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George Seed
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Journal Articles

Abstract B020: BCL2 expression is enriched in AR-independent advanced prostate cancer

Daniel Westaby, Juan M. Jimenez-Vacas, Ines Figueiredo, Claire Pettinger, Bora Gurel, Denisa Bogdan, Jan Rekowski, Lorenzo Buroni, Antje Neeb, Ruth Riisnaes, Mateus Crespo, Susana Miranda, Ana Ferreira, Daniel Nava Rodrigues, George Seed, Claudia Bertan, Maria de los Dolores Fenor de la Maza, Christina Guo, Juliet Carmichael, Rafael Grochot, Khobe Chandran, Andreas Varkaris, Steven P. Balk, Wei Yuan, Suzanne Carreira, Peter S. Nelson, Michael Haffner, Eva Corey, Johann de Bono, Adam Sharp
Journal: Cancer Research
Cancer Res (2023) 83 (11_Supplement): B020.
https://doi.org/10.1158/1538-7445.PRCA2023-B020
Published: 02 June 2023
View article titled, Abstract B020: BCL2 expression is enriched in AR-independent advanced prostate cancer
Journal Articles

Abstract 2898: HPN424, a Tri-specific T-cell Activating Construct, induces T cell-mediated cytotoxicity against human metastatic castration-resistant prostate cancers (mCRPC)

Veronica Gil, Christina Guo, George Seed, Antje Neeb, Lorenzo Buroni, Bora Gurel, Ines Figueiredo, Golzar Hemmati, Wade Aaron, Johann S. de Bono
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2898.
https://doi.org/10.1158/1538-7445.AM2022-2898
Published: 15 June 2022
View article titled, Abstract 2898: HPN424, a Tri-specific T-cell Activating Construct, induces T cell-mediated cytotoxicity against human metastatic castration-resistant prostate cancers (mCRPC)
Journal Articles

Abstract 2807: HER3 is an actionable target in advanced prostate cancer

Susana Miranda, Veronica Gil, Ruth Riisnaes, Bora Gurel, Mariantonietta D’Ambrosio, Alessandro Vasciaveo, Mateus Crespo, Ana Ferreira, Daniela Brina, Martina Troiani, Adam Sharp, Beshara Sheehan, Rossitza Christova, George Seed, Ines Figueiredo, Maryou Lambros, David Dolling, Jan Rekowski, Abdullah Alajati, Matthew Clarke, Rita Pereira, Penny Flohr, Gemma Fowler, Gunther Boysen, Semini Sumanasuriya, Diletta Bianchini, Pasquale Rescigno, Caterina Aversa, Nina Tunariu, Christina Guo, Alec Paschalis, Claudia Bertan, Lorenzo Buroni, Jian Ning, Suzanne Carreira, Paul Workman, Amanda Swain, Andrea Califano, Michael M. Shen, Andrea Alimonti, Antje Neeb, SU2C/PCF International Prostate Cancer Dream Team, Jonathan Welti, Wei Yuan, Johann de Bono
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2807.
https://doi.org/10.1158/1538-7445.AM2022-2807
Published: 15 June 2022
View article titled, Abstract 2807: HER3 is an actionable target in advanced prostate cancer
Journal Articles

HER3 Is an Actionable Target in Advanced Prostate Cancer

Veronica Gil, Susana Miranda, Ruth Riisnaes, Bora Gurel, Mariantonietta D’Ambrosio, Alessandro Vasciaveo, Mateus Crespo, Ana Ferreira, Daniela Brina, Martina Troiani, Adam Sharp, Beshara Sheehan, Rossitza Christova, George Seed, Ines Figueiredo, Maryou Lambros, David Dolling, Jan Rekowski, Abdullah Alajati, Matthew Clarke, Rita Pereira, Penny Flohr, Gemma Fowler, Gunther Boysen, Semini Sumanasuriya, Diletta Bianchini, Pasquale Rescigno, Caterina Aversa, Nina Tunariu, Christina Guo, Alec Paschalis, Claudia Bertan, Lorenzo Buroni, Jian Ning, Suzanne Carreira, Paul Workman, Amanda Swain, Andrea Califano, Michael M. Shen, Andrea Alimonti, Antje Neeb, PCF/SU2C International Prostate Cancer Dream Team, Jonathan Welti, Wei Yuan, Johann de Bono
Journal: Cancer Research
Cancer Res (2021) 81 (24): 6207–6218.
https://doi.org/10.1158/0008-5472.CAN-21-3360
Published: 15 December 2021
View article titled, HER3 Is an Actionable Target in Advanced Prostate Cancer
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Includes: Supplementary data
Journal Articles

Abstract CT161: A homologous recombination repair (HRR) functional assay to stratify patients with metastatic prostate cancer for PARP inhibitor treatment in the TOPARP-B clinical trial

