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George Somlo
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Journal Articles

Abstract OT2-08-03: Immunogenicity of pembrolizumab and doxorubicin in a phase I trial for patients with metastatic triple negative breast cancer

Colt A. Egelston, Weihua Guo, Susan E. Yost, Xuan Ge, Jin Sun Lee, Paul H. Frankel, Yujie Cui, Christopher Ruel, Daniel Schmolze, Mireya Murga, Aileen Tang, Norma Martinez, Misagh Karimi, George Somlo, Peter Lee, James Waisman, Yuan Yuan
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): OT2-08-03.
https://doi.org/10.1158/1538-7445.SABCS22-OT2-08-03
Published: 01 March 2023
View articletitled, Abstract OT2-08-03: Immunogenicity of pembrolizumab and doxorubicin in a phase I trial for patients with metastatic triple negative breast cancer
Journal Articles

Abstract PD5-01: PD5-01 Genomic and epigenomic BRCA alterations predict adaptive resistance and response to platinum-based therapy in triple negative breast cancer and ovarian carcinoma

Francesca Menghi, Kalyan Banda, Pooja Kumar, Robert Straub, Lacey E. Dobrolecki, Isabel Rodriguez, Susan E. Yost, Harshpreet Chandok, Marc Radke, George Somlo, Yuan Yuan, Michael T. Lewis, Elizabeth Swisher, Edison Liu
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): PD5-01.
https://doi.org/10.1158/1538-7445.SABCS22-PD5-01
Published: 01 March 2023
View articletitled, Abstract PD5-01: PD5-01 Genomic and epigenomic BRCA alterations predict adaptive resistance and response to platinum-based therapy in triple negative breast cancer and ovarian carcinoma
Journal Articles

Abstract P3-11-05: Efficacy of Gonadal steroids on aromatase inhibitor-resistant ER+ breast cancer: Insights from single-cell trajectory analysis of a patient-derived xenograft model

Hitomi Mori, Kohei Saeki, Gregory Chang, Jinhui Wang, Xiwei Wu, Noriko Kanaya, George Somlo, Shiuan Chen
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P3-11-05.
https://doi.org/10.1158/1538-7445.SABCS22-P3-11-05
Published: 01 March 2023
View articletitled, Abstract P3-11-05: Efficacy of Gonadal steroids on aromatase inhibitor-resistant ER+ breast cancer: Insights from single-cell trajectory analysis of a patient-derived xenograft model
Journal Articles

Abstract PD1-04: Estrogen-mediated mechanisms in estrogen receptor-positive breast cancer at the single cell level

Hitomi Mori, Kohei Saeki, Gregory Chang, Jinhui Wang, Xiwei Wu, Pei-Yin Hsu, Noriko Kanaya, George Somlo, Masafumi Nakamura, Andrea Bild, Shiuan Chen
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): PD1-04.
https://doi.org/10.1158/1538-7445.SABCS21-PD1-04
Published: 15 February 2022
View articletitled, Abstract PD1-04: Estrogen-mediated mechanisms in estrogen receptor-positive breast cancer at the single cell level
Journal Articles

Abstract PD7-02: Estrogen-induced cell cycle arrest as an unexpected outcome of aromatase inhibitor-resistance: Insights from single-cell trajectory analysis of a patient-derived xenograft model

Hitomi Mori, Kohei Saeki, Gregory Chang, Xiwei Wu, Pei-Yin Hsu, Noriko Kanaya, George Somlo, Shiuan Chen
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PD7-02.
https://doi.org/10.1158/1538-7445.SABCS20-PD7-02
Published: 15 February 2021
View articletitled, Abstract PD7-02: Estrogen-induced cell cycle arrest as an unexpected outcome of aromatase inhibitor-resistance: Insights from single-cell trajectory analysis of a patient-derived xenograft model
Journal Articles

Abstract P1-08-01: Estrogen-induced cell cycle arrest and apoptosis in aromatase inhibitor-resistant breast cancer: Insights from single cells analysis of a patient-derived xenograft model

Hitomi Mori, Kohei Saeki, Gregory Chang, Xiwei Wu, Pei-Yin Hsu, Noriko Kanaya, George Somlo, Shiuan Chen
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P1-08-01.
https://doi.org/10.1158/1538-7445.SABCS19-P1-08-01
Published: 15 February 2020
View articletitled, Abstract P1-08-01: Estrogen-induced cell cycle arrest and apoptosis in aromatase inhibitor-resistant breast cancer: Insights from single cells analysis of a patient-derived xenograft model
Journal Articles

Abstract 419: Integrative analysis of multi-omics tumor profiles identifies pathways associated with resistance to anti-HER2 therapy in early stage breast cancer

