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Garrett M. Frampton
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Journal Articles

Computational and Functional Analyses of HER2 Mutations Reveal Allosteric Activation Mechanisms and Altered Pharmacologic Effects

Noboru Ishiyama, Matthew O'Connor, Andrei Salomatov, Darlene Romashko, Shalabh Thakur, Ahmet Mentes, Julia F. Hopkins, Garrett M. Frampton, Lee A. Albacker, Anna Kohlmann, Christopher Roberts, Elizabeth Buck
Journal: Cancer Research
Cancer Res canres.0940.2021.
DOI: https://doi.org/10.1158/0008-5472.CAN-21-0940
Published: 03 May 2022
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Abstract 472: Tumor mutational burden reveals tumor-specific patterns with intra-patient stability from multiple longitudinal tissue biopsies from 3,402 patients

Smruthy Sivakumar, Ethan S. Sokol, Garrett M. Frampton, David Fabrizio, Brian Alexander, Priti S. Hegde, Axel Grothey
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 472.
DOI: https://doi.org/10.1158/1538-7445.AM2021-472
Published: 01 July 2021
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Abstract 2233: Landscape of driver mutations in MAPK/PI3K/AKT signaling pathways reveals insights into therapeutic targeting strategies

Smruthy Sivakumar, Ethan S. Sokol, Garrett M. Frampton, Priti S. Hegde, David Fabrizio
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2233.
DOI: https://doi.org/10.1158/1538-7445.AM2021-2233
Published: 01 July 2021
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Abstract PS5-04: Therapeutic considerations in microsatellite instability high (MSI- H) breast cancers (BC) identified by comprehensive genomic profiling (CGP)

Kimberly McGregor, Natalie Danzinger, Jeffrey S. Ross, Kyle Gowen, Alexa B. Schrock, Garrett M. Frampton, Dean C. Pavlick, Jan W. Davis, Carl R. Gray, Jeffrey M. Venstrom
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PS5-04.
DOI: https://doi.org/10.1158/1538-7445.SABCS20-PS5-04
Published: 15 February 2021
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Abstract PD8-01: Comprehensive genomic profiling (CGP) of metastatic invasive lobular carcinomas reveals heterogeneity in immune biomarkers and resistance alterations across biopsy sites

Ethan Sokol, Dexter X Jin, Jeffrey Ross, Garrett M Frampton, Steffi Oesterreich
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PD8-01.
DOI: https://doi.org/10.1158/1538-7445.SABCS20-PD8-01
Published: 15 February 2021
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Abstract 5705: Mechanisms and therapeutic implications of hypermutation in gliomas

Mehdi Touat, Yvonne Y. Li, Adam N. Boynton, Liam F. Spurr, Bryan Iorgulescu, Craig L. Bohrson, Isidro Cortes-Ciriano, Jack E. Geduldig, Kristine Pelton, Mary J. Lim-Fat, Sangita Pal, Shakti H. Ramkissoon, Frank Dubois, Charlotte Bellamy, Naomi Currimjee, Kenin Qian, Seth Malinowski, Aniket Shetty, Kin-Hoe Chow, Maïté Verreault, Erell Guillerm, Samy Ammari, Frédéric Beuvon, Karima Mokhtari, Agusti Alentorn, Caroline Dehais, Caroline Houillier, Florence Laigle-Donadey, Dimitri Psimaras, Alexandre Carpentier, Philippe Cornu, Laurent Capelle, Bertrand Mathon, Jill S. Barnholtz-Sloan, Arnab Chakravarti, Wenya L. Bi, Garrett M. Frampton, Marc Sanson, Brian M. Alexander, Andrew Cherniack, Patrick Y. Wen, David A. Reardon, Aurelien Marabelle, Peter J. Park, Ahmed Idbaih, Rameen Beroukhim, Pratiti Bandopadhayay, Franck Bielle, Keith L. Ligon
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5705.
DOI: https://doi.org/10.1158/1538-7445.AM2020-5705
Published: 15 August 2020
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Abstract CT072: Exploration of impact of tumor BRCA zygosity and genomic loss-of-heterozygosity (gLOH) on efficacy in Phase 3 EMBRACA study of talazoparib in patients (pts) with HER2-negative (HER2−) advanced breast cancer (ABC) and a germline BRCA1/2 (gBRCA1/2) mutation

