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Journal Articles

Abstract PO4-23-08: Estrogen therapy induces receptor-dependent DNA damage enhanced by PARP inhibition in ER+ breast cancer

Nicole Traphagen, Gary Schwartz, Steven Tau, Alyssa Roberts, Amanda Jiang, Sarah Hosford, Jonathan Marotti, Abigail Goen, Bianca Romo, Anneka Johnson, Emily Duffy, Eugene Demidenko, Paul Heverly, Yaron Mosesson, Shannon Soucy, Fred Kolling, Todd Miller
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO4-23-08.
https://doi.org/10.1158/1538-7445.SABCS23-PO4-23-08
Published: 02 May 2024
View article titled, Abstract PO4-23-08: Estrogen therapy induces receptor-dependent DNA damage enhanced by PARP inhibition in ER+ breast cancer
Journal Articles

Abstract 3517: Multi-modal single-cell and spatial genomics reveals genomic, adaptive and microenvironmental features of human non-small cell lung cancer brain metastasis

Somnath Tagore, Lindsay Caprio, Amit Dipak Amin, Irving Barrera, Johannes Melms, Karan Luthria, Yiping Wang, Yohanna Georgis, Abhi Jaiswal, Galina G. Lagos, Zachary Walsh, Parin Shah, Jana Biermann, Neha Sheikh, Priyanka Ramaradj, Niroshana Anandasabapathy, Hanina Hibshoosh, Gary Schwartz, Brian Henick, Alison Taylor, Fei Chen, Benjamin Izar
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3517.
https://doi.org/10.1158/1538-7445.AM2023-3517
Published: 04 April 2023
View article titled, Abstract 3517: Multi-modal single-cell and spatial genomics reveals genomic, adaptive and microenvironmental features of human non-small cell lung cancer brain metastasis
Journal Articles

Abstract 2367: Role of miR-34a-MET axis in head and neck cancer squamous cell carcinoma

Xun Wu, Yi-Shing Lisa Cheng, Methew Matthen, Angela Yoon, Gary Schwartz, Shashi Bala, Alison M. Taylor, Fatemeh Momen-Heravi
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2367.
https://doi.org/10.1158/1538-7445.AM2021-2367
Published: 01 July 2021
View article titled, Abstract 2367: Role of miR-34a-MET axis in head and neck cancer squamous cell carcinoma
Journal Articles

Abstract LB-224: Tyrosine phosphorylation of p27Kip1 associates with Palbociclib responsiveness in breast cancer

Stacy W. Blain, Susan R.S. Gottesman, Jonathan Somma, Vladislav Tsiperson, Julia McGuinness, Matthew Ingham, Kevin Kalinsky, Gary Schwartz, Elina Tress, Hanina Hibshoosh, Mohamed Mh Kahila, Bachar Samra Samra, Evelyn Taiwo, Steve Xie
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-224.
https://doi.org/10.1158/1538-7445.AM2019-LB-224
Published: 01 July 2019
View article titled, Abstract LB-224: Tyrosine phosphorylation of p27Kip1 associates with Palbociclib responsiveness in breast cancer
Journal Articles

Abstract P1-03-02: CYP2D6 intermediate metabolizers includes patient groups with distinct metabolic activity

Daniel L Hertz, Anna C Snavely, Howard L McLeod, Christine M Walko, Joseph G Ibrahim, Steven Anderson, Karen E Weck, Peter Rubin, Oludamilola Olajide, Susan Moore, Rachel Raab, Daniel R Carrizosa, Steven Corso, Gary Schwartz, Jeffrey M Peppercorn, James P Evans, Zeruesenay Desta, David A Flockhart, Lisa A Carey, William J Irvin, Jr
Journal: Cancer Research
Cancer Res (2015) 75 (9_Supplement): P1-03-02.
https://doi.org/10.1158/1538-7445.SABCS14-P1-03-02
Published: 01 May 2015
View article titled, Abstract P1-03-02: CYP2D6 intermediate metabolizers includes patient groups with distinct metabolic activity
Journal Articles

Abstract A67: Stromal expression of microRNA-21 identifies high-risk group in triple negative breast cancer

Todd MacKenzie, Gary Schwartz, Wendy Wells, Lorenzo Sempere
Journal: Cancer Research
Cancer Res (2015) 75 (1_Supplement): A67.
https://doi.org/10.1158/1538-7445.CHTME14-A67
Published: 12 January 2015
View article titled, Abstract A67: Stromal expression of microRNA-21 identifies high-risk group in triple negative breast cancer
Journal Articles

Abstract LB-200: Potent antitumor activity of MLN0128, an investigational selective mTORC1/2 kinase inhibitor, in preclinical models of rhabdomyosarcoma

Emily Slotkin, Parag Patwardhan, Shyamprasad Vasudeva Deraje, Gary Schwartz, Tap William
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): LB-200.
https://doi.org/10.1158/1538-7445.AM2014-LB-200
Published: 01 October 2014
View article titled, Abstract LB-200: Potent antitumor activity of MLN0128, an investigational selective mTORC1/2 kinase inhibitor, in preclinical models of rhabdomyosarcoma
Journal Articles

Abstract 2706: Crizotinib, a selective c-Met inhibitor, prevents metastasis to the liver and lungs in a primary uveal melanoma mouse model.

