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Gergely Szakács
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Journal Articles

Abstract 1939: Improved activity and paraptosis-induction of anticancer thiosemicarbazones requires high copper(II) complex stability and slow reduction kinetics

Free
Sonja Hager, Veronika F. Pape, Vivien Pósa, Bianca Montsch, Lukas Uhlik, Gergely Szakàcs, Szilárd Tóth, Nikolett Jabronka, Bernhard K. Keppler, Walter Berger, Christian R. Kowol, Éva A. Enyedy, Petra Heffeter
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1939.
https://doi.org/10.1158/1538-7445.AM2020-1939
Published: 15 August 2020
View articletitled, Abstract 1939: Improved activity and paraptosis-induction of anticancer thiosemicarbazones requires high copper(II) complex stability and slow reduction kinetics
Journal Articles

Unshielding Multidrug Resistant Cancer through Selective Iron Depletion of P-Glycoprotein–Expressing Cells

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Mihály Cserepes, Dóra Türk, Szilárd Tóth, Veronika F.S. Pape, Anikó Gaál, Melinda Gera, Judit E. Szabó, Nóra Kucsma, György Várady, Beáta G. Vértessy, Christina Streli, Pál T. Szabó, Jozsef Tovari, Norbert Szoboszlai, Gergely Szakács
Journal: Cancer Research
Cancer Res (2020) 80 (4): 663–674.
https://doi.org/10.1158/0008-5472.CAN-19-1407
Published: 14 February 2020
View articletitled, Unshielding Multidrug Resistant Cancer through Selective Iron Depletion of P-Glycoprotein–Expressing Cells
Open the PDF for Unshielding Multidrug Resistant Cancer through Selective Iron Depletion of P-Glycoprotein–Expressing Cells in another window
Includes: Supplementary data
Journal Articles

Abstract 2119: Acquired nintedanib resistance in FGFR1-driven small cell but not non-small cell lung cancer is mediated by ABCB1

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Bernhard Englinger, Daniela Lötsch, Christine Pirker, Sushilla van Schoonhoven, Bernd Boidol, Charles Lardeau, Stefan Kubicek, Pal Szabó, Gergely Szakacs, Walter Berger
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2119.
https://doi.org/10.1158/1538-7445.AM2016-2119
Published: 15 July 2016
View articletitled, Abstract 2119: Acquired nintedanib resistance in FGFR1-driven small cell but not non-small cell lung cancer is mediated by ABCB1
Journal Articles

Identification of Compounds Selectively Killing Multidrug-Resistant Cancer Cells

Free
Dóra Türk, Matthew D. Hall, Benjamin F. Chu, Joseph A. Ludwig, Henry M. Fales, Michael M. Gottesman, Gergely Szakács
Journal: Cancer Research
Cancer Res (2009) 69 (21): 8293–8301.
https://doi.org/10.1158/0008-5472.CAN-09-2422
Published: 28 October 2009
View articletitled, Identification of Compounds Selectively Killing Multidrug-Resistant Cancer Cells
Open the PDF for Identification of Compounds Selectively Killing Multidrug-Resistant Cancer Cells in another window
Includes: Supplementary data
Journal Articles

Identifying the SLC transporters that confer drug sensitivity to cancer cells

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Mitsunori Okabe, Gergely Szakacs, Toshihiro Suzuki, Mark Reimers, Michael Gottesman
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 2290.
Published: 01 May 2007
View articletitled, Identifying the SLC transporters that confer drug sensitivity to cancer cells
Journal Articles

Selective toxicity of NSC73306 in MDR1-positive cells as a new strategy to circumvent multidrug resistance in cancer.

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Joseph A. Ludwig IV, Gergely Szakacs, Scott E. Martin, Natasha J. Caplen, Michael M. Gottesman
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1274–1275.
Published: 15 April 2006
View articletitled, Selective toxicity of NSC73306 in MDR1-positive cells as a new strategy to circumvent multidrug resistance in cancer.
Journal Articles

Mining the National Cancer Institute’s drug screening database in search for antineoplastics that selectively target MDR1/P-glycoprotein-overexpressing cancer cells

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Gergely Szakacs, Benjamin F. Chu, Joseph A. Ludwig, Michael M. Gottesman
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 295–296.
Published: 15 April 2006
View articletitled, Mining the National Cancer Institute’s drug screening database in search for antineoplastics that selectively target MDR1/P-glycoprotein-overexpressing cancer cells
Journal Articles

Profiling SLC22 and SLCO genes in the NCI-60 cancer cell lines to identify candidate substrates

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Mitsunori Okabe, Gergely Szakacs, Mark Reimers, Michael M. Gottesman
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 296.
Published: 15 April 2006
View articletitled, Profiling SLC22 and SLCO genes in the NCI-60 cancer cell lines to identify candidate substrates
Journal Articles

New daunorubicin analog exhibits anticancer activity and overcomes P-gp-mediated drug resistance.

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Lanyan Fang, Guisheng Zhang, Chenglong Li, Xincheng Zheng, Lizhi Zhu, Jim J. Xiao, Gergely Szakacs, Kenneth K. Chan, George P. Wang, Duxin Sun
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1270.
Published: 15 April 2006
View articletitled, New daunorubicin analog exhibits anticancer activity and overcomes P-gp-mediated drug resistance.
Journal Articles

The study and application of RNAi against cancer-related genes.

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Scott E. Martin, Tamara L. Jones, Cheryl L. Thomas, Dac Nguyen, Timothy Runfola, Gergely Szakacs, Michael M. Gottesman, Joseph A. Ludwig, John N. Weinstein, Michele Gunsior, Paul Goldsmith, Eric Lader, Konrad Huppi, Natasha J. Caplen
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1319.
Published: 15 April 2006
View articletitled, The study and application of RNAi against cancer-related genes.
Journal Articles

RNAi analysis of cancer associated genes

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Scott E. Martin, Tamara L. Jones, Dac A. Nguyen, Konrad Huppi, Peter Fitzgerald, Gergely Szakacs, Michael M. Gottesman, Eric Lader, Natasha J. Caplen
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1437.
Published: 01 May 2005
View articletitled, RNAi analysis of cancer associated genes
Journal Articles

A pharmacogenomic analysis reveals increased sensitivity of MDR1/P-glycoprotein-overexpressing cancer cells to thiosemicarbazone-derivatives

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Gergely Szakacs, Joseph A. Ludwig, Ben Chu, Henry M. Fales, Michael M. Gottesman
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 621.
Published: 01 May 2005
View articletitled, A pharmacogenomic analysis reveals increased sensitivity of MDR1/P-glycoprotein-overexpressing cancer cells to thiosemicarbazone-derivatives
Journal Articles

The role of ABCB6 in multidrug resistance

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Jill K. Paterson, Gergely Szakacs, Tokushi Tachiwada, Shin-Ichi Akiyama, Michael M. Gottesman
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 122.
Published: 01 May 2005
View articletitled, The role of ABCB6 in multidrug resistance
Journal Articles

Transcriptional profiling of the ABC transporter superfamily by quantitative RT-PCR in the NCI60 panel identifies new mechanisms of drug resistance.

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Gergely Szakacs, Jean-Philippe Annereau, Samir Lababidi, Uma Shankavaram, Kim Bussey, William Reinhold, John Weinstein, Michael Gottesman
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 518.
Published: 01 April 2004
View articletitled, Transcriptional profiling of the ABC transporter superfamily by quantitative RT-PCR in the NCI60 panel identifies new mechanisms of drug resistance.