Jennifer K. Litton, A. Douglas Laird, Hope S. Rugo, Johannes Ettl, Sara A. Hurvitz, Miguel Martin, Henri Roché, Young-Hyuck Im, Annabel Goodwin, Joanne L. Blum, Wolfgang Eiermann, Ying Chen, Silvana Lanzalone, Jijumon Chelliserry, Akos Czibere, Lee A. Albacker, Garrett M. Frampton, Lida A. Mina
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): CT072.
DOI: https://doi.org/10.1158/1538-7445.AM2020-CT072
Published: 15 August 2020
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Abstract 3538: Microsatellite instability (MSI) and homologous recombination deficiency (HRD) are mutually exclusive mechanisms of genomic instability

Dexter X. Jin, Ethan S. Sokol, Sally E. Trabucco, Garrett M. Frampton, Luciana Molinero
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3538.
DOI: https://doi.org/10.1158/1538-7445.AM2020-3538
Published: 15 August 2020
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Abstract 2337: Pan-cancer analysis of sex differences and their associations with ancestry and genomic biomarkers in a large comprehensive genomic profiling dataset

Benjamin G. Kaplan, Peter Halmos, Justin Y. Newberg, Ethan S. Sokol, Meagan Montesion, Lee A. Albacker, Vincent Miller, Jeff S. Ross, Garrett M. Frampton, Jonathon K. Killian
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 2337.
DOI: https://doi.org/10.1158/1538-7445.AM2020-2337
Published: 15 August 2020
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Journal Articles

Abstract 4003: Comprehensive genomic profiling of Merkel cell carcinoma samples reveals bimodal distribution of tumor mutational burden and two mutually exclusive candidate mechanisms of malignant transformation

Meagan Montesion, Ethan S. Sokol, Todd C. Knepper, Andrew S. Brohl, Garrett M. Frampton, Phil J. Stephens, James A. DeCaprio, Kenneth Y. Tsai, Lee A. Albacker
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4003.
DOI: https://doi.org/10.1158/1538-7445.AM2018-4003
Published: 01 July 2018
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Abstract 1227: Somatic genome alterations in cancer as compared to inferred patient ancestry

Caitlin F. Connelly, Jian Carrot-Zhang, Philip J. Stephens, Garrett M. Frampton
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1227.
DOI: https://doi.org/10.1158/1538-7445.AM2018-1227
Published: 01 July 2018
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Abstract 2363: Novel CDH1 mutations in breast invasive lobular carcinoma

Garrett M. Frampton, Ryan Hartmaier, Ethan Sokol, Anika Gupta, Joel Greenbowe, Steven Roels, Laurie Gay, Philip J. Stephens
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2363.
DOI: https://doi.org/10.1158/1538-7445.AM2018-2363
Published: 01 July 2018
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Abstract 3406: Comprehensive genomic profiling of hematologic malignancies identifies recurrent somatic splicing factor mutations in non-Hodgkin's lymphoma (NHL) and multiple myeloma (MM)

Lee A. Albacker, Silvia Buonamici, Garrett M. Frampton, Peter Smith, Philip J. Stephens, Markus Warmuth, Ping Zhu, Lihua Yu
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3406.
DOI: https://doi.org/10.1158/1538-7445.AM2018-3406
Published: 01 July 2018
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Abstract 3394: CGP identifies largely non-overlapping high tumor mutational burden and HRD genomic alterations in 721 clinically advanced prostate acinar adenocarcinoma cases

