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George P. Studzinski
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Journal Articles

Abstract 1811: Sorafenib-mediated apoptotic and autophagic cell death is increased by carnosic acid and a vitamin D2 analog in hepatocellular carcinoma (HCC)

Xuening Wang, Qunfeng Wu, Kien Pham, Aesis Luna, Michael Danilenko, Chen Liu, George P. Studzinski
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1811.
https://doi.org/10.1158/1538-7445.AM2020-1811
Published: 15 August 2020
View articletitled, Abstract 1811: Sorafenib-mediated apoptotic and autophagic cell death is increased by carnosic acid and a vitamin D2 analog in hepatocellular carcinoma (HCC)
Journal Articles

Abstract 315: Cell death of AML blasts induced by cytarabine and enhanced by the Vitamin D2/Carnosic acid cell differentiating combination involves apoptosis signal-regulating kinase 1 (ASK1) activation

Xuening Wang, Jonathan S. Harrison, George P. Studzinski
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 315.
https://doi.org/10.1158/1538-7445.AM2018-315
Published: 01 July 2018
View articletitled, Abstract 315: Cell death of AML blasts induced by cytarabine and enhanced by the Vitamin D2/Carnosic acid cell differentiating combination involves apoptosis signal-regulating kinase 1 (ASK1) activation
Journal Articles

Abstract 1185: Translational study of the enhancement of cytarabine toxicity to AML blasts by a differentiation agent combination

Xuening Wang, Jonathan Harrison, George P. Studzinski
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1185.
https://doi.org/10.1158/1538-7445.AM2016-1185
Published: 15 July 2016
View articletitled, Abstract 1185: Translational study of the enhancement of cytarabine toxicity to AML blasts by a differentiation agent combination
Journal Articles

Abstract 4655: Plant polyphenols inhibit cellular 24-hydroxylase (CYP24A1) expression and elevate serum 25-hydroxyvitamin D levels

Ehud Sharony, Ze'ev Barvish, Victoria Novik, Marina Khanin, Merav Cohen-Lahav, Doron Amichay, Yoav Sharoni, George P. Studzinski, Michael Danilenko
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4655.
https://doi.org/10.1158/1538-7445.AM2015-4655
Published: 01 August 2015
View articletitled, Abstract 4655: Plant polyphenols inhibit cellular 24-hydroxylase (CYP24A1) expression and elevate serum 25-hydroxyvitamin D levels
Journal Articles

Abstract 4233: Mef2C enhances 1,25-dihydroxyvitamin D3-induced monocytic differentiation of human myeloid leukemia cells by regulating C/EBPβ expression

Ruifang Zheng, Xuening Wang, George P. Studzinski
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4233.
https://doi.org/10.1158/1538-7445.AM2014-4233
Published: 01 October 2014
View articletitled, Abstract 4233: Mef2C enhances 1,25-dihydroxyvitamin D3-induced monocytic differentiation of human myeloid leukemia cells by regulating C/EBPβ expression
Journal Articles

Abstract 2184: The roles of intracellular calcium and ER stress in the synergistic apoptotic effect of the plant polyphenols curcumin and carnosic acid in acute myeloid leukemia cells.

Stella Pesakhov, Nasma Aqaqe, George P. Studzinski, Daniel Fishman, Michael Danilenko
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2184.
https://doi.org/10.1158/1538-7445.AM2013-2184
Published: 15 April 2013
View articletitled, Abstract 2184: The roles of intracellular calcium and ER stress in the synergistic apoptotic effect of the plant polyphenols curcumin and carnosic acid in acute myeloid leukemia cells.
Journal Articles

Abstract 5451: Inhibition of the MEK5/ERK5 pathway can redirect 1,25-dihydroxyvitamin D3-treated human AML cells from monocytic to granulocytic lineage of differentiation.

