXB9) sustains anti-VEGF treatment resistance in gastrointestinal tumors
Journal Articles

Abstract CT061: A phase Ib study of alpelisib (BYL719) + everolimus ± exemestane in patients with advanced solid tumors or HR+/HER2-breast cancer

Jose Baselga, Giuseppe Curigliano, Miguel Martín, Fabrice André, J. Thaddeus Beck, Giampaolo Tortora, Celine Wilke, Laure Charbonnier, Lars Blumenstein, Valerie Donnet, Nicola Fazio
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): CT061.
https://doi.org/10.1158/1538-7445.AM2016-CT061
Published: 15 July 2016
View article titled, Abstract CT061: A phase Ib study of alpelisib (BYL719) + everolimus ± exemestane in patients with advanced solid tumors or HR+/HER2-breast cancer
Journal Articles

Abstract 579: TAK1-regulated expression of BIRC3 is responsible for chemoradiotherapy (CRT) resistance in esophagogastric junction (EGJ) adenocarcinoma

Geny Piro, Simone Giacopuzzi, Maria Bencivenga, Carmine Carbone, Giuseppe Verlato, Melissa Frizziero, Maria Mihaela Mina, Marco Zanotto, Valeria Merz, Giovanni De Manzoni, Giampaolo Tortora, Davide Melisi
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 579.
https://doi.org/10.1158/1538-7445.AM2015-579
Published: 01 August 2015
View article titled, Abstract 579: TAK1-regulated expression of BIRC3 is responsible for chemoradiotherapy (CRT) resistance in esophagogastric junction (EGJ) adenocarcinoma
Journal Articles

Abstract 3605: Combined inhibition of IL-1, CXCR1/2, and TGFβ signaling pathways modulates in vivo acquired resistance to anti-VEGF treatment

Carmine Carbone, Anna Tamburrino, Geny Piro, Marco Zanotto, Maria Mihaela Mina, Silvia Zanini, Federico Boschi, Aldo Scarpa, Giampaolo Tortora, Davide Melisi
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3605.
https://doi.org/10.1158/1538-7445.AM2015-3605
Published: 01 August 2015
View article titled, Abstract 3605: Combined inhibition of IL-1, CXCR1/2, and TGFβ signaling pathways modulates in vivo acquired resistance to anti-VEGF treatment
Journal Articles

Abstract 616: R1507, the human monoclonal antibody targeting the insulin-like growth factor receptor (IGF-1R), in combination with cetuximab, can reverse acquired resistance to cetuximab in pancreatic and colon cancer models

Davide Melisi, Roberta Rosa, Roberto Bianco, Carmine Carbone, Giampaolo Tortora, Alfredo Budillon, James L. Abbruzzese, Paul J. Chiao, Milind Javle
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 616.
https://doi.org/10.1158/1538-7445.AM10-616
Published: 15 April 2010
View article titled, Abstract 616: R1507, the human monoclonal antibody targeting the insulin-like growth factor receptor (IGF-1R), in combination with cetuximab, can reverse acquired resistance to cetuximab in pancreatic and colon cancer models
Journal Articles

Abstract 615: Novel Toll-like Receptor 9 (TLR9) agonist IMO inhibits tumor growth and cooperates with cetuximab in K-Ras mutant colon and pancreatic cancers

Giampaolo Tortora, Roberta Rosa, Davide Melisi, Roberto Bianco, Teresa Gelardi, Sonia Garofalo, Roberta Marciano, Luigi Formisano, Lucia Nappi, Vincenzo Damiano
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 615.
https://doi.org/10.1158/1538-7445.AM10-615
Published: 15 April 2010
View article titled, Abstract 615: Novel Toll-like Receptor 9 (TLR9) agonist IMO inhibits tumor growth and cooperates with cetuximab in K-Ras mutant colon and pancreatic cancers
Journal Articles

Abstract 5401: The mTOR inhibitor everolimus cooperates with the Toll-like receptor 9 (TLR9) agonist IMO in renal cell carcinoma by interfering with both tumor cells and microenvironment

Giampaolo Tortora, Roberta Rosa, Teresa Gelardi, Vincenzo Damiano, Roberta Marciano, Lucia Nappi, Luigi Formisano, Roberto Bianco
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5401.
https://doi.org/10.1158/1538-7445.AM10-5401
Published: 15 April 2010
View article titled, Abstract 5401: The mTOR inhibitor everolimus cooperates with the Toll-like receptor 9 (TLR9) agonist IMO in renal cell carcinoma by interfering with both tumor cells and microenvironment
Journal Articles