Salendra Singh, Hannah Gilmore, Maysa Abu-Khalaf, George Somlo, William Sikov, Lyndsay Harris, Vinay Varadan
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 419.
https://doi.org/10.1158/1538-7445.AM2017-419
Published: 01 July 2017
View articletitled, Abstract 419: Integrative analysis of multi-omics tumor profiles identifies pathways associated with resistance to anti-HER2 therapy in early stage breast cancer
Journal Articles

Abstract 2160: Targeting SMC1 in combination therapy for triple negative breast cancer

Sushma Yadav, David Berz, George Somlo, Kimlin Ashing, Yate-Ching Yuan, Robert J. Hickey, Sailee Yadav, Arthur D. Riggs
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2160.
https://doi.org/10.1158/1538-7445.AM2016-2160
Published: 15 July 2016
View articletitled, Abstract 2160: Targeting SMC1 in combination therapy for triple negative breast cancer
Journal Articles

Abstract 304: HER2 basal tumors have frequent mutation of HER3 and are more resistant to HER2-targeted therapy

Vinay Varadan, Salendra Singh, Hannah Gilmore, Shikha Parsai, George Somlo, Maysa Abu-Khalaf, William Sikov, Lyndsay N. Harris
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 304.
https://doi.org/10.1158/1538-7445.AM2016-304
Published: 15 July 2016
View articletitled, Abstract 304: HER2 basal tumors have frequent mutation of HER3 and are more resistant to HER2-targeted therapy
Journal Articles

Abstract S4-05: Impact of intrinsic subtype by PAM50 and other gene signatures on pathologic complete response (pCR) rates in triple-negative breast cancer (TNBC) after neoadjuvant chemotherapy (NACT) +/- carboplatin (Cb) or bevacizumab (Bev): CALGB 40603/150709 (Allianc

William M Sikov, William T Barry, Katherine A Hoadley, Brandelyn N Pitcher, Baljit Singh, Sara M Tolaney, Charles S Kuzma, Timothy J Pluard, George Somlo, Elisa R Port, Mehra Golshan, Donald A Berry, Olwen M Hahn, Lisa A Carey, Charles M Perou, Clifford A Hudis, Eric P Winer
Journal: Cancer Research
Cancer Res (2015) 75 (9_Supplement): S4-05.
https://doi.org/10.1158/1538-7445.SABCS14-S4-05
Published: 01 May 2015
View articletitled, Abstract S4-05: Impact of intrinsic subtype by PAM50 and other gene signatures on pathologic complete response (pCR) rates in triple-negative breast cancer (TNBC) after neoadjuvant chemotherapy (NACT) +/- carboplatin (Cb) or bevacizumab (Bev): CALGB 40603/150709 (Allianc
Journal Articles

Abstract P6-01-07: Association of baseline pro-inflammatory (IL-6, CRP) and coagulation (D-dimer) markers with baseline functional status in women with breast cancer (BC) undergoing chemotherapy

Yuan Yuan, Nilesh Vora, Tao Feng, Joanne Mortimer, Thehang Luu, George Somlo, Joseph Chao, Vivi Tran, Shu Mi, Tim Synold, James Waisman, Laura Zavala, Vani Katheria, Arti Hurria
Journal: Cancer Research
Cancer Res (2015) 75 (9_Supplement): P6-01-07.
https://doi.org/10.1158/1538-7445.SABCS14-P6-01-07
Published: 01 May 2015
View articletitled, Abstract P6-01-07: Association of baseline pro-inflammatory (IL-6, CRP) and coagulation (D-dimer) markers with baseline functional status in women with breast cancer (BC) undergoing chemotherapy
Journal Articles

Abstract OT2-1-01: Fulvestrant alone versus fulvestrant and everolimus versus fulvestrant, everolimus and anastrozole: A Phase III randomized, placebo-controlled trial in postmenopausal patients with hormone-receptor-positive stage IV breast cancer: SWOG-Clinical Trials Ini

George Somlo, William Barlow, Halle Moore, Julie Gralow, Anne Schott, Daniel Hayes, Peter Kuhn, James Hicks, Danika Lew, Debu Tripathy, Gabriel Hortobagyl
Journal: Cancer Research
Cancer Res (2015) 75 (9_Supplement): OT2-1-01.
https://doi.org/10.1158/1538-7445.SABCS14-OT2-1-01
Published: 01 May 2015
View articletitled, Abstract OT2-1-01: Fulvestrant alone versus fulvestrant and everolimus versus fulvestrant, everolimus and anastrozole: A Phase III randomized, placebo-controlled trial in postmenopausal patients with hormone-receptor-positive stage IV breast cancer: SWOG-Clinical Trials Ini
Journal Articles

Abstract 3330: Overcoming drug resistance in triple negative breast cancer by targeting SMC1 and PARP.