Oliver Surriga, Rajasekhar Vinagolu, Grazia Ambrosini, Gary Schwartz
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2706.
https://doi.org/10.1158/1538-7445.AM2013-2706
Published: 15 April 2013
View article titled, Abstract 2706: Crizotinib, a selective c-Met inhibitor, prevents metastasis to the liver and lungs in a primary uveal melanoma mouse model.
Journal Articles

Abstract B13: Automated multiplex assay for diagnostic application of contextual microRNA signatures in breast cancer

Wendy Wells, Sung-hee Choi, Gary Schwartz, Lorenzo F. Sempere
Journal: Cancer Research
Cancer Res (2012) 72 (2_Supplement): B13.
https://doi.org/10.1158/1538-7445.NONRNA12-B13
Published: 03 April 2013
View article titled, Abstract B13: Automated multiplex assay for diagnostic application of contextual microRNA signatures in breast cancer
Journal Articles

Abstract #4667: Suppression of Notch signaling with gamma-secretase inhibitors sensitizes malignant peripheral nerve sheath tumors to inhibitors of the Ras/Raf and PI3K/Akt pathways

Raymond Meng, Christopher Shelton, Yue-Ming Li, Gary Schwartz
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 4667.
Published: 01 May 2009
View article titled, Abstract #4667: Suppression of Notch signaling with gamma-secretase inhibitors sensitizes malignant peripheral nerve sheath tumors to inhibitors of the Ras/Raf and PI3K/Akt pathways
Journal Articles

Abstract #2488: Chk1 inhibition after replicative stress causes a double strand break response mediated primarily by DNA-dependent protein kinase

Samuel McNeely, Chiara Conti, Tahir Sheikh, Yves Pommier, Gary Schwartz, Archie Tse
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 2488.
Published: 01 May 2009
View article titled, Abstract #2488: Chk1 inhibition after replicative stress causes a double strand break response mediated primarily by DNA-dependent protein kinase
Journal Articles

Dual inhibition of the Notch and Hedgehog developmental pathways in colon cancers suppresses viability by combined downregulation of the PI3K/Akt pathway

Raymond Meng, Christopher Shelton, Yue-Ming Li, Gary Schwartz
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 1528.
Published: 01 May 2008
View article titled, Dual inhibition of the Notch and Hedgehog developmental pathways in colon cancers suppresses viability by combined downregulation of the PI3K/Akt pathway
Journal Articles

A selective Aurora B kinase inhibitor with potent anticancer activity either as a single agent or in combination with irinotecan (CPT-11) in colon cancer cells

Jayasree Nair, Gary Schwartz
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2304.
Published: 01 May 2008
View article titled, A selective Aurora B kinase inhibitor with potent anticancer activity either as a single agent or in combination with irinotecan (CPT-11) in colon cancer cells
Journal Articles

Altered MicroRNA Expression Confined to Specific Epithelial Cell Subpopulations in Breast Cancer

Lorenzo F. Sempere, Mette Christensen, Asli Silahtaroglu, Mads Bak, Catherine V. Heath, Gary Schwartz, Wendy Wells, Sakari Kauppinen, Charles N. Cole
Journal: Cancer Research
Cancer Res (2007) 67 (24): 11612–11620.
https://doi.org/10.1158/0008-5472.CAN-07-5019
Published: 18 December 2007
View article titled, Altered MicroRNA Expression Confined to Specific Epithelial Cell Subpopulations in Breast Cancer
Open the PDF for Altered MicroRNA Expression Confined to Specific Epithelial Cell Subpopulations in Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Gamma-secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity

Raymond Meng, Christopher Shelton, Haidar Cheema, Yueming Li, Gary Schwartz
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 5742.
Published: 01 May 2007
View article titled, Gamma-secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity
Journal Articles

Safingol (l-threo-dihydrosphingosine) induces ceramide-independent autophagy involving inhibition of PKCϵ and PI3k.

Jesse Coward, Grazia Ambrosini, Jean-Philip Truman, Adriana Haimovitz-Friedman, Alfred Merrill, Gary Schwartz
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 2757.
Published: 01 May 2007
View article titled, Safingol (l-<em>threo</em>-dihydrosphingosine) induces ceramide-independent autophagy involving inhibition of PKCϵ and PI3k.
Journal Articles

Inhibition of the kinesin motor protein Eg5 by AZ138 in HCT116 cell lines results in sustained mitotic arrest followed by delayed cell death

Alan Ho, Gary Schwartz
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 1436.
Published: 01 May 2007
View article titled, Inhibition of the kinesin motor protein Eg5 by AZ138 in HCT116 cell lines results in sustained mitotic arrest followed by delayed cell death
Journal Articles

The cyclin dependent kinase inhibitor flavopiridol potentiates the effects of Topo I poisons by suppressing Rad51 expression in a p53-dependent manner.

Grazia Ambrosini, Sharon Seelman, Haider Cheema, Gary Schwartz
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 5397.
Published: 01 May 2007
View article titled, The cyclin dependent kinase inhibitor flavopiridol potentiates the effects of Topo I poisons by suppressing Rad51 expression in a p53-dependent manner.
Journal Articles

β-catenin loss-of-function and its putative role as a tumor suppressor in sarcomagenesis

Igor Matushansky, Eva Hernando, Sam Singer, Gary Schwartz, Carlos Cordon-Cardo, Robert Maki
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1082.
Published: 15 April 2006
View article titled, β-catenin loss-of-function and its putative role as a tumor suppressor in sarcomagenesis
Journal Articles

CHIR 124, a novel and potent inhibitor of chk1, potentiates the anti-tumor activity of topoisomerase I poisons in vitro and in vivo.

Archie N. Tse, Millicent Embry, Kim Aardalen, Yi Shao, Katherine Rendahl, Daniel Menezes, Barbara Hibner, Tom Gesner, Gary Schwartz
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 537.
Published: 01 April 2004
View article titled, CHIR 124, a novel and potent inhibitor of chk1, potentiates the anti-tumor activity of topoisomerase I poisons <em>in vitro</em> and <em>in vivo</em>.