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George Coukos
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Journal Articles

Abstract 1256: B-cell infiltration is associated with survival outcomes in nivolumab-treated head and neck squamous cell carcinoma (HNSCC): NCT 03652142

Niki Gavrielatou, Ekaterina Fortis, Aris Spathis, Maria Anastasiou, Panagiota Economopoulou, Maria Gkotzamanidou, Sylvie Rusakiewics, Ioannis Vathiotis, Thazin Nwe Aung, Ioannis Kotsantis, Elena Mihal Vagia, Ioannis Panayiotides, David Rimm, George Coukos, Periklis Foukas, Amanda Psyrri
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1256.
https://doi.org/10.1158/1538-7445.AM2022-1256
Published: 15 June 2022
View article titled, Abstract 1256: B-cell infiltration is associated with survival outcomes in nivolumab-treated head and neck squamous cell carcinoma (HNSCC): NCT 03652142
Journal Articles

Going Beyond the Sequences: TCR Binding Patterns at the Service of Cancer Detection

Vincent Zoete, George Coukos
Journal: Cancer Research
Cancer Res (2019) 79 (7): 1299–1301.
https://doi.org/10.1158/0008-5472.CAN-19-0225
Published: 01 April 2019
View article titled, Going Beyond the Sequences: TCR Binding Patterns at the Service of Cancer Detection
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Journal Articles

Abstract 2570: OFF-switch CAR T cell for safety-enhanced cancer immunotherapy

Elise F. Gray-Gaillard, Greta Giordano Attianese, Pablo Gainza-Cirauqui, Sabrina Vollers, Sailan Shui, Bruno Correia, Melita Irving, George Coukos
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2570.
https://doi.org/10.1158/1538-7445.AM2018-2570
Published: 01 July 2018
View article titled, Abstract 2570: OFF-switch CAR T cell for safety-enhanced cancer immunotherapy
Journal Articles

Combine and Conquer: Double CTLA-4 and PD-1 Blockade Combined with Whole Tumor Antigen Vaccine Cooperate to Eradicate Tumors

Krisztian Homicsko, Jaikumar Duraiswamy, Marie-Agnès Doucey, George Coukos
Journal: Cancer Research
Cancer Res (2016) 76 (23): 6765–6767.
https://doi.org/10.1158/0008-5472.CAN-16-2868
Published: 30 November 2016
View article titled, Combine and Conquer: Double CTLA-4 and PD-1 Blockade Combined with Whole Tumor Antigen Vaccine Cooperate to Eradicate Tumors
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Journal Articles

Abstract 1071: Adoptive transfer of T cells overcomes barriers of homing to the tumor microenvironment in ovarian cancer

Emese Zsiros, Priyanka Duttagupta, Thomas Garrabrant, Janos L. Tanyi, Lana E. Kandalaft, George Coukos
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1071.
https://doi.org/10.1158/1538-7445.AM2014-1071
Published: 01 October 2014
View article titled, Abstract 1071: Adoptive transfer of T cells overcomes barriers of homing to the tumor microenvironment in ovarian cancer
Journal Articles

Abstract PR15: Autologous whole-tumor antigen combinatorial immunotherapy for recurrent ovarian cancer.

Lana E. Kandalaft, Janos Tanyi, Cheryl Lai-Lai Chiang, Drew Torigian, Daniel J. Powell, Jr., George Coukos
Journal: Cancer Research
Cancer Res (2013) 73 (1_Supplement): PR15.
https://doi.org/10.1158/1538-7445.TUMIMM2012-PR15
Published: 02 April 2014
View article titled, Abstract PR15: Autologous whole-tumor antigen combinatorial immunotherapy for recurrent ovarian cancer.
Journal Articles

Dual Blockade of PD-1 and CTLA-4 Combined with Tumor Vaccine Effectively Restores T-Cell Rejection Function in Tumors—Response