Sushma Yadav, Zeynep Eroglu, Archana Sehrawat, George Somlo, Yate-Ching Yuan, Yogesh C. Awasthi, Sanjay Awasthi
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3330.
https://doi.org/10.1158/1538-7445.AM2013-3330
Published: 15 April 2013
View articletitled, Abstract 3330: Overcoming drug resistance in triple negative breast cancer by targeting SMC1 and PARP.
Journal Articles

Abstract 4666: A phase 2 study investigating the safety, efficacy and surrogate biomarkers of response of 5-azacitidine (5-AZA) andentinostat (MS-275) in patients with triple-negative advanced breast cancer.

Roisin M. Connolly, Rachel C. Jankowitz, Cynthia A. Zahnow, Zhe Zhang, Michelle A. Rudek, Stacie C. Jeter, Shannon Slater, Penny Powers, Antonio C. Wolff, John Fetting, Adam M. Brufsky, Richard Piekarz, Nita Ahuja, George Somlo, Augustin Garcia, Steven Baylin, Nancy E. Davidson, Vered Stearns
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4666.
https://doi.org/10.1158/1538-7445.AM2013-4666
Published: 15 April 2013
View articletitled, Abstract 4666: A phase 2 study investigating the safety, efficacy and surrogate biomarkers of response of 5-azacitidine (5-AZA) andentinostat (MS-275) in patients with triple-negative advanced breast cancer.
Journal Articles

Abstract A9: De novo sequencing of circulating microRNAs identifies novel markers predicting clinical outcome of locally advanced breast cancer

Xiwei Wu, George Somlo, Melanie Palomares, Yun Yen, John Rossi, Harry Gao, Shizhen Emily Wang
Journal: Cancer Research
Cancer Res (2012) 72 (2_Supplement): A9.
https://doi.org/10.1158/1538-7445.NONRNA12-A9
Published: 03 April 2013
View articletitled, Abstract A9: De novo sequencing of circulating microRNAs identifies novel markers predicting clinical outcome of locally advanced breast cancer
Journal Articles

CCL2 Mediates Cross-talk between Cancer Cells and Stromal Fibroblasts That Regulates Breast Cancer Stem Cells

Akihiro Tsuyada, Amy Chow, Jun Wu, George Somlo, Peiguo Chu, Sofia Loera, Thehang Luu, Arthur Xuejun Li, Xiwei Wu, Wei Ye, Shiuan Chen, Weiying Zhou, Yang Yu, Yuan-Zhong Wang, Xiubao Ren, Hui Li, Peggy Scherle, Yukio Kuroki, Shizhen Emily Wang
Journal: Cancer Research
Cancer Res (2012) 72 (11): 2768–2779.
https://doi.org/10.1158/0008-5472.CAN-11-3567
Published: 31 May 2012
View articletitled, CCL2 Mediates Cross-talk between Cancer Cells and Stromal Fibroblasts That Regulates Breast Cancer Stem Cells
Open the PDF for CCL2 Mediates Cross-talk between Cancer Cells and Stromal Fibroblasts That Regulates Breast Cancer Stem Cells in another window
Includes: Supplementary data
Journal Articles

Abstract 1196: FZD7 plays a critical role in triple negative breast cancer proliferation

Lixin Yang, Xiwei Wu, Xutao Deng, Sean Lau, George Somlo, Yun Yen
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 1196.
https://doi.org/10.1158/1538-7445.AM2011-1196
Published: 15 April 2011
View articletitled, Abstract 1196: FZD7 plays a critical role in triple negative breast cancer proliferation
Journal Articles

Abstract #2606: Quantification of multiple biomarker expression in circulating tumor cells

H Hsieh, Kelly Bethel, Douglas Curry, Stephanie Jeffrey, Robert Krivacic, Peter Kuhn, Nicole Lazarus, Dena Marrinucci, Jorge Nieva, Erich Schwartz, George Somlo, Heather Wakelee, Richard Bruce
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 2606.
Published: 01 May 2009
View articletitled, Abstract #2606: Quantification of multiple biomarker expression in circulating tumor cells
Journal Articles

Personalized monitoring for breast cancer recurrence

Qiang Liu, Zhenbin Chen, Chunmei Yang, Jinong Feng, Jin Yan, George Somlo, Melanie Palomares, Steve Sommer
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 4519.
Published: 01 May 2008
View articletitled, Personalized monitoring for breast cancer recurrence
Journal Articles

Expression of wild type or specific mutations of FGFR3 in multiple myeloma cells is associated with variable PS-341 therapeutic effects

Min Guan, Lijun Zhu, George Somlo, Alison Hughes, Bingsen Zhou, Yun Yen
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 743.
Published: 01 May 2007
View articletitled, Expression of wild type or specific mutations of FGFR3 in multiple myeloma cells is associated with variable PS-341 therapeutic effects