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Gheath Alatrash
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Journal Articles

Abstract 1236: Characterization of CBX-250, a first-in-class TCR-mimetic-based T-cell engager targeting a cathepsin G peptide-HLA complex for the treatment of myeloid leukemia

Geraldine Paulus, Benjamin Lee, Preethi Sankaran, Tanzila Rahman, Jessica Jimenez, Delainey O'Connor, Simon Yue, Yu Huang, Melissa Bikowitz, Sarah Jaffe, Shawn O'Malley, Bhupal Ban, Galina Gabriely, Tao Wang, Amanda Mak, Michael Princiotta, Chunhua Shi, Helen He, Ningping Feng, Jun Yan, Timothy Heffernan, Gheath Alatrash, Jeffrey Molldrem, Dmitri Wiederschain
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1236.
https://doi.org/10.1158/1538-7445.AM2024-1236
Published: 22 March 2024
View article titled, Abstract 1236: Characterization of CBX-250, a first-in-class TCR-mimetic-based T-cell engager targeting a cathepsin G peptide-HLA complex for the treatment of myeloid leukemia
Journal Articles

Abstract 44: A novel, codon-based method to modulate off-tumor toxicity of chimeric antigen receptor (CAR) T cells

Rolando A. Vedia, Sijie Lu, Anne V. Philips, Anna Sergeeva, Lisa S. St John, Karen Clise-Dwyer, Gheath Alatrash, Jeffrey J. Molldrem
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 44.
https://doi.org/10.1158/1538-7445.AM2024-44
Published: 22 March 2024
View article titled, Abstract 44: A novel, codon-based method to modulate off-tumor toxicity of chimeric antigen receptor (CAR) T cells
Journal Articles

Abstract CT101: Phase I study of the T-cell receptor-like antibody Hu8F4 in patients with advanced hematologic malignancies

Tapan M. Kadia, Hagop Kantarjian, Gheath Alatrash, Anna Sergeeva, Hong He, Lisa St. John, Priya Koppikar, Celine Kerros, Abhishek Maiti, Courtney Dinardo, Elias Jabbour, Serge Vesrstovsek, Naveen Pemmaraju, Nitin Jain, Ghayas Issa, Guillermo Montalban-Bravo, Aditi Shastri, Daniel Couriel, Rhona Pinsoy, Sapna Parshottam, Richard Champlin, Jorge Cortes, Jeffrey Molldrem
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT101.
https://doi.org/10.1158/1538-7445.AM2023-CT101
Published: 14 April 2023
View article titled, Abstract CT101: Phase I study of the T-cell receptor-like antibody Hu8F4 in patients with advanced hematologic malignancies
Journal Articles

Abstract 2995: Cross-presented serine proteases as immunotherapy targets for lung cancer and osteosarcoma

Amber Gibson, Pariya Sukhumalchandra, Celine Kerros, Na Qiao, Anne Philips, Mao Zhang, Sami Alkoutami, Scott Semelsberger, Yoshimi Lu, Lauren Byers, Ze Tian, Chunhua Shi, Jun Yan, Dongxing Zha, Alejandro Marinos, Anne Sergeeva, Hong He, Lisa St. John, Jeffrey J. Molldrem, Gheath Alatrash
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2995.
https://doi.org/10.1158/1538-7445.AM2023-2995
Published: 04 April 2023
View article titled, Abstract 2995: Cross-presented serine proteases as immunotherapy targets for lung cancer and osteosarcoma
Journal Articles

Abstract P4-07-23: Results of a Phase 2 Trial of Combination Immunotherapy with Concurrent Nelipepimut-S + GM-CSF and Trastuzumab in High-risk HER2+ Breast Cancer Patients

Ankur Tiwari, Guy Clifton, Carmen Calfa, Gheath Alatrash, Jarrod Holmes, Isabelle Bedrosian, George Peoples, Elizabeth A. Mittendorf
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P4-07-23.
https://doi.org/10.1158/1538-7445.SABCS22-P4-07-23
Published: 01 March 2023
View article titled, Abstract P4-07-23: Results of a Phase 2 Trial of Combination Immunotherapy with Concurrent Nelipepimut-S + GM-CSF and Trastuzumab in High-risk HER2+ Breast Cancer Patients
Journal Articles