Xuening Wang, Ajay Menon, Elzbieta Gocek, Michael Danilenko, Jonathan S. Harrison, George P. Studzinski
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5451.
https://doi.org/10.1158/1538-7445.AM2013-5451
Published: 15 April 2013
View articletitled, Abstract 5451: Inhibition of the MEK5/ERK5 pathway can redirect 1,25-dihydroxyvitamin D3-treated human AML cells from monocytic to granulocytic lineage of differentiation.
Journal Articles

Abstract 2287: Inhibition of microRNA-32 leads to decreased expression of the survival-enhancing scaffold protein hKSR2 in human myeloid leukemia cells treated with vitamin D derivatives

Xuening Wang, Xiangwen Chen-Deutsch, Jonathan S. Harrison, George P. Studzinski
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2287.
https://doi.org/10.1158/1538-7445.AM2012-2287
Published: 15 April 2012
View articletitled, Abstract 2287: Inhibition of microRNA-32 leads to decreased expression of the survival-enhancing scaffold protein hKSR2 in human myeloid leukemia cells treated with vitamin D derivatives
Journal Articles

Abstract 1837: Cellular glutathione is an essential mediator of the enhancing effect of plant polyphenolic antioxidants on vitamin D-induced differentiation of acute myeloid leukemia cells

Victoria Novik, Stella Pesakhov, Yoav Sharoni, George P. Studzinski, Michael Danilenko
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1837.
https://doi.org/10.1158/1538-7445.AM2012-1837
Published: 15 April 2012
View articletitled, Abstract 1837: Cellular glutathione is an essential mediator of the enhancing effect of plant polyphenolic antioxidants on vitamin D-induced differentiation of acute myeloid leukemia cells
Journal Articles

MicroRNA-32 Upregulation by 1,25-Dihydroxyvitamin D3 in Human Myeloid Leukemia Cells Leads to Bim Targeting and Inhibition of AraC-Induced Apoptosis

Elzbieta Gocek, Xuening Wang, Xiuping Liu, Chang-Gong Liu, George P. Studzinski
Journal: Cancer Research
Cancer Res (2011) 71 (19): 6230–6239.
https://doi.org/10.1158/0008-5472.CAN-11-1717
Published: 29 September 2011
View articletitled, MicroRNA-32 Upregulation by 1,25-Dihydroxyvitamin D3 in Human Myeloid Leukemia Cells Leads to Bim Targeting and Inhibition of AraC-Induced Apoptosis
Open the PDF for MicroRNA-32 Upregulation by 1,25-Dihydroxyvitamin D3 in Human Myeloid Leukemia Cells Leads to Bim Targeting and Inhibition of AraC-Induced Apoptosis in another window
Journal Articles

Abstract 282A: The Nrf2 transcription factor is a positive regulator of differentiation of acute myeloid leukemia cells induced by vitamin D derivatives and plant polyphenols

Victoria Novik, Irene Bobilev, Andrzej Kutner, Itai Levi, Ofer Shpilberg, Yoav Sharoni, George P. Studzinski, Michael Danilenko
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 282A.
https://doi.org/10.1158/1538-7445.AM2011-282A
Published: 15 April 2011
View articletitled, Abstract 282A: The Nrf2 transcription factor is a positive regulator of differentiation of acute myeloid leukemia cells induced by vitamin D derivatives and plant polyphenols
Journal Articles

Abstract 3529: Evaluation of PRI vitamin D analogues, alone or with enhancers, as antileukemia agents

Jing Zhang, Hanna Baurska, Xiangwen Chen-Deutsch, Elzbieta Gocek, Jonathan S. Harrison, Marek Kielbinski, Michael Danilenko, Andrzej Kutner, Ewa Marcinkowska, George P. Studzinski
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 3529.
https://doi.org/10.1158/1538-7445.AM2011-3529
Published: 15 April 2011
View articletitled, Abstract 3529: Evaluation of PRI vitamin D analogues, alone or with enhancers, as antileukemia agents
Journal Articles

Abstract 1540: MAPK signaling profiles differ between 1,25D-sensitive HL60G and 1,25D-resistant 40AF human leukemia cells

Xiangwen Chen-Deutsch, George P. Studzinski
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1540.
https://doi.org/10.1158/1538-7445.AM10-1540
Published: 15 April 2010
View articletitled, Abstract 1540: MAPK signaling profiles differ between 1,25D-sensitive HL60G and 1,25D-resistant 40AF human leukemia cells
Journal Articles