Ninad Dewal, Yuting He, Richard J. Lee, Alexa B. Schrock, Jon Chung, Christopher Hoimes, Zachary R. Chalmers, Garrett M. Frampton, James X. Sun, Primo N. Lara, Neeraj Agrawal, Paul Matthew, Philip J. Stephens, Vincent A. Miller, Jeffrey S. Ross, Siraj M. Ali
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3394.
DOI: https://doi.org/10.1158/1538-7445.AM2017-3394
Published: 01 July 2017
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Journal Articles

Abstract 1775: The interaction of PD-L1, TMB, and genomic alterations in NSCLC

Michael E. Goldberg, Laurie M. Gay, David Fabrizio, Garrett M. Frampton, Julia A. Elvin, Jeffrey S. Ross, Vincent A. Miller, Philip J. Stephens, Lee A. Albacker
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1775.
DOI: https://doi.org/10.1158/1538-7445.AM2017-1775
Published: 01 July 2017
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Abstract 2987: Validation and clinical feasibility of a comprehensive genomic profiling assay to identify likely immunotherapy responders through tumor mutational burden (TMB)

Daniel S. Lieber, Mark R. Kennedy, Douglas B. Johnson, Jonathan E. Rosenberg, Marcin Kowanetz, Joel R. Greenbowe, Garrett M. Frampton, Caitlin F. Connelly, Alexa B. Schrock, Jeffrey S. Ross, Philip J. Stephens, Siraj M. Ali, Vincent A. Miller, David A. Fabrizio
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2987.
DOI: https://doi.org/10.1158/1538-7445.AM2017-2987
Published: 01 July 2017
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Abstract 398: Using off-target data from comprehensive genomic profiling to characterize the genomic architecture of copy number alterations in tumor sequencing data

Caitlin F. Connelly, Zachary R. Chalmers, Philip J. Stephens, Garrett M. Frampton
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 398.
DOI: https://doi.org/10.1158/1538-7445.AM2017-398
Published: 01 July 2017
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High-Throughput Genomic Profiling of Adult Solid Tumors Reveals Novel Insights into Cancer Pathogenesis

Ryan J. Hartmaier, Lee A. Albacker, Juliann Chmielecki, Mark Bailey, Jie He, Michael E. Goldberg, Shakti Ramkissoon, James Suh, Julia A. Elvin, Samuel Chiacchia, Garrett M. Frampton, Jeffrey S. Ross, Vincent Miller, Philip J. Stephens, Doron Lipson
Journal: Cancer Research
Series: Author Choice
Cancer Res (2017) 77 (9): 2464–2475.
DOI: https://doi.org/10.1158/0008-5472.CAN-16-2479
Published: 30 April 2017
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Genomic Profiling of a Large Set of Diverse Pediatric Cancers Identifies Known and Novel Mutations across Tumor Spectra

Juliann Chmielecki, Mark Bailey, Jie He, Julia Elvin, Jo-Anne Vergilio, Shakti Ramkissoon, James Suh, Garrett M. Frampton, James X. Sun, Samantha Morley, Daniel Spritz, Siraj Ali, Laurie Gay, Rachel L. Erlich, Jeffrey S. Ross, Joana Buxhaku, Hilary Davies, Vinny Faso, Alexis Germain, Blair Glanville, Vincent A. Miller, Philip J. Stephens, Katherine A. Janeway, John M. Maris, Soheil Meshinchi, Trevor J. Pugh, Jack F. Shern, Doron Lipson
Journal: Cancer Research
Series: Author Choice
Cancer Res (2017) 77 (2): 509–519.
DOI: https://doi.org/10.1158/0008-5472.CAN-16-1106
Published: 16 January 2017
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Abstract LB-178: Genomic profiling of 1239 diverse pediatric cancers identifies novel discoveries across tumors

Juliann Chmielecki, Mark Bailey, Jie He, Julia Elvin, Jo-Anne Vergilio, Shakti Ramkissoon, James Suh, Garrett M. Frampton, Siraj Ali, Jeffrey Ross, Vincent A. Miller, Philip J. Stephens, Doron Lipson
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-178.
DOI: https://doi.org/10.1158/1538-7445.AM2016-LB-178
Published: 15 July 2016
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