Trastuzumab Increases HER2 Uptake and Cross-Presentation by Dendritic Cells

Victor A. Gall, Anne V. Philips, Na Qiao, Karen Clise-Dwyer, Alexander A. Perakis, Mao Zhang, Guy T. Clifton, Pariya Sukhumalchandra, Qing Ma, Sangeetha M. Reddy, Dihua Yu, Jeffrey J. Molldrem, George E. Peoples, Gheath Alatrash, Elizabeth A. Mittendorf
Journal: Cancer Research
Series: Author Choice
Cancer Res (2017) 77 (19): 5374–5383.
https://doi.org/10.1158/0008-5472.CAN-16-2774
Published: 01 October 2017
View article titled, Trastuzumab Increases HER2 Uptake and Cross-Presentation by Dendritic Cells
Open the PDF for Trastuzumab Increases HER2 Uptake and Cross-Presentation by Dendritic Cells in another window
Includes: Supplementary data
Journal Articles

Abstract 3984: Neuropilin-1 mediates neutrophil elastase uptake and antigen cross-presentation in breast cancer cells

Celine Kerros, Satyendra C. Tripathi, Dongxing Zha, Sergeeva Anna, Haley L. Peters, Hiroyuki Katayama, Pariya Sukhumalchandra, Kathryn R. Cox, Alexander A. Perakis, Lisa S. St John, Gheath Alatrash, Elizabeth A. Mittendorf, Karen C. Dwyer, Samir M. Hanash, Jeffrey J. Molldrem
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3984.
https://doi.org/10.1158/1538-7445.AM2017-3984
Published: 01 July 2017
View article titled, Abstract 3984: Neuropilin-1 mediates neutrophil elastase uptake and antigen cross-presentation in breast cancer cells
Journal Articles

Abstract IA17: T cell receptor-like antibody 8F4 targets leukemia and non-hematopoietic cancer

Jeffrey J. Molldrem, Anna Sergeeva, Hong He, Amanda C. Herrmann, Tian-Hui Yang, Celine Kerros, Haley Peters, Jin Seon Im, Sapna Parshottam, Sijie Lu, Qing Ma, Karen C. Dwyer, Elizabeth Mittendorf, Gheath Alatrash
Journal: Cancer Research
Cancer Res (2016) 76 (15_Supplement): IA17.
https://doi.org/10.1158/1538-7445.TME16-IA17
Published: 28 July 2016
View article titled, Abstract IA17: T cell receptor-like antibody 8F4 targets leukemia and non-hematopoietic cancer
Journal Articles

Abstract 534: Trastuzumab increases uptake and cross-presentation of HER2-derived antigens by dendritic cells

Victor A. Gall, Anne V. Philips, Na Qiao, Karen C. Dwyer, Alexander A. Perakis, Mao Zhang, Pariya Sukhumalchandra, Jeffrey J. Molldrem, Gheath Alatrash, Elizabeth A. Mittendorf
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 534.
https://doi.org/10.1158/1538-7445.AM2016-534
Published: 15 July 2016
View article titled, Abstract 534: Trastuzumab increases uptake and cross-presentation of HER2-derived antigens by dendritic cells
Journal Articles

Abstract 3243: Neutrophil elastase regulates PD-L1 expression in breast cancer

Victor Gall, Anne V. Philips, Akhil Chawla, Na Qiao, Lisa S. St. John, Pariya Sukhumalchandra, Mao Zhang, Jeffrey J. Molldrem, Gheath Alatrash, Elizabeth A. Mittendorf
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3243.
https://doi.org/10.1158/1538-7445.AM2016-3243
Published: 15 July 2016
View article titled, Abstract 3243: Neutrophil elastase regulates PD-L1 expression in breast cancer
Journal Articles

Abstract LB-222: Long-term subclonal evolution of CLL from immune selective pressure after allogeneic stem cell transplant and donor lymphocyte infusion

Haven R. Garber, Hannah Beird, Yu Cao, Jianhua Zhang, Rachel Sargent, Pei Lin, Sahil Seth, Xingzhi Song, Huandong Sun, Xizeng Mao, Lisa St John, Karen Clise-Dwyer, Gheath Alatrash, P. Andrew Futreal, Jeffrey J. Molldrem
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): LB-222.
https://doi.org/10.1158/1538-7445.AM2015-LB-222
Published: 01 August 2015
View article titled, Abstract LB-222: Long-term subclonal evolution of CLL from immune selective pressure after allogeneic stem cell transplant and donor lymphocyte infusion
Journal Articles

Abstract P5-04-07: Multispectral imaging allows visualization and quantification of multiple immunologic cell types in breast tumor tissues

