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George L. Scheffer
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Journal Articles

Substrate Overlap between Mrp4 and Abcg2/Bcrp Affects Purine Analogue Drug Cytotoxicity and Tissue Distribution

Kazumasa Takenaka, Jessica A. Morgan, George L. Scheffer, Masashi Adachi, Clinton F. Stewart, Daxi Sun, Markos Leggas, Karin F.K. Ejendal, Christine A. Hrycyna, John D. Schuetz
Journal: Cancer Research
Cancer Res (2007) 67 (14): 6965–6972.
https://doi.org/10.1158/0008-5472.CAN-06-4720
Published: 17 July 2007
View article titled, Substrate Overlap between Mrp4 and Abcg2/Bcrp Affects Purine Analogue Drug Cytotoxicity and Tissue Distribution
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Includes: Supplementary data
Journal Articles

Immunohistochemical analysis of multidrug resistance associated protein-4 (MRP4) expression in human normal and tumor tissues

Markos Leggas, Rodica P. Bunaciu, Michael J. Roberts, Guoqing Du, Jatinder Lamba, George L. Scheffer, Clinton F. Stewart, John D. Schuetz
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 141.
Published: 15 April 2006
View article titled, Immunohistochemical analysis of multidrug resistance associated protein-4 (MRP4) expression in human normal and tumor tissues
Journal Articles

Multidrug resistance-related ATP-binding cassette (ABC) transporters in dendritic cell functions

Rieneke Van de Ven, Mariska C. De Jong, Anneke W. Reurs, Antoinet J. Schoonderwoerd, Gerrit Jansen, Jan H. Hooijberg, George L. Scheffer, Tanja D. De Gruijl, Rik J. Scheper
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1145.
Published: 15 April 2006
View article titled, Multidrug resistance-related ATP-binding cassette (ABC) transporters in dendritic cell functions
Journal Articles

Novel Extracellular Vesicles Mediate an ABCG2-Dependent Anticancer Drug Sequestration and Resistance

Ilan Ifergan, George L. Scheffer, Yehuda G. Assaraf
Journal: Cancer Research
Cancer Res (2005) 65 (23): 10952–10958.
https://doi.org/10.1158/0008-5472.CAN-05-2021
Published: 01 December 2005
View article titled, Novel Extracellular Vesicles Mediate an ABCG2-Dependent Anticancer Drug Sequestration and Resistance
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Journal Articles

Expression of multidrug transporter MRP4 is a marker of poor prognosis in neuroblastoma and confers resistance to CPT-11 in vitro

John D. Allen, Murray D. Norris, Janice Smith, Peter Tobin, Kara Tanabe, George L. Scheffer, Peter Wielinga, Glenn M. Marshall, Michelle Haber
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 116.
Published: 01 April 2004
View article titled, Expression of multidrug transporter MRP4 is a marker of poor prognosis in neuroblastoma and confers resistance to CPT-11 in vitro
Journal Articles

Multidrug resistance protein 4 (Mrp4) is expressed at the blood-cerebrospinal and blood-brain barriers and restricts topotecan brain penetration

Markos Leggas, Masashi Adachi, Daxi Sun, Guoqing Du, Kelly E. Mercer, John C. Panetta, Yanli Zhuang, George L. Scheffer, Rik J. Scheper, Peter Wielinga, Piet Borst, Clinton F. Stewart, John D. Schuetz
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 115–116.
Published: 01 April 2004
View article titled, Multidrug resistance protein 4 (Mrp4) is expressed at the blood-cerebrospinal and blood-brain barriers and restricts topotecan brain penetration
Journal Articles

Vaults and drug resistance: What we learn from an MVP/LRP knockout mouse model.

Erik A. Wiemer, Arend Van Zon, Marieke H. Mossink, George L. Scheffer, Rik J. Scheper, Pieter Sonneveld
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 568.
Published: 01 April 2004
View article titled, Vaults and drug resistance: What we learn from an <em>MVP/LRP</em> knockout mouse model.
Journal Articles

Disruption of the Murine Major Vault Protein (MVP/LRP) Gene Does Not Induce Hypersensitivity to Cytostatics

Marieke H. Mossink, Arend van Zon, Erna Fränzel-Luiten, Martijn Schoester, Valerie A. Kickhoefer, George L. Scheffer, Rik J. Scheper, Pieter Sonneveld, Erik A. C. Wiemer
Journal: Cancer Research
Cancer Res (2002) 62 (24): 7298–7304.
Published: 15 December 2002
View article titled, Disruption of the Murine Major Vault Protein (MVP/LRP) Gene Does Not Induce Hypersensitivity to Cytostatics
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Journal Articles