Jaikumar Duraiswamy, Gordon J. Freeman, George Coukos
Journal: Cancer Research
Cancer Res (2014) 74 (2): 633–634.
https://doi.org/10.1158/0008-5472.CAN-13-2752
Published: 16 January 2014
View article titled, Dual Blockade of PD-1 and CTLA-4 Combined with Tumor Vaccine Effectively Restores T-Cell Rejection Function in Tumors—Response
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Journal Articles

Therapeutic PD-1 Pathway Blockade Augments with Other Modalities of Immunotherapy T-Cell Function to Prevent Immune Decline in Ovarian Cancer

Jaikumar Duraiswamy, Gordon J. Freeman, George Coukos
Journal: Cancer Research
Series: Author Choice
Cancer Res (2013) 73 (23): 6900–6912.
https://doi.org/10.1158/0008-5472.CAN-13-1550
Published: 01 December 2013
View article titled, Therapeutic PD-1 Pathway Blockade Augments with Other Modalities of Immunotherapy T-Cell Function to Prevent Immune Decline in Ovarian Cancer
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Includes: Supplementary data
Journal Articles

Dual Blockade of PD-1 and CTLA-4 Combined with Tumor Vaccine Effectively Restores T-Cell Rejection Function in Tumors

Jaikumar Duraiswamy, Karen M. Kaluza, Gordon J. Freeman, George Coukos
Journal: Cancer Research
Series: Author Choice
Cancer Res (2013) 73 (12): 3591–3603.
https://doi.org/10.1158/0008-5472.CAN-12-4100
Published: 13 June 2013
View article titled, Dual Blockade of PD-1 and CTLA-4 Combined with Tumor Vaccine Effectively Restores T-Cell Rejection Function in Tumors
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Includes: Supplementary data
Journal Articles

Abstract 1421: Interleukin-22, a protective factor for ovarian cancer during TNFa-induced apoptosis.

Klara Balint, Tamara Seedial, Phyllis Gimotty, George Coukos, Andrea Facciabene
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1421.
https://doi.org/10.1158/1538-7445.AM2013-1421
Published: 15 April 2013
View article titled, Abstract 1421: Interleukin-22, a protective factor for ovarian cancer during TNFa-induced apoptosis.
Journal Articles

Abstract 4985: Expression of FasL on the tumor endothelium establishes a selective immune barrier in ovarian cancer.

Greg Motz, George Coukos
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4985.
https://doi.org/10.1158/1538-7445.AM2013-4985
Published: 15 April 2013
View article titled, Abstract 4985: Expression of FasL on the tumor endothelium establishes a selective immune barrier in ovarian cancer.
Journal Articles

Abstract LB-335: Autologous whole-tumor antigen vaccination in combination with adoptive T cell therapy for patients with recurrent ovarian cancer.

Lana E. Kandalaft, Janos Tanyi, Cheryl Chiang, Daniel Powell, George coukos
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): LB-335.
https://doi.org/10.1158/1538-7445.AM2013-LB-335
Published: 15 April 2013
View article titled, Abstract LB-335: Autologous whole-tumor antigen vaccination in combination with adoptive T cell therapy for patients with recurrent ovarian cancer.
Journal Articles

Abstract 3968: Ovarian cancer chemokine microenvironment is conducive to homing of CD3/CD28 co-stimulated T cells prepared for adoptive transfer therapy.

Emese Zsiros, Hongzhe Lee, Ian S. Hagemann, Priyanka Duttagupta, Renee Frank, Thomas Garrabrant, Bruce L. Levine, Carl H. June, Janos Tanyi, Lana Kandalaft, Michael Feldman, George Coukos
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3968.
https://doi.org/10.1158/1538-7445.AM2013-3968
Published: 15 April 2013
View article titled, Abstract 3968: Ovarian cancer chemokine microenvironment is conducive to homing of CD3/CD28 co-stimulated T cells prepared for adoptive transfer therapy.
Journal Articles