Abstract 3491: Differential antileukemic activity of plant polyphenol combinations in acute myeloid leukemia (AML) cells

Stella Pesakhov, Marina Khanin, George P. Studzinski, Michael Danilenko
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3491.
https://doi.org/10.1158/1538-7445.AM10-3491
Published: 15 April 2010
View articletitled, Abstract 3491: Differential antileukemic activity of plant polyphenol combinations in acute myeloid leukemia (AML) cells
Journal Articles

The Requirement for and Changing Composition of the Activating Protein-1 Transcription Factor during Differentiation of Human Leukemia HL60 Cells Induced by 1,25-Dihydroxyvitamin D3

Xuening Wang, George P. Studzinski
Journal: Cancer Research
Cancer Res (2006) 66 (8): 4402–4409.
https://doi.org/10.1158/0008-5472.CAN-05-3109
Published: 17 April 2006
View articletitled, The Requirement for and Changing Composition of the Activating Protein-1 Transcription Factor during Differentiation of Human Leukemia HL60 Cells Induced by 1,25-Dihydroxyvitamin D3
Open the PDF for The Requirement for and Changing Composition of the Activating Protein-1 Transcription Factor during Differentiation of Human Leukemia HL60 Cells Induced by 1,25-Dihydroxyvitamin D3 in another window
Journal Articles

Cooperative anticancer effects of vitamin D compounds and plant polyphenols on WEHI-3B murine leukemia cells in vitro and in vivo

Eugene Izumchenko, Rita Kreinin, Yoav Sharoni, Joseph Levy, Mike Kafka, George P. Studzinski, Michael Danilenko
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1204.
Published: 01 May 2005
View articletitled, Cooperative anticancer effects of vitamin D compounds and plant polyphenols on WEHI-3B murine leukemia cells in vitro and in vivo
Journal Articles

Is the activation of PI3K/PDK1/Akt signaling pathway a sufficient signal for the survival of 1α, 25-dihydroxyvitamin D3-treated leukemia cells?

Yingyu Zhang, George P. Studzinski
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1083.
Published: 01 May 2005
View articletitled, Is the activation of PI3K/PDK1/Akt signaling pathway a sufficient signal for the survival of 1α, 25-dihydroxyvitamin D3-treated leukemia cells?
Journal Articles

Characterization of resistance to 1,25(OH)2 vitamin D3 in HL60-40AF myeloid leukemia cells

Edward Garay, Xuening Wang, Irini Fadel, Milan Uskokovic, George P. Studzinski
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 779.
Published: 01 May 2005
View articletitled, Characterization of resistance to 1,25(OH)2 vitamin D3 in HL60-40AF myeloid leukemia cells
Journal Articles

The disparate effects of “MEK-specific” inhibitors PD09059 and U0126 on1,25D3-induced differentiation of HL60 cells

Jing Zhang, Xuening Wang, George P. Studzinski
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1300–1301.
Published: 01 May 2005
View articletitled, The disparate effects of “MEK-specific” inhibitors PD09059 and U0126 on1,25D3-induced differentiation of HL60 cells
Journal Articles

Up-Regulation of Egr1 by 1,25-Dihydroxyvitamin D3 Contributes to Increased Expression of p35 Activator of Cyclin-Dependent Kinase 5 and Consequent Onset of the Terminal Phase of HL60 Cell Differentiation

Fei Chen, Qing Wang, Xuening Wang, George P. Studzinski
Journal: Cancer Research
Cancer Res (2004) 64 (15): 5425–5433.
https://doi.org/10.1158/0008-5472.CAN-04-0806
Published: 01 August 2004
View articletitled, Up-Regulation of Egr1 by 1,25-Dihydroxyvitamin D3 Contributes to Increased Expression of p35 Activator of Cyclin-Dependent Kinase 5 and Consequent Onset of the Terminal Phase of HL60 Cell Differentiation
Open the PDF for Up-Regulation of Egr1 by 1,25-Dihydroxyvitamin D3 Contributes to Increased Expression of p35 Activator of Cyclin-Dependent Kinase 5 and Consequent Onset of the Terminal Phase of HL60 Cell Differentiation in another window