Elizabeth A Mittendorf, Chichung Wang, Peng Yau, Kristin Roman, Yun Wu, Gheath Alatrash, Clifford Hoyt
Journal: Cancer Research
Cancer Res (2015) 75 (9_Supplement): P5-04-07.
https://doi.org/10.1158/1538-7445.SABCS14-P5-04-07
Published: 01 May 2015
View article titled, Abstract P5-04-07: Multispectral imaging allows visualization and quantification of multiple immunologic cell types in breast tumor tissues
Journal Articles

Abstract 4843: Neutrophil elastase enhances adaptive immunity via increase of peptide presentation and downregulation of T cell inhibitory molecules

Akhil Chawla, Anne V. Philips, Na Qiao, Pariya Sukhumalchandra, Celine Kerros, Gheath Alatrash, Jeffrey J. Molldrem, Elizabeth A. Mittendorf
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4843.
https://doi.org/10.1158/1538-7445.AM2014-4843
Published: 01 October 2014
View article titled, Abstract 4843: Neutrophil elastase enhances adaptive immunity via increase of peptide presentation and downregulation of T cell inhibitory molecules
Journal Articles

Abstract 1271: A novel method to identify HER2-derived HLA-A2 epitopes for use in combination immunotherapy with Trastuzumab.

Na Qiao, Akhil Chawla, Gheath Alatrash, Anne Philips, George Peoples, Sathibalan Ponniah, Elizabeth A. Mittendorf
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1271.
https://doi.org/10.1158/1538-7445.AM2013-1271
Published: 15 April 2013
View article titled, Abstract 1271: A novel method to identify HER2-derived HLA-A2 epitopes for use in combination immunotherapy with Trastuzumab.
Journal Articles

Breast Cancer Cell Uptake of the Inflammatory Mediator Neutrophil Elastase Triggers an Anticancer Adaptive Immune Response

Elizabeth A. Mittendorf, Gheath Alatrash, Na Qiao, Yun Wu, Pariya Sukhumalchandra, Lisa S. St. John, Anne V. Philips, Haile Xiao, Mao Zhang, Kathryn Ruisaard, Karen Clise-Dwyer, Sijie Lu, Jeffrey J. Molldrem
Journal: Cancer Research
Cancer Res (2012) 72 (13): 3153–3162.
https://doi.org/10.1158/0008-5472.CAN-11-4135
Published: 01 July 2012
View article titled, Breast Cancer Cell Uptake of the Inflammatory Mediator Neutrophil Elastase Triggers an Anticancer Adaptive Immune Response
Open the PDF for Breast Cancer Cell Uptake of the Inflammatory Mediator Neutrophil Elastase Triggers an Anticancer Adaptive Immune Response in another window
Includes: Supplementary data
Journal Articles

Abstract 788: Uptake and cross-presentation of the leukemia associated antigens neutrophil elastase (NE) and proteinase-3 (P3) increases susceptibility of solid tumors to PR1-targeted immunotherapy

Gheath Alatrash, Elizabeth Mittendorf, Anna Sergeeva, Pariya Sukhumalchandra, Na Qiao, Mao Zhang, Kathryn Quintanilla, Haile Xiao, Karen Clise-Dwyer, Sijie Lu, Jeffrey Molldrem
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 788.
https://doi.org/10.1158/1538-7445.AM2011-788
Published: 15 April 2011
View article titled, Abstract 788: Uptake and cross-presentation of the leukemia associated antigens neutrophil elastase (NE) and proteinase-3 (P3) increases susceptibility of solid tumors to PR1-targeted immunotherapy
Journal Articles

Abstract 801: Uptake of exogenous neutrophil elastase by breast cancer cells: A novel link between innate immunity, inflammation and breast cancer immunity

Elizabeth A. Mittendorf, Gheath Alatrash, Na Qiao, Haile Xiao, Pariya Sukhumalchandra, Kathryn Quintanilla, Karen Clise-Dwyer, Jeffrey Molldrem
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 801.
https://doi.org/10.1158/1538-7445.AM2011-801
Published: 15 April 2011
View article titled, Abstract 801: Uptake of exogenous neutrophil elastase by breast cancer cells: A novel link between innate immunity, inflammation and breast cancer immunity
Journal Articles

Mistrafficking of primary granule proteins (pgps) in leukemia simultaneously promotes pgp cross-priming and increases susceptibility to ctl killing

Gheath Alatrash, Yoko Ono, Anna Sergeeva, Sijie Lu, Changqing Wang, Eric Wieder, Jeffrey Molldrem
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 1034.
Published: 01 May 2008
View article titled, Mistrafficking of primary granule proteins (pgps) in leukemia simultaneously promotes pgp cross-priming and increases susceptibility to ctl killing