A Novel 7-modified Camptothecin Analog Overcomes Breast Cancer Resistance Protein-associated Resistance in a Mitoxantrone-selected Colon Carcinoma Cell Line

Paola Perego, Michelandrea De Cesare, Paola De Isabella, Nives Carenini, Gino Beggiolin, Gabriella Pezzoni, Manlio Palumbo, Loris Tartaglia, Graziella Pratesi, Claudio Pisano, Paolo Carminati, George L. Scheffer, Franco Zunino
Journal: Cancer Research
Cancer Res (2001) 61 (16): 6034–6037.
Published: 01 August 2001
View article titled, A Novel 7-modified Camptothecin Analog Overcomes Breast Cancer Resistance Protein-associated Resistance in a Mitoxantrone-selected Colon Carcinoma Cell Line
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Journal Articles

Subcellular Localization and Distribution of the Breast Cancer Resistance Protein Transporter in Normal Human Tissues

Marc Maliepaard, George L. Scheffer, Ian F. Faneyte, Margôt A. van Gastelen, Adriana C. L. M. Pijnenborg, Alfred H. Schinkel, Marc J. van de Vijver, Rik J. Scheper, Jan H. M. Schellens
Journal: Cancer Research
Cancer Res (2001) 61 (8): 3458–3464.
Published: 15 April 2001
View article titled, Subcellular Localization and Distribution of the Breast Cancer Resistance Protein Transporter in Normal Human Tissues
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Journal Articles

Peptide Transport by the Multidrug Resistance Protein MRP1

Mariska C. de Jong, Jerry W. Slootstra, George L. Scheffer, Anouk B. Schroeijers, Wouter C. Puijk, Remco Dinkelberg, Marcel Kool, Henk J. Broxterman, Rob H. Meloen, Rik J. Scheper
Journal: Cancer Research
Cancer Res (2001) 61 (6): 2552–2557.
Published: 03 March 2001
View article titled, Peptide Transport by the Multidrug Resistance Protein MRP1
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Journal Articles

The HER Tyrosine Kinase Inhibitor CI1033 Enhances Cytotoxicity of 7-Ethyl-10-hydroxycamptothecin and Topotecan by Inhibiting Breast Cancer Resistance Protein-mediated Drug Efflux

Charles Erlichman, Scott A. Boerner, Christopher G. Hallgren, Rebecca Spieker, Xiao-Yang Wang, C. David James, George L. Scheffer, Marc Maliepaard, Douglas D. Ross, Keith C. Bible, Scott H. Kaufmann
Journal: Cancer Research
Cancer Res (2001) 61 (2): 739–748.
Published: 01 January 2001
View article titled, The HER Tyrosine Kinase Inhibitor CI1033 Enhances Cytotoxicity of 7-Ethyl-10-hydroxycamptothecin and Topotecan by Inhibiting Breast Cancer Resistance Protein-mediated Drug Efflux
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Journal Articles

Specific Detection of Multidrug Resistance Proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-Glycoprotein with a Panel of Monoclonal Antibodies

George L. Scheffer, Marcel Kool, Marc Heijn, Marcel de Haas, Adriana C. L. M. Pijnenborg, Jan Wijnholds, Ardy van Helvoort, Mariska C. de Jong, Jan H. Hooijberg, Carla A. A. M. Mol, Marcel van der Linden, J. Marleen L. de Vree, Paul van der Valk, Ronald P. J. Oude Elferink, Piet Borst, Rik J. Scheper
Journal: Cancer Research
Cancer Res (2000) 60 (18): 5269–5277.
Published: 01 September 2000
View article titled, Specific Detection of Multidrug Resistance Proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-Glycoprotein with a Panel of Monoclonal Antibodies
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Journal Articles

Breast Cancer Resistance Protein Is Localized at the Plasma Membrane in Mitoxantrone- and Topotecan-resistant Cell Lines