Sara Arce-Gallego, Alba Llop-Guevara, Suzanne Carreira, Nuria Porta, Roberta Fasani, Diletta Bianchini, George Seed, Pasquale Rescigno, Alec Paschalis, Claudia Bertan, Chloe Baker, Jane Goodall, Susana Miranda, Ruth Riisnaes, Ines Figueiredo, Ana Ferreira, Rita Pereira, Bora Gurel, Daniel Nava Rodrigues, Wei Yuan, Jan Rekowski, Emma Hall, Violeta Serra, Johann S. de Bono, Joaquin Mateo
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): CT161.
https://doi.org/10.1158/1538-7445.AM2021-CT161
Published: 01 July 2021
View article titled, Abstract CT161: A homologous recombination repair (HRR) functional assay to stratify patients with metastatic prostate cancer for PARP inhibitor treatment in the TOPARP-B clinical trial
Journal Articles

Abstract LB035: B7-H3 as a therapeutic target in prostate cancer

Christina Guo, Ines Figueiredo, Bora Gurel, Matues Crespo, Jan Rekowski, Suzanne Carreira, Antje Neeb, Adam Sharp, Maria D. Fenor de la Maza, Pasquale Rescigno, Khobe Chandran, Ana Ferreira, Ruth Riisnaes, Susana Miranda, Rita Pereira, Veronica Gil, George Seed, Claudia Bertan, Chloe Baker, Wei Yuan, Johann S. de Bono
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB035.
https://doi.org/10.1158/1538-7445.AM2021-LB035
Published: 01 July 2021
View article titled, Abstract LB035: B7-H3 as a therapeutic target in prostate cancer
Journal Articles

Abstract LB-075: CDK12-mutated lethal prostate cancers: How hot are these tumors

Bora Gurel, Pasquale Rescigno, Wei Yuan, Rita Pereira, Mateus Crespo, Mattia Rediti, Ines Figueiredo, Maialen Barrero, Diletta Bianchini, Maria D. Fenor de la Maza, Khobe Chandran, Juliet Carmichael, Alec Paschalis, Adam Sharp, George Seed, Ruth Riisnaes, Claudia Bertan, Suzanne Carreira, Johann S. De Bono
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): LB-075.
https://doi.org/10.1158/1538-7445.AM2020-LB-075
Published: 15 August 2020
View article titled, Abstract LB-075: CDK12-mutated lethal prostate cancers: How hot are these tumors
Journal Articles

Abstract LB-270: Discovery of genomic correlates and tumor purity as an independent clinical factor of poor outcome in advanced prostate cancer lpWGS CNA data

George Seed, Semini Sumanasuriya, Claudia Bertan, Harry Parr, Gemma Fowler, Rossitza Christova, Lorna Pope, Jane Goodall, Maryou Lambros, Pasquale Rescigno, Penelope Flohr, Suzanne Carreira, Wei Yuan, Mustapha Chadjaa, Sandrine Mace, Johann De Bono
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): LB-270.
https://doi.org/10.1158/1538-7445.AM2020-LB-270
Published: 15 August 2020
View article titled, Abstract LB-270: Discovery of genomic correlates and tumor purity as an independent clinical factor of poor outcome in advanced prostate cancer lpWGS CNA data
Journal Articles

Abstract CT129: HyPeR: A phase 1, dose escalation and expansion trial of guadecitabine (SGI-110), a second-generation hypomethylating agent in combination with pembrolizumab (MK3475) in patients with refractory solid tumors

Dionysis Papadatos-Pastos, Abhijit Pal, Melek Akay, Malaka Ameratunga, Sanjena Mithra, Joo-Ern Ang, Sofia Levva, Reece Caldwell, Ruth Riisnaes, Mateus Crespo, Wei Yuan, George Seed, Bora Gurel, Ines Figueiredo, Rita Pereira, Susana Miranda, Anna Ferreira, Suzanne Carreira, Claudia Bertan, Chloe Baker, Ricardo Morilla, Robert Brown, Nahal Masrour, Toby Prout, Anna Zachariou, Alison Turner, Mona Parmar, Mark Van de Velde, Ben Jenkins, Christina Yap, Nina Tunariu, Udai Banerji, Juanita Lopez, Anna Minchom, Johann De Bono
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): CT129.
https://doi.org/10.1158/1538-7445.AM2020-CT129
Published: 15 August 2020
View article titled, Abstract CT129: HyPeR: A phase 1, dose escalation and expansion trial of guadecitabine (SGI-110), a second-generation hypomethylating agent in combination with pembrolizumab (MK3475) in patients with refractory solid tumors
Journal Articles

Abstract 4679: Mismatch repair defects in lethal prostate cancer

Pasquale Rescigno, Daniel Nava Rodrigues, Wei Yuan, Suzanne Carreira, Maryou Lambros, George Seed, Ruth Riisnaes, Susana Miranda, David Dolling, Matthew Clarke, Mateus Crespo, Claudia Bertan, Gunther Boysen, Joaquin Mateo, Ana Ferreira, Adam Sharp, Ines Figueiredo, Semini Sumanasuriya, Mariane Sousa Fontes, Diletta Bianchini, Zafeiris Zafeiriou, Johann Sebastian de Bono
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4679.
https://doi.org/10.1158/1538-7445.AM2017-4679
Published: 01 July 2017
View article titled, Abstract 4679: Mismatch repair defects in lethal prostate cancer
Journal Articles