Abstract #2778: Toll-like receptor 9 (TLR9) interacts with ErbB receptors at membrane level and a TLR9 agonist synergizes with trastuzumab in trastuzumab-resistant breast cancer xenografts via modulation of ErbB signalling

Giampaolo Tortora, Sonia Garofalo, Rosa Caputo, Roberto Bianco, Roberta Rosa, Teresa Gelardi, Gerardina Merola, Luigi Racioppi, Corrado Garbi, Ekambar Kandimalla, Sudhir Agrawal, Vincenzo Damiano
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 2778.
Published: 01 May 2009
View article titled, Abstract #2778: Toll-like receptor 9 (TLR9) interacts with ErbB receptors at membrane level and a TLR9 agonist synergizes with trastuzumab in trastuzumab-resistant breast cancer xenografts via modulation of ErbB signalling
Journal Articles

Combined Targeting of Endothelin A Receptor and Epidermal Growth Factor Receptor in Ovarian Cancer Shows Enhanced Antitumor Activity

Laura Rosanò, Valeriana Di Castro, Francesca Spinella, Giampaolo Tortora, Maria Rita Nicotra, Pier Giorgio Natali, Anna Bagnato
Journal: Cancer Research
Cancer Res (2007) 67 (13): 6351–6359.
https://doi.org/10.1158/0008-5472.CAN-07-0883
Published: 06 July 2007
View article titled, Combined Targeting of Endothelin A Receptor and Epidermal Growth Factor Receptor in Ovarian Cancer Shows Enhanced Antitumor Activity
Open the PDF for Combined Targeting of Endothelin A Receptor and Epidermal Growth Factor Receptor in Ovarian Cancer Shows Enhanced Antitumor Activity in another window
Journal Articles

Human cancer cell lines resistant to EGFR inhibitors acquire an altered expression of VEGFR-1/Flt-1 and become sensitive to ZD6474

Roberto Bianco, Gennaro Daniele, Terese Gelardi, Concetta Tuccillo, Anderson J. Ryan, A. Raffaele Bianco, Sabino De Placido, Fortunato Ciardiello, Giampaolo Tortora
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 888.
Published: 15 April 2006
View article titled, Human cancer cell lines resistant to EGFR inhibitors acquire an altered expression of VEGFR-1/Flt-1 and become sensitive to ZD6474
Journal Articles

The protein kinase C beta antagonist enzastaurin (LY317615.HCL) inhibits cancer cell growth by multiple mechanisms and is active in EGFR inhibitors-resistant cancer cells

Bianco Roberto, Vincenzo Damiano, Teresa Gelardi, Gennaro Daniele, Rosa Caputo, Davide Melisi, Angelo Raffaele Bianco, Michael Lahn, Fortunato Ciardiello, Giampaolo Tortora
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 518.
Published: 15 April 2006
View article titled, The protein kinase C beta antagonist enzastaurin (LY317615.HCL) inhibits cancer cell growth by multiple mechanisms and is active in EGFR inhibitors-resistant cancer cells
Journal Articles

Enhancement of cytotoxic activity of gemcitabine and ionizing radiation by combined treatment with the VEGF and EGF receptor tyrosine kinase inhibitor ZD6474 against pancreatic cancer cells in vitro

Cataldo Bianco, Elisa Giovannetti, Romano Danesi, Fortunato Ciardiello, Valentina Mey, Giampaolo Tortora, Urraca Gambardella, Francesco Pasqualetti, Giuseppe Pasqualetti, Sara Nannizzi, Luca Cionini, David Raben, Mario Del Tacca
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1121.
Published: 01 May 2005
View article titled, Enhancement of cytotoxic activity of gemcitabine and ionizing radiation by combined treatment with the VEGF and EGF receptor tyrosine kinase inhibitor ZD6474 against pancreatic cancer cells in vitro
Journal Articles

Antitumor activity of ZD6474, a VEGF and EGF receptor tyrosine kinase inhibitor, in combination with SC-236, a cyclooxygenase-2 inhibitor

Fortunato Ciardiello, Marco Romano, Concetta Tuccillo, Rosa Caputo, Vincenzo Damiano, Teresa Troiani, Ferdinando De Vita, Sabino De Placido, A. R. Bianco, Giampaolo Tortora
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 1048–1049.
Published: 01 April 2004
View article titled, Antitumor activity of ZD6474, a VEGF and EGF receptor tyrosine kinase inhibitor, in combination with SC-236, a cyclooxygenase-2 inhibitor