George L. Scheffer, Marc Maliepaard, Adriana C. L. M. Pijnenborg, Margôt A. van Gastelen, Mariska C. de Jong, Anouk B. Schroeijers, Dorina M. van der Kolk, John D. Allen, Douglas D. Ross, Paul van der Valk, William S. Dalton, Jan H. M. Schellens, Rik J. Scheper
Journal: Cancer Research
Cancer Res (2000) 60 (10): 2589–2593.
Published: 15 May 2000
View article titled, Breast Cancer Resistance Protein Is Localized at the Plasma Membrane in Mitoxantrone- and Topotecan-resistant Cell Lines
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Journal Articles

The Mr 193,000 Vault Protein Is Up-Regulated in Multidrug-resistant Cancer Cell Lines

Anouk B. Schroeijers, Amara C. Siva, George L. Scheffer, Mariska C. de Jong, Sophie C. E. Bolick, Danny F. Dukers, Jerry W. Slootstra, Rob H. Meloen, Erik Wiemer, Valerie A. Kickhoefer, Leonard H. Rome, Rik J. Scheper
Journal: Cancer Research
Cancer Res (2000) 60 (4): 1104–1110.
Published: 01 February 2000
View article titled, The <em>M</em><sub>r</sub> 193,000 Vault Protein Is Up-Regulated in Multidrug-resistant Cancer Cell Lines
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Journal Articles

Analysis of Expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, Homologues of the Multidrug Resistance-associated Protein Gene (MRP1), in Human Cancer Cell Lines

Marcel Kool, Marcel de Haas, George L. Scheffer, Rik J. Scheper, Michiel J.T. van Eijk, Jenneke A. Juijn, Frank Baas, Piet Borst
Journal: Cancer Research
Cancer Res (1997) 57 (16): 3537–3547.
Published: 01 August 1997
View article titled, Analysis of Expression of <em>cMOAT (MRP2), MRP3, MRP4</em>, and <em>MRP5</em>, Homologues of the Multidrug Resistance-associated Protein Gene (<em>MRP1</em>), in Human Cancer Cell Lines
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Journal Articles

The LRP Gene Encoding a Major Vault Protein Associated with Drug Resistance Maps Proximal to MRP on Chromosome 16: Evidence That Chromosome Breakage Plays a Key Role in MRP or LRP Gene Amplification

Marilyn L. Slovak, Jennifer Pelkey Ho, Susan P. C. Cole, Roger G. Deeley, Lee Greenberger, Elisabeth G. E. de Vries, Henricus J. Broxterman, George L. Scheffer, Rik J. Scheper
Journal: Cancer Research
Cancer Res (1995) 55 (19): 4214–4219.
Published: 01 October 1995
View article titled, The <em>LRP</em> Gene Encoding a Major Vault Protein Associated with Drug Resistance Maps Proximal to <em>MRP</em> on Chromosome 16: Evidence That Chromosome Breakage Plays a Key Role in <em>MRP</em> or <em>LRP</em> Gene Amplification
Open the PDF for The <em>LRP</em> Gene Encoding a Major Vault Protein Associated with Drug Resistance Maps Proximal to <em>MRP</em> on Chromosome 16: Evidence That Chromosome Breakage Plays a Key Role in <em>MRP</em> or <em>LRP</em> Gene Amplification in another window
Journal Articles

Immunochemical Detection of the Multidrug Resistance-associated Protein MRP in Human Multidrug-resistant Tumor Cells by Monoclonal Antibodies

Marcel J. Flens, Miguel A. Izquierdo, George L. Scheffer, Jan M. Fritz, Chris J. L. M. Meijer, Rik J. Scheper, Guido J. R. Zaman
Journal: Cancer Research
Cancer Res (1994) 54 (17): 4557–4563.
Published: 01 September 1994
View article titled, Immunochemical Detection of the Multidrug Resistance-associated Protein MRP in Human Multidrug-resistant Tumor Cells by Monoclonal Antibodies
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Journal Articles

Overexpression of a Mr 110,000 Vesicular Protein in Non-P-Glycoprotein-mediated Multidrug Resistance

Rik J. Scheper, Henricus J. Broxterman, George L. Scheffer, Patricia Kaaijk, William S. Dalton, Theodorus H. M. van Heijningen, Coen K. van Kalken, Marilyn L. Slovak, Elisabeth G. E. de Vries, Paul van der Valk, Chris J. L. M. Meijer, Herbert M. Pinedo
Journal: Cancer Research
Cancer Res (1993) 53 (7): 1475–1479.
Published: 01 April 1993
View article titled, Overexpression of a <em>M</em><sub>r</sub> 110,000 Vesicular Protein in Non-P-Glycoprotein-mediated Multidrug Resistance
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