T-Regulatory Cells: Key Players in Tumor Immune Escape and Angiogenesis

Andrea Facciabene, Gregory T. Motz, George Coukos
Journal: Cancer Research
Cancer Res (2012) 72 (9): 2162–2171.
https://doi.org/10.1158/0008-5472.CAN-11-3687
Published: 30 April 2012
View article titled, T-Regulatory Cells: Key Players in Tumor Immune Escape and Angiogenesis
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Journal Articles

Abstract 1567: mTERT genetic vaccine chemotherapy combination augment antigen-specific immune response and confer tumor protection in time dependent fashion

Stefano Ugel, John Facciaponte, Elisa Scarselli, Carmela Mennuni, Nicla La Monica, George Coukos, Andrea Facciabene
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1567.
https://doi.org/10.1158/1538-7445.AM2012-1567
Published: 15 April 2012
View article titled, Abstract 1567: mTERT genetic vaccine chemotherapy combination augment antigen-specific immune response and confer tumor protection in time dependent fashion
Journal Articles

Abstract LB-133: Vaccination with dendritic cells pulsed with autologous oxidized whole tumor lysate induced strong and long-lasting anti-tumor immunity in recurrent ovarian cancer patients

Cheryl L-L Chiang, Lana Kandalaft, Janos Tanyi, Gina Mantina, Emese Zsiros, Daniel J. Powell, George Coukos
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): LB-133.
https://doi.org/10.1158/1538-7445.AM2012-LB-133
Published: 15 April 2012
View article titled, Abstract LB-133: Vaccination with dendritic cells pulsed with autologous oxidized whole tumor lysate induced strong and long-lasting anti-tumor immunity in recurrent ovarian cancer patients
Journal Articles

Abstract 308: Tumor hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells

Andrea Facciabene, George Coukos
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 308.
https://doi.org/10.1158/1538-7445.AM2012-308
Published: 15 April 2012
View article titled, Abstract 308: Tumor hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells
Journal Articles

A Combined Array-Based Comparative Genomic Hybridization and Functional Library Screening Approach Identifies mir-30d As an Oncomir in Cancer

Ning Li, Sippy Kaur, Joel Greshock, Heini Lassus, Xiaomin Zhong, Yanling Wang, Arto Leminen, Zhongjun Shao, Xiaowen Hu, Shun Liang, Dionyssios Katsaros, Qihong Huang, Ralf Bützow, Barbara L. Weber, George Coukos, Lin Zhang
Journal: Cancer Research
Cancer Res (2012) 72 (1): 154–164.
https://doi.org/10.1158/0008-5472.CAN-11-2484
Published: 02 January 2012
View article titled, A Combined Array-Based Comparative Genomic Hybridization and Functional Library Screening Approach Identifies mir-30d As an Oncomir in Cancer
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Includes: Supplementary data
Journal Articles

In Vivo Persistence, Tumor Localization, and Antitumor Activity of CAR-Engineered T Cells Is Enhanced by Costimulatory Signaling through CD137 (4-1BB)

De-Gang Song, Qunrui Ye, Carmine Carpenito, Mathilde Poussin, Li-Ping Wang, Chunyan Ji, Mariangela Figini, Carl H. June, George Coukos, Daniel J. Powell, Jr.
Journal: Cancer Research
Cancer Res (2011) 71 (13): 4617–4627.
https://doi.org/10.1158/0008-5472.CAN-11-0422
Published: 30 June 2011
View article titled, <em>In Vivo</em> Persistence, Tumor Localization, and Antitumor Activity of CAR-Engineered T Cells Is Enhanced by Costimulatory Signaling through CD137 (4-1BB)
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Includes: Supplementary data
Journal Articles

Abstract 4745: TLR8 agonist and Doxil chemotherapy potently activate human antitumor immune response in a human immune system mouse model

Andrea Facciabene, Alexander Malykhin, Maura Mathews, Chungyun Fang, Greg Dietsch, Rob Hershberg, George Coukos
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4745.
https://doi.org/10.1158/1538-7445.AM2011-4745
Published: 15 April 2011
View article titled, Abstract 4745: TLR8 agonist and Doxil chemotherapy potently activate human antitumor immune response in a human immune system mouse model