Abstract LB-044: Copy number estimation from targeted amplicon-based next-generation sequencing of castration-resistant prostate cancer biopsies: analytic validation and clinical qualification for a iPARP clinical trial

George Seed, Wei Yuan, Joaquin Mateo, Suzanne Carreira, Maryou Lambros, Gunther Boysen, Roberta Ferraldeschi, Susana Miranda, Ines Figueiredo, Ruth Riisnaes, Mateus Crespo, Daniel Nava Rodrigues, Eric Talevich, Dan Robinson, Priya Kunju, Yi-mi Wu, Robert Lonigro, Shahneen Sandhu, Arul Chinnayan, Johann De Bono
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): LB-044.
https://doi.org/10.1158/1538-7445.AM2017-LB-044
Published: 01 July 2017
View article titled, Abstract LB-044: Copy number estimation from targeted amplicon-based next-generation sequencing of castration-resistant prostate cancer biopsies: analytic validation and clinical qualification for a iPARP clinical trial
Journal Articles

Abstract 993: Diagnostic leukapheresis (DLA): Molecular characterisation and organoid culture of circulating tumor cells (CTC) from metastatic castration resistant prostate cancer (mCRPC)

Maryou B. Lambros, Veronica S. Gil, Mateus Crespo, Mariane S. Fontes, Rui N. Neves, Niven Mahra, Gemma Fowler, Berni Ebbs, Penny Flohr, George Seed, Wei Yuan, Joanne Hunt, Deirdre Moloney, Dionne Ayanda, Joost F. Swennenhuis, Kiki C. Andree, Semini Sumanasuriya, Matthew Clarke, Pasquale Rescigno, Zafeiris Zafeiriou, Joaquin Mateo, Diletta Bianchini, Nikolas H. Stoecklein, Leon W. Terstappen, Gunther Boysen, Johann S. De Bono
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 993.
https://doi.org/10.1158/1538-7445.AM2017-993
Published: 01 July 2017
View article titled, Abstract 993: Diagnostic leukapheresis (DLA): Molecular characterisation and organoid culture of circulating tumor cells (CTC) from metastatic castration resistant prostate cancer (mCRPC)
Journal Articles

Second-Generation HSP90 Inhibitor Onalespib Blocks mRNA Splicing of Androgen Receptor Variant 7 in Prostate Cancer Cells

Roberta Ferraldeschi, Jonathan Welti, Marissa V. Powers, Wei Yuan, Tomoko Smyth, George Seed, Ruth Riisnaes, Somaieh Hedayat, Hannah Wang, Mateus Crespo, Daniel Nava Rodrigues, Ines Figueiredo, Susana Miranda, Suzanne Carreira, John F. Lyons, Swee Sharp, Stephen R. Plymate, Gerhardt Attard, Nicola Wallis, Paul Workman, Johann S. de Bono
Journal: Cancer Research
Series: Author Choice
Cancer Res (2016) 76 (9): 2731–2742.
https://doi.org/10.1158/0008-5472.CAN-15-2186
Published: 01 May 2016
View article titled, Second-Generation HSP90 Inhibitor Onalespib Blocks mRNA Splicing of Androgen Receptor Variant 7 in Prostate Cancer Cells
Open the PDF for Second-Generation HSP90 Inhibitor Onalespib Blocks mRNA Splicing of Androgen Receptor Variant 7 in Prostate Cancer Cells in another window
Journal Articles

Abstract CT322: DNA repair defects and antitumor activity with PARP inhibition: TOPARP, a phase II trial of olaparib in metastatic castration resistant prostate cancer

Joaquin Mateo, Shahneen Sandhu, Susana Miranda, Suzanne Carreira, Suneil Jain, Christy Ralph, Andrew Protheroe, Syed Hussain, Robert Jones, Tony Elliot, Ursula McGovern, Alexa Gillman, Claire Paulding, Helen Mossop, Nuria Porta, Diletta Bianchini, Zafeiris Zafeiriou, Gunther Boysen, Daniel Nava Rodrigues, Penelope Flohr, George Seed, Jane Goodall, Ines Figueiredo, Raquel Perez-Lopez, Nina Tunariu, Aurelius Omlin, Roberta Ferraldeschi, Lakshmi P. Kunju, Rosalind Eeles, Gerhardt Attard, Dan Robinson, Arul Chinnaiyan, Emma Hall, Johann S. de Bono
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): CT322.
https://doi.org/10.1158/1538-7445.AM2015-CT322
Published: 01 August 2015
View article titled, Abstract CT322: DNA repair defects and antitumor activity with PARP inhibition: TOPARP, a phase II trial of olaparib in metastatic castration resistant prostate cancer